LeishMANIAdb
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ATP-binding cassette protein subfamily G, member 1, putative

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
ATP-binding cassette protein subfamily G, member 1, putative
Gene product:
ATP-binding cassette protein subfamily G, member 1, putative
Species:
Leishmania donovani
UniProt:
A0A3S7WPC2_LEIDO
TriTrypDb:
LdCL_060005900 , LDHU3_06.0140
Length:
279

Annotations

LeishMANIAdb annotations

Proteins belonging to the subfamily G of Eukaryotic ABC transporters. Probably functional as dimers, with broad substrate specificity.. Expanded in Kinetoplastids (also in free-living forms)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 5
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 4
NetGPI no yes: 0, no: 4
Cellular components
Term Name Level Count
GO:0016020 membrane 2 5
GO:0110165 cellular anatomical entity 1 5

Expansion

Sequence features

A0A3S7WPC2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WPC2

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 1
GO:0009987 cellular process 1 1
GO:0051179 localization 1 1
GO:0051234 establishment of localization 2 1
GO:0055085 transmembrane transport 2 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 5
GO:0005215 transporter activity 1 5
GO:0005488 binding 1 5
GO:0005524 ATP binding 5 5
GO:0015399 primary active transmembrane transporter activity 4 5
GO:0017076 purine nucleotide binding 4 5
GO:0022804 active transmembrane transporter activity 3 5
GO:0022857 transmembrane transporter activity 2 5
GO:0030554 adenyl nucleotide binding 5 5
GO:0032553 ribonucleotide binding 3 5
GO:0032555 purine ribonucleotide binding 4 5
GO:0032559 adenyl ribonucleotide binding 5 5
GO:0035639 purine ribonucleoside triphosphate binding 4 5
GO:0036094 small molecule binding 2 5
GO:0042626 ATPase-coupled transmembrane transporter activity 2 5
GO:0043167 ion binding 2 5
GO:0043168 anion binding 3 5
GO:0097159 organic cyclic compound binding 2 5
GO:0097367 carbohydrate derivative binding 2 5
GO:0140359 ABC-type transporter activity 3 5
GO:0140657 ATP-dependent activity 1 5
GO:1901265 nucleoside phosphate binding 3 5
GO:1901363 heterocyclic compound binding 2 5

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 93 97 PF00656 0.547
CLV_NRD_NRD_1 190 192 PF00675 0.316
CLV_NRD_NRD_1 242 244 PF00675 0.403
CLV_NRD_NRD_1 27 29 PF00675 0.266
CLV_NRD_NRD_1 69 71 PF00675 0.266
CLV_PCSK_FUR_1 25 29 PF00082 0.266
CLV_PCSK_KEX2_1 188 190 PF00082 0.319
CLV_PCSK_KEX2_1 241 243 PF00082 0.404
CLV_PCSK_KEX2_1 27 29 PF00082 0.266
CLV_PCSK_KEX2_1 71 73 PF00082 0.266
CLV_PCSK_PC1ET2_1 188 190 PF00082 0.319
CLV_PCSK_PC1ET2_1 71 73 PF00082 0.266
CLV_PCSK_SKI1_1 192 196 PF00082 0.347
CLV_PCSK_SKI1_1 207 211 PF00082 0.373
CLV_PCSK_SKI1_1 84 88 PF00082 0.266
DOC_CKS1_1 13 18 PF01111 0.466
DOC_CKS1_1 198 203 PF01111 0.656
DOC_CYCLIN_yCln2_LP_2 13 19 PF00134 0.466
DOC_MAPK_gen_1 241 247 PF00069 0.501
DOC_MAPK_gen_1 49 58 PF00069 0.425
DOC_MAPK_gen_1 70 79 PF00069 0.466
DOC_MAPK_MEF2A_6 227 236 PF00069 0.626
DOC_MAPK_MEF2A_6 70 79 PF00069 0.466
DOC_PP4_FxxP_1 161 164 PF00568 0.466
DOC_USP7_MATH_1 162 166 PF00917 0.425
DOC_USP7_UBL2_3 184 188 PF12436 0.521
DOC_WW_Pin1_4 165 170 PF00397 0.466
DOC_WW_Pin1_4 197 202 PF00397 0.552
DOC_WW_Pin1_4 228 233 PF00397 0.626
DOC_WW_Pin1_4 8 13 PF00397 0.480
LIG_14-3-3_CanoR_1 112 118 PF00244 0.640
LIG_14-3-3_CanoR_1 199 208 PF00244 0.575
LIG_BRCT_BRCA1_1 157 161 PF00533 0.466
LIG_FHA_1 123 129 PF00498 0.466
LIG_FHA_1 180 186 PF00498 0.569
LIG_FHA_1 201 207 PF00498 0.569
LIG_FHA_1 90 96 PF00498 0.466
LIG_FHA_2 13 19 PF00498 0.461
LIG_FHA_2 166 172 PF00498 0.466
LIG_LIR_Apic_2 158 164 PF02991 0.466
LIG_LIR_Gen_1 130 138 PF02991 0.466
LIG_LIR_Gen_1 14 24 PF02991 0.466
LIG_LIR_Gen_1 154 164 PF02991 0.552
LIG_LIR_Gen_1 170 181 PF02991 0.386
LIG_LIR_Nem_3 130 135 PF02991 0.466
LIG_LIR_Nem_3 14 20 PF02991 0.466
LIG_LIR_Nem_3 154 159 PF02991 0.552
LIG_LIR_Nem_3 170 176 PF02991 0.386
LIG_Pex14_2 272 276 PF04695 0.202
LIG_RPA_C_Fungi 207 219 PF08784 0.577
LIG_SH2_CRK 173 177 PF00017 0.313
LIG_SH2_STAP1 17 21 PF00017 0.313
LIG_SH2_STAP1 257 261 PF00017 0.256
LIG_SH2_STAT3 257 260 PF00017 0.458
LIG_SH2_STAT5 119 122 PF00017 0.407
LIG_SH2_STAT5 131 134 PF00017 0.313
LIG_SH2_STAT5 155 158 PF00017 0.313
LIG_SH2_STAT5 167 170 PF00017 0.313
LIG_SH2_STAT5 193 196 PF00017 0.426
LIG_SH2_STAT5 224 227 PF00017 0.566
LIG_SH2_STAT5 253 256 PF00017 0.445
LIG_SH2_STAT5 257 260 PF00017 0.383
LIG_SH3_1 195 201 PF00018 0.441
LIG_SH3_3 195 201 PF00018 0.441
LIG_SH3_3 53 59 PF00018 0.313
LIG_SUMO_SIM_anti_2 133 139 PF11976 0.313
LIG_SUMO_SIM_anti_2 41 47 PF11976 0.252
LIG_SUMO_SIM_par_1 173 180 PF11976 0.458
LIG_SUMO_SIM_par_1 84 90 PF11976 0.313
LIG_TYR_ITSM 168 175 PF00017 0.458
MOD_CK1_1 11 17 PF00069 0.313
MOD_CK1_1 165 171 PF00069 0.412
MOD_CK1_1 180 186 PF00069 0.212
MOD_CK1_1 213 219 PF00069 0.426
MOD_CK1_1 23 29 PF00069 0.313
MOD_CK1_1 248 254 PF00069 0.411
MOD_CK1_1 97 103 PF00069 0.395
MOD_CK2_1 208 214 PF00069 0.561
MOD_CK2_1 63 69 PF00069 0.313
MOD_GlcNHglycan 214 218 PF01048 0.521
MOD_GlcNHglycan 65 68 PF01048 0.307
MOD_GlcNHglycan 92 95 PF01048 0.411
MOD_GlcNHglycan 99 102 PF01048 0.388
MOD_GSK3_1 113 120 PF00069 0.409
MOD_GSK3_1 145 152 PF00069 0.313
MOD_GSK3_1 208 215 PF00069 0.580
MOD_GSK3_1 23 30 PF00069 0.313
MOD_GSK3_1 8 15 PF00069 0.313
MOD_GSK3_1 90 97 PF00069 0.404
MOD_NEK2_1 110 115 PF00069 0.407
MOD_NEK2_1 136 141 PF00069 0.305
MOD_NEK2_1 177 182 PF00069 0.313
MOD_NEK2_1 20 25 PF00069 0.313
MOD_NEK2_1 208 213 PF00069 0.446
MOD_NEK2_1 255 260 PF00069 0.256
MOD_PIKK_1 136 142 PF00454 0.313
MOD_PK_1 71 77 PF00069 0.458
MOD_PKA_1 27 33 PF00069 0.313
MOD_PKA_1 71 77 PF00069 0.458
MOD_PKA_2 248 254 PF00069 0.449
MOD_PKA_2 27 33 PF00069 0.313
MOD_PKA_2 51 57 PF00069 0.305
MOD_PKA_2 71 77 PF00069 0.175
MOD_PKB_1 25 33 PF00069 0.313
MOD_Plk_2-3 127 133 PF00069 0.313
MOD_Plk_4 127 133 PF00069 0.313
MOD_Plk_4 248 254 PF00069 0.411
MOD_Plk_4 41 47 PF00069 0.256
MOD_ProDKin_1 165 171 PF00069 0.313
MOD_ProDKin_1 197 203 PF00069 0.430
MOD_ProDKin_1 228 234 PF00069 0.531
MOD_ProDKin_1 8 14 PF00069 0.332
MOD_SUMO_rev_2 78 86 PF00179 0.313
TRG_ENDOCYTIC_2 17 20 PF00928 0.313
TRG_ENDOCYTIC_2 172 175 PF00928 0.317
TRG_ER_diArg_1 24 27 PF00400 0.313
TRG_ER_diArg_1 241 243 PF00400 0.264
TRG_ER_diArg_1 46 49 PF00400 0.283
TRG_NES_CRM1_1 127 140 PF08389 0.313
TRG_NLS_MonoExtC_3 187 192 PF00514 0.378

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PBQ3 Leptomonas seymouri 89% 100%
E9AG66 Leishmania infantum 99% 100%
Q48C94 Pseudomonas savastanoi pv. phaseolicola (strain 1448A / Race 6) 31% 100%
Q48PN3 Pseudomonas savastanoi pv. phaseolicola (strain 1448A / Race 6) 28% 74%
Q4QJ69 Leishmania major 95% 100%
Q73XU8 Mycolicibacterium paratuberculosis (strain ATCC BAA-968 / K-10) 26% 77%
Q87GB5 Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633) 29% 75%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS