Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WPG5_LEIDO

TriTrypDb:

LdBPK_060550.1 , LdCL_060010600 , LDHU3_06.0650

Length:

293

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WPG5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WPG5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	205	207	PF00675	0.639
CLV_PCSK_KEX2_1	205	207	PF00082	0.625
CLV_PCSK_KEX2_1	96	98	PF00082	0.523
CLV_PCSK_PC1ET2_1	96	98	PF00082	0.523
CLV_PCSK_SKI1_1	163	167	PF00082	0.687
CLV_PCSK_SKI1_1	93	97	PF00082	0.589
DOC_CKS1_1	231	236	PF01111	0.432
DOC_CYCLIN_RxL_1	237	246	PF00134	0.543
DOC_PP1_RVXF_1	238	245	PF00149	0.402
DOC_PP2B_LxvP_1	35	38	PF13499	0.544
DOC_USP7_MATH_1	12	16	PF00917	0.711
DOC_USP7_MATH_1	128	132	PF00917	0.763
DOC_USP7_MATH_1	146	150	PF00917	0.666
DOC_USP7_MATH_1	188	192	PF00917	0.713
DOC_USP7_MATH_1	5	9	PF00917	0.704
DOC_USP7_MATH_1	57	61	PF00917	0.614
DOC_USP7_MATH_1	76	80	PF00917	0.598
DOC_WW_Pin1_4	136	141	PF00397	0.715
DOC_WW_Pin1_4	158	163	PF00397	0.688
DOC_WW_Pin1_4	230	235	PF00397	0.431
DOC_WW_Pin1_4	40	45	PF00397	0.645
LIG_14-3-3_CanoR_1	156	165	PF00244	0.658
LIG_14-3-3_CanoR_1	169	175	PF00244	0.487
LIG_14-3-3_CanoR_1	286	291	PF00244	0.564
LIG_14-3-3_CanoR_1	83	91	PF00244	0.620
LIG_BIR_II_1	1	5	PF00653	0.672
LIG_BRCT_BRCA1_1	2	6	PF00533	0.752
LIG_BRCT_BRCA1_1	288	292	PF00533	0.642
LIG_CSL_BTD_1	218	221	PF09270	0.410
LIG_CSL_BTD_1	231	234	PF09270	0.408
LIG_deltaCOP1_diTrp_1	235	244	PF00928	0.407
LIG_FHA_1	168	174	PF00498	0.634
LIG_FHA_1	17	23	PF00498	0.707
LIG_FHA_1	231	237	PF00498	0.434
LIG_FHA_1	28	34	PF00498	0.574
LIG_HCF-1_HBM_1	246	249	PF13415	0.485
LIG_LIR_Gen_1	246	256	PF02991	0.389
LIG_LIR_Nem_3	210	214	PF02991	0.634
LIG_LIR_Nem_3	246	252	PF02991	0.396
LIG_REV1ctd_RIR_1	88	97	PF16727	0.548
LIG_SH2_CRK	249	253	PF00017	0.442
LIG_SH2_NCK_1	69	73	PF00017	0.505
LIG_SH2_SRC	69	72	PF00017	0.563
LIG_SH2_STAP1	270	274	PF00017	0.438
LIG_SH2_STAP1	80	84	PF00017	0.470
LIG_SH2_STAT5	153	156	PF00017	0.685
LIG_SH2_STAT5	243	246	PF00017	0.529
LIG_SH3_3	191	197	PF00018	0.683
LIG_SH3_3	41	47	PF00018	0.662
LIG_SUMO_SIM_anti_2	227	233	PF11976	0.554
LIG_SUMO_SIM_par_1	227	233	PF11976	0.469
LIG_TRAF2_1	139	142	PF00917	0.665
LIG_UBA3_1	33	39	PF00899	0.594
MOD_CAAXbox	290	293	PF01239	0.657
MOD_CDK_SPK_2	158	163	PF00069	0.631
MOD_CK1_1	15	21	PF00069	0.622
MOD_CK1_1	179	185	PF00069	0.724
MOD_CK1_1	43	49	PF00069	0.719
MOD_CK1_1	7	13	PF00069	0.661
MOD_CK2_1	136	142	PF00069	0.678
MOD_CMANNOS	219	222	PF00535	0.487
MOD_GlcNHglycan	148	151	PF01048	0.652
MOD_GlcNHglycan	15	18	PF01048	0.660
MOD_GlcNHglycan	170	173	PF01048	0.586
MOD_GlcNHglycan	188	191	PF01048	0.651
MOD_GlcNHglycan	7	10	PF01048	0.673
MOD_GlcNHglycan	85	88	PF01048	0.602
MOD_GSK3_1	101	108	PF00069	0.593
MOD_GSK3_1	111	118	PF00069	0.662
MOD_GSK3_1	12	19	PF00069	0.675
MOD_N-GLC_1	12	17	PF02516	0.746
MOD_N-GLC_1	128	133	PF02516	0.645
MOD_NEK2_1	252	257	PF00069	0.432
MOD_PIKK_1	156	162	PF00454	0.661
MOD_PIKK_1	176	182	PF00454	0.424
MOD_PKA_2	168	174	PF00069	0.498
MOD_PKA_2	252	258	PF00069	0.447
MOD_PKA_2	280	286	PF00069	0.654
MOD_PKB_1	284	292	PF00069	0.642
MOD_Plk_4	198	204	PF00069	0.564
MOD_Plk_4	207	213	PF00069	0.524
MOD_Plk_4	224	230	PF00069	0.464
MOD_ProDKin_1	136	142	PF00069	0.711
MOD_ProDKin_1	158	164	PF00069	0.688
MOD_ProDKin_1	230	236	PF00069	0.432
MOD_ProDKin_1	40	46	PF00069	0.637
MOD_SUMO_for_1	165	168	PF00179	0.685
TRG_ENDOCYTIC_2	249	252	PF00928	0.396
TRG_ER_diArg_1	204	206	PF00400	0.645
TRG_Pf-PMV_PEXEL_1	97	102	PF00026	0.633

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6B6	Leptomonas seymouri	69%	96%
A0A0S4J612	Bodo saltans	31%	100%
A0A1X0NKM4	Trypanosomatidae	43%	97%
A0A422NGX7	Trypanosoma rangeli	42%	100%
A4H4L9	Leishmania braziliensis	81%	100%
A4HSU5	Leishmania infantum	99%	100%
C9ZTF5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9AKT2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4QJ25	Leishmania major	92%	100%
V5B7V6	Trypanosoma cruzi	45%	100%