Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WPA3_LEIDO

TriTrypDb:

LdBPK_051130.1 , LdCL_050016600 , LDHU3_05.1280

Length:

508

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7WPA3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WPA3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	170	174	PF00656	0.663
CLV_C14_Caspase3-7	184	188	PF00656	0.665
CLV_C14_Caspase3-7	489	493	PF00656	0.768
CLV_NRD_NRD_1	15	17	PF00675	0.718
CLV_NRD_NRD_1	221	223	PF00675	0.511
CLV_NRD_NRD_1	63	65	PF00675	0.544
CLV_PCSK_KEX2_1	15	17	PF00082	0.621
CLV_PCSK_KEX2_1	221	223	PF00082	0.511
CLV_PCSK_KEX2_1	356	358	PF00082	0.481
CLV_PCSK_KEX2_1	63	65	PF00082	0.544
CLV_PCSK_PC1ET2_1	356	358	PF00082	0.515
CLV_PCSK_SKI1_1	102	106	PF00082	0.469
CLV_PCSK_SKI1_1	2	6	PF00082	0.575
CLV_PCSK_SKI1_1	213	217	PF00082	0.369
CLV_PCSK_SKI1_1	283	287	PF00082	0.368
CLV_PCSK_SKI1_1	311	315	PF00082	0.403
CLV_PCSK_SKI1_1	427	431	PF00082	0.573
CLV_PCSK_SKI1_1	458	462	PF00082	0.448
DEG_Nend_UBRbox_1	1	4	PF02207	0.560
DEG_SPOP_SBC_1	444	448	PF00917	0.551
DOC_CKS1_1	179	184	PF01111	0.717
DOC_CKS1_1	369	374	PF01111	0.610
DOC_CYCLIN_RxL_1	332	342	PF00134	0.538
DOC_CYCLIN_yCln2_LP_2	337	343	PF00134	0.394
DOC_MAPK_gen_1	425	434	PF00069	0.594
DOC_MAPK_gen_1	456	464	PF00069	0.427
DOC_MAPK_MEF2A_6	213	220	PF00069	0.412
DOC_MAPK_MEF2A_6	335	343	PF00069	0.463
DOC_MAPK_MEF2A_6	456	464	PF00069	0.557
DOC_PP2B_LxvP_1	337	340	PF13499	0.411
DOC_PP2B_LxvP_1	341	344	PF13499	0.374
DOC_PP2B_LxvP_1	362	365	PF13499	0.407
DOC_SPAK_OSR1_1	166	170	PF12202	0.605
DOC_SPAK_OSR1_1	347	351	PF12202	0.369
DOC_USP7_MATH_1	226	230	PF00917	0.371
DOC_USP7_MATH_1	33	37	PF00917	0.614
DOC_USP7_MATH_1	333	337	PF00917	0.546
DOC_USP7_MATH_1	436	440	PF00917	0.523
DOC_USP7_MATH_1	487	491	PF00917	0.722
DOC_USP7_MATH_1	494	498	PF00917	0.629
DOC_WW_Pin1_4	14	19	PF00397	0.632
DOC_WW_Pin1_4	175	180	PF00397	0.581
DOC_WW_Pin1_4	368	373	PF00397	0.584
DOC_WW_Pin1_4	386	391	PF00397	0.435
DOC_WW_Pin1_4	501	506	PF00397	0.721
LIG_14-3-3_CanoR_1	486	494	PF00244	0.522
LIG_14-3-3_CanoR_1	69	73	PF00244	0.433
LIG_14-3-3_CanoR_1	84	91	PF00244	0.480
LIG_Actin_WH2_2	139	157	PF00022	0.543
LIG_BIR_III_4	395	399	PF00653	0.375
LIG_BRCT_BRCA1_1	69	73	PF00533	0.452
LIG_deltaCOP1_diTrp_1	351	358	PF00928	0.390
LIG_FHA_1	184	190	PF00498	0.665
LIG_FHA_1	303	309	PF00498	0.386
LIG_FHA_1	312	318	PF00498	0.401
LIG_FHA_1	417	423	PF00498	0.579
LIG_FHA_1	7	13	PF00498	0.645
LIG_FHA_2	182	188	PF00498	0.648
LIG_FHA_2	292	298	PF00498	0.530
LIG_FHA_2	369	375	PF00498	0.545
LIG_FHA_2	406	412	PF00498	0.544
LIG_FHA_2	444	450	PF00498	0.489
LIG_FHA_2	69	75	PF00498	0.432
LIG_GSK3_LRP6_1	368	373	PF00069	0.536
LIG_Integrin_RGD_1	295	297	PF01839	0.570
LIG_LIR_Gen_1	3	12	PF02991	0.594
LIG_LIR_Gen_1	408	417	PF02991	0.560
LIG_LIR_LC3C_4	459	463	PF02991	0.559
LIG_LIR_Nem_3	3	8	PF02991	0.589
LIG_LIR_Nem_3	342	348	PF02991	0.436
LIG_LIR_Nem_3	352	358	PF02991	0.238
LIG_LIR_Nem_3	408	412	PF02991	0.568
LIG_LIR_Nem_3	439	444	PF02991	0.467
LIG_PCNA_PIPBox_1	147	156	PF02747	0.510
LIG_Pex14_1	355	359	PF04695	0.417
LIG_Pex14_2	354	358	PF04695	0.356
LIG_Pex14_2	95	99	PF04695	0.500
LIG_PTB_Apo_2	229	236	PF02174	0.472
LIG_REV1ctd_RIR_1	2	11	PF16727	0.580
LIG_SH2_CRK	263	267	PF00017	0.404
LIG_SH2_CRK	359	363	PF00017	0.488
LIG_SH2_CRK	441	445	PF00017	0.547
LIG_SH2_SRC	441	444	PF00017	0.434
LIG_SH2_STAT5	210	213	PF00017	0.352
LIG_SH2_STAT5	303	306	PF00017	0.400
LIG_SH2_STAT5	392	395	PF00017	0.461
LIG_SH3_1	15	21	PF00018	0.654
LIG_SH3_3	15	21	PF00018	0.636
LIG_SH3_3	176	182	PF00018	0.679
LIG_SH3_3	29	35	PF00018	0.413
LIG_SH3_3	362	368	PF00018	0.422
LIG_SH3_3	497	503	PF00018	0.793
LIG_SH3_4	271	278	PF00018	0.562
LIG_Sin3_3	251	258	PF02671	0.500
LIG_SUMO_SIM_anti_2	459	466	PF11976	0.512
LIG_SUMO_SIM_par_1	459	466	PF11976	0.519
LIG_TRAF2_1	134	137	PF00917	0.479
LIG_TRAF2_1	371	374	PF00917	0.557
LIG_TYR_ITIM	261	266	PF00017	0.401
LIG_WRC_WIRS_1	1	6	PF05994	0.581
LIG_WRC_WIRS_1	406	411	PF05994	0.543
LIG_WRC_WIRS_1	464	469	PF05994	0.571
MOD_CDK_SPK_2	178	183	PF00069	0.711
MOD_CDK_SPxxK_3	501	508	PF00069	0.726
MOD_CK1_1	3	9	PF00069	0.610
MOD_CK2_1	368	374	PF00069	0.540
MOD_CK2_1	443	449	PF00069	0.481
MOD_CK2_1	501	507	PF00069	0.722
MOD_CK2_1	54	60	PF00069	0.540
MOD_GlcNHglycan	475	478	PF01048	0.561
MOD_GlcNHglycan	496	499	PF01048	0.700
MOD_GlcNHglycan	56	59	PF01048	0.479
MOD_GSK3_1	181	188	PF00069	0.662
MOD_GSK3_1	262	269	PF00069	0.526
MOD_GSK3_1	298	305	PF00069	0.436
MOD_GSK3_1	3	10	PF00069	0.674
MOD_GSK3_1	307	314	PF00069	0.353
MOD_GSK3_1	315	322	PF00069	0.322
MOD_NEK2_1	11	16	PF00069	0.648
MOD_NEK2_1	266	271	PF00069	0.580
MOD_NEK2_1	291	296	PF00069	0.507
MOD_NEK2_2	185	190	PF00069	0.687
MOD_OFUCOSY	87	93	PF10250	0.410
MOD_PKA_2	473	479	PF00069	0.589
MOD_PKA_2	68	74	PF00069	0.437
MOD_PKA_2	83	89	PF00069	0.481
MOD_Plk_1	204	210	PF00069	0.475
MOD_Plk_1	240	246	PF00069	0.541
MOD_Plk_4	205	211	PF00069	0.454
MOD_Plk_4	226	232	PF00069	0.388
MOD_Plk_4	68	74	PF00069	0.417
MOD_Plk_4	7	13	PF00069	0.551
MOD_ProDKin_1	14	20	PF00069	0.623
MOD_ProDKin_1	175	181	PF00069	0.574
MOD_ProDKin_1	368	374	PF00069	0.586
MOD_ProDKin_1	386	392	PF00069	0.423
MOD_ProDKin_1	501	507	PF00069	0.722
MOD_SUMO_rev_2	373	377	PF00179	0.684
MOD_SUMO_rev_2	424	432	PF00179	0.524
TRG_DiLeu_BaEn_1	126	131	PF01217	0.543
TRG_DiLeu_BaEn_1	282	287	PF01217	0.536
TRG_DiLeu_BaEn_4	204	210	PF01217	0.465
TRG_DiLeu_BaLyEn_6	281	286	PF01217	0.420
TRG_ENDOCYTIC_2	263	266	PF00928	0.393
TRG_ENDOCYTIC_2	345	348	PF00928	0.386
TRG_ENDOCYTIC_2	359	362	PF00928	0.488
TRG_ENDOCYTIC_2	441	444	PF00928	0.450
TRG_ER_diArg_1	220	222	PF00400	0.520
TRG_ER_diArg_1	242	245	PF00400	0.440
TRG_Pf-PMV_PEXEL_1	166	170	PF00026	0.605

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2F7	Leptomonas seymouri	80%	100%
A0A0S4IPB6	Bodo saltans	43%	97%
A0A1X0NKA7	Trypanosomatidae	51%	87%
A0A3R7NCC1	Trypanosoma rangeli	55%	96%
A4H4F8	Leishmania braziliensis	91%	100%
A4HSN5	Leishmania infantum	100%	100%
C9ZND9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	77%
E9AKM0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
Q4QJ89	Leishmania major	97%	100%
V5D7S2	Trypanosoma cruzi	55%	98%