Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3S7WPA4_LEIDO

TriTrypDb:

LdBPK_051150.1 , LdCL_050016800 , LDHU3_05.1300

Length:

916

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	6
GO:0042995	cell projection	2	6
GO:0043226	organelle	2	6
GO:0043227	membrane-bounded organelle	3	6
GO:0110165	cellular anatomical entity	1	6
GO:0120025	plasma membrane bounded cell projection	3	6

Expansion

Sequence features

A0A3S7WPA4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WPA4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	129	133	PF00656	0.504
CLV_C14_Caspase3-7	223	227	PF00656	0.825
CLV_C14_Caspase3-7	384	388	PF00656	0.581
CLV_NRD_NRD_1	138	140	PF00675	0.617
CLV_NRD_NRD_1	429	431	PF00675	0.570
CLV_NRD_NRD_1	483	485	PF00675	0.704
CLV_NRD_NRD_1	7	9	PF00675	0.647
CLV_NRD_NRD_1	832	834	PF00675	0.651
CLV_NRD_NRD_1	881	883	PF00675	0.467
CLV_PCSK_KEX2_1	138	140	PF00082	0.617
CLV_PCSK_KEX2_1	429	431	PF00082	0.570
CLV_PCSK_KEX2_1	483	485	PF00082	0.704
CLV_PCSK_KEX2_1	642	644	PF00082	0.815
CLV_PCSK_KEX2_1	7	9	PF00082	0.625
CLV_PCSK_KEX2_1	831	833	PF00082	0.666
CLV_PCSK_KEX2_1	881	883	PF00082	0.467
CLV_PCSK_PC1ET2_1	642	644	PF00082	0.815
CLV_PCSK_SKI1_1	429	433	PF00082	0.584
CLV_PCSK_SKI1_1	514	518	PF00082	0.720
CLV_PCSK_SKI1_1	685	689	PF00082	0.708
CLV_PCSK_SKI1_1	856	860	PF00082	0.550
CLV_PCSK_SKI1_1	90	94	PF00082	0.534
DEG_APCC_DBOX_1	513	521	PF00400	0.605
DEG_SCF_FBW7_2	159	166	PF00400	0.498
DEG_SPOP_SBC_1	397	401	PF00917	0.627
DEG_SPOP_SBC_1	572	576	PF00917	0.793
DEG_SPOP_SBC_1	65	69	PF00917	0.672
DEG_SPOP_SBC_1	747	751	PF00917	0.783
DEG_SPOP_SBC_1	757	761	PF00917	0.728
DOC_ANK_TNKS_1	255	262	PF00023	0.683
DOC_CKS1_1	160	165	PF01111	0.510
DOC_CKS1_1	431	436	PF01111	0.704
DOC_CKS1_1	688	693	PF01111	0.718
DOC_CKS1_1	732	737	PF01111	0.702
DOC_CYCLIN_yCln2_LP_2	44	50	PF00134	0.607
DOC_CYCLIN_yCln2_LP_2	586	592	PF00134	0.673
DOC_CYCLIN_yCln2_LP_2	630	636	PF00134	0.671
DOC_CYCLIN_yCln2_LP_2	904	910	PF00134	0.686
DOC_MAPK_gen_1	138	145	PF00069	0.588
DOC_MAPK_gen_1	622	632	PF00069	0.778
DOC_MAPK_gen_1	694	703	PF00069	0.814
DOC_MAPK_MEF2A_6	360	367	PF00069	0.539
DOC_MAPK_RevD_3	818	832	PF00069	0.539
DOC_PP2B_LxvP_1	630	633	PF13499	0.641
DOC_PP2B_LxvP_1	689	692	PF13499	0.661
DOC_PP2B_LxvP_1	904	907	PF13499	0.766
DOC_PP2B_LxvP_1	908	911	PF13499	0.750
DOC_PP4_FxxP_1	535	538	PF00568	0.605
DOC_PP4_FxxP_1	688	691	PF00568	0.723
DOC_USP7_MATH_1	127	131	PF00917	0.555
DOC_USP7_MATH_1	161	165	PF00917	0.738
DOC_USP7_MATH_1	183	187	PF00917	0.682
DOC_USP7_MATH_1	188	192	PF00917	0.672
DOC_USP7_MATH_1	214	218	PF00917	0.636
DOC_USP7_MATH_1	298	302	PF00917	0.700
DOC_USP7_MATH_1	319	323	PF00917	0.686
DOC_USP7_MATH_1	441	445	PF00917	0.698
DOC_USP7_MATH_1	49	53	PF00917	0.737
DOC_USP7_MATH_1	540	544	PF00917	0.721
DOC_USP7_MATH_1	546	550	PF00917	0.705
DOC_USP7_MATH_1	553	557	PF00917	0.575
DOC_USP7_MATH_1	573	577	PF00917	0.733
DOC_USP7_MATH_1	65	69	PF00917	0.608
DOC_USP7_MATH_1	681	685	PF00917	0.747
DOC_USP7_MATH_1	727	731	PF00917	0.817
DOC_USP7_MATH_1	75	79	PF00917	0.657
DOC_USP7_MATH_1	757	761	PF00917	0.607
DOC_USP7_MATH_1	780	784	PF00917	0.684
DOC_USP7_MATH_1	803	807	PF00917	0.693
DOC_USP7_MATH_1	809	813	PF00917	0.660
DOC_USP7_MATH_1	91	95	PF00917	0.496
DOC_WW_Pin1_4	159	164	PF00397	0.640
DOC_WW_Pin1_4	169	174	PF00397	0.736
DOC_WW_Pin1_4	231	236	PF00397	0.714
DOC_WW_Pin1_4	340	345	PF00397	0.647
DOC_WW_Pin1_4	430	435	PF00397	0.667
DOC_WW_Pin1_4	437	442	PF00397	0.669
DOC_WW_Pin1_4	536	541	PF00397	0.770
DOC_WW_Pin1_4	585	590	PF00397	0.726
DOC_WW_Pin1_4	644	649	PF00397	0.759
DOC_WW_Pin1_4	655	660	PF00397	0.670
DOC_WW_Pin1_4	687	692	PF00397	0.721
DOC_WW_Pin1_4	712	717	PF00397	0.675
DOC_WW_Pin1_4	731	736	PF00397	0.612
LIG_14-3-3_CanoR_1	297	306	PF00244	0.688
LIG_14-3-3_CanoR_1	373	378	PF00244	0.574
LIG_14-3-3_CanoR_1	406	415	PF00244	0.643
LIG_14-3-3_CanoR_1	506	510	PF00244	0.814
LIG_14-3-3_CanoR_1	514	524	PF00244	0.640
LIG_14-3-3_CanoR_1	529	538	PF00244	0.538
LIG_14-3-3_CanoR_1	567	573	PF00244	0.673
LIG_14-3-3_CanoR_1	725	735	PF00244	0.688
LIG_14-3-3_CanoR_1	839	847	PF00244	0.538
LIG_14-3-3_CanoR_1	90	96	PF00244	0.617
LIG_Actin_WH2_2	9	26	PF00022	0.664
LIG_BIR_III_2	341	345	PF00653	0.711
LIG_BRCT_BRCA1_1	518	522	PF00533	0.630
LIG_BRCT_BRCA1_1	531	535	PF00533	0.496
LIG_FHA_1	115	121	PF00498	0.492
LIG_FHA_1	236	242	PF00498	0.737
LIG_FHA_1	29	35	PF00498	0.589
LIG_FHA_1	312	318	PF00498	0.632
LIG_FHA_1	399	405	PF00498	0.669
LIG_FHA_1	602	608	PF00498	0.703
LIG_FHA_1	757	763	PF00498	0.721
LIG_FHA_1	800	806	PF00498	0.626
LIG_FHA_1	808	814	PF00498	0.674
LIG_FHA_1	843	849	PF00498	0.601
LIG_FHA_1	859	865	PF00498	0.441
LIG_FHA_1	901	907	PF00498	0.659
LIG_FHA_1	94	100	PF00498	0.472
LIG_FHA_2	127	133	PF00498	0.499
LIG_FHA_2	172	178	PF00498	0.611
LIG_FHA_2	411	417	PF00498	0.515
LIG_FHA_2	506	512	PF00498	0.660
LIG_FHA_2	852	858	PF00498	0.633
LIG_LIR_Apic_2	532	538	PF02991	0.595
LIG_LIR_Gen_1	144	153	PF02991	0.490
LIG_LIR_Gen_1	174	183	PF02991	0.671
LIG_LIR_Gen_1	219	229	PF02991	0.715
LIG_LIR_Gen_1	582	592	PF02991	0.690
LIG_LIR_Nem_3	144	150	PF02991	0.481
LIG_LIR_Nem_3	174	179	PF02991	0.664
LIG_LIR_Nem_3	219	225	PF02991	0.718
LIG_LIR_Nem_3	582	587	PF02991	0.697
LIG_LIR_Nem_3	761	767	PF02991	0.659
LIG_MYND_1	403	407	PF01753	0.515
LIG_NRBOX	94	100	PF00104	0.580
LIG_PCNA_yPIPBox_3	554	567	PF02747	0.727
LIG_SH2_CRK	176	180	PF00017	0.670
LIG_SH2_CRK	330	334	PF00017	0.641
LIG_SH2_NCK_1	147	151	PF00017	0.580
LIG_SH2_PTP2	142	145	PF00017	0.470
LIG_SH2_STAP1	640	644	PF00017	0.702
LIG_SH2_STAT5	142	145	PF00017	0.470
LIG_SH2_STAT5	421	424	PF00017	0.546
LIG_SH3_2	732	737	PF14604	0.702
LIG_SH3_3	331	337	PF00018	0.812
LIG_SH3_3	341	347	PF00018	0.702
LIG_SH3_3	435	441	PF00018	0.637
LIG_SH3_3	711	717	PF00018	0.675
LIG_SH3_3	729	735	PF00018	0.767
LIG_SH3_3	896	902	PF00018	0.633
LIG_SUMO_SIM_anti_2	116	122	PF11976	0.583
LIG_SUMO_SIM_anti_2	611	616	PF11976	0.635
LIG_SUMO_SIM_anti_2	789	795	PF11976	0.492
LIG_SUMO_SIM_par_1	116	124	PF11976	0.580
LIG_SUMO_SIM_par_1	156	162	PF11976	0.429
LIG_SUMO_SIM_par_1	240	248	PF11976	0.773
LIG_SUMO_SIM_par_1	312	318	PF11976	0.632
LIG_SUMO_SIM_par_1	362	368	PF11976	0.600
LIG_SUMO_SIM_par_1	792	797	PF11976	0.487
LIG_TRAF2_1	81	84	PF00917	0.569
LIG_TRAF2_1	865	868	PF00917	0.533
LIG_TYR_ITIM	140	145	PF00017	0.473
LIG_WW_3	691	695	PF00397	0.811
LIG_WW_3	734	738	PF00397	0.713
MOD_CDK_SPxK_1	159	165	PF00069	0.496
MOD_CDK_SPxK_1	430	436	PF00069	0.647
MOD_CDK_SPxK_1	646	652	PF00069	0.766
MOD_CDK_SPxK_1	731	737	PF00069	0.705
MOD_CDK_SPxxK_3	687	694	PF00069	0.718
MOD_CK1_1	146	152	PF00069	0.590
MOD_CK1_1	169	175	PF00069	0.778
MOD_CK1_1	184	190	PF00069	0.560
MOD_CK1_1	237	243	PF00069	0.732
MOD_CK1_1	244	250	PF00069	0.698
MOD_CK1_1	284	290	PF00069	0.731
MOD_CK1_1	293	299	PF00069	0.613
MOD_CK1_1	301	307	PF00069	0.524
MOD_CK1_1	322	328	PF00069	0.682
MOD_CK1_1	439	445	PF00069	0.713
MOD_CK1_1	515	521	PF00069	0.649
MOD_CK1_1	585	591	PF00069	0.771
MOD_CK1_1	655	661	PF00069	0.780
MOD_CK1_1	662	668	PF00069	0.822
MOD_CK1_1	69	75	PF00069	0.709
MOD_CK1_1	706	712	PF00069	0.756
MOD_CK1_1	749	755	PF00069	0.781
MOD_CK1_1	78	84	PF00069	0.738
MOD_CK2_1	183	189	PF00069	0.734
MOD_CK2_1	193	199	PF00069	0.684
MOD_CK2_1	78	84	PF00069	0.594
MOD_CK2_1	851	857	PF00069	0.632
MOD_GlcNHglycan	195	198	PF01048	0.670
MOD_GlcNHglycan	300	303	PF01048	0.662
MOD_GlcNHglycan	317	320	PF01048	0.552
MOD_GlcNHglycan	321	324	PF01048	0.639
MOD_GlcNHglycan	350	353	PF01048	0.728
MOD_GlcNHglycan	384	387	PF01048	0.623
MOD_GlcNHglycan	444	447	PF01048	0.756
MOD_GlcNHglycan	462	466	PF01048	0.534
MOD_GlcNHglycan	480	483	PF01048	0.505
MOD_GlcNHglycan	531	534	PF01048	0.634
MOD_GlcNHglycan	542	545	PF01048	0.689
MOD_GlcNHglycan	575	578	PF01048	0.788
MOD_GlcNHglycan	634	637	PF01048	0.702
MOD_GlcNHglycan	654	657	PF01048	0.741
MOD_GlcNHglycan	709	712	PF01048	0.745
MOD_GlcNHglycan	729	732	PF01048	0.595
MOD_GlcNHglycan	73	76	PF01048	0.742
MOD_GlcNHglycan	781	785	PF01048	0.769
MOD_GlcNHglycan	786	789	PF01048	0.772
MOD_GlcNHglycan	799	802	PF01048	0.610
MOD_GlcNHglycan	813	816	PF01048	0.601
MOD_GlcNHglycan	83	89	PF01048	0.506
MOD_GSK3_1	184	191	PF00069	0.736
MOD_GSK3_1	231	238	PF00069	0.745
MOD_GSK3_1	241	248	PF00069	0.667
MOD_GSK3_1	250	257	PF00069	0.585
MOD_GSK3_1	298	305	PF00069	0.706
MOD_GSK3_1	311	318	PF00069	0.546
MOD_GSK3_1	348	355	PF00069	0.656
MOD_GSK3_1	437	444	PF00069	0.683
MOD_GSK3_1	488	495	PF00069	0.707
MOD_GSK3_1	512	519	PF00069	0.729
MOD_GSK3_1	525	532	PF00069	0.564
MOD_GSK3_1	536	543	PF00069	0.700
MOD_GSK3_1	568	575	PF00069	0.760
MOD_GSK3_1	61	68	PF00069	0.770
MOD_GSK3_1	655	662	PF00069	0.800
MOD_GSK3_1	693	700	PF00069	0.727
MOD_GSK3_1	703	710	PF00069	0.710
MOD_GSK3_1	71	78	PF00069	0.664
MOD_GSK3_1	727	734	PF00069	0.725
MOD_GSK3_1	746	753	PF00069	0.753
MOD_GSK3_1	780	787	PF00069	0.814
MOD_GSK3_1	799	806	PF00069	0.638
MOD_GSK3_1	807	814	PF00069	0.767
MOD_GSK3_1	838	845	PF00069	0.648
MOD_N-GLC_1	34	39	PF02516	0.479
MOD_N-GLC_1	470	475	PF02516	0.618
MOD_NEK2_1	121	126	PF00069	0.480
MOD_NEK2_1	245	250	PF00069	0.705
MOD_NEK2_1	34	39	PF00069	0.587
MOD_NEK2_1	365	370	PF00069	0.567
MOD_NEK2_1	415	420	PF00069	0.508
MOD_NEK2_1	461	466	PF00069	0.593
MOD_NEK2_1	478	483	PF00069	0.522
MOD_NEK2_1	48	53	PF00069	0.525
MOD_NEK2_1	560	565	PF00069	0.679
MOD_NEK2_1	726	731	PF00069	0.678
MOD_NEK2_1	748	753	PF00069	0.701
MOD_NEK2_1	794	799	PF00069	0.675
MOD_NEK2_1	858	863	PF00069	0.523
MOD_NEK2_2	579	584	PF00069	0.792
MOD_PIKK_1	328	334	PF00454	0.788
MOD_PIKK_1	49	55	PF00454	0.672
MOD_PIKK_1	741	747	PF00454	0.660
MOD_PK_1	697	703	PF00069	0.817
MOD_PKA_1	483	489	PF00069	0.708
MOD_PKA_2	296	302	PF00069	0.707
MOD_PKA_2	483	489	PF00069	0.708
MOD_PKA_2	492	498	PF00069	0.731
MOD_PKA_2	505	511	PF00069	0.605
MOD_PKA_2	693	699	PF00069	0.810
MOD_PKA_2	784	790	PF00069	0.528
MOD_PKA_2	838	844	PF00069	0.553
MOD_PKB_1	371	379	PF00069	0.489
MOD_Plk_1	143	149	PF00069	0.567
MOD_Plk_1	284	290	PF00069	0.677
MOD_Plk_1	302	308	PF00069	0.507
MOD_Plk_1	311	317	PF00069	0.558
MOD_Plk_1	512	518	PF00069	0.676
MOD_Plk_1	610	616	PF00069	0.637
MOD_Plk_1	697	703	PF00069	0.784
MOD_Plk_1	757	763	PF00069	0.640
MOD_Plk_1	84	90	PF00069	0.574
MOD_Plk_1	842	848	PF00069	0.649
MOD_Plk_1	851	857	PF00069	0.487
MOD_Plk_2-3	492	498	PF00069	0.680
MOD_Plk_4	104	110	PF00069	0.480
MOD_Plk_4	116	122	PF00069	0.448
MOD_Plk_4	579	585	PF00069	0.790
MOD_Plk_4	610	616	PF00069	0.637
MOD_Plk_4	703	709	PF00069	0.743
MOD_ProDKin_1	159	165	PF00069	0.647
MOD_ProDKin_1	169	175	PF00069	0.734
MOD_ProDKin_1	231	237	PF00069	0.713
MOD_ProDKin_1	340	346	PF00069	0.649
MOD_ProDKin_1	430	436	PF00069	0.679
MOD_ProDKin_1	437	443	PF00069	0.671
MOD_ProDKin_1	536	542	PF00069	0.771
MOD_ProDKin_1	585	591	PF00069	0.726
MOD_ProDKin_1	644	650	PF00069	0.756
MOD_ProDKin_1	655	661	PF00069	0.667
MOD_ProDKin_1	687	693	PF00069	0.718
MOD_ProDKin_1	712	718	PF00069	0.679
MOD_ProDKin_1	731	737	PF00069	0.619
MOD_SUMO_rev_2	852	861	PF00179	0.639
TRG_DiLeu_BaEn_4	84	90	PF01217	0.547
TRG_DiLeu_BaLyEn_6	341	346	PF01217	0.713
TRG_DiLeu_BaLyEn_6	400	405	PF01217	0.569
TRG_ENDOCYTIC_2	142	145	PF00928	0.470
TRG_ENDOCYTIC_2	147	150	PF00928	0.475
TRG_ENDOCYTIC_2	176	179	PF00928	0.695
TRG_ENDOCYTIC_2	764	767	PF00928	0.662
TRG_ENDOCYTIC_2	834	837	PF00928	0.590
TRG_ER_diArg_1	138	140	PF00400	0.617
TRG_ER_diArg_1	372	375	PF00400	0.514
TRG_ER_diArg_1	428	430	PF00400	0.571
TRG_ER_diArg_1	483	485	PF00400	0.761
TRG_ER_diArg_1	830	833	PF00400	0.550
TRG_ER_diArg_1	880	882	PF00400	0.471
TRG_NES_CRM1_1	879	892	PF08389	0.520
TRG_Pf-PMV_PEXEL_1	8	12	PF00026	0.546
TRG_Pf-PMV_PEXEL_1	835	840	PF00026	0.546
TRG_Pf-PMV_PEXEL_1	881	886	PF00026	0.508

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I133	Leptomonas seymouri	38%	100%
A4H4G0	Leishmania braziliensis	67%	100%
A4HSN7	Leishmania infantum	99%	100%
E9AKM2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	93%