dUTPase family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

deoxyuridine triphosphatase, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WPH8_LEIDO

TriTrypDb:

LdBPK_060580.1 , LdCL_060010900 , LDHU3_06.0680

Length:

268

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7WPH8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WPH8

PDB structure(s): 2cje_A , 2yay_A , 2yaz_A , 2yaz_B , 2yaz_D , 2yaz_E , 2yb0_A , 2yb0_B , 2yb0_D , 2yb0_E

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	8
GO:0004170	dUTP diphosphatase activity	7	8
GO:0016462	pyrophosphatase activity	5	8
GO:0016787	hydrolase activity	2	8
GO:0016817	hydrolase activity, acting on acid anhydrides	3	8
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	8
GO:0047429	nucleoside triphosphate diphosphatase activity	6	8
GO:0005488	binding	1	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	19	23	PF00656	0.513
CLV_C14_Caspase3-7	220	224	PF00656	0.556
CLV_C14_Caspase3-7	248	252	PF00656	0.598
CLV_C14_Caspase3-7	51	55	PF00656	0.428
CLV_NRD_NRD_1	248	250	PF00675	0.545
CLV_PCSK_KEX2_1	2	4	PF00082	0.787
CLV_PCSK_PC1ET2_1	2	4	PF00082	0.818
CLV_PCSK_SKI1_1	105	109	PF00082	0.489
DEG_APCC_DBOX_1	73	81	PF00400	0.496
DEG_APCC_KENBOX_2	259	263	PF00400	0.587
DEG_Nend_UBRbox_1	1	4	PF02207	0.762
DEG_SCF_FBW7_2	91	98	PF00400	0.575
DOC_PP4_FxxP_1	103	106	PF00568	0.533
DOC_SPAK_OSR1_1	153	157	PF12202	0.549
DOC_USP7_MATH_1	138	142	PF00917	0.512
DOC_USP7_MATH_1	230	234	PF00917	0.567
DOC_USP7_MATH_1	34	38	PF00917	0.537
DOC_WW_Pin1_4	64	69	PF00397	0.513
DOC_WW_Pin1_4	91	96	PF00397	0.575
LIG_14-3-3_CanoR_1	3	10	PF00244	0.659
LIG_14-3-3_CanoR_1	33	39	PF00244	0.513
LIG_FHA_1	110	116	PF00498	0.578
LIG_FHA_1	48	54	PF00498	0.532
LIG_FHA_1	65	71	PF00498	0.561
LIG_FHA_2	92	98	PF00498	0.551
LIG_LIR_Gen_1	167	178	PF02991	0.405
LIG_LIR_Gen_1	193	203	PF02991	0.576
LIG_LIR_Nem_3	122	128	PF02991	0.467
LIG_LIR_Nem_3	141	145	PF02991	0.296
LIG_LIR_Nem_3	167	173	PF02991	0.405
LIG_LIR_Nem_3	193	199	PF02991	0.549
LIG_LIR_Nem_3	253	258	PF02991	0.599
LIG_LYPXL_SIV_4	174	182	PF13949	0.485
LIG_PCNA_yPIPBox_3	21	33	PF02747	0.476
LIG_PCNA_yPIPBox_3	226	239	PF02747	0.588
LIG_PDZ_Class_2	263	268	PF00595	0.733
LIG_SH2_CRK	125	129	PF00017	0.498
LIG_SH2_PTP2	196	199	PF00017	0.509
LIG_SH2_STAT5	176	179	PF00017	0.428
LIG_SH2_STAT5	196	199	PF00017	0.339
LIG_SH2_STAT5	227	230	PF00017	0.514
LIG_SH3_3	125	131	PF00018	0.575
LIG_TRAF2_1	217	220	PF00917	0.485
LIG_WRC_WIRS_1	111	116	PF05994	0.549
LIG_WRC_WIRS_1	139	144	PF05994	0.428
MOD_CK2_1	13	19	PF00069	0.513
MOD_CK2_1	214	220	PF00069	0.649
MOD_CMANNOS	58	61	PF00535	0.428
MOD_GlcNHglycan	188	191	PF01048	0.506
MOD_GlcNHglycan	5	8	PF01048	0.664
MOD_GlcNHglycan	85	88	PF01048	0.421
MOD_GSK3_1	43	50	PF00069	0.451
MOD_N-GLC_1	64	69	PF02516	0.513
MOD_NEK2_1	132	137	PF00069	0.458
MOD_NEK2_1	52	57	PF00069	0.428
MOD_NEK2_1	81	86	PF00069	0.428
MOD_NEK2_2	138	143	PF00069	0.444
MOD_PIKK_1	132	138	PF00454	0.549
MOD_Plk_1	214	220	PF00069	0.587
MOD_Plk_4	110	116	PF00069	0.498
MOD_Plk_4	157	163	PF00069	0.468
MOD_Plk_4	192	198	PF00069	0.561
MOD_Plk_4	230	236	PF00069	0.526
MOD_ProDKin_1	64	70	PF00069	0.513
MOD_ProDKin_1	91	97	PF00069	0.575
MOD_SUMO_rev_2	246	252	PF00179	0.611
TRG_DiLeu_BaEn_1	204	209	PF01217	0.481
TRG_DiLeu_BaEn_1	48	53	PF01217	0.428
TRG_ENDOCYTIC_2	125	128	PF00928	0.545
TRG_ENDOCYTIC_2	196	199	PF00928	0.509
TRG_ENDOCYTIC_2	239	242	PF00928	0.535
TRG_Pf-PMV_PEXEL_1	105	109	PF00026	0.485

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDS6	Leptomonas seymouri	76%	100%
A0A0S4J015	Bodo saltans	54%	100%
A0A1X0NL80	Trypanosomatidae	56%	95%
A0A422NGY7	Trypanosoma rangeli	47%	97%
A4H4M2	Leishmania braziliensis	82%	100%
A4HSU8	Leishmania infantum	100%	100%
C9ZTF8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	93%
E9AKT5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
O15826	Leishmania major	97%	100%
V5BXQ7	Trypanosoma cruzi	51%	95%