Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WP68_LEIDO

TriTrypDb:

LdBPK_050730.1 , LdCL_050012400 , LDHU3_05.0820

Length:

741

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WP68

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WP68

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	2	6	PF00656	0.469
CLV_C14_Caspase3-7	207	211	PF00656	0.742
CLV_NRD_NRD_1	118	120	PF00675	0.807
CLV_NRD_NRD_1	305	307	PF00675	0.567
CLV_NRD_NRD_1	391	393	PF00675	0.821
CLV_NRD_NRD_1	552	554	PF00675	0.836
CLV_NRD_NRD_1	579	581	PF00675	0.761
CLV_NRD_NRD_1	587	589	PF00675	0.642
CLV_PCSK_FUR_1	707	711	PF00082	0.646
CLV_PCSK_KEX2_1	118	120	PF00082	0.807
CLV_PCSK_KEX2_1	293	295	PF00082	0.647
CLV_PCSK_KEX2_1	305	307	PF00082	0.529
CLV_PCSK_KEX2_1	391	393	PF00082	0.821
CLV_PCSK_KEX2_1	551	553	PF00082	0.841
CLV_PCSK_KEX2_1	579	581	PF00082	0.745
CLV_PCSK_KEX2_1	709	711	PF00082	0.648
CLV_PCSK_PC1ET2_1	293	295	PF00082	0.599
CLV_PCSK_PC1ET2_1	709	711	PF00082	0.609
CLV_PCSK_SKI1_1	171	175	PF00082	0.737
CLV_PCSK_SKI1_1	297	301	PF00082	0.576
CLV_PCSK_SKI1_1	34	38	PF00082	0.598
CLV_PCSK_SKI1_1	710	714	PF00082	0.647
DEG_APCC_DBOX_1	33	41	PF00400	0.609
DEG_APCC_DBOX_1	674	682	PF00400	0.511
DEG_SCF_FBW7_1	524	531	PF00400	0.836
DEG_SPOP_SBC_1	178	182	PF00917	0.852
DEG_SPOP_SBC_1	204	208	PF00917	0.742
DOC_CKS1_1	525	530	PF01111	0.837
DOC_CYCLIN_RxL_1	293	304	PF00134	0.560
DOC_MAPK_gen_1	234	241	PF00069	0.780
DOC_MAPK_MEF2A_6	234	241	PF00069	0.683
DOC_MAPK_MEF2A_6	680	689	PF00069	0.528
DOC_PP1_RVXF_1	13	19	PF00149	0.427
DOC_PP1_RVXF_1	715	721	PF00149	0.630
DOC_PP2B_LxvP_1	284	287	PF13499	0.721
DOC_PP2B_LxvP_1	366	369	PF13499	0.759
DOC_USP7_MATH_1	178	182	PF00917	0.774
DOC_USP7_MATH_1	29	33	PF00917	0.520
DOC_USP7_MATH_1	322	326	PF00917	0.506
DOC_USP7_MATH_1	353	357	PF00917	0.748
DOC_USP7_MATH_1	430	434	PF00917	0.797
DOC_USP7_MATH_1	440	444	PF00917	0.692
DOC_USP7_MATH_1	448	452	PF00917	0.581
DOC_USP7_MATH_1	480	484	PF00917	0.816
DOC_USP7_UBL2_3	611	615	PF12436	0.549
DOC_USP7_UBL2_3	709	713	PF12436	0.615
DOC_WW_Pin1_4	209	214	PF00397	0.795
DOC_WW_Pin1_4	239	244	PF00397	0.808
DOC_WW_Pin1_4	266	271	PF00397	0.846
DOC_WW_Pin1_4	299	304	PF00397	0.686
DOC_WW_Pin1_4	351	356	PF00397	0.821
DOC_WW_Pin1_4	469	474	PF00397	0.752
DOC_WW_Pin1_4	47	52	PF00397	0.626
DOC_WW_Pin1_4	524	529	PF00397	0.837
DOC_WW_Pin1_4	56	61	PF00397	0.576
DOC_WW_Pin1_4	580	585	PF00397	0.812
DOC_WW_Pin1_4	592	597	PF00397	0.549
DOC_WW_Pin1_4	733	738	PF00397	0.752
DOC_WW_Pin1_4	85	90	PF00397	0.741
LIG_14-3-3_CanoR_1	183	193	PF00244	0.855
LIG_14-3-3_CanoR_1	263	268	PF00244	0.650
LIG_14-3-3_CanoR_1	343	353	PF00244	0.760
LIG_14-3-3_CanoR_1	415	424	PF00244	0.661
LIG_14-3-3_CanoR_1	464	470	PF00244	0.716
LIG_14-3-3_CanoR_1	552	558	PF00244	0.839
LIG_14-3-3_CanoR_1	579	583	PF00244	0.703
LIG_14-3-3_CanoR_1	700	708	PF00244	0.593
LIG_Actin_WH2_2	708	725	PF00022	0.637
LIG_BIR_II_1	1	5	PF00653	0.703
LIG_EVH1_1	366	370	PF00568	0.721
LIG_FHA_1	184	190	PF00498	0.779
LIG_FHA_1	23	29	PF00498	0.613
LIG_FHA_1	525	531	PF00498	0.757
LIG_FHA_1	632	638	PF00498	0.756
LIG_FHA_2	205	211	PF00498	0.743
LIG_FHA_2	262	268	PF00498	0.658
LIG_FHA_2	659	665	PF00498	0.695
LIG_FHA_2	674	680	PF00498	0.651
LIG_LIR_Gen_1	38	45	PF02991	0.495
LIG_LIR_Gen_1	698	708	PF02991	0.632
LIG_LIR_Nem_3	38	44	PF02991	0.571
LIG_LIR_Nem_3	421	427	PF02991	0.706
LIG_LIR_Nem_3	698	704	PF02991	0.571
LIG_NRBOX	62	68	PF00104	0.537
LIG_PCNA_yPIPBox_3	700	712	PF02747	0.668
LIG_PDZ_Class_1	736	741	PF00595	0.688
LIG_SH2_CRK	176	180	PF00017	0.785
LIG_SH2_CRK	41	45	PF00017	0.475
LIG_SH2_CRK	424	428	PF00017	0.664
LIG_SH2_CRK	701	705	PF00017	0.680
LIG_SH2_STAP1	205	209	PF00017	0.744
LIG_SH2_STAP1	41	45	PF00017	0.397
LIG_SH2_STAT5	205	208	PF00017	0.785
LIG_SH2_STAT5	43	46	PF00017	0.537
LIG_SH2_STAT5	526	529	PF00017	0.758
LIG_SH2_STAT5	636	639	PF00017	0.754
LIG_SH2_STAT5	701	704	PF00017	0.624
LIG_SH3_1	121	127	PF00018	0.677
LIG_SH3_1	265	271	PF00018	0.735
LIG_SH3_3	120	126	PF00018	0.776
LIG_SH3_3	265	271	PF00018	0.735
LIG_SH3_3	295	301	PF00018	0.700
LIG_SH3_3	364	370	PF00018	0.767
LIG_SH3_3	489	495	PF00018	0.844
LIG_SH3_3	522	528	PF00018	0.835
LIG_SH3_3	539	545	PF00018	0.566
LIG_SH3_3	558	564	PF00018	0.766
LIG_SH3_3	621	627	PF00018	0.632
LIG_SH3_4	171	178	PF00018	0.779
LIG_SH3_CIN85_PxpxPR_1	225	230	PF14604	0.776
LIG_TRAF2_1	308	311	PF00917	0.657
LIG_TRAF2_1	317	320	PF00917	0.530
LIG_TRAF2_1	662	665	PF00917	0.680
LIG_TYR_ITIM	174	179	PF00017	0.747
MOD_CDC14_SPxK_1	302	305	PF00782	0.684
MOD_CDK_SPxK_1	299	305	PF00069	0.688
MOD_CDK_SPxK_1	528	534	PF00069	0.831
MOD_CDK_SPxxK_3	299	306	PF00069	0.685
MOD_CK1_1	139	145	PF00069	0.849
MOD_CK1_1	158	164	PF00069	0.544
MOD_CK1_1	181	187	PF00069	0.849
MOD_CK1_1	208	214	PF00069	0.743
MOD_CK1_1	22	28	PF00069	0.358
MOD_CK1_1	266	272	PF00069	0.762
MOD_CK1_1	338	344	PF00069	0.796
MOD_CK1_1	354	360	PF00069	0.648
MOD_CK1_1	380	386	PF00069	0.779
MOD_CK1_1	4	10	PF00069	0.564
MOD_CK1_1	402	408	PF00069	0.827
MOD_CK1_1	413	419	PF00069	0.630
MOD_CK1_1	443	449	PF00069	0.803
MOD_CK1_1	463	469	PF00069	0.571
MOD_CK1_1	485	491	PF00069	0.833
MOD_CK1_1	595	601	PF00069	0.671
MOD_CK2_1	134	140	PF00069	0.844
MOD_CK2_1	47	53	PF00069	0.549
MOD_CK2_1	567	573	PF00069	0.813
MOD_CK2_1	658	664	PF00069	0.707
MOD_CK2_1	673	679	PF00069	0.652
MOD_CK2_1	90	96	PF00069	0.770
MOD_Cter_Amidation	586	589	PF01082	0.605
MOD_DYRK1A_RPxSP_1	592	596	PF00069	0.701
MOD_DYRK1A_RPxSP_1	733	737	PF00069	0.665
MOD_GlcNHglycan	207	210	PF01048	0.800
MOD_GlcNHglycan	253	256	PF01048	0.797
MOD_GlcNHglycan	271	274	PF01048	0.539
MOD_GlcNHglycan	325	328	PF01048	0.728
MOD_GlcNHglycan	346	349	PF01048	0.680
MOD_GlcNHglycan	360	363	PF01048	0.618
MOD_GlcNHglycan	394	397	PF01048	0.854
MOD_GlcNHglycan	412	415	PF01048	0.561
MOD_GlcNHglycan	432	435	PF01048	0.558
MOD_GlcNHglycan	455	458	PF01048	0.784
MOD_GlcNHglycan	584	587	PF01048	0.805
MOD_GlcNHglycan	738	741	PF01048	0.707
MOD_GSK3_1	132	139	PF00069	0.647
MOD_GSK3_1	155	162	PF00069	0.783
MOD_GSK3_1	177	184	PF00069	0.855
MOD_GSK3_1	19	26	PF00069	0.528
MOD_GSK3_1	204	211	PF00069	0.778
MOD_GSK3_1	288	295	PF00069	0.657
MOD_GSK3_1	351	358	PF00069	0.825
MOD_GSK3_1	402	409	PF00069	0.846
MOD_GSK3_1	439	446	PF00069	0.803
MOD_GSK3_1	448	455	PF00069	0.684
MOD_GSK3_1	460	467	PF00069	0.660
MOD_GSK3_1	482	489	PF00069	0.825
MOD_GSK3_1	514	521	PF00069	0.810
MOD_GSK3_1	524	531	PF00069	0.671
MOD_GSK3_1	563	570	PF00069	0.783
MOD_GSK3_1	578	585	PF00069	0.700
MOD_GSK3_1	631	638	PF00069	0.747
MOD_GSK3_1	669	676	PF00069	0.555
MOD_GSK3_1	699	706	PF00069	0.693
MOD_GSK3_1	729	736	PF00069	0.708
MOD_N-GLC_1	566	571	PF02516	0.814
MOD_NEK2_1	179	184	PF00069	0.784
MOD_NEK2_1	23	28	PF00069	0.536
MOD_NEK2_1	462	467	PF00069	0.783
MOD_NEK2_1	635	640	PF00069	0.756
MOD_NEK2_1	683	688	PF00069	0.510
MOD_NEK2_2	631	636	PF00069	0.749
MOD_PIKK_1	213	219	PF00454	0.764
MOD_PIKK_1	514	520	PF00454	0.809
MOD_PIKK_1	555	561	PF00454	0.842
MOD_PIKK_1	567	573	PF00454	0.614
MOD_PIKK_1	673	679	PF00454	0.652
MOD_PIKK_1	699	705	PF00454	0.695
MOD_PIKK_1	731	737	PF00454	0.651
MOD_PK_1	185	191	PF00069	0.778
MOD_PKA_1	391	397	PF00069	0.822
MOD_PKA_2	114	120	PF00069	0.676
MOD_PKA_2	142	148	PF00069	0.828
MOD_PKA_2	184	190	PF00069	0.849
MOD_PKA_2	338	344	PF00069	0.750
MOD_PKA_2	391	397	PF00069	0.826
MOD_PKA_2	400	406	PF00069	0.745
MOD_PKA_2	463	469	PF00069	0.676
MOD_PKA_2	533	539	PF00069	0.846
MOD_PKA_2	578	584	PF00069	0.703
MOD_PKA_2	699	705	PF00069	0.610
MOD_PKA_2	729	735	PF00069	0.625
MOD_PKB_1	183	191	PF00069	0.777
MOD_PKB_1	551	559	PF00069	0.724
MOD_Plk_1	19	25	PF00069	0.434
MOD_Plk_1	4	10	PF00069	0.607
MOD_Plk_1	567	573	PF00069	0.813
MOD_Plk_1	658	664	PF00069	0.629
MOD_Plk_1	669	675	PF00069	0.583
MOD_Plk_1	683	689	PF00069	0.516
MOD_Plk_4	185	191	PF00069	0.855
MOD_Plk_4	23	29	PF00069	0.391
MOD_Plk_4	377	383	PF00069	0.776
MOD_Plk_4	4	10	PF00069	0.605
MOD_Plk_4	572	578	PF00069	0.808
MOD_Plk_4	631	637	PF00069	0.749
MOD_Plk_4	669	675	PF00069	0.617
MOD_ProDKin_1	209	215	PF00069	0.792
MOD_ProDKin_1	239	245	PF00069	0.806
MOD_ProDKin_1	266	272	PF00069	0.843
MOD_ProDKin_1	299	305	PF00069	0.688
MOD_ProDKin_1	351	357	PF00069	0.823
MOD_ProDKin_1	469	475	PF00069	0.754
MOD_ProDKin_1	47	53	PF00069	0.630
MOD_ProDKin_1	524	530	PF00069	0.838
MOD_ProDKin_1	56	62	PF00069	0.571
MOD_ProDKin_1	580	586	PF00069	0.812
MOD_ProDKin_1	592	598	PF00069	0.540
MOD_ProDKin_1	733	739	PF00069	0.761
MOD_ProDKin_1	85	91	PF00069	0.743
MOD_SUMO_rev_2	319	325	PF00179	0.681
TRG_DiLeu_BaEn_2	596	602	PF01217	0.722
TRG_DiLeu_BaEn_4	310	316	PF01217	0.657
TRG_DiLeu_BaLyEn_6	295	300	PF01217	0.704
TRG_ENDOCYTIC_2	176	179	PF00928	0.864
TRG_ENDOCYTIC_2	41	44	PF00928	0.570
TRG_ENDOCYTIC_2	424	427	PF00928	0.665
TRG_ENDOCYTIC_2	701	704	PF00928	0.624
TRG_ER_diArg_1	13	16	PF00400	0.531
TRG_ER_diArg_1	227	230	PF00400	0.783
TRG_ER_diArg_1	390	392	PF00400	0.773
TRG_ER_diArg_1	551	553	PF00400	0.845
TRG_Pf-PMV_PEXEL_1	615	619	PF00026	0.736

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4H4B6	Leishmania braziliensis	51%	97%
A4HSJ5	Leishmania infantum	100%	100%
E9AKH9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	98%
Q4QJC9	Leishmania major	91%	100%