Monocarboxylate transporter-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

monocarboxylate transporter-like protein

Species:

Leishmania donovani

UniProt:

A0A3S7WP49_LEIDO

TriTrypDb:

LdBPK_050480.1 , LdCL_050009800 , LDHU3_05.0550

Length:

574

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

A0A3S7WP49

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WP49

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	8
GO:0022857	transmembrane transporter activity	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	150	152	PF00675	0.323
CLV_NRD_NRD_1	206	208	PF00675	0.281
CLV_NRD_NRD_1	332	334	PF00675	0.562
CLV_NRD_NRD_1	353	355	PF00675	0.419
CLV_PCSK_KEX2_1	149	151	PF00082	0.323
CLV_PCSK_KEX2_1	206	208	PF00082	0.280
CLV_PCSK_KEX2_1	353	355	PF00082	0.419
CLV_PCSK_SKI1_1	12	16	PF00082	0.442
CLV_PCSK_SKI1_1	302	306	PF00082	0.521
CLV_PCSK_SKI1_1	353	357	PF00082	0.446
CLV_PCSK_SKI1_1	362	366	PF00082	0.355
CLV_PCSK_SKI1_1	368	372	PF00082	0.274
CLV_Separin_Metazoa	359	363	PF03568	0.550
DEG_Nend_UBRbox_3	1	3	PF02207	0.659
DEG_SCF_FBW7_1	407	412	PF00400	0.371
DEG_SPOP_SBC_1	409	413	PF00917	0.381
DOC_CKS1_1	252	257	PF01111	0.683
DOC_MAPK_gen_1	562	570	PF00069	0.619
DOC_MAPK_HePTP_8	490	502	PF00069	0.586
DOC_MAPK_MEF2A_6	246	253	PF00069	0.676
DOC_MAPK_MEF2A_6	358	365	PF00069	0.590
DOC_MAPK_MEF2A_6	493	502	PF00069	0.592
DOC_MAPK_MEF2A_6	90	97	PF00069	0.523
DOC_MAPK_NFAT4_5	246	254	PF00069	0.679
DOC_PP1_RVXF_1	351	358	PF00149	0.635
DOC_PP1_RVXF_1	360	366	PF00149	0.591
DOC_PP4_FxxP_1	495	498	PF00568	0.597
DOC_PP4_FxxP_1	516	519	PF00568	0.364
DOC_USP7_MATH_1	115	119	PF00917	0.306
DOC_USP7_MATH_1	143	147	PF00917	0.481
DOC_USP7_MATH_1	237	241	PF00917	0.742
DOC_USP7_MATH_1	297	301	PF00917	0.733
DOC_USP7_MATH_1	308	312	PF00917	0.740
DOC_USP7_MATH_1	392	396	PF00917	0.348
DOC_USP7_UBL2_3	290	294	PF12436	0.652
DOC_WW_Pin1_4	135	140	PF00397	0.323
DOC_WW_Pin1_4	222	227	PF00397	0.518
DOC_WW_Pin1_4	251	256	PF00397	0.717
DOC_WW_Pin1_4	261	266	PF00397	0.738
DOC_WW_Pin1_4	304	309	PF00397	0.744
DOC_WW_Pin1_4	405	410	PF00397	0.386
DOC_WW_Pin1_4	74	79	PF00397	0.328
LIG_14-3-3_CanoR_1	184	188	PF00244	0.334
LIG_14-3-3_CanoR_1	353	358	PF00244	0.634
LIG_14-3-3_CanoR_1	362	368	PF00244	0.560
LIG_BRCT_BRCA1_1	110	114	PF00533	0.383
LIG_BRCT_BRCA1_1	365	369	PF00533	0.563
LIG_BRCT_BRCA1_1	415	419	PF00533	0.342
LIG_BRCT_BRCA1_1	76	80	PF00533	0.383
LIG_BRCT_BRCA1_2	110	116	PF00533	0.441
LIG_FHA_1	184	190	PF00498	0.327
LIG_FHA_1	265	271	PF00498	0.752
LIG_FHA_1	342	348	PF00498	0.534
LIG_FHA_1	455	461	PF00498	0.356
LIG_FHA_1	478	484	PF00498	0.384
LIG_FHA_1	97	103	PF00498	0.332
LIG_FHA_2	273	279	PF00498	0.750
LIG_FHA_2	340	346	PF00498	0.604
LIG_FHA_2	354	360	PF00498	0.619
LIG_HP1_1	93	97	PF01393	0.523
LIG_LIR_Apic_2	494	498	PF02991	0.592
LIG_LIR_Gen_1	122	131	PF02991	0.323
LIG_LIR_Gen_1	191	200	PF02991	0.334
LIG_LIR_Gen_1	402	410	PF02991	0.369
LIG_LIR_Gen_1	42	52	PF02991	0.280
LIG_LIR_Gen_1	465	473	PF02991	0.315
LIG_LIR_Nem_3	122	128	PF02991	0.323
LIG_LIR_Nem_3	191	196	PF02991	0.334
LIG_LIR_Nem_3	20	25	PF02991	0.511
LIG_LIR_Nem_3	371	376	PF02991	0.409
LIG_LIR_Nem_3	382	387	PF02991	0.290
LIG_LIR_Nem_3	402	407	PF02991	0.287
LIG_LIR_Nem_3	42	48	PF02991	0.293
LIG_LIR_Nem_3	420	425	PF02991	0.421
LIG_LIR_Nem_3	465	469	PF02991	0.323
LIG_LIR_Nem_3	534	538	PF02991	0.283
LIG_LIR_Nem_3	544	549	PF02991	0.332
LIG_LIR_Nem_3	77	83	PF02991	0.383
LIG_NRBOX	549	555	PF00104	0.441
LIG_PCNA_yPIPBox_3	559	567	PF02747	0.690
LIG_PDZ_Class_3	569	574	PF00595	0.563
LIG_Pex14_1	183	187	PF04695	0.280
LIG_Pex14_2	105	109	PF04695	0.323
LIG_Pex14_2	365	369	PF04695	0.544
LIG_Pex14_2	421	425	PF04695	0.323
LIG_REV1ctd_RIR_1	362	372	PF16727	0.510
LIG_SH2_CRK	125	129	PF00017	0.383
LIG_SH2_CRK	384	388	PF00017	0.383
LIG_SH2_CRK	535	539	PF00017	0.283
LIG_SH2_NCK_1	404	408	PF00017	0.383
LIG_SH2_PTP2	388	391	PF00017	0.321
LIG_SH2_SRC	404	407	PF00017	0.375
LIG_SH2_STAP1	125	129	PF00017	0.360
LIG_SH2_STAP1	446	450	PF00017	0.383
LIG_SH2_STAP1	466	470	PF00017	0.205
LIG_SH2_STAT5	25	28	PF00017	0.323
LIG_SH2_STAT5	388	391	PF00017	0.299
LIG_SH2_STAT5	393	396	PF00017	0.299
LIG_SH2_STAT5	446	449	PF00017	0.328
LIG_SH2_STAT5	552	555	PF00017	0.386
LIG_SH3_3	386	392	PF00018	0.379
LIG_SUMO_SIM_anti_2	248	254	PF11976	0.656
LIG_SUMO_SIM_par_1	248	254	PF11976	0.721
LIG_SUMO_SIM_par_1	25	30	PF11976	0.323
LIG_TRAF2_1	242	245	PF00917	0.697
LIG_TYR_ITIM	386	391	PF00017	0.343
LIG_TYR_ITIM	550	555	PF00017	0.323
LIG_TYR_ITSM	400	407	PF00017	0.440
LIG_UBA3_1	486	493	PF00899	0.510
LIG_WRC_WIRS_1	418	423	PF05994	0.323
LIG_WRC_WIRS_1	436	441	PF05994	0.323
LIG_WW_3	91	95	PF00397	0.323
MOD_CDC14_SPxK_1	225	228	PF00782	0.377
MOD_CDK_SPxK_1	222	228	PF00069	0.377
MOD_CDK_SPxxK_3	261	268	PF00069	0.704
MOD_CK1_1	130	136	PF00069	0.378
MOD_CK1_1	264	270	PF00069	0.749
MOD_CK1_1	272	278	PF00069	0.797
MOD_CK1_1	396	402	PF00069	0.585
MOD_CK1_1	413	419	PF00069	0.279
MOD_CK1_1	46	52	PF00069	0.327
MOD_CK1_1	541	547	PF00069	0.377
MOD_CK1_1	62	68	PF00069	0.373
MOD_CK2_1	114	120	PF00069	0.441
MOD_CK2_1	239	245	PF00069	0.636
MOD_CK2_1	272	278	PF00069	0.773
MOD_CK2_1	353	359	PF00069	0.506
MOD_Cter_Amidation	331	334	PF01082	0.685
MOD_GlcNHglycan	117	120	PF01048	0.366
MOD_GlcNHglycan	132	135	PF01048	0.444
MOD_GlcNHglycan	166	169	PF01048	0.332
MOD_GlcNHglycan	190	193	PF01048	0.357
MOD_GlcNHglycan	29	32	PF01048	0.326
MOD_GlcNHglycan	299	302	PF01048	0.614
MOD_GlcNHglycan	398	401	PF01048	0.568
MOD_GlcNHglycan	516	519	PF01048	0.425
MOD_GlcNHglycan	61	64	PF01048	0.396
MOD_GSK3_1	110	117	PF00069	0.388
MOD_GSK3_1	119	126	PF00069	0.392
MOD_GSK3_1	304	311	PF00069	0.715
MOD_GSK3_1	335	342	PF00069	0.654
MOD_GSK3_1	392	399	PF00069	0.506
MOD_GSK3_1	405	412	PF00069	0.398
MOD_GSK3_1	413	420	PF00069	0.428
MOD_GSK3_1	444	451	PF00069	0.360
MOD_GSK3_1	538	545	PF00069	0.323
MOD_GSK3_1	64	71	PF00069	0.338
MOD_LATS_1	351	357	PF00433	0.581
MOD_N-GLC_1	531	536	PF02516	0.379
MOD_N-GLC_2	159	161	PF02516	0.377
MOD_NEK2_1	108	113	PF00069	0.313
MOD_NEK2_1	114	119	PF00069	0.290
MOD_NEK2_1	127	132	PF00069	0.171
MOD_NEK2_1	198	203	PF00069	0.383
MOD_NEK2_1	269	274	PF00069	0.712
MOD_NEK2_1	444	449	PF00069	0.332
MOD_NEK2_1	455	460	PF00069	0.354
MOD_NEK2_1	462	467	PF00069	0.346
MOD_NEK2_1	48	53	PF00069	0.394
MOD_NEK2_1	68	73	PF00069	0.177
MOD_NEK2_1	96	101	PF00069	0.338
MOD_NEK2_2	183	188	PF00069	0.383
MOD_NEK2_2	379	384	PF00069	0.377
MOD_OFUCOSY	537	542	PF10250	0.383
MOD_PIKK_1	335	341	PF00454	0.714
MOD_PKA_1	353	359	PF00069	0.564
MOD_PKA_2	183	189	PF00069	0.399
MOD_PKA_2	353	359	PF00069	0.622
MOD_Plk_1	312	318	PF00069	0.735
MOD_Plk_1	41	47	PF00069	0.323
MOD_Plk_1	531	537	PF00069	0.430
MOD_Plk_4	123	129	PF00069	0.360
MOD_Plk_4	143	149	PF00069	0.323
MOD_Plk_4	173	179	PF00069	0.383
MOD_Plk_4	198	204	PF00069	0.383
MOD_Plk_4	312	318	PF00069	0.688
MOD_Plk_4	399	405	PF00069	0.486
MOD_Plk_4	414	420	PF00069	0.364
MOD_Plk_4	427	433	PF00069	0.323
MOD_Plk_4	455	461	PF00069	0.488
MOD_Plk_4	471	477	PF00069	0.364
MOD_Plk_4	98	104	PF00069	0.387
MOD_ProDKin_1	135	141	PF00069	0.323
MOD_ProDKin_1	222	228	PF00069	0.377
MOD_ProDKin_1	251	257	PF00069	0.655
MOD_ProDKin_1	261	267	PF00069	0.685
MOD_ProDKin_1	304	310	PF00069	0.691
MOD_ProDKin_1	405	411	PF00069	0.471
MOD_ProDKin_1	74	80	PF00069	0.328
TRG_DiLeu_BaEn_3	244	250	PF01217	0.705
TRG_ENDOCYTIC_2	125	128	PF00928	0.301
TRG_ENDOCYTIC_2	384	387	PF00928	0.332
TRG_ENDOCYTIC_2	388	391	PF00928	0.334
TRG_ENDOCYTIC_2	404	407	PF00928	0.275
TRG_ENDOCYTIC_2	466	469	PF00928	0.378
TRG_ENDOCYTIC_2	535	538	PF00928	0.328
TRG_ENDOCYTIC_2	552	555	PF00928	0.171
TRG_ER_diArg_1	148	151	PF00400	0.383
TRG_ER_diArg_1	352	354	PF00400	0.558

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2L5	Leptomonas seymouri	70%	100%
A4H494	Leishmania braziliensis	76%	95%
A4HSH0	Leishmania infantum	100%	100%
C9ZND1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
E9AKF4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4QJF4	Leishmania major	95%	100%
Q57VW6	Trypanosoma brucei brucei (strain 927/4 GUTat10.1)	48%	100%