Hypothetical_protein_conserved

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WP53_LEIDO

TriTrypDb:

LdBPK_050780.1 , LdCL_050012900 , LDHU3_05.0870

Length:

147

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A0A3S7WP53

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WP53

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	97	101	PF00082	0.328
DEG_Nend_Nbox_1	1	3	PF02207	0.659
DOC_CYCLIN_yCln2_LP_2	73	79	PF00134	0.676
DOC_PP1_RVXF_1	108	114	PF00149	0.368
DOC_PP1_RVXF_1	50	57	PF00149	0.663
DOC_PP4_FxxP_1	99	102	PF00568	0.599
DOC_USP7_MATH_1	109	113	PF00917	0.408
DOC_USP7_MATH_1	58	62	PF00917	0.696
DOC_WW_Pin1_4	72	77	PF00397	0.642
LIG_14-3-3_CanoR_1	110	114	PF00244	0.408
LIG_14-3-3_CanoR_1	35	40	PF00244	0.658
LIG_Actin_WH2_2	20	37	PF00022	0.687
LIG_AP2alpha_2	66	68	PF02296	0.678
LIG_APCC_ABBA_1	41	46	PF00400	0.733
LIG_deltaCOP1_diTrp_1	136	144	PF00928	0.636
LIG_FHA_1	36	42	PF00498	0.697
LIG_FHA_1	72	78	PF00498	0.711
LIG_LIR_Apic_2	61	67	PF02991	0.698
LIG_LIR_Nem_3	112	117	PF02991	0.391
LIG_LIR_Nem_3	66	71	PF02991	0.638
LIG_Pex14_2	84	88	PF04695	0.380
LIG_SH2_STAP1	126	130	PF00017	0.551
LIG_SH2_STAT5	33	36	PF00017	0.658
LIG_SH3_1	64	70	PF00018	0.706
LIG_SH3_3	64	70	PF00018	0.635
LIG_SH3_3	77	83	PF00018	0.647
MOD_CDC14_SPxK_1	75	78	PF00782	0.680
MOD_CDK_SPxK_1	72	78	PF00069	0.653
MOD_CK1_1	122	128	PF00069	0.376
MOD_CK1_1	16	22	PF00069	0.716
MOD_CK2_1	22	28	PF00069	0.690
MOD_CK2_1	6	12	PF00069	0.672
MOD_CMANNOS	105	108	PF00535	0.645
MOD_CMANNOS	56	59	PF00535	0.427
MOD_GlcNHglycan	15	18	PF01048	0.440
MOD_GlcNHglycan	3	6	PF01048	0.465
MOD_GlcNHglycan	8	11	PF01048	0.449
MOD_GlcNHglycan	84	87	PF01048	0.408
MOD_GSK3_1	109	116	PF00069	0.485
MOD_GSK3_1	12	19	PF00069	0.722
MOD_NEK2_1	1	6	PF00069	0.645
MOD_NEK2_1	113	118	PF00069	0.452
MOD_NEK2_1	34	39	PF00069	0.749
MOD_NEK2_2	109	114	PF00069	0.408
MOD_PKA_2	109	115	PF00069	0.444
MOD_PKA_2	34	40	PF00069	0.707
MOD_PKA_2	6	12	PF00069	0.668
MOD_Plk_4	109	115	PF00069	0.444
MOD_ProDKin_1	72	78	PF00069	0.645
TRG_ENDOCYTIC_2	33	36	PF00928	0.640
TRG_ER_diArg_1	49	52	PF00400	0.631

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P790	Leptomonas seymouri	76%	100%
A0A1X0NK03	Trypanosomatidae	63%	100%
A0A422NJC6	Trypanosoma rangeli	60%	99%
A4H4C1	Leishmania braziliensis	83%	100%
A4HSK0	Leishmania infantum	100%	100%
C9ZU94	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	64%	95%
E9AKI4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
Q4QJC4	Leishmania major	98%	100%