FHA domain containing protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

FHA domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WPD3_LEIDO

TriTrypDb:

LdBPK_060210.1 , LdCL_060007200 , LDHU3_06.0270

Length:

667

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WPD3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WPD3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0003729	mRNA binding	5	1
GO:0005488	binding	1	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	123	127	PF00656	0.376
CLV_C14_Caspase3-7	357	361	PF00656	0.602
CLV_C14_Caspase3-7	530	534	PF00656	0.414
CLV_NRD_NRD_1	20	22	PF00675	0.403
CLV_NRD_NRD_1	330	332	PF00675	0.674
CLV_NRD_NRD_1	429	431	PF00675	0.724
CLV_NRD_NRD_1	588	590	PF00675	0.658
CLV_PCSK_KEX2_1	20	22	PF00082	0.403
CLV_PCSK_KEX2_1	330	332	PF00082	0.674
CLV_PCSK_KEX2_1	428	430	PF00082	0.695
CLV_PCSK_KEX2_1	442	444	PF00082	0.677
CLV_PCSK_KEX2_1	588	590	PF00082	0.656
CLV_PCSK_KEX2_1	592	594	PF00082	0.693
CLV_PCSK_PC1ET2_1	442	444	PF00082	0.596
CLV_PCSK_PC1ET2_1	592	594	PF00082	0.631
CLV_PCSK_PC7_1	588	594	PF00082	0.800
CLV_PCSK_SKI1_1	222	226	PF00082	0.467
CLV_PCSK_SKI1_1	230	234	PF00082	0.458
CLV_PCSK_SKI1_1	309	313	PF00082	0.680
DEG_SPOP_SBC_1	70	74	PF00917	0.362
DOC_CKS1_1	115	120	PF01111	0.362
DOC_CKS1_1	248	253	PF01111	0.663
DOC_CKS1_1	362	367	PF01111	0.558
DOC_CKS1_1	616	621	PF01111	0.455
DOC_CYCLIN_yCln2_LP_2	366	372	PF00134	0.652
DOC_MAPK_gen_1	20	26	PF00069	0.395
DOC_MAPK_gen_1	501	510	PF00069	0.574
DOC_MAPK_MEF2A_6	504	512	PF00069	0.509
DOC_MAPK_MEF2A_6	524	531	PF00069	0.271
DOC_PP1_RVXF_1	550	557	PF00149	0.376
DOC_PP2B_LxvP_1	217	220	PF13499	0.497
DOC_PP2B_LxvP_1	658	661	PF13499	0.569
DOC_PP4_FxxP_1	301	304	PF00568	0.616
DOC_USP7_MATH_1	236	240	PF00917	0.496
DOC_USP7_MATH_1	243	247	PF00917	0.581
DOC_USP7_MATH_1	325	329	PF00917	0.791
DOC_USP7_MATH_1	421	425	PF00917	0.798
DOC_USP7_MATH_1	493	497	PF00917	0.665
DOC_USP7_MATH_1	511	515	PF00917	0.376
DOC_USP7_MATH_1	572	576	PF00917	0.611
DOC_USP7_MATH_1	659	663	PF00917	0.517
DOC_USP7_MATH_1	71	75	PF00917	0.387
DOC_USP7_MATH_1	86	90	PF00917	0.222
DOC_USP7_MATH_2	471	477	PF00917	0.496
DOC_USP7_UBL2_3	592	596	PF12436	0.634
DOC_WW_Pin1_4	104	109	PF00397	0.431
DOC_WW_Pin1_4	114	119	PF00397	0.220
DOC_WW_Pin1_4	212	217	PF00397	0.481
DOC_WW_Pin1_4	247	252	PF00397	0.624
DOC_WW_Pin1_4	28	33	PF00397	0.429
DOC_WW_Pin1_4	289	294	PF00397	0.572
DOC_WW_Pin1_4	300	305	PF00397	0.611
DOC_WW_Pin1_4	361	366	PF00397	0.783
DOC_WW_Pin1_4	419	424	PF00397	0.799
DOC_WW_Pin1_4	429	434	PF00397	0.609
DOC_WW_Pin1_4	457	462	PF00397	0.492
DOC_WW_Pin1_4	478	483	PF00397	0.577
DOC_WW_Pin1_4	594	599	PF00397	0.630
DOC_WW_Pin1_4	612	617	PF00397	0.579
DOC_WW_Pin1_4	652	657	PF00397	0.448
DOC_WW_Pin1_4	79	84	PF00397	0.329
DOC_WW_Pin1_4	88	93	PF00397	0.315
LIG_14-3-3_CanoR_1	13	19	PF00244	0.395
LIG_14-3-3_CanoR_1	200	207	PF00244	0.547
LIG_14-3-3_CanoR_1	21	27	PF00244	0.576
LIG_14-3-3_CanoR_1	330	336	PF00244	0.672
LIG_14-3-3_CanoR_1	342	347	PF00244	0.587
LIG_14-3-3_CanoR_1	37	45	PF00244	0.428
LIG_BIR_II_1	1	5	PF00653	0.452
LIG_BIR_III_4	395	399	PF00653	0.466
LIG_BRCT_BRCA1_1	47	51	PF00533	0.451
LIG_deltaCOP1_diTrp_1	550	556	PF00928	0.374
LIG_deltaCOP1_diTrp_1	624	630	PF00928	0.379
LIG_DLG_GKlike_1	331	339	PF00625	0.666
LIG_eIF4E_1	187	193	PF01652	0.421
LIG_eIF4E_1	212	218	PF01652	0.495
LIG_EVH1_2	206	210	PF00568	0.495
LIG_FHA_1	131	137	PF00498	0.369
LIG_FHA_1	213	219	PF00498	0.443
LIG_FHA_1	300	306	PF00498	0.675
LIG_FHA_1	350	356	PF00498	0.707
LIG_FHA_1	515	521	PF00498	0.376
LIG_FHA_1	560	566	PF00498	0.481
LIG_FHA_1	595	601	PF00498	0.732
LIG_FHA_1	607	613	PF00498	0.504
LIG_FHA_2	105	111	PF00498	0.502
LIG_FHA_2	121	127	PF00498	0.362
LIG_FHA_2	281	287	PF00498	0.621
LIG_FHA_2	342	348	PF00498	0.712
LIG_FHA_2	76	82	PF00498	0.345
LIG_LIR_Apic_2	185	190	PF02991	0.463
LIG_LIR_Gen_1	473	482	PF02991	0.521
LIG_LIR_Gen_1	6	15	PF02991	0.384
LIG_LIR_Nem_3	473	478	PF02991	0.518
LIG_LIR_Nem_3	6	12	PF02991	0.382
LIG_PDZ_Class_2	662	667	PF00595	0.528
LIG_Pex14_1	626	630	PF04695	0.365
LIG_PTB_Apo_2	388	395	PF02174	0.397
LIG_PTB_Phospho_1	388	394	PF10480	0.451
LIG_SH2_CRK	384	388	PF00017	0.380
LIG_SH2_PTP2	507	510	PF00017	0.383
LIG_SH2_STAT3	634	637	PF00017	0.401
LIG_SH2_STAT5	137	140	PF00017	0.299
LIG_SH2_STAT5	212	215	PF00017	0.483
LIG_SH2_STAT5	507	510	PF00017	0.383
LIG_SH3_3	21	27	PF00018	0.418
LIG_SH3_3	372	378	PF00018	0.532
LIG_SH3_3	448	454	PF00018	0.530
LIG_SH3_3	505	511	PF00018	0.461
LIG_SH3_3	516	522	PF00018	0.325
LIG_SH3_3	562	568	PF00018	0.517
LIG_SH3_3	613	619	PF00018	0.553
LIG_SH3_3	636	642	PF00018	0.401
LIG_SH3_3	9	15	PF00018	0.368
LIG_SUMO_SIM_anti_2	332	338	PF11976	0.664
LIG_SUMO_SIM_par_1	223	229	PF11976	0.527
LIG_SUMO_SIM_par_1	641	646	PF11976	0.457
LIG_TRAF2_1	315	318	PF00917	0.659
LIG_TRAF2_1	348	351	PF00917	0.680
LIG_TRAF2_1	400	403	PF00917	0.603
LIG_TYR_ITIM	382	387	PF00017	0.391
LIG_UBA3_1	59	65	PF00899	0.299
MOD_CDK_SPK_2	114	119	PF00069	0.266
MOD_CDK_SPK_2	289	294	PF00069	0.566
MOD_CDK_SPxK_1	434	440	PF00069	0.609
MOD_CDK_SPxxK_3	419	426	PF00069	0.674
MOD_CDK_SPxxK_3	478	485	PF00069	0.583
MOD_CDK_SPxxK_3	615	622	PF00069	0.464
MOD_CK1_1	144	150	PF00069	0.323
MOD_CK1_1	247	253	PF00069	0.697
MOD_CK1_1	28	34	PF00069	0.453
MOD_CK1_1	303	309	PF00069	0.671
MOD_CK1_1	361	367	PF00069	0.694
MOD_CK1_1	432	438	PF00069	0.682
MOD_CK1_1	496	502	PF00069	0.633
MOD_CK1_1	514	520	PF00069	0.240
MOD_CK1_1	548	554	PF00069	0.478
MOD_CK1_1	559	565	PF00069	0.630
MOD_CK1_1	580	586	PF00069	0.612
MOD_CK1_1	615	621	PF00069	0.539
MOD_CK1_1	66	72	PF00069	0.332
MOD_CK1_1	74	80	PF00069	0.318
MOD_CK2_1	341	347	PF00069	0.685
MOD_CK2_1	350	356	PF00069	0.560
MOD_CK2_1	75	81	PF00069	0.218
MOD_CMANNOS	553	556	PF00535	0.352
MOD_Cter_Amidation	328	331	PF01082	0.675
MOD_GlcNHglycan	154	157	PF01048	0.295
MOD_GlcNHglycan	201	204	PF01048	0.563
MOD_GlcNHglycan	252	255	PF01048	0.721
MOD_GlcNHglycan	276	279	PF01048	0.749
MOD_GlcNHglycan	327	330	PF01048	0.671
MOD_GlcNHglycan	350	355	PF01048	0.683
MOD_GlcNHglycan	419	422	PF01048	0.749
MOD_GlcNHglycan	423	426	PF01048	0.726
MOD_GlcNHglycan	434	437	PF01048	0.588
MOD_GlcNHglycan	495	498	PF01048	0.661
MOD_GlcNHglycan	545	548	PF01048	0.429
MOD_GlcNHglycan	574	577	PF01048	0.638
MOD_GlcNHglycan	662	665	PF01048	0.599
MOD_GSK3_1	136	143	PF00069	0.316
MOD_GSK3_1	206	213	PF00069	0.565
MOD_GSK3_1	232	239	PF00069	0.466
MOD_GSK3_1	243	250	PF00069	0.697
MOD_GSK3_1	299	306	PF00069	0.607
MOD_GSK3_1	325	332	PF00069	0.667
MOD_GSK3_1	417	424	PF00069	0.783
MOD_GSK3_1	45	52	PF00069	0.544
MOD_GSK3_1	496	503	PF00069	0.695
MOD_GSK3_1	510	517	PF00069	0.289
MOD_GSK3_1	602	609	PF00069	0.685
MOD_GSK3_1	659	666	PF00069	0.535
MOD_GSK3_1	66	73	PF00069	0.433
MOD_GSK3_1	75	82	PF00069	0.299
MOD_LATS_1	307	313	PF00433	0.678
MOD_N-GLC_1	144	149	PF02516	0.302
MOD_N-GLC_1	28	33	PF02516	0.411
MOD_N-GLC_1	390	395	PF02516	0.449
MOD_NEK2_1	141	146	PF00069	0.335
MOD_NEK2_1	210	215	PF00069	0.428
MOD_NEK2_1	22	27	PF00069	0.470
MOD_NEK2_1	232	237	PF00069	0.461
MOD_NEK2_1	49	54	PF00069	0.366
MOD_PIKK_1	335	341	PF00454	0.660
MOD_PIKK_1	452	458	PF00454	0.505
MOD_PIKK_1	50	56	PF00454	0.299
MOD_PIKK_1	556	562	PF00454	0.479
MOD_PK_1	596	602	PF00069	0.665
MOD_PKA_2	131	137	PF00069	0.321
MOD_PKA_2	152	158	PF00069	0.286
MOD_PKA_2	199	205	PF00069	0.535
MOD_PKA_2	22	28	PF00069	0.561
MOD_PKA_2	329	335	PF00069	0.644
MOD_PKA_2	341	347	PF00069	0.638
MOD_PKA_2	36	42	PF00069	0.477
MOD_PKA_2	500	506	PF00069	0.638
MOD_PKA_2	572	578	PF00069	0.698
MOD_Plk_1	390	396	PF00069	0.434
MOD_Plk_2-3	266	272	PF00069	0.612
MOD_Plk_4	144	150	PF00069	0.299
MOD_Plk_4	331	337	PF00069	0.706
MOD_Plk_4	45	51	PF00069	0.412
MOD_Plk_4	514	520	PF00069	0.373
MOD_Plk_4	55	61	PF00069	0.299
MOD_ProDKin_1	104	110	PF00069	0.431
MOD_ProDKin_1	114	120	PF00069	0.220
MOD_ProDKin_1	212	218	PF00069	0.481
MOD_ProDKin_1	247	253	PF00069	0.623
MOD_ProDKin_1	28	34	PF00069	0.425
MOD_ProDKin_1	289	295	PF00069	0.572
MOD_ProDKin_1	300	306	PF00069	0.609
MOD_ProDKin_1	361	367	PF00069	0.782
MOD_ProDKin_1	419	425	PF00069	0.799
MOD_ProDKin_1	429	435	PF00069	0.610
MOD_ProDKin_1	457	463	PF00069	0.493
MOD_ProDKin_1	478	484	PF00069	0.581
MOD_ProDKin_1	594	600	PF00069	0.632
MOD_ProDKin_1	612	618	PF00069	0.565
MOD_ProDKin_1	652	658	PF00069	0.461
MOD_ProDKin_1	79	85	PF00069	0.329
MOD_ProDKin_1	88	94	PF00069	0.315
TRG_DiLeu_BaEn_1	228	233	PF01217	0.464
TRG_DiLeu_BaEn_4	228	234	PF01217	0.524
TRG_ENDOCYTIC_2	384	387	PF00928	0.382
TRG_ENDOCYTIC_2	507	510	PF00928	0.356
TRG_ER_diArg_1	20	23	PF00400	0.420
TRG_ER_diArg_1	428	430	PF00400	0.701
TRG_NLS_Bipartite_1	428	446	PF00514	0.642
TRG_NLS_MonoExtC_3	441	447	PF00514	0.590
TRG_NLS_MonoExtN_4	439	446	PF00514	0.584
TRG_Pf-PMV_PEXEL_1	230	234	PF00026	0.520
TRG_Pf-PMV_PEXEL_1	404	409	PF00026	0.626

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4Z7	Leptomonas seymouri	44%	100%
A4HSR2	Leishmania infantum	99%	100%
E9AKP9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4QJ58	Leishmania major	91%	100%