Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WPF9_LEIDO

TriTrypDb:

LdBPK_060510.1 , LdCL_060010200 , LDHU3_06.0610

Length:

486

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WPF9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WPF9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	304	308	PF00656	0.525
CLV_C14_Caspase3-7	395	399	PF00656	0.483
CLV_NRD_NRD_1	37	39	PF00675	0.564
CLV_NRD_NRD_1	425	427	PF00675	0.481
CLV_NRD_NRD_1	462	464	PF00675	0.506
CLV_NRD_NRD_1	5	7	PF00675	0.587
CLV_PCSK_KEX2_1	266	268	PF00082	0.528
CLV_PCSK_KEX2_1	37	39	PF00082	0.579
CLV_PCSK_KEX2_1	425	427	PF00082	0.481
CLV_PCSK_PC1ET2_1	266	268	PF00082	0.528
CLV_PCSK_SKI1_1	123	127	PF00082	0.456
CLV_PCSK_SKI1_1	266	270	PF00082	0.510
CLV_PCSK_SKI1_1	28	32	PF00082	0.720
CLV_PCSK_SKI1_1	282	286	PF00082	0.527
CLV_PCSK_SKI1_1	344	348	PF00082	0.580
CLV_PCSK_SKI1_1	378	382	PF00082	0.532
CLV_PCSK_SKI1_1	470	474	PF00082	0.522
DEG_APCC_DBOX_1	362	370	PF00400	0.552
DEG_SCF_FBW7_1	18	24	PF00400	0.635
DEG_SCF_FBW7_1	97	104	PF00400	0.425
DOC_ANK_TNKS_1	56	63	PF00023	0.407
DOC_CKS1_1	18	23	PF01111	0.636
DOC_CKS1_1	278	283	PF01111	0.503
DOC_CKS1_1	362	367	PF01111	0.548
DOC_CKS1_1	98	103	PF01111	0.427
DOC_CYCLIN_RxL_1	120	128	PF00134	0.443
DOC_CYCLIN_yCln2_LP_2	65	71	PF00134	0.479
DOC_MAPK_DCC_7	215	225	PF00069	0.472
DOC_MAPK_gen_1	246	255	PF00069	0.470
DOC_MAPK_gen_1	37	44	PF00069	0.535
DOC_MAPK_MEF2A_6	246	255	PF00069	0.514
DOC_MAPK_MEF2A_6	296	305	PF00069	0.490
DOC_PP1_RVXF_1	121	128	PF00149	0.445
DOC_PP1_RVXF_1	194	200	PF00149	0.402
DOC_PP1_RVXF_1	244	251	PF00149	0.479
DOC_PP1_RVXF_1	318	324	PF00149	0.630
DOC_PP2B_LxvP_1	253	256	PF13499	0.547
DOC_PP2B_LxvP_1	303	306	PF13499	0.579
DOC_PP2B_LxvP_1	65	68	PF13499	0.477
DOC_PP4_FxxP_1	367	370	PF00568	0.558
DOC_USP7_MATH_1	116	120	PF00917	0.441
DOC_USP7_MATH_1	162	166	PF00917	0.413
DOC_USP7_MATH_1	189	193	PF00917	0.586
DOC_USP7_MATH_1	21	25	PF00917	0.734
DOC_USP7_MATH_1	386	390	PF00917	0.641
DOC_USP7_UBL2_3	460	464	PF12436	0.581
DOC_WW_Pin1_4	145	150	PF00397	0.466
DOC_WW_Pin1_4	17	22	PF00397	0.724
DOC_WW_Pin1_4	266	271	PF00397	0.512
DOC_WW_Pin1_4	277	282	PF00397	0.526
DOC_WW_Pin1_4	361	366	PF00397	0.526
DOC_WW_Pin1_4	97	102	PF00397	0.431
LIG_14-3-3_CanoR_1	123	128	PF00244	0.457
LIG_14-3-3_CanoR_1	313	323	PF00244	0.513
LIG_14-3-3_CanoR_1	344	354	PF00244	0.505
LIG_14-3-3_CanoR_1	438	442	PF00244	0.650
LIG_AP2alpha_1	402	406	PF02296	0.483
LIG_BIR_II_1	1	5	PF00653	0.564
LIG_BRCT_BRCA1_1	147	151	PF00533	0.449
LIG_BRCT_BRCA1_1	467	471	PF00533	0.555
LIG_FHA_1	198	204	PF00498	0.408
LIG_FHA_1	300	306	PF00498	0.537
LIG_FHA_1	329	335	PF00498	0.524
LIG_FHA_1	94	100	PF00498	0.456
LIG_FHA_2	224	230	PF00498	0.503
LIG_FHA_2	278	284	PF00498	0.519
LIG_FHA_2	302	308	PF00498	0.528
LIG_LIR_Apic_2	364	370	PF02991	0.535
LIG_LIR_Gen_1	126	134	PF02991	0.483
LIG_LIR_Gen_1	247	258	PF02991	0.600
LIG_LIR_Gen_1	389	399	PF02991	0.570
LIG_LIR_Nem_3	126	130	PF02991	0.482
LIG_LIR_Nem_3	206	210	PF02991	0.399
LIG_LIR_Nem_3	247	253	PF02991	0.599
LIG_LIR_Nem_3	295	301	PF02991	0.506
LIG_LIR_Nem_3	389	394	PF02991	0.577
LIG_LIR_Nem_3	440	444	PF02991	0.641
LIG_LIR_Nem_3	468	472	PF02991	0.561
LIG_Pex14_2	264	268	PF04695	0.542
LIG_Pex14_2	343	347	PF04695	0.582
LIG_Pex14_2	402	406	PF04695	0.483
LIG_SH2_CRK	362	366	PF00017	0.526
LIG_SH2_PTP2	476	479	PF00017	0.537
LIG_SH2_STAT3	45	48	PF00017	0.642
LIG_SH2_STAT5	207	210	PF00017	0.398
LIG_SH2_STAT5	337	340	PF00017	0.504
LIG_SH2_STAT5	45	48	PF00017	0.584
LIG_SH2_STAT5	476	479	PF00017	0.539
LIG_SH2_STAT5	58	61	PF00017	0.310
LIG_SH3_3	110	116	PF00018	0.447
LIG_SH3_3	12	18	PF00018	0.635
LIG_SH3_3	253	259	PF00018	0.479
LIG_SH3_3	95	101	PF00018	0.438
LIG_SUMO_SIM_anti_2	274	280	PF11976	0.474
LIG_SUMO_SIM_par_1	274	280	PF11976	0.474
LIG_SUMO_SIM_par_1	301	307	PF11976	0.540
LIG_SUMO_SIM_par_1	95	100	PF11976	0.440
LIG_TRAF2_1	226	229	PF00917	0.513
LIG_TYR_ITIM	439	444	PF00017	0.665
LIG_WRC_WIRS_1	124	129	PF05994	0.467
LIG_WW_2	256	259	PF00397	0.480
MOD_CDK_SPK_2	277	282	PF00069	0.491
MOD_CK1_1	114	120	PF00069	0.466
MOD_CK1_1	316	322	PF00069	0.551
MOD_CK1_1	437	443	PF00069	0.646
MOD_CK2_1	223	229	PF00069	0.508
MOD_Cter_Amidation	4	7	PF01082	0.710
MOD_GlcNHglycan	116	119	PF01048	0.450
MOD_GlcNHglycan	160	163	PF01048	0.492
MOD_GlcNHglycan	191	194	PF01048	0.541
MOD_GlcNHglycan	200	203	PF01048	0.443
MOD_GlcNHglycan	23	26	PF01048	0.732
MOD_GlcNHglycan	331	334	PF01048	0.567
MOD_GlcNHglycan	357	360	PF01048	0.546
MOD_GlcNHglycan	8	11	PF01048	0.565
MOD_GSK3_1	158	165	PF00069	0.495
MOD_GSK3_1	17	24	PF00069	0.627
MOD_GSK3_1	240	247	PF00069	0.620
MOD_GSK3_1	284	291	PF00069	0.543
MOD_GSK3_1	394	401	PF00069	0.559
MOD_GSK3_1	404	411	PF00069	0.547
MOD_GSK3_1	93	100	PF00069	0.448
MOD_N-GLC_1	111	116	PF02516	0.467
MOD_N-GLC_1	299	304	PF02516	0.524
MOD_N-GLC_1	352	357	PF02516	0.662
MOD_NEK2_1	111	116	PF00069	0.492
MOD_NEK2_1	244	249	PF00069	0.559
MOD_NEK2_1	292	297	PF00069	0.550
MOD_NEK2_1	314	319	PF00069	0.527
MOD_NEK2_1	328	333	PF00069	0.517
MOD_NEK2_1	354	359	PF00069	0.533
MOD_NEK2_1	408	413	PF00069	0.539
MOD_NEK2_2	284	289	PF00069	0.518
MOD_NEK2_2	386	391	PF00069	0.641
MOD_OFUCOSY	167	174	PF10250	0.405
MOD_PIKK_1	101	107	PF00454	0.329
MOD_PIKK_1	269	275	PF00454	0.485
MOD_PIKK_1	51	57	PF00454	0.504
MOD_PIKK_1	85	91	PF00454	0.567
MOD_PKA_1	6	12	PF00069	0.563
MOD_PKA_2	197	203	PF00069	0.405
MOD_PKA_2	240	246	PF00069	0.574
MOD_PKA_2	288	294	PF00069	0.521
MOD_PKA_2	437	443	PF00069	0.640
MOD_PKA_2	93	99	PF00069	0.453
MOD_PKB_1	196	204	PF00069	0.410
MOD_Plk_1	111	117	PF00069	0.470
MOD_Plk_1	221	227	PF00069	0.500
MOD_Plk_1	299	305	PF00069	0.526
MOD_Plk_2-3	398	404	PF00069	0.555
MOD_Plk_4	116	122	PF00069	0.432
MOD_Plk_4	147	153	PF00069	0.440
MOD_Plk_4	288	294	PF00069	0.522
MOD_Plk_4	338	344	PF00069	0.501
MOD_Plk_4	437	443	PF00069	0.599
MOD_Plk_4	475	481	PF00069	0.500
MOD_Plk_4	93	99	PF00069	0.453
MOD_ProDKin_1	145	151	PF00069	0.460
MOD_ProDKin_1	17	23	PF00069	0.724
MOD_ProDKin_1	266	272	PF00069	0.513
MOD_ProDKin_1	277	283	PF00069	0.533
MOD_ProDKin_1	361	367	PF00069	0.529
MOD_ProDKin_1	97	103	PF00069	0.426
MOD_SUMO_for_1	157	160	PF00179	0.384
MOD_SUMO_rev_2	277	287	PF00179	0.523
TRG_ENDOCYTIC_2	207	210	PF00928	0.398
TRG_ENDOCYTIC_2	441	444	PF00928	0.665
TRG_ENDOCYTIC_2	476	479	PF00928	0.537
TRG_ENDOCYTIC_2	58	61	PF00928	0.364
TRG_ER_diArg_1	195	198	PF00400	0.414
TRG_ER_diArg_1	425	427	PF00400	0.481
TRG_NLS_MonoExtC_3	462	467	PF00514	0.579
TRG_NLS_MonoExtN_4	460	467	PF00514	0.579
TRG_Pf-PMV_PEXEL_1	123	128	PF00026	0.457
TRG_Pf-PMV_PEXEL_1	470	474	PF00026	0.539

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I218	Leptomonas seymouri	89%	84%
A0A0S4KH91	Bodo saltans	72%	91%
A0A1X0NLE5	Trypanosomatidae	74%	80%
A0A3S5IR64	Trypanosoma rangeli	81%	83%
A4H4L5	Leishmania braziliensis	94%	100%
A4HSU1	Leishmania infantum	100%	100%
C9ZTF3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	75%	85%
E9AKS8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
Q4QJ29	Leishmania major	99%	100%