Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WPD6_LEIDO

TriTrypDb:

LdBPK_060440.1 , LdCL_060009500 , LDHU3_06.0540

Length:

572

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WPD6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WPD6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	381	383	PF00675	0.839
CLV_NRD_NRD_1	425	427	PF00675	0.842
CLV_NRD_NRD_1	434	436	PF00675	0.683
CLV_NRD_NRD_1	509	511	PF00675	0.714
CLV_NRD_NRD_1	514	516	PF00675	0.690
CLV_NRD_NRD_1	547	549	PF00675	0.802
CLV_NRD_NRD_1	70	72	PF00675	0.668
CLV_NRD_NRD_1	93	95	PF00675	0.651
CLV_PCSK_FUR_1	379	383	PF00082	0.778
CLV_PCSK_KEX2_1	234	236	PF00082	0.706
CLV_PCSK_KEX2_1	268	270	PF00082	0.842
CLV_PCSK_KEX2_1	381	383	PF00082	0.684
CLV_PCSK_KEX2_1	425	427	PF00082	0.842
CLV_PCSK_KEX2_1	434	436	PF00082	0.683
CLV_PCSK_KEX2_1	513	515	PF00082	0.714
CLV_PCSK_KEX2_1	70	72	PF00082	0.668
CLV_PCSK_PC1ET2_1	234	236	PF00082	0.706
CLV_PCSK_PC1ET2_1	268	270	PF00082	0.842
CLV_PCSK_PC1ET2_1	513	515	PF00082	0.714
CLV_PCSK_PC7_1	510	516	PF00082	0.866
CLV_PCSK_SKI1_1	269	273	PF00082	0.782
CLV_PCSK_SKI1_1	40	44	PF00082	0.705
DEG_APCC_DBOX_1	268	276	PF00400	0.779
DEG_SPOP_SBC_1	528	532	PF00917	0.632
DOC_CKS1_1	325	330	PF01111	0.714
DOC_MAPK_gen_1	268	275	PF00069	0.843
DOC_MAPK_gen_1	351	360	PF00069	0.861
DOC_PP2B_LxvP_1	358	361	PF13499	0.560
DOC_USP7_MATH_1	166	170	PF00917	0.732
DOC_USP7_MATH_1	176	180	PF00917	0.696
DOC_USP7_MATH_1	182	186	PF00917	0.578
DOC_USP7_MATH_1	189	193	PF00917	0.603
DOC_USP7_MATH_1	227	231	PF00917	0.763
DOC_USP7_MATH_1	267	271	PF00917	0.839
DOC_USP7_MATH_1	300	304	PF00917	0.750
DOC_USP7_MATH_1	350	354	PF00917	0.765
DOC_USP7_MATH_1	408	412	PF00917	0.715
DOC_USP7_MATH_1	419	423	PF00917	0.648
DOC_USP7_MATH_1	49	53	PF00917	0.745
DOC_USP7_MATH_1	554	558	PF00917	0.628
DOC_WW_Pin1_4	200	205	PF00397	0.815
DOC_WW_Pin1_4	283	288	PF00397	0.813
DOC_WW_Pin1_4	324	329	PF00397	0.686
DOC_WW_Pin1_4	344	349	PF00397	0.660
DOC_WW_Pin1_4	386	391	PF00397	0.688
DOC_WW_Pin1_4	45	50	PF00397	0.717
DOC_WW_Pin1_4	558	563	PF00397	0.663
LIG_14-3-3_CanoR_1	12	17	PF00244	0.654
LIG_14-3-3_CanoR_1	256	261	PF00244	0.645
LIG_14-3-3_CanoR_1	279	287	PF00244	0.855
LIG_14-3-3_CanoR_1	394	403	PF00244	0.741
LIG_14-3-3_CanoR_1	50	54	PF00244	0.732
LIG_14-3-3_CanoR_1	514	518	PF00244	0.807
LIG_14-3-3_CanoR_1	558	562	PF00244	0.760
LIG_14-3-3_CanoR_1	567	572	PF00244	0.614
LIG_APCC_ABBAyCdc20_2	289	295	PF00400	0.798
LIG_BIR_III_4	336	340	PF00653	0.744
LIG_BRCT_BRCA1_1	411	415	PF00533	0.614
LIG_deltaCOP1_diTrp_1	101	109	PF00928	0.648
LIG_FHA_1	109	115	PF00498	0.573
LIG_FHA_1	13	19	PF00498	0.770
LIG_FHA_1	304	310	PF00498	0.769
LIG_FHA_1	324	330	PF00498	0.687
LIG_FHA_1	49	55	PF00498	0.739
LIG_FHA_1	561	567	PF00498	0.646
LIG_FHA_1	58	64	PF00498	0.627
LIG_FHA_2	154	160	PF00498	0.695
LIG_FHA_2	305	311	PF00498	0.715
LIG_FHA_2	500	506	PF00498	0.759
LIG_LIR_Gen_1	495	501	PF02991	0.810
LIG_LIR_Nem_3	495	500	PF02991	0.807
LIG_PTB_Apo_2	493	500	PF02174	0.642
LIG_PTB_Phospho_1	493	499	PF10480	0.642
LIG_SH2_CRK	438	442	PF00017	0.651
LIG_SH2_SRC	459	462	PF00017	0.817
LIG_SH2_STAP1	110	114	PF00017	0.597
LIG_SH2_STAP1	456	460	PF00017	0.611
LIG_SH2_STAT3	110	113	PF00017	0.634
LIG_SH2_STAT5	110	113	PF00017	0.634
LIG_SH2_STAT5	155	158	PF00017	0.689
LIG_SH2_STAT5	459	462	PF00017	0.817
LIG_SH2_STAT5	497	500	PF00017	0.810
LIG_SH2_STAT5	529	532	PF00017	0.734
LIG_SH2_STAT5	53	56	PF00017	0.813
LIG_SH3_3	13	19	PF00018	0.692
LIG_SH3_3	288	294	PF00018	0.839
LIG_SH3_3	322	328	PF00018	0.747
LIG_SH3_3	338	344	PF00018	0.610
LIG_SH3_3	479	485	PF00018	0.773
LIG_Sin3_3	398	405	PF02671	0.752
LIG_SUMO_SIM_par_1	326	332	PF11976	0.716
MOD_CDC14_SPxK_1	286	289	PF00782	0.804
MOD_CDK_SPK_2	45	50	PF00069	0.801
MOD_CDK_SPxK_1	200	206	PF00069	0.752
MOD_CDK_SPxK_1	283	289	PF00069	0.801
MOD_CDK_SPxxK_3	344	351	PF00069	0.802
MOD_CK1_1	169	175	PF00069	0.782
MOD_CK1_1	217	223	PF00069	0.811
MOD_CK1_1	24	30	PF00069	0.757
MOD_CK1_1	240	246	PF00069	0.647
MOD_CK1_1	283	289	PF00069	0.801
MOD_CK1_1	303	309	PF00069	0.553
MOD_CK1_1	31	37	PF00069	0.760
MOD_CK1_1	314	320	PF00069	0.765
MOD_CK1_1	359	365	PF00069	0.773
MOD_CK1_1	386	392	PF00069	0.669
MOD_CK1_1	48	54	PF00069	0.754
MOD_CK1_1	516	522	PF00069	0.771
MOD_CK1_1	557	563	PF00069	0.813
MOD_CK2_1	153	159	PF00069	0.720
MOD_CK2_1	212	218	PF00069	0.792
MOD_CK2_1	53	59	PF00069	0.798
MOD_Cter_Amidation	423	426	PF01082	0.803
MOD_GlcNHglycan	138	141	PF01048	0.530
MOD_GlcNHglycan	171	174	PF01048	0.821
MOD_GlcNHglycan	178	181	PF01048	0.678
MOD_GlcNHglycan	184	187	PF01048	0.626
MOD_GlcNHglycan	191	194	PF01048	0.548
MOD_GlcNHglycan	200	203	PF01048	0.620
MOD_GlcNHglycan	214	217	PF01048	0.604
MOD_GlcNHglycan	23	26	PF01048	0.738
MOD_GlcNHglycan	239	242	PF01048	0.714
MOD_GlcNHglycan	252	255	PF01048	0.665
MOD_GlcNHglycan	258	261	PF01048	0.707
MOD_GlcNHglycan	269	272	PF01048	0.553
MOD_GlcNHglycan	282	285	PF01048	0.582
MOD_GlcNHglycan	31	34	PF01048	0.640
MOD_GlcNHglycan	336	340	PF01048	0.747
MOD_GlcNHglycan	344	347	PF01048	0.762
MOD_GlcNHglycan	35	38	PF01048	0.592
MOD_GlcNHglycan	362	365	PF01048	0.587
MOD_GlcNHglycan	391	394	PF01048	0.756
MOD_GlcNHglycan	396	399	PF01048	0.810
MOD_GlcNHglycan	410	414	PF01048	0.583
MOD_GlcNHglycan	415	418	PF01048	0.688
MOD_GlcNHglycan	421	424	PF01048	0.616
MOD_GlcNHglycan	445	448	PF01048	0.806
MOD_GlcNHglycan	477	480	PF01048	0.740
MOD_GlcNHglycan	502	505	PF01048	0.748
MOD_GlcNHglycan	519	522	PF01048	0.835
MOD_GlcNHglycan	531	534	PF01048	0.628
MOD_GSK3_1	141	148	PF00069	0.718
MOD_GSK3_1	167	174	PF00069	0.760
MOD_GSK3_1	187	194	PF00069	0.538
MOD_GSK3_1	223	230	PF00069	0.804
MOD_GSK3_1	236	243	PF00069	0.625
MOD_GSK3_1	24	31	PF00069	0.792
MOD_GSK3_1	299	306	PF00069	0.735
MOD_GSK3_1	350	357	PF00069	0.783
MOD_GSK3_1	360	367	PF00069	0.635
MOD_GSK3_1	389	396	PF00069	0.623
MOD_GSK3_1	409	416	PF00069	0.712
MOD_GSK3_1	437	444	PF00069	0.680
MOD_GSK3_1	445	452	PF00069	0.625
MOD_GSK3_1	45	52	PF00069	0.757
MOD_GSK3_1	513	520	PF00069	0.762
MOD_GSK3_1	523	530	PF00069	0.681
MOD_GSK3_1	53	60	PF00069	0.692
MOD_GSK3_1	554	561	PF00069	0.817
MOD_N-GLC_1	227	232	PF02516	0.692
MOD_N-GLC_1	235	240	PF02516	0.645
MOD_N-GLC_1	29	34	PF02516	0.776
MOD_N-GLC_1	449	454	PF02516	0.777
MOD_N-GLC_1	506	511	PF02516	0.675
MOD_NEK2_1	128	133	PF00069	0.615
MOD_NEK2_1	136	141	PF00069	0.561
MOD_NEK2_1	280	285	PF00069	0.793
MOD_NEK2_1	29	34	PF00069	0.776
MOD_NEK2_1	441	446	PF00069	0.659
MOD_NEK2_1	460	465	PF00069	0.768
MOD_NEK2_1	487	492	PF00069	0.739
MOD_NEK2_1	517	522	PF00069	0.791
MOD_PIKK_1	364	370	PF00454	0.724
MOD_PIKK_1	542	548	PF00454	0.661
MOD_PKA_1	513	519	PF00069	0.713
MOD_PKA_1	548	554	PF00069	0.752
MOD_PKA_2	11	17	PF00069	0.634
MOD_PKA_2	255	261	PF00069	0.674
MOD_PKA_2	278	284	PF00069	0.737
MOD_PKA_2	314	320	PF00069	0.705
MOD_PKA_2	350	356	PF00069	0.694
MOD_PKA_2	393	399	PF00069	0.670
MOD_PKA_2	413	419	PF00069	0.777
MOD_PKA_2	424	430	PF00069	0.659
MOD_PKA_2	49	55	PF00069	0.657
MOD_PKA_2	492	498	PF00069	0.602
MOD_PKA_2	513	519	PF00069	0.713
MOD_PKA_2	557	563	PF00069	0.761
MOD_Plk_1	128	134	PF00069	0.618
MOD_Plk_1	158	164	PF00069	0.605
MOD_Plk_1	449	455	PF00069	0.749
MOD_Plk_1	58	64	PF00069	0.770
MOD_Plk_4	304	310	PF00069	0.812
MOD_Plk_4	49	55	PF00069	0.746
MOD_ProDKin_1	200	206	PF00069	0.818
MOD_ProDKin_1	283	289	PF00069	0.816
MOD_ProDKin_1	324	330	PF00069	0.686
MOD_ProDKin_1	344	350	PF00069	0.656
MOD_ProDKin_1	386	392	PF00069	0.690
MOD_ProDKin_1	45	51	PF00069	0.718
MOD_ProDKin_1	558	564	PF00069	0.660
TRG_ENDOCYTIC_2	438	441	PF00928	0.673
TRG_ENDOCYTIC_2	459	462	PF00928	0.611
TRG_ENDOCYTIC_2	497	500	PF00928	0.810
TRG_ER_diArg_1	205	208	PF00400	0.812
TRG_ER_diArg_1	378	381	PF00400	0.832
TRG_NLS_MonoCore_2	509	514	PF00514	0.796
TRG_NLS_MonoExtC_3	509	514	PF00514	0.796
TRG_NLS_MonoExtN_4	510	517	PF00514	0.866
TRG_Pf-PMV_PEXEL_1	117	122	PF00026	0.607
TRG_Pf-PMV_PEXEL_1	126	130	PF00026	0.560
TRG_Pf-PMV_PEXEL_1	94	98	PF00026	0.643

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HST4	Leishmania infantum	100%	100%
E9AI22	Leishmania braziliensis	59%	100%
E9AKS1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	98%
Q4QJ36	Leishmania major	87%	100%