Zinc-finger of a C2HC-type, putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

zinc-finger of a C2HC-type, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WP70_LEIDO

TriTrypDb:

LdBPK_050850.1 , LdCL_050013600 , LDHU3_05.0940

Length:

667

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005815	microtubule organizing center	2	1
GO:0036064	ciliary basal body	3	1
GO:0051286	cell tip	3	1
GO:0060187	cell pole	2	1
GO:0097542	ciliary tip	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7WP70

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WP70

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	429	431	PF00675	0.741
CLV_NRD_NRD_1	506	508	PF00675	0.469
CLV_NRD_NRD_1	527	529	PF00675	0.658
CLV_NRD_NRD_1	637	639	PF00675	0.411
CLV_PCSK_KEX2_1	21	23	PF00082	0.588
CLV_PCSK_KEX2_1	212	214	PF00082	0.578
CLV_PCSK_KEX2_1	429	431	PF00082	0.741
CLV_PCSK_KEX2_1	506	508	PF00082	0.397
CLV_PCSK_PC1ET2_1	21	23	PF00082	0.588
CLV_PCSK_PC1ET2_1	212	214	PF00082	0.578
CLV_PCSK_PC7_1	502	508	PF00082	0.397
CLV_PCSK_SKI1_1	127	131	PF00082	0.577
CLV_PCSK_SKI1_1	265	269	PF00082	0.528
CLV_PCSK_SKI1_1	417	421	PF00082	0.840
CLV_PCSK_SKI1_1	528	532	PF00082	0.615
CLV_PCSK_SKI1_1	651	655	PF00082	0.564
CLV_PCSK_SKI1_1	95	99	PF00082	0.735
DEG_SPOP_SBC_1	240	244	PF00917	0.731
DEG_SPOP_SBC_1	366	370	PF00917	0.790
DEG_SPOP_SBC_1	476	480	PF00917	0.670
DOC_CKS1_1	134	139	PF01111	0.577
DOC_CYCLIN_RxL_1	260	270	PF00134	0.531
DOC_CYCLIN_yCln2_LP_2	292	298	PF00134	0.834
DOC_MAPK_DCC_7	82	91	PF00069	0.764
DOC_MAPK_gen_1	506	512	PF00069	0.513
DOC_MAPK_MEF2A_6	506	514	PF00069	0.513
DOC_MAPK_MEF2A_6	82	91	PF00069	0.764
DOC_PP2B_LxvP_1	292	295	PF13499	0.755
DOC_PP2B_LxvP_1	436	439	PF13499	0.629
DOC_PP2B_LxvP_1	89	92	PF13499	0.774
DOC_PP4_MxPP_1	474	477	PF00568	0.784
DOC_PP4_MxPP_1	616	619	PF00568	0.724
DOC_SPAK_OSR1_1	507	511	PF12202	0.397
DOC_USP7_MATH_1	240	244	PF00917	0.718
DOC_USP7_MATH_1	312	316	PF00917	0.690
DOC_USP7_MATH_1	338	342	PF00917	0.755
DOC_USP7_MATH_1	365	369	PF00917	0.817
DOC_USP7_MATH_1	373	377	PF00917	0.689
DOC_USP7_MATH_1	409	413	PF00917	0.655
DOC_USP7_MATH_1	419	423	PF00917	0.835
DOC_USP7_MATH_1	48	52	PF00917	0.740
DOC_USP7_MATH_1	551	555	PF00917	0.660
DOC_USP7_MATH_1	56	60	PF00917	0.597
DOC_USP7_MATH_1	65	69	PF00917	0.510
DOC_WW_Pin1_4	106	111	PF00397	0.598
DOC_WW_Pin1_4	133	138	PF00397	0.583
DOC_WW_Pin1_4	153	158	PF00397	0.779
DOC_WW_Pin1_4	242	247	PF00397	0.804
DOC_WW_Pin1_4	367	372	PF00397	0.748
DOC_WW_Pin1_4	44	49	PF00397	0.697
DOC_WW_Pin1_4	57	62	PF00397	0.780
DOC_WW_Pin1_4	6	11	PF00397	0.667
DOC_WW_Pin1_4	95	100	PF00397	0.782
LIG_14-3-3_CanoR_1	238	248	PF00244	0.797
LIG_14-3-3_CanoR_1	351	360	PF00244	0.659
LIG_14-3-3_CanoR_1	435	439	PF00244	0.711
LIG_14-3-3_CanoR_1	44	48	PF00244	0.668
LIG_14-3-3_CanoR_1	507	513	PF00244	0.417
LIG_14-3-3_CanoR_1	8	18	PF00244	0.619
LIG_Actin_WH2_2	192	207	PF00022	0.623
LIG_BRCT_BRCA1_1	375	379	PF00533	0.662
LIG_FHA_1	10	16	PF00498	0.620
LIG_FHA_1	353	359	PF00498	0.759
LIG_LIR_Gen_1	60	69	PF02991	0.735
LIG_LIR_Nem_3	60	66	PF02991	0.732
LIG_NRP_CendR_1	666	667	PF00754	0.710
LIG_Pex14_1	466	470	PF04695	0.674
LIG_PTB_Apo_2	171	178	PF02174	0.657
LIG_PTB_Phospho_1	171	177	PF10480	0.653
LIG_SH2_CRK	406	410	PF00017	0.737
LIG_SH2_CRK	63	67	PF00017	0.737
LIG_SH2_NCK_1	63	67	PF00017	0.814
LIG_SH2_STAP1	627	631	PF00017	0.585
LIG_SH2_STAT5	120	123	PF00017	0.604
LIG_SH2_STAT5	210	213	PF00017	0.688
LIG_SH2_STAT5	63	66	PF00017	0.817
LIG_SH3_3	151	157	PF00018	0.675
LIG_SH3_3	359	365	PF00018	0.612
LIG_SH3_3	405	411	PF00018	0.712
LIG_SH3_3	616	622	PF00018	0.661
LIG_SH3_3	628	634	PF00018	0.409
LIG_SH3_3	81	87	PF00018	0.773
LIG_SUMO_SIM_par_1	167	173	PF11976	0.748
LIG_TRAF2_1	497	500	PF00917	0.471
MOD_CDC14_SPxK_1	109	112	PF00782	0.726
MOD_CDC14_SPxK_1	47	50	PF00782	0.636
MOD_CDK_SPK_2	57	62	PF00069	0.696
MOD_CDK_SPxK_1	106	112	PF00069	0.735
MOD_CDK_SPxK_1	44	50	PF00069	0.618
MOD_CK1_1	103	109	PF00069	0.805
MOD_CK1_1	165	171	PF00069	0.679
MOD_CK1_1	173	179	PF00069	0.753
MOD_CK1_1	200	206	PF00069	0.579
MOD_CK1_1	242	248	PF00069	0.649
MOD_CK1_1	336	342	PF00069	0.730
MOD_CK1_1	434	440	PF00069	0.789
MOD_CK2_1	312	318	PF00069	0.737
MOD_Cter_Amidation	504	507	PF01082	0.397
MOD_Cter_Amidation	636	639	PF01082	0.411
MOD_DYRK1A_RPxSP_1	153	157	PF00069	0.782
MOD_GlcNHglycan	102	105	PF01048	0.765
MOD_GlcNHglycan	157	160	PF01048	0.669
MOD_GlcNHglycan	179	182	PF01048	0.735
MOD_GlcNHglycan	300	303	PF01048	0.819
MOD_GlcNHglycan	341	344	PF01048	0.705
MOD_GlcNHglycan	375	378	PF01048	0.768
MOD_GlcNHglycan	381	384	PF01048	0.787
MOD_GlcNHglycan	412	415	PF01048	0.797
MOD_GlcNHglycan	421	424	PF01048	0.679
MOD_GlcNHglycan	442	445	PF01048	0.791
MOD_GlcNHglycan	50	53	PF01048	0.759
MOD_GlcNHglycan	553	556	PF01048	0.781
MOD_GlcNHglycan	67	70	PF01048	0.684
MOD_GSK3_1	173	180	PF00069	0.700
MOD_GSK3_1	186	193	PF00069	0.670
MOD_GSK3_1	200	207	PF00069	0.452
MOD_GSK3_1	242	249	PF00069	0.642
MOD_GSK3_1	332	339	PF00069	0.697
MOD_GSK3_1	349	356	PF00069	0.617
MOD_GSK3_1	421	428	PF00069	0.845
MOD_GSK3_1	44	51	PF00069	0.728
MOD_GSK3_1	547	554	PF00069	0.682
MOD_GSK3_1	57	64	PF00069	0.647
MOD_GSK3_1	67	74	PF00069	0.690
MOD_GSK3_1	91	98	PF00069	0.719
MOD_N-GLC_1	173	178	PF02516	0.676
MOD_N-GLC_1	57	62	PF02516	0.730
MOD_NEK2_1	170	175	PF00069	0.657
MOD_NEK2_1	195	200	PF00069	0.644
MOD_NEK2_1	204	209	PF00069	0.533
MOD_NEK2_1	241	246	PF00069	0.760
MOD_NEK2_1	248	253	PF00069	0.801
MOD_NEK2_1	256	261	PF00069	0.812
MOD_NEK2_1	298	303	PF00069	0.754
MOD_NEK2_1	379	384	PF00069	0.755
MOD_NEK2_1	508	513	PF00069	0.411
MOD_PIKK_1	127	133	PF00454	0.587
MOD_PIKK_1	254	260	PF00454	0.720
MOD_PKA_2	204	210	PF00069	0.545
MOD_PKA_2	298	304	PF00069	0.743
MOD_PKA_2	353	359	PF00069	0.622
MOD_PKA_2	43	49	PF00069	0.665
MOD_PKA_2	434	440	PF00069	0.821
MOD_PKA_2	508	514	PF00069	0.411
MOD_Plk_1	173	179	PF00069	0.669
MOD_Plk_4	165	171	PF00069	0.642
MOD_ProDKin_1	106	112	PF00069	0.596
MOD_ProDKin_1	133	139	PF00069	0.582
MOD_ProDKin_1	153	159	PF00069	0.776
MOD_ProDKin_1	242	248	PF00069	0.805
MOD_ProDKin_1	367	373	PF00069	0.751
MOD_ProDKin_1	44	50	PF00069	0.704
MOD_ProDKin_1	57	63	PF00069	0.782
MOD_ProDKin_1	6	12	PF00069	0.660
MOD_ProDKin_1	95	101	PF00069	0.783
MOD_SUMO_for_1	211	214	PF00179	0.578
MOD_SUMO_rev_2	123	129	PF00179	0.570
TRG_ENDOCYTIC_2	63	66	PF00928	0.740
TRG_ER_diArg_1	429	431	PF00400	0.740
TRG_ER_diArg_1	506	508	PF00400	0.397
TRG_ER_diArg_1	665	667	PF00400	0.704
TRG_ER_diArg_1	92	95	PF00400	0.816
TRG_NLS_MonoCore_2	347	352	PF00514	0.733
TRG_Pf-PMV_PEXEL_1	260	264	PF00026	0.741
TRG_Pf-PMV_PEXEL_1	265	270	PF00026	0.687
TRG_Pf-PMV_PEXEL_1	30	34	PF00026	0.595

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1II98	Leptomonas seymouri	56%	100%
A4H4C7	Leishmania braziliensis	73%	99%
A4HSK7	Leishmania infantum	98%	100%
E9AKJ1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	96%
Q4QJB7	Leishmania major	93%	99%