Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WPD9_LEIDO

TriTrypDb:

LdBPK_060190.1 , LdCL_060006800 , LDHU3_06.0230

Length:

587

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WPD9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WPD9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	293	297	PF00656	0.466
CLV_NRD_NRD_1	151	153	PF00675	0.602
CLV_NRD_NRD_1	583	585	PF00675	0.635
CLV_PCSK_KEX2_1	151	153	PF00082	0.626
CLV_PCSK_KEX2_1	417	419	PF00082	0.614
CLV_PCSK_KEX2_1	583	585	PF00082	0.637
CLV_PCSK_PC1ET2_1	417	419	PF00082	0.636
CLV_PCSK_PC1ET2_1	583	585	PF00082	0.637
CLV_PCSK_PC7_1	413	419	PF00082	0.637
CLV_PCSK_SKI1_1	352	356	PF00082	0.531
DEG_Nend_Nbox_1	1	3	PF02207	0.557
DEG_SCF_FBW7_2	538	544	PF00400	0.553
DEG_SPOP_SBC_1	230	234	PF00917	0.614
DEG_SPOP_SBC_1	573	577	PF00917	0.620
DOC_CDC14_PxL_1	443	451	PF14671	0.581
DOC_CKS1_1	181	186	PF01111	0.522
DOC_CKS1_1	342	347	PF01111	0.617
DOC_CKS1_1	538	543	PF01111	0.548
DOC_CYCLIN_RxL_1	528	542	PF00134	0.556
DOC_PP1_RVXF_1	198	205	PF00149	0.451
DOC_PP2B_LxvP_1	449	452	PF13499	0.648
DOC_PP4_FxxP_1	498	501	PF00568	0.494
DOC_USP7_MATH_1	130	134	PF00917	0.632
DOC_USP7_MATH_1	161	165	PF00917	0.600
DOC_USP7_MATH_1	219	223	PF00917	0.738
DOC_USP7_MATH_1	239	243	PF00917	0.578
DOC_USP7_MATH_1	252	256	PF00917	0.670
DOC_USP7_MATH_1	438	442	PF00917	0.738
DOC_USP7_MATH_1	555	559	PF00917	0.616
DOC_USP7_MATH_1	567	571	PF00917	0.804
DOC_USP7_MATH_1	573	577	PF00917	0.610
DOC_USP7_MATH_1	85	89	PF00917	0.578
DOC_USP7_UBL2_3	583	587	PF12436	0.642
DOC_WW_Pin1_4	159	164	PF00397	0.603
DOC_WW_Pin1_4	180	185	PF00397	0.760
DOC_WW_Pin1_4	326	331	PF00397	0.546
DOC_WW_Pin1_4	341	346	PF00397	0.620
DOC_WW_Pin1_4	388	393	PF00397	0.627
DOC_WW_Pin1_4	537	542	PF00397	0.534
DOC_WW_Pin1_4	551	556	PF00397	0.504
DOC_WW_Pin1_4	577	582	PF00397	0.763
DOC_WW_Pin1_4	88	93	PF00397	0.588
LIG_14-3-3_CanoR_1	231	236	PF00244	0.638
LIG_14-3-3_CanoR_1	362	369	PF00244	0.549
LIG_14-3-3_CanoR_1	411	420	PF00244	0.714
LIG_14-3-3_CanoR_1	571	581	PF00244	0.793
LIG_14-3-3_CanoR_1	75	81	PF00244	0.488
LIG_14-3-3_CterR_2	584	587	PF00244	0.590
LIG_APCC_ABBA_1	494	499	PF00400	0.507
LIG_deltaCOP1_diTrp_1	207	212	PF00928	0.571
LIG_EVH1_2	108	112	PF00568	0.658
LIG_FHA_1	181	187	PF00498	0.570
LIG_FHA_1	23	29	PF00498	0.431
LIG_FHA_1	438	444	PF00498	0.560
LIG_FHA_1	65	71	PF00498	0.386
LIG_FHA_1	9	15	PF00498	0.634
LIG_FHA_2	13	19	PF00498	0.513
LIG_FHA_2	187	193	PF00498	0.592
LIG_FHA_2	289	295	PF00498	0.392
LIG_FHA_2	373	379	PF00498	0.620
LIG_FHA_2	452	458	PF00498	0.594
LIG_Integrin_RGD_1	82	84	PF01839	0.485
LIG_LIR_Gen_1	296	303	PF02991	0.483
LIG_LIR_Gen_1	35	45	PF02991	0.481
LIG_LIR_Nem_3	209	215	PF02991	0.537
LIG_LIR_Nem_3	296	301	PF02991	0.481
LIG_LIR_Nem_3	35	41	PF02991	0.508
LIG_LIR_Nem_3	52	56	PF02991	0.404
LIG_LIR_Nem_3	60	65	PF02991	0.409
LIG_PCNA_TLS_4	292	299	PF02747	0.489
LIG_PCNA_yPIPBox_3	500	511	PF02747	0.544
LIG_Pex14_1	73	77	PF04695	0.391
LIG_REV1ctd_RIR_1	495	500	PF16727	0.503
LIG_SH2_CRK	77	81	PF00017	0.485
LIG_SH2_NCK_1	511	515	PF00017	0.536
LIG_SH2_STAP1	187	191	PF00017	0.603
LIG_SH2_STAP1	474	478	PF00017	0.450
LIG_SH2_STAT5	23	26	PF00017	0.560
LIG_SH2_STAT5	56	59	PF00017	0.528
LIG_SH3_1	213	219	PF00018	0.566
LIG_SH3_2	347	352	PF14604	0.585
LIG_SH3_3	178	184	PF00018	0.530
LIG_SH3_3	213	219	PF00018	0.566
LIG_SH3_3	248	254	PF00018	0.574
LIG_SH3_3	339	345	PF00018	0.620
LIG_SH3_3	441	447	PF00018	0.671
LIG_SH3_3	89	95	PF00018	0.591
LIG_SUMO_SIM_par_1	528	533	PF11976	0.525
LIG_SUMO_SIM_par_1	94	100	PF11976	0.577
LIG_TRAF2_1	473	476	PF00917	0.469
MOD_CDK_SPK_2	392	397	PF00069	0.611
MOD_CDK_SPxK_1	577	583	PF00069	0.667
MOD_CDK_SPxxK_3	326	333	PF00069	0.544
MOD_CDK_SPxxK_3	577	584	PF00069	0.668
MOD_CK1_1	118	124	PF00069	0.607
MOD_CK1_1	12	18	PF00069	0.583
MOD_CK1_1	133	139	PF00069	0.630
MOD_CK1_1	154	160	PF00069	0.724
MOD_CK1_1	244	250	PF00069	0.543
MOD_CK1_1	326	332	PF00069	0.644
MOD_CK1_1	363	369	PF00069	0.595
MOD_CK1_1	370	376	PF00069	0.634
MOD_CK1_1	539	545	PF00069	0.565
MOD_CK1_1	574	580	PF00069	0.725
MOD_CK1_1	88	94	PF00069	0.559
MOD_CK2_1	12	18	PF00069	0.547
MOD_CK2_1	186	192	PF00069	0.567
MOD_CK2_1	252	258	PF00069	0.592
MOD_CK2_1	288	294	PF00069	0.402
MOD_CK2_1	372	378	PF00069	0.619
MOD_CK2_1	451	457	PF00069	0.534
MOD_Cter_Amidation	149	152	PF01082	0.626
MOD_Cter_Amidation	581	584	PF01082	0.605
MOD_GlcNHglycan	113	116	PF01048	0.635
MOD_GlcNHglycan	120	123	PF01048	0.675
MOD_GlcNHglycan	128	131	PF01048	0.751
MOD_GlcNHglycan	132	135	PF01048	0.629
MOD_GlcNHglycan	140	144	PF01048	0.627
MOD_GlcNHglycan	153	156	PF01048	0.606
MOD_GlcNHglycan	221	224	PF01048	0.653
MOD_GlcNHglycan	235	238	PF01048	0.615
MOD_GlcNHglycan	243	246	PF01048	0.570
MOD_GlcNHglycan	330	333	PF01048	0.653
MOD_GlcNHglycan	357	360	PF01048	0.706
MOD_GlcNHglycan	365	368	PF01048	0.553
MOD_GlcNHglycan	372	375	PF01048	0.633
MOD_GlcNHglycan	399	402	PF01048	0.749
MOD_GlcNHglycan	408	411	PF01048	0.671
MOD_GlcNHglycan	541	544	PF01048	0.626
MOD_GlcNHglycan	556	560	PF01048	0.558
MOD_GlcNHglycan	576	579	PF01048	0.545
MOD_GlcNHglycan	86	90	PF01048	0.520
MOD_GSK3_1	107	114	PF00069	0.627
MOD_GSK3_1	126	133	PF00069	0.677
MOD_GSK3_1	225	232	PF00069	0.626
MOD_GSK3_1	324	331	PF00069	0.714
MOD_GSK3_1	363	370	PF00069	0.625
MOD_GSK3_1	388	395	PF00069	0.613
MOD_GSK3_1	447	454	PF00069	0.637
MOD_GSK3_1	551	558	PF00069	0.633
MOD_GSK3_1	561	568	PF00069	0.735
MOD_GSK3_1	572	579	PF00069	0.686
MOD_GSK3_1	8	15	PF00069	0.569
MOD_LATS_1	137	143	PF00433	0.637
MOD_LATS_1	404	410	PF00433	0.703
MOD_N-GLC_1	115	120	PF02516	0.628
MOD_N-GLC_1	367	372	PF02516	0.664
MOD_NEK2_1	170	175	PF00069	0.622
MOD_NEK2_1	186	191	PF00069	0.498
MOD_NEK2_1	2	7	PF00069	0.553
MOD_NEK2_1	22	27	PF00069	0.432
MOD_NEK2_1	308	313	PF00069	0.547
MOD_NEK2_1	315	320	PF00069	0.503
MOD_NEK2_1	360	365	PF00069	0.606
MOD_NEK2_1	478	483	PF00069	0.572
MOD_NEK2_1	536	541	PF00069	0.589
MOD_NEK2_2	455	460	PF00069	0.455
MOD_NEK2_2	561	566	PF00069	0.583
MOD_NEK2_2	64	69	PF00069	0.417
MOD_PIKK_1	225	231	PF00454	0.555
MOD_PKA_1	151	157	PF00069	0.628
MOD_PKA_2	144	150	PF00069	0.653
MOD_PKA_2	151	157	PF00069	0.643
MOD_PKA_2	230	236	PF00069	0.634
MOD_PKA_2	355	361	PF00069	0.662
MOD_PKA_2	396	402	PF00069	0.666
MOD_PKB_1	411	419	PF00069	0.630
MOD_Plk_1	352	358	PF00069	0.527
MOD_Plk_1	367	373	PF00069	0.609
MOD_Plk_1	382	388	PF00069	0.532
MOD_Plk_1	447	453	PF00069	0.693
MOD_ProDKin_1	159	165	PF00069	0.601
MOD_ProDKin_1	180	186	PF00069	0.761
MOD_ProDKin_1	326	332	PF00069	0.542
MOD_ProDKin_1	341	347	PF00069	0.621
MOD_ProDKin_1	388	394	PF00069	0.629
MOD_ProDKin_1	537	543	PF00069	0.538
MOD_ProDKin_1	551	557	PF00069	0.504
MOD_ProDKin_1	577	583	PF00069	0.762
MOD_ProDKin_1	88	94	PF00069	0.587
TRG_DiLeu_BaEn_2	196	202	PF01217	0.452
TRG_DiLeu_BaEn_2	293	299	PF01217	0.387
TRG_DiLeu_BaLyEn_6	181	186	PF01217	0.634
TRG_DiLeu_BaLyEn_6	92	97	PF01217	0.588
TRG_ENDOCYTIC_2	511	514	PF00928	0.472
TRG_ENDOCYTIC_2	77	80	PF00928	0.413
TRG_ER_diArg_1	151	153	PF00400	0.598
TRG_ER_diLys_1	583	587	PF00400	0.698
TRG_NES_CRM1_1	293	306	PF08389	0.493
TRG_NLS_MonoExtC_3	147	152	PF00514	0.623
TRG_NLS_MonoExtC_3	582	587	PF00514	0.642
TRG_NLS_MonoExtN_4	145	152	PF00514	0.624
TRG_NLS_MonoExtN_4	581	587	PF00514	0.667

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6W1	Leptomonas seymouri	47%	79%
A4H4I5	Leishmania braziliensis	70%	100%
A4HSR0	Leishmania infantum	99%	100%
E9AKP7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4QJ60	Leishmania major	92%	100%