Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WPI0_LEIDO

TriTrypDb:

LdBPK_060710.1 , LdCL_060012200 , LDHU3_06.0830

Length:

407

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0031390	Ctf18 RFC-like complex	3	5
GO:0032991	protein-containing complex	1	5
GO:0140513	nuclear protein-containing complex	2	5

Expansion

Sequence features

A0A3S7WPI0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WPI0

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	5
GO:0007062	sister chromatid cohesion	3	5
GO:0007064	mitotic sister chromatid cohesion	4	5
GO:0009987	cellular process	1	5
GO:0016043	cellular component organization	3	5
GO:0022402	cell cycle process	2	5
GO:0051276	chromosome organization	5	5
GO:0071840	cellular component organization or biogenesis	2	5
GO:1903047	mitotic cell cycle process	3	5

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	265	269	PF00656	0.723
CLV_C14_Caspase3-7	353	357	PF00656	0.595
CLV_NRD_NRD_1	148	150	PF00675	0.602
CLV_NRD_NRD_1	162	164	PF00675	0.611
CLV_NRD_NRD_1	173	175	PF00675	0.319
CLV_NRD_NRD_1	226	228	PF00675	0.530
CLV_NRD_NRD_1	230	232	PF00675	0.540
CLV_NRD_NRD_1	39	41	PF00675	0.577
CLV_NRD_NRD_1	43	45	PF00675	0.547
CLV_NRD_NRD_1	48	50	PF00675	0.540
CLV_PCSK_FUR_1	44	48	PF00082	0.557
CLV_PCSK_KEX2_1	148	150	PF00082	0.602
CLV_PCSK_KEX2_1	162	164	PF00082	0.675
CLV_PCSK_KEX2_1	173	175	PF00082	0.461
CLV_PCSK_KEX2_1	193	195	PF00082	0.254
CLV_PCSK_KEX2_1	212	214	PF00082	0.232
CLV_PCSK_KEX2_1	230	232	PF00082	0.449
CLV_PCSK_KEX2_1	342	344	PF00082	0.689
CLV_PCSK_KEX2_1	38	40	PF00082	0.582
CLV_PCSK_KEX2_1	43	45	PF00082	0.538
CLV_PCSK_KEX2_1	46	48	PF00082	0.541
CLV_PCSK_PC1ET2_1	193	195	PF00082	0.321
CLV_PCSK_PC1ET2_1	212	214	PF00082	0.227
CLV_PCSK_PC1ET2_1	342	344	PF00082	0.689
CLV_PCSK_PC7_1	189	195	PF00082	0.321
CLV_PCSK_PC7_1	208	214	PF00082	0.227
CLV_PCSK_PC7_1	39	45	PF00082	0.580
CLV_PCSK_SKI1_1	240	244	PF00082	0.672
CLV_PCSK_SKI1_1	246	250	PF00082	0.679
CLV_PCSK_SKI1_1	33	37	PF00082	0.529
DEG_Nend_Nbox_1	1	3	PF02207	0.539
DEG_SCF_FBW7_1	272	279	PF00400	0.552
DEG_SPOP_SBC_1	137	141	PF00917	0.669
DEG_SPOP_SBC_1	75	79	PF00917	0.615
DOC_MAPK_gen_1	173	180	PF00069	0.331
DOC_MAPK_gen_1	193	199	PF00069	0.254
DOC_MAPK_gen_1	212	218	PF00069	0.227
DOC_MAPK_MEF2A_6	173	182	PF00069	0.394
DOC_MAPK_RevD_3	180	194	PF00069	0.320
DOC_PP4_FxxP_1	211	214	PF00568	0.385
DOC_USP7_MATH_1	136	140	PF00917	0.696
DOC_USP7_MATH_1	142	146	PF00917	0.639
DOC_USP7_MATH_1	169	173	PF00917	0.342
DOC_USP7_MATH_1	318	322	PF00917	0.670
DOC_USP7_MATH_1	325	329	PF00917	0.680
DOC_USP7_MATH_1	51	55	PF00917	0.628
DOC_USP7_MATH_1	76	80	PF00917	0.597
DOC_WW_Pin1_4	149	154	PF00397	0.662
DOC_WW_Pin1_4	157	162	PF00397	0.627
DOC_WW_Pin1_4	165	170	PF00397	0.265
DOC_WW_Pin1_4	219	224	PF00397	0.385
DOC_WW_Pin1_4	268	273	PF00397	0.640
DOC_WW_Pin1_4	358	363	PF00397	0.665
LIG_14-3-3_CanoR_1	148	153	PF00244	0.669
LIG_14-3-3_CanoR_1	194	198	PF00244	0.370
LIG_14-3-3_CanoR_1	208	212	PF00244	0.271
LIG_Actin_WH2_2	15	32	PF00022	0.489
LIG_AP2alpha_1	299	303	PF02296	0.636
LIG_BRCT_BRCA1_1	394	398	PF00533	0.408
LIG_CtBP_PxDLS_1	71	75	PF00389	0.544
LIG_eIF4E_1	383	389	PF01652	0.429
LIG_FHA_1	194	200	PF00498	0.385
LIG_FHA_1	276	282	PF00498	0.662
LIG_FHA_2	351	357	PF00498	0.639
LIG_FHA_2	63	69	PF00498	0.614
LIG_FHA_2	96	102	PF00498	0.657
LIG_LIR_Apic_2	209	214	PF02991	0.383
LIG_LIR_Gen_1	385	392	PF02991	0.550
LIG_LIR_Nem_3	381	386	PF02991	0.627
LIG_Pex14_2	211	215	PF04695	0.385
LIG_Pex14_2	299	303	PF04695	0.636
LIG_SH2_NCK_1	386	390	PF00017	0.453
LIG_SH3_1	163	169	PF00018	0.643
LIG_SH3_2	158	163	PF14604	0.622
LIG_SH3_3	150	156	PF00018	0.668
LIG_SH3_3	158	164	PF00018	0.633
LIG_SH3_3	175	181	PF00018	0.220
LIG_SH3_3	230	236	PF00018	0.497
LIG_SH3_3	239	245	PF00018	0.532
LIG_SH3_3	356	362	PF00018	0.772
LIG_UBA3_1	15	21	PF00899	0.537
MOD_CDC14_SPxK_1	160	163	PF00782	0.622
MOD_CDK_SPK_2	157	162	PF00069	0.625
MOD_CDK_SPxK_1	157	163	PF00069	0.624
MOD_CDK_SPxK_1	219	225	PF00069	0.385
MOD_CK1_1	127	133	PF00069	0.606
MOD_CK1_1	157	163	PF00069	0.606
MOD_CK1_1	207	213	PF00069	0.385
MOD_CK1_1	294	300	PF00069	0.618
MOD_CK1_1	328	334	PF00069	0.679
MOD_CK1_1	361	367	PF00069	0.617
MOD_CK1_1	79	85	PF00069	0.622
MOD_CK1_1	87	93	PF00069	0.561
MOD_CK1_1	94	100	PF00069	0.557
MOD_CK2_1	39	45	PF00069	0.558
MOD_DYRK1A_RPxSP_1	165	169	PF00069	0.342
MOD_GlcNHglycan	129	132	PF01048	0.624
MOD_GlcNHglycan	140	143	PF01048	0.625
MOD_GlcNHglycan	144	147	PF01048	0.587
MOD_GlcNHglycan	169	172	PF01048	0.356
MOD_GlcNHglycan	265	268	PF01048	0.592
MOD_GlcNHglycan	309	314	PF01048	0.701
MOD_GlcNHglycan	320	323	PF01048	0.624
MOD_GlcNHglycan	325	328	PF01048	0.600
MOD_GlcNHglycan	330	333	PF01048	0.624
MOD_GlcNHglycan	366	369	PF01048	0.661
MOD_GlcNHglycan	372	375	PF01048	0.579
MOD_GlcNHglycan	53	56	PF01048	0.611
MOD_GlcNHglycan	82	85	PF01048	0.588
MOD_GSK3_1	123	130	PF00069	0.614
MOD_GSK3_1	138	145	PF00069	0.582
MOD_GSK3_1	165	172	PF00069	0.335
MOD_GSK3_1	268	275	PF00069	0.687
MOD_GSK3_1	276	283	PF00069	0.655
MOD_GSK3_1	314	321	PF00069	0.631
MOD_GSK3_1	323	330	PF00069	0.596
MOD_GSK3_1	366	373	PF00069	0.651
MOD_GSK3_1	374	381	PF00069	0.509
MOD_GSK3_1	70	77	PF00069	0.637
MOD_GSK3_1	79	86	PF00069	0.581
MOD_GSK3_1	87	94	PF00069	0.519
MOD_NEK2_1	397	402	PF00069	0.529
MOD_NEK2_2	198	203	PF00069	0.385
MOD_PKA_1	148	154	PF00069	0.572
MOD_PKA_1	193	199	PF00069	0.320
MOD_PKA_1	38	44	PF00069	0.567
MOD_PKA_2	147	153	PF00069	0.641
MOD_PKA_2	193	199	PF00069	0.326
MOD_PKA_2	207	213	PF00069	0.271
MOD_PKA_2	38	44	PF00069	0.567
MOD_PKA_2	392	398	PF00069	0.413
MOD_PKA_2	88	94	PF00069	0.613
MOD_Plk_1	276	282	PF00069	0.653
MOD_Plk_4	276	282	PF00069	0.653
MOD_Plk_4	294	300	PF00069	0.618
MOD_Plk_4	378	384	PF00069	0.615
MOD_Plk_4	392	398	PF00069	0.447
MOD_Plk_4	70	76	PF00069	0.537
MOD_ProDKin_1	149	155	PF00069	0.664
MOD_ProDKin_1	157	163	PF00069	0.626
MOD_ProDKin_1	165	171	PF00069	0.265
MOD_ProDKin_1	219	225	PF00069	0.385
MOD_ProDKin_1	268	274	PF00069	0.638
MOD_ProDKin_1	358	364	PF00069	0.666
TRG_DiLeu_BaEn_1	244	249	PF01217	0.639
TRG_ENDOCYTIC_2	386	389	PF00928	0.587
TRG_ER_diArg_1	147	149	PF00400	0.585
TRG_ER_diArg_1	161	163	PF00400	0.599
TRG_ER_diArg_1	229	231	PF00400	0.548
TRG_ER_diArg_1	38	40	PF00400	0.582
TRG_ER_diArg_1	46	49	PF00400	0.542
TRG_NLS_Bipartite_1	212	231	PF00514	0.342
TRG_NLS_MonoExtC_3	226	231	PF00514	0.539
TRG_NLS_MonoExtN_4	225	231	PF00514	0.532
TRG_Pf-PMV_PEXEL_1	227	232	PF00026	0.556

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4H4N4	Leishmania braziliensis	61%	93%
A4HSW0	Leishmania infantum	97%	99%
E9AKU8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	99%
Q4QJ09	Leishmania major	88%	99%