Dipeptidyl peptidase 3

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

dipeptidyl-peptidase III, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WP65_LEIDO

TriTrypDb:

LdBPK_050960.1 , LdCL_050014700 , LDHU3_05.1060

Length:

679

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 1
Forrest at al. (metacyclic)	no	yes: 1
Forrest at al. (procyclic)	no	yes: 1
Silverman et al.	no	yes: 1
Pissara et al.	yes	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 3

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 3

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

A0A3S7WP65

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WP65

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	8
GO:0006807	nitrogen compound metabolic process	2	8
GO:0008152	metabolic process	1	8
GO:0019538	protein metabolic process	3	8
GO:0043170	macromolecule metabolic process	3	8
GO:0044238	primary metabolic process	2	8
GO:0071704	organic substance metabolic process	2	8
GO:1901564	organonitrogen compound metabolic process	3	8

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	8
GO:0004177	aminopeptidase activity	5	7
GO:0005488	binding	1	8
GO:0008233	peptidase activity	3	7
GO:0008235	metalloexopeptidase activity	5	7
GO:0008237	metallopeptidase activity	4	7
GO:0008238	exopeptidase activity	4	7
GO:0008239	dipeptidyl-peptidase activity	5	7
GO:0016787	hydrolase activity	2	8
GO:0043167	ion binding	2	8
GO:0043169	cation binding	3	8
GO:0046872	metal ion binding	4	8
GO:0140096	catalytic activity, acting on a protein	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	441	445	PF00656	0.565
CLV_NRD_NRD_1	242	244	PF00675	0.493
CLV_NRD_NRD_1	635	637	PF00675	0.439
CLV_NRD_NRD_1	638	640	PF00675	0.439
CLV_PCSK_KEX2_1	609	611	PF00082	0.565
CLV_PCSK_KEX2_1	635	637	PF00082	0.493
CLV_PCSK_PC1ET2_1	609	611	PF00082	0.565
CLV_PCSK_SKI1_1	123	127	PF00082	0.583
CLV_PCSK_SKI1_1	160	164	PF00082	0.480
CLV_PCSK_SKI1_1	193	197	PF00082	0.439
CLV_PCSK_SKI1_1	25	29	PF00082	0.521
CLV_PCSK_SKI1_1	345	349	PF00082	0.439
CLV_PCSK_SKI1_1	583	587	PF00082	0.408
CLV_PCSK_SKI1_1	62	66	PF00082	0.555
DEG_APCC_DBOX_1	525	533	PF00400	0.439
DEG_COP1_1	109	119	PF00400	0.548
DOC_CDC14_PxL_1	495	503	PF14671	0.565
DOC_CKS1_1	534	539	PF01111	0.493
DOC_CKS1_1	7	12	PF01111	0.572
DOC_MAPK_MEF2A_6	487	495	PF00069	0.439
DOC_MAPK_MEF2A_6	526	534	PF00069	0.493
DOC_MAPK_MEF2A_6	559	567	PF00069	0.458
DOC_MAPK_MEF2A_6	572	579	PF00069	0.515
DOC_PP4_FxxP_1	348	351	PF00568	0.416
DOC_PP4_FxxP_1	534	537	PF00568	0.439
DOC_SPAK_OSR1_1	550	554	PF12202	0.439
DOC_USP7_UBL2_3	274	278	PF12436	0.439
DOC_USP7_UBL2_3	317	321	PF12436	0.439
DOC_USP7_UBL2_3	341	345	PF12436	0.493
DOC_WW_Pin1_4	131	136	PF00397	0.679
DOC_WW_Pin1_4	164	169	PF00397	0.493
DOC_WW_Pin1_4	25	30	PF00397	0.390
DOC_WW_Pin1_4	347	352	PF00397	0.470
DOC_WW_Pin1_4	51	56	PF00397	0.547
DOC_WW_Pin1_4	533	538	PF00397	0.439
DOC_WW_Pin1_4	6	11	PF00397	0.496
LIG_14-3-3_CanoR_1	379	383	PF00244	0.565
LIG_14-3-3_CanoR_1	583	592	PF00244	0.439
LIG_APCC_ABBA_1	270	275	PF00400	0.351
LIG_BIR_II_1	1	5	PF00653	0.684
LIG_BRCT_BRCA1_1	349	353	PF00533	0.474
LIG_BRCT_BRCA1_1	472	476	PF00533	0.493
LIG_BRCT_BRCA1_1	611	615	PF00533	0.461
LIG_Clathr_ClatBox_1	529	533	PF01394	0.493
LIG_Clathr_ClatBox_1	576	580	PF01394	0.493
LIG_deltaCOP1_diTrp_1	307	311	PF00928	0.439
LIG_deltaCOP1_diTrp_1	336	343	PF00928	0.351
LIG_FHA_1	111	117	PF00498	0.593
LIG_FHA_1	15	21	PF00498	0.481
LIG_FHA_1	199	205	PF00498	0.467
LIG_FHA_1	221	227	PF00498	0.448
LIG_FHA_1	433	439	PF00498	0.439
LIG_FHA_1	651	657	PF00498	0.565
LIG_FHA_2	169	175	PF00498	0.493
LIG_FHA_2	352	358	PF00498	0.463
LIG_FHA_2	395	401	PF00498	0.435
LIG_FHA_2	404	410	PF00498	0.367
LIG_FHA_2	507	513	PF00498	0.493
LIG_Integrin_isoDGR_2	220	222	PF01839	0.493
LIG_LIR_Apic_2	163	168	PF02991	0.493
LIG_LIR_Apic_2	296	301	PF02991	0.439
LIG_LIR_Apic_2	346	351	PF02991	0.416
LIG_LIR_Apic_2	464	468	PF02991	0.496
LIG_LIR_Apic_2	533	537	PF02991	0.439
LIG_LIR_Gen_1	122	131	PF02991	0.513
LIG_LIR_Gen_1	309	315	PF02991	0.439
LIG_LIR_Gen_1	350	361	PF02991	0.441
LIG_LIR_Gen_1	470	479	PF02991	0.493
LIG_LIR_Gen_1	492	502	PF02991	0.493
LIG_LIR_Gen_1	612	621	PF02991	0.446
LIG_LIR_Gen_1	95	104	PF02991	0.457
LIG_LIR_Nem_3	122	127	PF02991	0.516
LIG_LIR_Nem_3	307	311	PF02991	0.439
LIG_LIR_Nem_3	320	326	PF02991	0.439
LIG_LIR_Nem_3	350	356	PF02991	0.441
LIG_LIR_Nem_3	381	387	PF02991	0.565
LIG_LIR_Nem_3	407	413	PF02991	0.439
LIG_LIR_Nem_3	470	475	PF02991	0.448
LIG_LIR_Nem_3	492	497	PF02991	0.486
LIG_LIR_Nem_3	622	628	PF02991	0.464
LIG_LIR_Nem_3	95	100	PF02991	0.445
LIG_MLH1_MIPbox_1	611	615	PF16413	0.461
LIG_PCNA_yPIPBox_3	424	437	PF02747	0.439
LIG_PDZ_Class_2	674	679	PF00595	0.575
LIG_Pex14_1	339	343	PF04695	0.439
LIG_Pex14_2	93	97	PF04695	0.503
LIG_SH2_CRK	15	19	PF00017	0.525
LIG_SH2_CRK	323	327	PF00017	0.493
LIG_SH2_CRK	472	476	PF00017	0.493
LIG_SH2_CRK	7	11	PF00017	0.576
LIG_SH2_GRB2like	101	104	PF00017	0.455
LIG_SH2_NCK_1	472	476	PF00017	0.493
LIG_SH2_PTP2	642	645	PF00017	0.493
LIG_SH2_SRC	261	264	PF00017	0.484
LIG_SH2_SRC	34	37	PF00017	0.509
LIG_SH2_SRC	375	378	PF00017	0.439
LIG_SH2_STAP1	34	38	PF00017	0.470
LIG_SH2_STAP1	472	476	PF00017	0.493
LIG_SH2_STAT5	107	110	PF00017	0.454
LIG_SH2_STAT5	15	18	PF00017	0.405
LIG_SH2_STAT5	261	264	PF00017	0.493
LIG_SH2_STAT5	388	391	PF00017	0.421
LIG_SH2_STAT5	404	407	PF00017	0.491
LIG_SH2_STAT5	494	497	PF00017	0.493
LIG_SH2_STAT5	518	521	PF00017	0.493
LIG_SH2_STAT5	535	538	PF00017	0.439
LIG_SH2_STAT5	614	617	PF00017	0.511
LIG_SH2_STAT5	625	628	PF00017	0.451
LIG_SH2_STAT5	642	645	PF00017	0.493
LIG_SH2_STAT5	7	10	PF00017	0.491
LIG_SH2_STAT5	96	99	PF00017	0.482
LIG_SH3_1	114	120	PF00018	0.459
LIG_SH3_3	114	120	PF00018	0.459
LIG_SH3_4	637	644	PF00018	0.439
LIG_SUMO_SIM_anti_2	354	360	PF11976	0.493
LIG_SUMO_SIM_par_1	575	580	PF11976	0.439
LIG_SUMO_SIM_par_1	652	658	PF11976	0.565
LIG_TRAF2_1	482	485	PF00917	0.439
LIG_TYR_ITIM	13	18	PF00017	0.474
LIG_TYR_ITIM	626	631	PF00017	0.493
LIG_UBA3_1	504	511	PF00899	0.497
LIG_UBA3_1	595	603	PF00899	0.439
LIG_WRC_WIRS_1	107	112	PF05994	0.516
LIG_WRC_WIRS_1	667	672	PF05994	0.493
LIG_WRC_WIRS_1	73	78	PF05994	0.599
MOD_CDK_SPK_2	25	30	PF00069	0.582
MOD_CDK_SPK_2	6	11	PF00069	0.571
MOD_CDK_SPxK_1	533	539	PF00069	0.565
MOD_CDK_SPxxK_3	25	32	PF00069	0.542
MOD_CK1_1	394	400	PF00069	0.474
MOD_CK1_1	416	422	PF00069	0.351
MOD_CK1_1	440	446	PF00069	0.501
MOD_CK1_1	54	60	PF00069	0.473
MOD_CK1_1	650	656	PF00069	0.565
MOD_CK1_1	669	675	PF00069	0.493
MOD_CK2_1	273	279	PF00069	0.493
MOD_CK2_1	478	484	PF00069	0.492
MOD_CK2_1	506	512	PF00069	0.493
MOD_GlcNHglycan	129	132	PF01048	0.583
MOD_GlcNHglycan	300	304	PF01048	0.439
MOD_GlcNHglycan	363	366	PF01048	0.404
MOD_GlcNHglycan	393	396	PF01048	0.474
MOD_GlcNHglycan	457	460	PF01048	0.463
MOD_GlcNHglycan	611	614	PF01048	0.536
MOD_GlcNHglycan	649	652	PF01048	0.561
MOD_GlcNHglycan	68	71	PF01048	0.480
MOD_GSK3_1	106	113	PF00069	0.507
MOD_GSK3_1	127	134	PF00069	0.654
MOD_GSK3_1	160	167	PF00069	0.474
MOD_GSK3_1	347	354	PF00069	0.474
MOD_GSK3_1	387	394	PF00069	0.474
MOD_N-GLC_1	168	173	PF02516	0.493
MOD_N-GLC_1	250	255	PF02516	0.565
MOD_N-GLC_1	616	621	PF02516	0.518
MOD_NEK2_1	110	115	PF00069	0.310
MOD_NEK2_1	181	186	PF00069	0.474
MOD_NEK2_1	294	299	PF00069	0.439
MOD_NEK2_1	361	366	PF00069	0.439
MOD_NEK2_1	418	423	PF00069	0.405
MOD_NEK2_1	99	104	PF00069	0.421
MOD_NEK2_2	72	77	PF00069	0.597
MOD_PIKK_1	273	279	PF00454	0.439
MOD_PK_1	77	83	PF00069	0.564
MOD_PKA_1	609	615	PF00069	0.526
MOD_PKA_2	378	384	PF00069	0.541
MOD_PKA_2	609	615	PF00069	0.577
MOD_PKB_1	581	589	PF00069	0.493
MOD_Plk_1	210	216	PF00069	0.493
MOD_Plk_1	351	357	PF00069	0.439
MOD_Plk_1	450	456	PF00069	0.448
MOD_Plk_1	616	622	PF00069	0.416
MOD_Plk_2-3	151	157	PF00069	0.487
MOD_Plk_2-3	352	358	PF00069	0.493
MOD_Plk_2-3	450	456	PF00069	0.493
MOD_Plk_4	198	204	PF00069	0.493
MOD_Plk_4	413	419	PF00069	0.493
MOD_Plk_4	461	467	PF00069	0.489
MOD_Plk_4	471	477	PF00069	0.439
MOD_Plk_4	489	495	PF00069	0.493
MOD_Plk_4	616	622	PF00069	0.483
MOD_Plk_4	644	650	PF00069	0.493
MOD_Plk_4	666	672	PF00069	0.493
MOD_ProDKin_1	131	137	PF00069	0.676
MOD_ProDKin_1	164	170	PF00069	0.493
MOD_ProDKin_1	25	31	PF00069	0.383
MOD_ProDKin_1	347	353	PF00069	0.470
MOD_ProDKin_1	51	57	PF00069	0.543
MOD_ProDKin_1	533	539	PF00069	0.439
MOD_ProDKin_1	6	12	PF00069	0.503
MOD_SUMO_for_1	195	198	PF00179	0.565
MOD_SUMO_rev_2	109	116	PF00179	0.485
MOD_SUMO_rev_2	149	154	PF00179	0.497
MOD_SUMO_rev_2	444	454	PF00179	0.448
TRG_DiLeu_BaEn_1	198	203	PF01217	0.565
TRG_DiLeu_BaEn_2	306	312	PF01217	0.439
TRG_DiLeu_BaEn_2	88	94	PF01217	0.607
TRG_DiLeu_LyEn_5	56	61	PF01217	0.517
TRG_ENDOCYTIC_2	101	104	PF00928	0.441
TRG_ENDOCYTIC_2	107	110	PF00928	0.479
TRG_ENDOCYTIC_2	15	18	PF00928	0.472
TRG_ENDOCYTIC_2	267	270	PF00928	0.526
TRG_ENDOCYTIC_2	323	326	PF00928	0.493
TRG_ENDOCYTIC_2	375	378	PF00928	0.439
TRG_ENDOCYTIC_2	472	475	PF00928	0.493
TRG_ENDOCYTIC_2	494	497	PF00928	0.493
TRG_ENDOCYTIC_2	628	631	PF00928	0.539
TRG_ENDOCYTIC_2	96	99	PF00928	0.464
TRG_ER_diArg_1	547	550	PF00400	0.439
TRG_NES_CRM1_1	56	71	PF08389	0.600
TRG_NLS_MonoCore_2	635	640	PF00514	0.439
TRG_NLS_MonoExtC_3	635	640	PF00514	0.439
TRG_NLS_MonoExtN_4	635	640	PF00514	0.493
TRG_Pf-PMV_PEXEL_1	437	441	PF00026	0.493

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I084	Leptomonas seymouri	81%	100%
A0A0S4JJ29	Bodo saltans	55%	73%
A4H4D9	Leishmania braziliensis	89%	100%
A4HSL8	Leishmania infantum	100%	100%
A7RZW4	Nematostella vectensis	44%	93%
E9AKK2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
O55096	Rattus norvegicus	43%	92%
Q08225	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	37%	95%
Q4QJA6	Leishmania major	97%	100%
Q557H1	Dictyostelium discoideum	43%	98%
Q99KK7	Mus musculus	43%	92%
Q9NY33	Homo sapiens	43%	92%
Q9VHR8	Drosophila melanogaster	43%	86%