Protein phosphatase type 1 regulator-like protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein phosphatase type 1 regulator-like protein

Species:

Leishmania donovani

UniProt:

A0A3S7WPA7_LEIDO

TriTrypDb:

LdBPK_051200.1 , LdCL_050017400 , LDHU3_05.1360

Length:

396

Annotations

Annotations by Jardim et al.

Phosphatase, phosphatase type 1 regulator-like

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	yes	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 16

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	11
GO:0042995	cell projection	2	11
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0110165	cellular anatomical entity	1	12
GO:0120025	plasma membrane bounded cell projection	3	11
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1

Expansion

Sequence features

A0A3S7WPA7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WPA7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	168	172	PF00656	0.449
CLV_C14_Caspase3-7	191	195	PF00656	0.559
CLV_C14_Caspase3-7	234	238	PF00656	0.453
CLV_C14_Caspase3-7	35	39	PF00656	0.827
CLV_C14_Caspase3-7	372	376	PF00656	0.455
CLV_NRD_NRD_1	122	124	PF00675	0.441
CLV_NRD_NRD_1	164	166	PF00675	0.570
CLV_NRD_NRD_1	245	247	PF00675	0.485
CLV_NRD_NRD_1	393	395	PF00675	0.651
CLV_NRD_NRD_1	93	95	PF00675	0.432
CLV_PCSK_KEX2_1	358	360	PF00082	0.482
CLV_PCSK_KEX2_1	393	395	PF00082	0.664
CLV_PCSK_PC1ET2_1	358	360	PF00082	0.459
CLV_PCSK_PC7_1	389	395	PF00082	0.676
CLV_PCSK_SKI1_1	126	130	PF00082	0.467
CLV_PCSK_SKI1_1	165	169	PF00082	0.590
CLV_PCSK_SKI1_1	73	77	PF00082	0.563
DEG_COP1_1	127	137	PF00400	0.539
DEG_Nend_Nbox_1	1	3	PF02207	0.769
DOC_CYCLIN_RxL_1	175	184	PF00134	0.419
DOC_CYCLIN_yClb5_NLxxxL_5	94	101	PF00134	0.432
DOC_MAPK_gen_1	358	368	PF00069	0.437
DOC_MAPK_MEF2A_6	361	370	PF00069	0.431
DOC_MAPK_NFAT4_5	363	371	PF00069	0.419
DOC_MAPK_RevD_3	80	95	PF00069	0.446
DOC_USP7_MATH_1	288	292	PF00917	0.579
DOC_USP7_MATH_1	30	34	PF00917	0.814
DOC_WW_Pin1_4	26	31	PF00397	0.718
LIG_14-3-3_CanoR_1	220	226	PF00244	0.453
LIG_14-3-3_CanoR_1	246	251	PF00244	0.383
LIG_14-3-3_CanoR_1	73	78	PF00244	0.444
LIG_14-3-3_CterR_2	393	396	PF00244	0.698
LIG_Actin_WH2_2	150	167	PF00022	0.495
LIG_Clathr_ClatBox_1	112	116	PF01394	0.528
LIG_Clathr_ClatBox_1	74	78	PF01394	0.441
LIG_deltaCOP1_diTrp_1	330	337	PF00928	0.507
LIG_FHA_1	344	350	PF00498	0.420
LIG_FHA_1	88	94	PF00498	0.474
LIG_FHA_2	153	159	PF00498	0.405
LIG_FHA_2	166	172	PF00498	0.414
LIG_FHA_2	174	180	PF00498	0.391
LIG_FHA_2	302	308	PF00498	0.531
LIG_FHA_2	370	376	PF00498	0.507
LIG_FHA_2	63	69	PF00498	0.571
LIG_FHA_2	74	80	PF00498	0.526
LIG_IBAR_NPY_1	268	270	PF08397	0.462
LIG_LIR_Gen_1	158	167	PF02991	0.403
LIG_LIR_Gen_1	194	204	PF02991	0.504
LIG_LIR_Gen_1	362	371	PF02991	0.424
LIG_LIR_Nem_3	158	164	PF02991	0.404
LIG_LIR_Nem_3	194	199	PF02991	0.553
LIG_LIR_Nem_3	296	302	PF02991	0.391
LIG_LIR_Nem_3	330	334	PF02991	0.409
LIG_LIR_Nem_3	362	368	PF02991	0.427
LIG_LIR_Nem_3	375	380	PF02991	0.454
LIG_LRP6_Inhibitor_1	117	123	PF00058	0.436
LIG_LRP6_Inhibitor_1	182	188	PF00058	0.413
LIG_LRP6_Inhibitor_1	204	210	PF00058	0.395
LIG_MAD2	16	24	PF02301	0.718
LIG_MYND_3	315	319	PF01753	0.492
LIG_PCNA_PIPBox_1	315	324	PF02747	0.439
LIG_PTB_Apo_2	364	371	PF02174	0.510
LIG_SH2_CRK	161	165	PF00017	0.419
LIG_SH2_CRK	365	369	PF00017	0.445
LIG_SH2_GRB2like	365	368	PF00017	0.517
LIG_SH2_STAT5	181	184	PF00017	0.412
LIG_SH2_STAT5	270	273	PF00017	0.514
LIG_SH2_STAT5	275	278	PF00017	0.345
LIG_SH2_STAT5	348	351	PF00017	0.451
LIG_SH3_3	131	137	PF00018	0.560
LIG_SH3_3	306	312	PF00018	0.509
LIG_SUMO_SIM_par_1	111	116	PF11976	0.531
LIG_TYR_ITIM	159	164	PF00017	0.390
LIG_UBA3_1	1	10	PF00899	0.732
LIG_WRC_WIRS_1	193	198	PF05994	0.502
MOD_CDK_SPxK_1	26	32	PF00069	0.722
MOD_CK1_1	172	178	PF00069	0.495
MOD_CK1_1	214	220	PF00069	0.505
MOD_CK1_1	221	227	PF00069	0.456
MOD_CK1_1	26	32	PF00069	0.760
MOD_CK2_1	173	179	PF00069	0.425
MOD_CK2_1	254	260	PF00069	0.478
MOD_CK2_1	279	285	PF00069	0.554
MOD_CK2_1	301	307	PF00069	0.571
MOD_CK2_1	34	40	PF00069	0.718
MOD_CK2_1	73	79	PF00069	0.426
MOD_GlcNHglycan	100	104	PF01048	0.606
MOD_GlcNHglycan	130	133	PF01048	0.568
MOD_GlcNHglycan	138	141	PF01048	0.700
MOD_GlcNHglycan	213	216	PF01048	0.421
MOD_GlcNHglycan	25	28	PF01048	0.648
MOD_GlcNHglycan	34	37	PF01048	0.616
MOD_GSK3_1	136	143	PF00069	0.559
MOD_GSK3_1	165	172	PF00069	0.522
MOD_GSK3_1	214	221	PF00069	0.444
MOD_GSK3_1	231	238	PF00069	0.313
MOD_GSK3_1	26	33	PF00069	0.712
MOD_GSK3_1	369	376	PF00069	0.534
MOD_GSK3_1	48	55	PF00069	0.615
MOD_GSK3_1	83	90	PF00069	0.432
MOD_NEK2_1	128	133	PF00069	0.463
MOD_NEK2_1	157	162	PF00069	0.380
MOD_NEK2_1	173	178	PF00069	0.472
MOD_NEK2_1	295	300	PF00069	0.476
MOD_NEK2_1	340	345	PF00069	0.434
MOD_NEK2_2	288	293	PF00069	0.497
MOD_PIKK_1	369	375	PF00454	0.552
MOD_PK_1	231	237	PF00069	0.419
MOD_PK_1	254	260	PF00069	0.455
MOD_PKA_1	165	171	PF00069	0.565
MOD_PKA_1	246	252	PF00069	0.482
MOD_Plk_1	157	163	PF00069	0.397
MOD_Plk_1	295	301	PF00069	0.417
MOD_Plk_1	99	105	PF00069	0.511
MOD_Plk_4	192	198	PF00069	0.448
MOD_Plk_4	221	227	PF00069	0.553
MOD_ProDKin_1	26	32	PF00069	0.722
MOD_SUMO_rev_2	114	122	PF00179	0.400
MOD_SUMO_rev_2	179	187	PF00179	0.407
MOD_SUMO_rev_2	3	11	PF00179	0.612
MOD_SUMO_rev_2	330	337	PF00179	0.503
MOD_SUMO_rev_2	81	91	PF00179	0.528
TRG_DiLeu_BaEn_1	386	391	PF01217	0.651
TRG_DiLeu_LyEn_5	386	391	PF01217	0.651
TRG_ENDOCYTIC_2	161	164	PF00928	0.406
TRG_ENDOCYTIC_2	365	368	PF00928	0.424
TRG_NES_CRM1_1	106	119	PF08389	0.442
TRG_NES_CRM1_1	171	184	PF08389	0.379
TRG_NES_CRM1_1	191	203	PF08389	0.320
TRG_NES_CRM1_1	68	81	PF08389	0.468
TRG_Pf-PMV_PEXEL_1	246	251	PF00026	0.448

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2J8	Leptomonas seymouri	76%	99%
A0A0S4IT07	Bodo saltans	57%	100%
A0A1X0NLS5	Trypanosomatidae	60%	99%
A0A3R7JZE2	Trypanosoma rangeli	59%	99%
A4H4G5	Leishmania braziliensis	92%	100%
A4HSP2	Leishmania infantum	100%	100%
C9ZNE6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	98%
E9AKM7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
O35125	Mus musculus	28%	100%
P21793	Bos taurus	27%	100%
P22194	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	31%	100%
P36047	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	34%	100%
P45969	Caenorhabditis elegans	35%	100%
Q15435	Homo sapiens	38%	100%
Q32PL1	Danio rerio	36%	100%
Q3T0W4	Bos taurus	37%	100%
Q3UM45	Mus musculus	37%	100%
Q4QJ81	Leishmania major	97%	100%
Q53EV4	Homo sapiens	25%	100%
Q54Q39	Dictyostelium discoideum	36%	100%
Q5HZV9	Rattus norvegicus	38%	100%
Q5RFS7	Pongo abelii	38%	100%
Q6DIQ3	Xenopus tropicalis	37%	100%
Q84WJ9	Arabidopsis thaliana	35%	100%
Q8AVI4	Xenopus laevis	26%	69%
Q8S7M7	Oryza sativa subsp. japonica	26%	73%
Q9DE68	Coturnix japonica	28%	100%
Q9TTE2	Ovis aries	27%	100%
V5ARU0	Trypanosoma cruzi	59%	99%