TPR_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WPE9_LEIDO

TriTrypDb:

LdBPK_060460.1 , LdCL_060009700 , LDHU3_06.0560

Length:

994

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

A0A3S7WPE9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WPE9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	483	487	PF00656	0.539
CLV_C14_Caspase3-7	605	609	PF00656	0.632
CLV_C14_Caspase3-7	922	926	PF00656	0.639
CLV_C14_Caspase3-7	944	948	PF00656	0.667
CLV_NRD_NRD_1	293	295	PF00675	0.535
CLV_NRD_NRD_1	296	298	PF00675	0.507
CLV_NRD_NRD_1	413	415	PF00675	0.534
CLV_NRD_NRD_1	659	661	PF00675	0.824
CLV_PCSK_FUR_1	294	298	PF00082	0.514
CLV_PCSK_KEX2_1	292	294	PF00082	0.531
CLV_PCSK_KEX2_1	296	298	PF00082	0.497
CLV_PCSK_KEX2_1	413	415	PF00082	0.534
CLV_PCSK_KEX2_1	655	657	PF00082	0.766
CLV_PCSK_KEX2_1	770	772	PF00082	0.625
CLV_PCSK_PC1ET2_1	655	657	PF00082	0.681
CLV_PCSK_PC1ET2_1	770	772	PF00082	0.625
CLV_PCSK_PC7_1	292	298	PF00082	0.514
CLV_PCSK_PC7_1	651	657	PF00082	0.662
CLV_PCSK_SKI1_1	234	238	PF00082	0.433
CLV_PCSK_SKI1_1	25	29	PF00082	0.635
CLV_PCSK_SKI1_1	413	417	PF00082	0.513
CLV_PCSK_SKI1_1	426	430	PF00082	0.554
CLV_PCSK_SKI1_1	803	807	PF00082	0.601
CLV_PCSK_SKI1_1	929	933	PF00082	0.682
CLV_Separin_Metazoa	187	191	PF03568	0.502
DEG_APCC_DBOX_1	24	32	PF00400	0.634
DEG_APCC_DBOX_1	429	437	PF00400	0.646
DEG_APCC_DBOX_1	928	936	PF00400	0.655
DEG_Nend_Nbox_1	1	3	PF02207	0.700
DEG_SCF_FBW7_2	133	140	PF00400	0.520
DEG_SPOP_SBC_1	546	550	PF00917	0.592
DEG_SPOP_SBC_1	814	818	PF00917	0.626
DEG_SPOP_SBC_1	918	922	PF00917	0.643
DEG_SPOP_SBC_1	973	977	PF00917	0.680
DOC_CKS1_1	134	139	PF01111	0.516
DOC_CKS1_1	840	845	PF01111	0.634
DOC_CYCLIN_yCln2_LP_2	429	435	PF00134	0.660
DOC_CYCLIN_yCln2_LP_2	87	93	PF00134	0.623
DOC_MAPK_MEF2A_6	464	471	PF00069	0.464
DOC_MAPK_MEF2A_6	703	710	PF00069	0.723
DOC_PP2B_LxvP_1	429	432	PF13499	0.579
DOC_PP2B_LxvP_1	75	78	PF13499	0.664
DOC_PP2B_LxvP_1	807	810	PF13499	0.560
DOC_PP2B_LxvP_1	823	826	PF13499	0.671
DOC_PP2B_LxvP_1	87	90	PF13499	0.643
DOC_PP4_FxxP_1	207	210	PF00568	0.485
DOC_PP4_FxxP_1	883	886	PF00568	0.651
DOC_USP7_MATH_1	162	166	PF00917	0.416
DOC_USP7_MATH_1	253	257	PF00917	0.390
DOC_USP7_MATH_1	368	372	PF00917	0.513
DOC_USP7_MATH_1	37	41	PF00917	0.662
DOC_USP7_MATH_1	517	521	PF00917	0.739
DOC_USP7_MATH_1	546	550	PF00917	0.609
DOC_USP7_MATH_1	606	610	PF00917	0.636
DOC_USP7_MATH_1	671	675	PF00917	0.729
DOC_USP7_MATH_1	776	780	PF00917	0.757
DOC_USP7_MATH_1	78	82	PF00917	0.698
DOC_USP7_MATH_1	794	798	PF00917	0.683
DOC_USP7_MATH_1	917	921	PF00917	0.626
DOC_USP7_MATH_1	974	978	PF00917	0.769
DOC_USP7_MATH_1	986	990	PF00917	0.562
DOC_USP7_MATH_2	822	828	PF00917	0.657
DOC_USP7_UBL2_3	529	533	PF12436	0.678
DOC_WW_Pin1_4	133	138	PF00397	0.564
DOC_WW_Pin1_4	175	180	PF00397	0.689
DOC_WW_Pin1_4	251	256	PF00397	0.449
DOC_WW_Pin1_4	33	38	PF00397	0.729
DOC_WW_Pin1_4	485	490	PF00397	0.623
DOC_WW_Pin1_4	564	569	PF00397	0.685
DOC_WW_Pin1_4	630	635	PF00397	0.641
DOC_WW_Pin1_4	717	722	PF00397	0.601
DOC_WW_Pin1_4	780	785	PF00397	0.639
DOC_WW_Pin1_4	839	844	PF00397	0.693
DOC_WW_Pin1_4	85	90	PF00397	0.786
DOC_WW_Pin1_4	976	981	PF00397	0.661
LIG_14-3-3_CanoR_1	190	199	PF00244	0.469
LIG_14-3-3_CanoR_1	297	306	PF00244	0.541
LIG_14-3-3_CanoR_1	389	397	PF00244	0.445
LIG_14-3-3_CanoR_1	56	60	PF00244	0.691
LIG_14-3-3_CanoR_1	587	591	PF00244	0.712
LIG_14-3-3_CanoR_1	70	76	PF00244	0.646
LIG_14-3-3_CanoR_1	964	970	PF00244	0.674
LIG_14-3-3_CterR_2	990	994	PF00244	0.702
LIG_BIR_III_4	947	951	PF00653	0.743
LIG_CtBP_PxDLS_1	707	711	PF00389	0.664
LIG_deltaCOP1_diTrp_1	350	357	PF00928	0.461
LIG_FHA_1	17	23	PF00498	0.556
LIG_FHA_1	176	182	PF00498	0.619
LIG_FHA_1	215	221	PF00498	0.460
LIG_FHA_1	301	307	PF00498	0.613
LIG_FHA_1	329	335	PF00498	0.601
LIG_FHA_1	376	382	PF00498	0.505
LIG_FHA_1	389	395	PF00498	0.465
LIG_FHA_1	70	76	PF00498	0.598
LIG_FHA_1	794	800	PF00498	0.672
LIG_FHA_1	858	864	PF00498	0.535
LIG_FHA_1	892	898	PF00498	0.689
LIG_FHA_1	9	15	PF00498	0.614
LIG_FHA_2	744	750	PF00498	0.590
LIG_FHA_2	920	926	PF00498	0.701
LIG_FHA_2	982	988	PF00498	0.640
LIG_LIR_Apic_2	206	210	PF02991	0.492
LIG_LIR_Apic_2	555	561	PF02991	0.615
LIG_LIR_Gen_1	155	163	PF02991	0.455
LIG_LIR_Gen_1	193	204	PF02991	0.430
LIG_LIR_Nem_3	155	161	PF02991	0.538
LIG_LIR_Nem_3	193	199	PF02991	0.414
LIG_LIR_Nem_3	407	412	PF02991	0.447
LIG_LIR_Nem_3	817	823	PF02991	0.682
LIG_MYND_1	133	137	PF01753	0.560
LIG_MYND_1	839	843	PF01753	0.567
LIG_PCNA_yPIPBox_3	529	542	PF02747	0.670
LIG_Pex14_2	864	868	PF04695	0.486
LIG_PTAP_UEV_1	772	777	PF05743	0.678
LIG_SH2_CRK	158	162	PF00017	0.519
LIG_SH2_CRK	265	269	PF00017	0.381
LIG_SH2_CRK	558	562	PF00017	0.551
LIG_SH2_CRK	566	570	PF00017	0.626
LIG_SH2_GRB2like	377	380	PF00017	0.511
LIG_SH2_NCK_1	158	162	PF00017	0.459
LIG_SH2_NCK_1	566	570	PF00017	0.623
LIG_SH2_NCK_1	889	893	PF00017	0.643
LIG_SH2_NCK_1	9	13	PF00017	0.660
LIG_SH2_SRC	574	577	PF00017	0.671
LIG_SH2_SRC	593	596	PF00017	0.523
LIG_SH2_SRC	679	682	PF00017	0.563
LIG_SH2_STAP1	158	162	PF00017	0.459
LIG_SH2_STAP1	377	381	PF00017	0.506
LIG_SH2_STAP1	574	578	PF00017	0.660
LIG_SH2_STAP1	593	597	PF00017	0.524
LIG_SH2_STAT3	498	501	PF00017	0.698
LIG_SH2_STAT5	377	380	PF00017	0.605
LIG_SH2_STAT5	875	878	PF00017	0.686
LIG_SH2_STAT5	889	892	PF00017	0.496
LIG_SH3_1	770	776	PF00018	0.609
LIG_SH3_2	765	770	PF14604	0.561
LIG_SH3_3	127	133	PF00018	0.712
LIG_SH3_3	429	435	PF00018	0.584
LIG_SH3_3	688	694	PF00018	0.832
LIG_SH3_3	762	768	PF00018	0.729
LIG_SH3_3	770	776	PF00018	0.631
LIG_SH3_3	83	89	PF00018	0.824
LIG_SH3_3	92	98	PF00018	0.553
LIG_SH3_3	927	933	PF00018	0.697
LIG_SUMO_SIM_par_1	821	828	PF11976	0.660
LIG_TRAF2_1	184	187	PF00917	0.555
LIG_TRAF2_1	390	393	PF00917	0.422
LIG_UBA3_1	211	216	PF00899	0.490
LIG_WRC_WIRS_1	406	411	PF05994	0.524
MOD_CDC14_SPxK_1	979	982	PF00782	0.577
MOD_CDK_SPK_2	976	981	PF00069	0.641
MOD_CDK_SPxK_1	976	982	PF00069	0.665
MOD_CK1_1	165	171	PF00069	0.541
MOD_CK1_1	371	377	PF00069	0.570
MOD_CK1_1	40	46	PF00069	0.684
MOD_CK1_1	515	521	PF00069	0.658
MOD_CK1_1	536	542	PF00069	0.697
MOD_CK1_1	620	626	PF00069	0.754
MOD_CK1_1	627	633	PF00069	0.649
MOD_CK1_1	659	665	PF00069	0.749
MOD_CK1_1	675	681	PF00069	0.841
MOD_CK1_1	752	758	PF00069	0.702
MOD_CK1_1	81	87	PF00069	0.721
MOD_CK1_1	857	863	PF00069	0.730
MOD_CK1_1	939	945	PF00069	0.731
MOD_CK1_1	968	974	PF00069	0.702
MOD_CK1_1	976	982	PF00069	0.625
MOD_CK2_1	235	241	PF00069	0.424
MOD_CK2_1	344	350	PF00069	0.455
MOD_CK2_1	937	943	PF00069	0.704
MOD_CK2_1	981	987	PF00069	0.643
MOD_Cter_Amidation	653	656	PF01082	0.684
MOD_GlcNHglycan	14	17	PF01048	0.562
MOD_GlcNHglycan	164	167	PF01048	0.446
MOD_GlcNHglycan	200	205	PF01048	0.512
MOD_GlcNHglycan	308	311	PF01048	0.589
MOD_GlcNHglycan	315	318	PF01048	0.671
MOD_GlcNHglycan	508	511	PF01048	0.703
MOD_GlcNHglycan	514	517	PF01048	0.650
MOD_GlcNHglycan	525	528	PF01048	0.556
MOD_GlcNHglycan	535	538	PF01048	0.656
MOD_GlcNHglycan	554	557	PF01048	0.527
MOD_GlcNHglycan	570	573	PF01048	0.550
MOD_GlcNHglycan	576	579	PF01048	0.642
MOD_GlcNHglycan	582	585	PF01048	0.657
MOD_GlcNHglycan	59	62	PF01048	0.671
MOD_GlcNHglycan	594	598	PF01048	0.576
MOD_GlcNHglycan	604	607	PF01048	0.624
MOD_GlcNHglycan	626	629	PF01048	0.786
MOD_GlcNHglycan	773	776	PF01048	0.787
MOD_GlcNHglycan	784	787	PF01048	0.596
MOD_GlcNHglycan	790	793	PF01048	0.558
MOD_GlcNHglycan	811	814	PF01048	0.613
MOD_GlcNHglycan	832	835	PF01048	0.688
MOD_GlcNHglycan	847	850	PF01048	0.558
MOD_GlcNHglycan	855	859	PF01048	0.672
MOD_GlcNHglycan	925	928	PF01048	0.616
MOD_GlcNHglycan	939	942	PF01048	0.631
MOD_GlcNHglycan	976	979	PF01048	0.648
MOD_GSK3_1	161	168	PF00069	0.557
MOD_GSK3_1	175	182	PF00069	0.620
MOD_GSK3_1	27	34	PF00069	0.548
MOD_GSK3_1	364	371	PF00069	0.454
MOD_GSK3_1	37	44	PF00069	0.585
MOD_GSK3_1	375	382	PF00069	0.566
MOD_GSK3_1	452	459	PF00069	0.662
MOD_GSK3_1	511	518	PF00069	0.725
MOD_GSK3_1	521	528	PF00069	0.687
MOD_GSK3_1	541	548	PF00069	0.660
MOD_GSK3_1	55	62	PF00069	0.645
MOD_GSK3_1	564	571	PF00069	0.650
MOD_GSK3_1	574	581	PF00069	0.602
MOD_GSK3_1	582	589	PF00069	0.669
MOD_GSK3_1	602	609	PF00069	0.577
MOD_GSK3_1	620	627	PF00069	0.824
MOD_GSK3_1	671	678	PF00069	0.788
MOD_GSK3_1	748	755	PF00069	0.677
MOD_GSK3_1	776	783	PF00069	0.638
MOD_GSK3_1	8	15	PF00069	0.653
MOD_GSK3_1	809	816	PF00069	0.751
MOD_GSK3_1	81	88	PF00069	0.799
MOD_GSK3_1	887	894	PF00069	0.631
MOD_GSK3_1	904	911	PF00069	0.539
MOD_GSK3_1	917	924	PF00069	0.581
MOD_GSK3_1	931	938	PF00069	0.655
MOD_GSK3_1	964	971	PF00069	0.722
MOD_GSK3_1	972	979	PF00069	0.652
MOD_GSK3_1	981	988	PF00069	0.615
MOD_LATS_1	454	460	PF00433	0.506
MOD_N-GLC_1	175	180	PF02516	0.601
MOD_N-GLC_1	298	303	PF02516	0.651
MOD_N-GLC_1	512	517	PF02516	0.635
MOD_N-GLC_1	521	526	PF02516	0.638
MOD_N-GLC_2	260	262	PF02516	0.355
MOD_NEK2_1	215	220	PF00069	0.385
MOD_NEK2_1	284	289	PF00069	0.374
MOD_NEK2_1	298	303	PF00069	0.445
MOD_NEK2_1	306	311	PF00069	0.516
MOD_NEK2_1	467	472	PF00069	0.438
MOD_NEK2_1	504	509	PF00069	0.705
MOD_NEK2_1	541	546	PF00069	0.614
MOD_NEK2_1	547	552	PF00069	0.490
MOD_NEK2_1	55	60	PF00069	0.738
MOD_NEK2_1	580	585	PF00069	0.662
MOD_NEK2_1	8	13	PF00069	0.637
MOD_NEK2_1	935	940	PF00069	0.670
MOD_NEK2_1	985	990	PF00069	0.801
MOD_PIKK_1	344	350	PF00454	0.601
MOD_PIKK_1	388	394	PF00454	0.423
MOD_PIKK_1	536	542	PF00454	0.693
MOD_PIKK_1	758	764	PF00454	0.691
MOD_PIKK_1	919	925	PF00454	0.665
MOD_PKA_1	981	987	PF00069	0.643
MOD_PKA_2	368	374	PF00069	0.488
MOD_PKA_2	388	394	PF00069	0.428
MOD_PKA_2	55	61	PF00069	0.688
MOD_PKA_2	586	592	PF00069	0.658
MOD_PKA_2	659	665	PF00069	0.710
MOD_PKA_2	69	75	PF00069	0.604
MOD_PKA_2	749	755	PF00069	0.608
MOD_PKA_2	766	772	PF00069	0.568
MOD_PKB_1	521	529	PF00069	0.681
MOD_Plk_1	113	119	PF00069	0.674
MOD_Plk_1	31	37	PF00069	0.626
MOD_Plk_1	986	992	PF00069	0.698
MOD_Plk_4	165	171	PF00069	0.535
MOD_Plk_4	379	385	PF00069	0.524
MOD_Plk_4	755	761	PF00069	0.660
MOD_Plk_4	816	822	PF00069	0.649
MOD_ProDKin_1	133	139	PF00069	0.550
MOD_ProDKin_1	175	181	PF00069	0.682
MOD_ProDKin_1	251	257	PF00069	0.444
MOD_ProDKin_1	33	39	PF00069	0.733
MOD_ProDKin_1	485	491	PF00069	0.628
MOD_ProDKin_1	564	570	PF00069	0.691
MOD_ProDKin_1	630	636	PF00069	0.635
MOD_ProDKin_1	717	723	PF00069	0.601
MOD_ProDKin_1	780	786	PF00069	0.642
MOD_ProDKin_1	839	845	PF00069	0.693
MOD_ProDKin_1	85	91	PF00069	0.787
MOD_ProDKin_1	976	982	PF00069	0.662
MOD_SUMO_rev_2	213	218	PF00179	0.479
TRG_DiLeu_BaEn_3	186	192	PF01217	0.426
TRG_DiLeu_BaLyEn_6	207	212	PF01217	0.520
TRG_DiLeu_BaLyEn_6	560	565	PF01217	0.523
TRG_ENDOCYTIC_2	158	161	PF00928	0.516
TRG_ENDOCYTIC_2	196	199	PF00928	0.413
TRG_ENDOCYTIC_2	265	268	PF00928	0.371
TRG_ENDOCYTIC_2	820	823	PF00928	0.682
TRG_ENDOCYTIC_2	888	891	PF00928	0.615
TRG_ER_diArg_1	292	294	PF00400	0.503
TRG_ER_diArg_1	296	298	PF00400	0.482
TRG_ER_diArg_1	412	414	PF00400	0.524
TRG_NES_CRM1_1	145	155	PF08389	0.486
TRG_NES_CRM1_1	280	291	PF08389	0.394
TRG_Pf-PMV_PEXEL_1	190	194	PF00026	0.499
TRG_Pf-PMV_PEXEL_1	244	248	PF00026	0.430
TRG_Pf-PMV_PEXEL_1	286	291	PF00026	0.405

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3R7KMM4	Trypanosoma rangeli	36%	100%
A4H4L0	Leishmania braziliensis	68%	95%
A4HST6	Leishmania infantum	98%	100%
E9AKS3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	99%
Q4QJ34	Leishmania major	90%	100%