Glutaminyl cyclase, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

glutaminyl cyclase, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WP80_LEIDO

TriTrypDb:

LdBPK_050950.1 , LdCL_050014600 , LDHU3_05.1050

Length:

907

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A0A3S7WP80

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WP80

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0017186	peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase	7	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018199	peptidyl-glutamine modification	6	1
GO:0019538	protein metabolic process	3	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044238	primary metabolic process	2	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0016603	glutaminyl-peptide cyclotransferase activity	4	5
GO:0016740	transferase activity	2	7
GO:0016746	acyltransferase activity	3	7
GO:0016755	aminoacyltransferase activity	3	5
GO:0140096	catalytic activity, acting on a protein	2	5
GO:0005488	binding	1	1
GO:0008270	zinc ion binding	6	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1
GO:0046914	transition metal ion binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	183	187	PF00656	0.514
CLV_C14_Caspase3-7	228	232	PF00656	0.488
CLV_C14_Caspase3-7	275	279	PF00656	0.457
CLV_NRD_NRD_1	10	12	PF00675	0.485
CLV_NRD_NRD_1	125	127	PF00675	0.691
CLV_NRD_NRD_1	13	15	PF00675	0.464
CLV_NRD_NRD_1	142	144	PF00675	0.549
CLV_NRD_NRD_1	161	163	PF00675	0.566
CLV_NRD_NRD_1	17	19	PF00675	0.430
CLV_NRD_NRD_1	245	247	PF00675	0.699
CLV_NRD_NRD_1	336	338	PF00675	0.647
CLV_NRD_NRD_1	365	367	PF00675	0.717
CLV_NRD_NRD_1	371	373	PF00675	0.713
CLV_NRD_NRD_1	49	51	PF00675	0.279
CLV_NRD_NRD_1	747	749	PF00675	0.689
CLV_NRD_NRD_1	837	839	PF00675	0.474
CLV_NRD_NRD_1	904	906	PF00675	0.680
CLV_PCSK_FUR_1	11	15	PF00082	0.482
CLV_PCSK_FUR_1	47	51	PF00082	0.395
CLV_PCSK_KEX2_1	13	15	PF00082	0.461
CLV_PCSK_KEX2_1	142	144	PF00082	0.670
CLV_PCSK_KEX2_1	150	152	PF00082	0.628
CLV_PCSK_KEX2_1	161	163	PF00082	0.565
CLV_PCSK_KEX2_1	17	19	PF00082	0.425
CLV_PCSK_KEX2_1	229	231	PF00082	0.641
CLV_PCSK_KEX2_1	244	246	PF00082	0.637
CLV_PCSK_KEX2_1	29	31	PF00082	0.320
CLV_PCSK_KEX2_1	336	338	PF00082	0.647
CLV_PCSK_KEX2_1	364	366	PF00082	0.713
CLV_PCSK_KEX2_1	49	51	PF00082	0.279
CLV_PCSK_KEX2_1	747	749	PF00082	0.687
CLV_PCSK_KEX2_1	837	839	PF00082	0.474
CLV_PCSK_KEX2_1	9	11	PF00082	0.492
CLV_PCSK_PC1ET2_1	150	152	PF00082	0.651
CLV_PCSK_PC1ET2_1	229	231	PF00082	0.641
CLV_PCSK_PC1ET2_1	29	31	PF00082	0.453
CLV_PCSK_PC7_1	9	15	PF00082	0.476
CLV_PCSK_SKI1_1	150	154	PF00082	0.682
CLV_PCSK_SKI1_1	230	234	PF00082	0.748
CLV_PCSK_SKI1_1	26	30	PF00082	0.373
CLV_PCSK_SKI1_1	266	270	PF00082	0.661
CLV_PCSK_SKI1_1	351	355	PF00082	0.729
CLV_PCSK_SKI1_1	373	377	PF00082	0.748
CLV_PCSK_SKI1_1	409	413	PF00082	0.711
CLV_PCSK_SKI1_1	420	424	PF00082	0.698
CLV_PCSK_SKI1_1	485	489	PF00082	0.474
CLV_PCSK_SKI1_1	49	53	PF00082	0.277
CLV_PCSK_SKI1_1	528	532	PF00082	0.657
CLV_PCSK_SKI1_1	692	696	PF00082	0.585
CLV_PCSK_SKI1_1	747	751	PF00082	0.692
CLV_PCSK_SKI1_1	840	844	PF00082	0.499
DEG_APCC_DBOX_1	141	149	PF00400	0.479
DEG_APCC_DBOX_1	48	56	PF00400	0.477
DEG_APCC_DBOX_1	536	544	PF00400	0.404
DEG_APCC_DBOX_1	586	594	PF00400	0.355
DEG_Nend_UBRbox_3	1	3	PF02207	0.683
DOC_CDC14_PxL_1	465	473	PF14671	0.299
DOC_CYCLIN_RxL_1	260	270	PF00134	0.446
DOC_CYCLIN_yClb5_NLxxxL_5	320	329	PF00134	0.276
DOC_CYCLIN_yCln2_LP_2	543	549	PF00134	0.397
DOC_MAPK_DCC_7	857	866	PF00069	0.326
DOC_MAPK_FxFP_2	200	203	PF00069	0.441
DOC_MAPK_gen_1	47	57	PF00069	0.520
DOC_MAPK_gen_1	720	729	PF00069	0.448
DOC_MAPK_gen_1	837	844	PF00069	0.299
DOC_MAPK_MEF2A_6	49	57	PF00069	0.477
DOC_MAPK_MEF2A_6	720	729	PF00069	0.436
DOC_MAPK_MEF2A_6	857	866	PF00069	0.326
DOC_MAPK_MEF2A_6	96	103	PF00069	0.496
DOC_MAPK_RevD_3	232	246	PF00069	0.455
DOC_PP1_RVXF_1	33	40	PF00149	0.598
DOC_PP2B_LxvP_1	201	204	PF13499	0.443
DOC_PP2B_PxIxI_1	596	602	PF00149	0.358
DOC_PP4_FxxP_1	200	203	PF00568	0.441
DOC_PP4_FxxP_1	327	330	PF00568	0.364
DOC_PP4_FxxP_1	557	560	PF00568	0.399
DOC_PP4_FxxP_1	827	830	PF00568	0.274
DOC_USP7_MATH_1	152	156	PF00917	0.477
DOC_USP7_MATH_1	163	167	PF00917	0.437
DOC_USP7_MATH_1	272	276	PF00917	0.428
DOC_USP7_MATH_1	330	334	PF00917	0.371
DOC_USP7_MATH_1	341	345	PF00917	0.492
DOC_USP7_MATH_1	473	477	PF00917	0.274
DOC_USP7_MATH_1	506	510	PF00917	0.448
DOC_USP7_MATH_1	672	676	PF00917	0.408
DOC_USP7_MATH_1	737	741	PF00917	0.473
DOC_USP7_MATH_1	808	812	PF00917	0.357
DOC_USP7_MATH_1	88	92	PF00917	0.556
DOC_WW_Pin1_4	259	264	PF00397	0.542
DOC_WW_Pin1_4	421	426	PF00397	0.458
DOC_WW_Pin1_4	542	547	PF00397	0.409
DOC_WW_Pin1_4	629	634	PF00397	0.416
DOC_WW_Pin1_4	730	735	PF00397	0.561
DOC_WW_Pin1_4	768	773	PF00397	0.545
DOC_WW_Pin1_4	79	84	PF00397	0.517
DOC_WW_Pin1_4	826	831	PF00397	0.413
LIG_14-3-3_CanoR_1	142	146	PF00244	0.483
LIG_14-3-3_CanoR_1	162	172	PF00244	0.375
LIG_14-3-3_CanoR_1	298	304	PF00244	0.366
LIG_14-3-3_CanoR_1	38	43	PF00244	0.680
LIG_14-3-3_CanoR_1	528	536	PF00244	0.420
LIG_14-3-3_CanoR_1	539	544	PF00244	0.404
LIG_14-3-3_CanoR_1	559	564	PF00244	0.342
LIG_14-3-3_CanoR_1	628	633	PF00244	0.416
LIG_14-3-3_CanoR_1	720	725	PF00244	0.396
LIG_14-3-3_CanoR_1	783	791	PF00244	0.271
LIG_Actin_RPEL_3	749	768	PF02755	0.490
LIG_AP2alpha_2	105	107	PF02296	0.471
LIG_AP2alpha_2	724	726	PF02296	0.463
LIG_BIR_III_4	426	430	PF00653	0.506
LIG_BRCT_BRCA1_1	196	200	PF00533	0.476
LIG_BRCT_BRCA1_1	461	465	PF00533	0.326
LIG_BRCT_BRCA1_1	674	678	PF00533	0.406
LIG_deltaCOP1_diTrp_1	294	303	PF00928	0.436
LIG_eIF4E_1	648	654	PF01652	0.367
LIG_FHA_1	305	311	PF00498	0.410
LIG_FHA_1	417	423	PF00498	0.570
LIG_FHA_1	46	52	PF00498	0.642
LIG_FHA_1	630	636	PF00498	0.501
LIG_FHA_1	744	750	PF00498	0.421
LIG_FHA_1	783	789	PF00498	0.299
LIG_FHA_1	853	859	PF00498	0.339
LIG_FHA_2	134	140	PF00498	0.426
LIG_FHA_2	166	172	PF00498	0.518
LIG_FHA_2	226	232	PF00498	0.446
LIG_FHA_2	365	371	PF00498	0.544
LIG_FHA_2	530	536	PF00498	0.549
LIG_FHA_2	578	584	PF00498	0.471
LIG_FHA_2	586	592	PF00498	0.342
LIG_FHA_2	782	788	PF00498	0.326
LIG_FHA_2	80	86	PF00498	0.515
LIG_FHA_2	870	876	PF00498	0.330
LIG_FHA_2	882	888	PF00498	0.229
LIG_FHA_2	893	899	PF00498	0.324
LIG_LIR_Apic_2	197	203	PF02991	0.493
LIG_LIR_Gen_1	193	203	PF02991	0.475
LIG_LIR_Gen_1	21	32	PF02991	0.637
LIG_LIR_Gen_1	300	311	PF02991	0.359
LIG_LIR_Gen_1	462	473	PF02991	0.326
LIG_LIR_Gen_1	646	656	PF02991	0.313
LIG_LIR_Gen_1	665	672	PF02991	0.362
LIG_LIR_Gen_1	723	734	PF02991	0.473
LIG_LIR_Gen_1	792	800	PF02991	0.310
LIG_LIR_Nem_3	136	140	PF02991	0.426
LIG_LIR_Nem_3	193	198	PF02991	0.420
LIG_LIR_Nem_3	21	27	PF02991	0.632
LIG_LIR_Nem_3	300	306	PF02991	0.357
LIG_LIR_Nem_3	462	468	PF02991	0.295
LIG_LIR_Nem_3	646	651	PF02991	0.322
LIG_LIR_Nem_3	652	657	PF02991	0.302
LIG_LIR_Nem_3	723	729	PF02991	0.480
LIG_LIR_Nem_3	765	769	PF02991	0.418
LIG_LIR_Nem_3	792	797	PF02991	0.310
LIG_MAD2	857	865	PF02301	0.274
LIG_MLH1_MIPbox_1	461	465	PF16413	0.326
LIG_MYND_1	259	263	PF01753	0.485
LIG_NRBOX	539	545	PF00104	0.402
LIG_NRBOX	887	893	PF00104	0.394
LIG_Pex14_1	460	464	PF04695	0.326
LIG_Pex14_2	790	794	PF04695	0.299
LIG_Pex14_2	866	870	PF04695	0.274
LIG_PTB_Apo_2	321	328	PF02174	0.411
LIG_Rb_pABgroove_1	651	659	PF01858	0.303
LIG_REV1ctd_RIR_1	554	559	PF16727	0.437
LIG_SH2_CRK	679	683	PF00017	0.350
LIG_SH2_CRK	769	773	PF00017	0.409
LIG_SH2_GRB2like	818	821	PF00017	0.308
LIG_SH2_NCK_1	648	652	PF00017	0.372
LIG_SH2_SRC	640	643	PF00017	0.393
LIG_SH2_STAP1	745	749	PF00017	0.457
LIG_SH2_STAT3	671	674	PF00017	0.383
LIG_SH2_STAT5	391	394	PF00017	0.466
LIG_SH2_STAT5	464	467	PF00017	0.326
LIG_SH2_STAT5	555	558	PF00017	0.378
LIG_SH2_STAT5	745	748	PF00017	0.571
LIG_SH2_STAT5	818	821	PF00017	0.326
LIG_SH3_3	100	106	PF00018	0.474
LIG_SH3_3	253	259	PF00018	0.514
LIG_SH3_3	274	280	PF00018	0.439
LIG_SH3_3	402	408	PF00018	0.529
LIG_SH3_3	419	425	PF00018	0.436
LIG_SH3_3	430	436	PF00018	0.495
LIG_SH3_3	80	86	PF00018	0.529
LIG_SH3_3	861	867	PF00018	0.263
LIG_SH3_3	92	98	PF00018	0.447
LIG_SUMO_SIM_anti_2	113	118	PF11976	0.465
LIG_SUMO_SIM_par_1	774	780	PF11976	0.456
LIG_SUMO_SIM_par_1	894	901	PF11976	0.381
LIG_TRAF2_1	831	834	PF00917	0.308
LIG_TRAF2_2	830	835	PF00917	0.299
LIG_TYR_ITIM	677	682	PF00017	0.412
LIG_UBA3_1	483	488	PF00899	0.310
MOD_CDK_SPK_2	259	264	PF00069	0.608
MOD_CDK_SPxxK_3	259	266	PF00069	0.560
MOD_CDK_SPxxK_3	421	428	PF00069	0.641
MOD_CK1_1	542	548	PF00069	0.566
MOD_CK1_1	631	637	PF00069	0.545
MOD_CK1_1	698	704	PF00069	0.509
MOD_CK1_1	740	746	PF00069	0.582
MOD_CK1_1	755	761	PF00069	0.522
MOD_CK1_1	77	83	PF00069	0.632
MOD_CK1_1	869	875	PF00069	0.383
MOD_CK2_1	133	139	PF00069	0.604
MOD_CK2_1	152	158	PF00069	0.420
MOD_CK2_1	315	321	PF00069	0.551
MOD_CK2_1	529	535	PF00069	0.526
MOD_CK2_1	577	583	PF00069	0.606
MOD_CK2_1	680	686	PF00069	0.451
MOD_CK2_1	730	736	PF00069	0.552
MOD_CK2_1	768	774	PF00069	0.489
MOD_CK2_1	79	85	PF00069	0.637
MOD_CK2_1	828	834	PF00069	0.358
MOD_CK2_1	892	898	PF00069	0.379
MOD_CK2_1	901	907	PF00069	0.495
MOD_CMANNOS	589	592	PF00535	0.409
MOD_Cter_Amidation	159	162	PF01082	0.592
MOD_Cter_Amidation	242	245	PF01082	0.598
MOD_DYRK1A_RPxSP_1	79	83	PF00069	0.586
MOD_GlcNHglycan	165	168	PF01048	0.676
MOD_GlcNHglycan	19	23	PF01048	0.507
MOD_GlcNHglycan	343	346	PF01048	0.721
MOD_GlcNHglycan	438	441	PF01048	0.669
MOD_GlcNHglycan	475	478	PF01048	0.310
MOD_GlcNHglycan	507	511	PF01048	0.597
MOD_GlcNHglycan	613	616	PF01048	0.524
MOD_GlcNHglycan	674	677	PF01048	0.429
MOD_GlcNHglycan	697	700	PF01048	0.580
MOD_GlcNHglycan	887	891	PF01048	0.258
MOD_GSK3_1	341	348	PF00069	0.620
MOD_GSK3_1	38	45	PF00069	0.591
MOD_GSK3_1	631	638	PF00069	0.473
MOD_GSK3_1	643	650	PF00069	0.421
MOD_GSK3_1	694	701	PF00069	0.509
MOD_GSK3_1	758	765	PF00069	0.575
MOD_GSK3_1	777	784	PF00069	0.193
MOD_GSK3_1	882	889	PF00069	0.269
MOD_N-GLC_1	304	309	PF02516	0.417
MOD_N-GLC_1	528	533	PF02516	0.599
MOD_N-GLC_1	752	757	PF02516	0.630
MOD_N-GLC_1	77	82	PF02516	0.540
MOD_NEK2_1	194	199	PF00069	0.609
MOD_NEK2_1	483	488	PF00069	0.296
MOD_NEK2_1	500	505	PF00069	0.530
MOD_NEK2_1	523	528	PF00069	0.508
MOD_NEK2_1	59	64	PF00069	0.314
MOD_NEK2_1	694	699	PF00069	0.516
MOD_NEK2_1	891	896	PF00069	0.385
MOD_PIKK_1	330	336	PF00454	0.444
MOD_PIKK_1	389	395	PF00454	0.668
MOD_PIKK_1	444	450	PF00454	0.598
MOD_PIKK_1	670	676	PF00454	0.446
MOD_PIKK_1	680	686	PF00454	0.416
MOD_PIKK_1	828	834	PF00454	0.345
MOD_PIKK_1	852	858	PF00454	0.310
MOD_PK_1	38	44	PF00069	0.544
MOD_PK_1	559	565	PF00069	0.608
MOD_PKA_1	364	370	PF00069	0.691
MOD_PKA_2	133	139	PF00069	0.633
MOD_PKA_2	141	147	PF00069	0.524
MOD_PKA_2	297	303	PF00069	0.457
MOD_PKA_2	364	370	PF00069	0.643
MOD_PKA_2	755	761	PF00069	0.547
MOD_PKA_2	782	788	PF00069	0.306
MOD_PKB_1	537	545	PF00069	0.568
MOD_Plk_1	18	24	PF00069	0.454
MOD_Plk_1	616	622	PF00069	0.411
MOD_Plk_1	709	715	PF00069	0.623
MOD_Plk_1	809	815	PF00069	0.345
MOD_Plk_2-3	585	591	PF00069	0.487
MOD_Plk_4	133	139	PF00069	0.531
MOD_Plk_4	152	158	PF00069	0.537
MOD_Plk_4	386	392	PF00069	0.628
MOD_Plk_4	539	545	PF00069	0.563
MOD_Plk_4	59	65	PF00069	0.314
MOD_Plk_4	631	637	PF00069	0.551
MOD_Plk_4	643	649	PF00069	0.366
MOD_Plk_4	892	898	PF00069	0.379
MOD_ProDKin_1	259	265	PF00069	0.678
MOD_ProDKin_1	421	427	PF00069	0.560
MOD_ProDKin_1	542	548	PF00069	0.493
MOD_ProDKin_1	629	635	PF00069	0.519
MOD_ProDKin_1	730	736	PF00069	0.712
MOD_ProDKin_1	768	774	PF00069	0.694
MOD_ProDKin_1	79	85	PF00069	0.657
MOD_ProDKin_1	826	832	PF00069	0.504
MOD_SUMO_rev_2	370	375	PF00179	0.686
MOD_SUMO_rev_2	424	430	PF00179	0.596
TRG_DiLeu_BaEn_1	321	326	PF01217	0.501
TRG_DiLeu_BaEn_1	566	571	PF01217	0.557
TRG_DiLeu_BaLyEn_6	23	28	PF01217	0.433
TRG_DiLeu_BaLyEn_6	725	730	PF01217	0.595
TRG_DiLeu_BaLyEn_6	745	750	PF01217	0.407
TRG_ENDOCYTIC_2	137	140	PF00928	0.517
TRG_ENDOCYTIC_2	553	556	PF00928	0.537
TRG_ENDOCYTIC_2	648	651	PF00928	0.425
TRG_ENDOCYTIC_2	657	660	PF00928	0.310
TRG_ENDOCYTIC_2	679	682	PF00928	0.410
TRG_ENDOCYTIC_2	800	803	PF00928	0.389
TRG_ER_diArg_1	117	120	PF00400	0.565
TRG_ER_diArg_1	13	15	PF00400	0.576
TRG_ER_diArg_1	244	246	PF00400	0.612
TRG_ER_diArg_1	335	337	PF00400	0.525
TRG_ER_diArg_1	364	366	PF00400	0.699
TRG_ER_diArg_1	47	50	PF00400	0.520
TRG_ER_diArg_1	636	639	PF00400	0.576
TRG_ER_diArg_1	689	692	PF00400	0.549
TRG_ER_diArg_1	747	749	PF00400	0.607
TRG_ER_diArg_1	836	838	PF00400	0.310
TRG_ER_diArg_1	9	11	PF00400	0.611
TRG_NES_CRM1_1	645	658	PF08389	0.366
TRG_Pf-PMV_PEXEL_1	266	270	PF00026	0.544
TRG_Pf-PMV_PEXEL_1	623	627	PF00026	0.409

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBR2	Leptomonas seymouri	52%	99%
A4H4D8	Leishmania braziliensis	81%	99%
A4HSL7	Leishmania infantum	100%	100%
E9AKK1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4QJA7	Leishmania major	95%	100%