Surp module, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Surp module, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WP43_LEIDO

TriTrypDb:

LdBPK_050610.1 , LdCL_050011200 , LDHU3_05.0690

Length:

978

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7WP43

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WP43

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	7
GO:0006396	RNA processing	6	7
GO:0006725	cellular aromatic compound metabolic process	3	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0016070	RNA metabolic process	5	7
GO:0034641	cellular nitrogen compound metabolic process	3	7
GO:0043170	macromolecule metabolic process	3	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0046483	heterocycle metabolic process	3	7
GO:0071704	organic substance metabolic process	2	7
GO:0090304	nucleic acid metabolic process	4	7
GO:1901360	organic cyclic compound metabolic process	3	7

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	7
GO:0003723	RNA binding	4	7
GO:0005488	binding	1	7
GO:0097159	organic cyclic compound binding	2	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	331	335	PF00656	0.613
CLV_C14_Caspase3-7	515	519	PF00656	0.576
CLV_NRD_NRD_1	14	16	PF00675	0.594
CLV_NRD_NRD_1	296	298	PF00675	0.483
CLV_NRD_NRD_1	360	362	PF00675	0.637
CLV_NRD_NRD_1	419	421	PF00675	0.685
CLV_NRD_NRD_1	530	532	PF00675	0.482
CLV_NRD_NRD_1	671	673	PF00675	0.469
CLV_NRD_NRD_1	715	717	PF00675	0.651
CLV_NRD_NRD_1	722	724	PF00675	0.594
CLV_PCSK_FUR_1	356	360	PF00082	0.629
CLV_PCSK_FUR_1	712	716	PF00082	0.650
CLV_PCSK_KEX2_1	244	246	PF00082	0.273
CLV_PCSK_KEX2_1	296	298	PF00082	0.483
CLV_PCSK_KEX2_1	358	360	PF00082	0.640
CLV_PCSK_KEX2_1	375	377	PF00082	0.673
CLV_PCSK_KEX2_1	530	532	PF00082	0.591
CLV_PCSK_KEX2_1	671	673	PF00082	0.469
CLV_PCSK_KEX2_1	714	716	PF00082	0.658
CLV_PCSK_KEX2_1	722	724	PF00082	0.630
CLV_PCSK_PC1ET2_1	244	246	PF00082	0.273
CLV_PCSK_PC1ET2_1	375	377	PF00082	0.690
CLV_PCSK_PC7_1	356	362	PF00082	0.583
CLV_PCSK_PC7_1	718	724	PF00082	0.691
CLV_PCSK_SKI1_1	424	428	PF00082	0.636
CLV_PCSK_SKI1_1	487	491	PF00082	0.529
CLV_PCSK_SKI1_1	537	541	PF00082	0.532
CLV_PCSK_SKI1_1	774	778	PF00082	0.709
CLV_PCSK_SKI1_1	877	881	PF00082	0.543
DEG_APCC_DBOX_1	269	277	PF00400	0.473
DEG_Nend_UBRbox_2	1	3	PF02207	0.584
DEG_SCF_FBW7_1	830	837	PF00400	0.613
DEG_SIAH_1	573	581	PF03145	0.515
DEG_SPOP_SBC_1	691	695	PF00917	0.555
DEG_SPOP_SBC_1	801	805	PF00917	0.642
DEG_SPOP_SBC_1	861	865	PF00917	0.654
DOC_CKS1_1	25	30	PF01111	0.756
DOC_CYCLIN_yCln2_LP_2	136	139	PF00134	0.662
DOC_CYCLIN_yCln2_LP_2	201	207	PF00134	0.485
DOC_CYCLIN_yCln2_LP_2	322	328	PF00134	0.609
DOC_CYCLIN_yCln2_LP_2	504	510	PF00134	0.529
DOC_MAPK_gen_1	209	218	PF00069	0.435
DOC_MAPK_gen_1	296	302	PF00069	0.443
DOC_MAPK_gen_1	671	677	PF00069	0.483
DOC_MAPK_MEF2A_6	877	884	PF00069	0.491
DOC_PP2B_LxvP_1	136	139	PF13499	0.626
DOC_PP2B_LxvP_1	201	204	PF13499	0.490
DOC_PP2B_LxvP_1	205	208	PF13499	0.470
DOC_PP2B_LxvP_1	210	213	PF13499	0.416
DOC_PP2B_LxvP_1	471	474	PF13499	0.573
DOC_PP2B_LxvP_1	890	893	PF13499	0.580
DOC_PP4_FxxP_1	122	125	PF00568	0.645
DOC_PP4_FxxP_1	261	264	PF00568	0.473
DOC_USP7_MATH_1	125	129	PF00917	0.778
DOC_USP7_MATH_1	172	176	PF00917	0.671
DOC_USP7_MATH_1	183	187	PF00917	0.567
DOC_USP7_MATH_1	328	332	PF00917	0.654
DOC_USP7_MATH_1	388	392	PF00917	0.584
DOC_USP7_MATH_1	451	455	PF00917	0.718
DOC_USP7_MATH_1	574	578	PF00917	0.620
DOC_USP7_MATH_1	580	584	PF00917	0.473
DOC_USP7_MATH_1	608	612	PF00917	0.674
DOC_USP7_MATH_1	636	640	PF00917	0.658
DOC_USP7_MATH_1	679	683	PF00917	0.656
DOC_USP7_MATH_1	691	695	PF00917	0.586
DOC_USP7_MATH_1	706	710	PF00917	0.748
DOC_USP7_MATH_1	801	805	PF00917	0.684
DOC_USP7_MATH_1	845	849	PF00917	0.672
DOC_USP7_MATH_1	860	864	PF00917	0.547
DOC_USP7_MATH_1	896	900	PF00917	0.623
DOC_USP7_MATH_1	927	931	PF00917	0.747
DOC_USP7_UBL2_3	788	792	PF12436	0.706
DOC_WW_Pin1_4	175	180	PF00397	0.681
DOC_WW_Pin1_4	2	7	PF00397	0.565
DOC_WW_Pin1_4	20	25	PF00397	0.604
DOC_WW_Pin1_4	446	451	PF00397	0.642
DOC_WW_Pin1_4	604	609	PF00397	0.749
DOC_WW_Pin1_4	656	661	PF00397	0.545
DOC_WW_Pin1_4	680	685	PF00397	0.745
DOC_WW_Pin1_4	699	704	PF00397	0.692
DOC_WW_Pin1_4	707	712	PF00397	0.609
DOC_WW_Pin1_4	721	726	PF00397	0.615
DOC_WW_Pin1_4	81	86	PF00397	0.603
DOC_WW_Pin1_4	830	835	PF00397	0.618
DOC_WW_Pin1_4	839	844	PF00397	0.721
DOC_WW_Pin1_4	892	897	PF00397	0.662
LIG_14-3-3_CanoR_1	148	158	PF00244	0.617
LIG_14-3-3_CanoR_1	272	277	PF00244	0.473
LIG_14-3-3_CanoR_1	424	429	PF00244	0.635
LIG_14-3-3_CanoR_1	481	490	PF00244	0.605
LIG_14-3-3_CanoR_1	678	684	PF00244	0.593
LIG_14-3-3_CanoR_1	973	977	PF00244	0.515
LIG_BRCT_BRCA1_1	974	978	PF00533	0.518
LIG_Clathr_ClatBox_1	942	946	PF01394	0.640
LIG_CSL_BTD_1	300	303	PF09270	0.456
LIG_deltaCOP1_diTrp_1	589	595	PF00928	0.432
LIG_eIF4E_1	956	962	PF01652	0.588
LIG_FHA_1	196	202	PF00498	0.624
LIG_FHA_1	21	27	PF00498	0.591
LIG_FHA_1	219	225	PF00498	0.470
LIG_FHA_1	227	233	PF00498	0.468
LIG_FHA_1	49	55	PF00498	0.618
LIG_FHA_1	500	506	PF00498	0.437
LIG_FHA_1	573	579	PF00498	0.637
LIG_FHA_1	806	812	PF00498	0.675
LIG_FHA_1	835	841	PF00498	0.605
LIG_FHA_1	930	936	PF00498	0.640
LIG_FHA_2	161	167	PF00498	0.645
LIG_FHA_2	180	186	PF00498	0.515
LIG_FHA_2	220	226	PF00498	0.309
LIG_FHA_2	235	241	PF00498	0.473
LIG_FHA_2	451	457	PF00498	0.709
LIG_FHA_2	513	519	PF00498	0.579
LIG_FHA_2	737	743	PF00498	0.478
LIG_FHA_2	85	91	PF00498	0.574
LIG_IBAR_NPY_1	506	508	PF08397	0.554
LIG_Integrin_RGD_1	431	433	PF01839	0.599
LIG_LIR_Apic_2	120	125	PF02991	0.650
LIG_LIR_Apic_2	126	132	PF02991	0.615
LIG_LIR_Apic_2	259	264	PF02991	0.473
LIG_LIR_Gen_1	34	41	PF02991	0.647
LIG_LIR_Gen_1	499	509	PF02991	0.491
LIG_LIR_Gen_1	664	675	PF02991	0.662
LIG_LIR_Gen_1	84	94	PF02991	0.607
LIG_LIR_Gen_1	972	978	PF02991	0.520
LIG_LIR_Nem_3	34	39	PF02991	0.563
LIG_LIR_Nem_3	499	504	PF02991	0.470
LIG_LIR_Nem_3	5	11	PF02991	0.534
LIG_LIR_Nem_3	589	595	PF02991	0.432
LIG_LIR_Nem_3	664	670	PF02991	0.660
LIG_LIR_Nem_3	84	89	PF02991	0.600
LIG_LIR_Nem_3	972	977	PF02991	0.516
LIG_MYND_1	134	138	PF01753	0.649
LIG_MYND_1	24	28	PF01753	0.597
LIG_NRBOX	222	228	PF00104	0.309
LIG_NRBOX	272	278	PF00104	0.473
LIG_NRBOX	551	557	PF00104	0.402
LIG_PCNA_yPIPBox_3	98	109	PF02747	0.626
LIG_PDZ_Class_2	973	978	PF00595	0.520
LIG_Pex14_1	875	879	PF04695	0.536
LIG_Pex14_2	879	883	PF04695	0.552
LIG_PTB_Apo_2	248	255	PF02174	0.458
LIG_SH2_CRK	129	133	PF00017	0.681
LIG_SH2_CRK	274	278	PF00017	0.512
LIG_SH2_CRK	956	960	PF00017	0.739
LIG_SH2_CRK	974	978	PF00017	0.448
LIG_SH2_GRB2like	141	144	PF00017	0.642
LIG_SH2_NCK_1	508	512	PF00017	0.551
LIG_SH2_PTP2	299	302	PF00017	0.398
LIG_SH2_STAP1	974	978	PF00017	0.518
LIG_SH2_STAT3	93	96	PF00017	0.628
LIG_SH2_STAT5	141	144	PF00017	0.689
LIG_SH2_STAT5	299	302	PF00017	0.398
LIG_SH2_STAT5	564	567	PF00017	0.531
LIG_SH2_STAT5	586	589	PF00017	0.527
LIG_SH2_STAT5	593	596	PF00017	0.426
LIG_SH2_STAT5	86	89	PF00017	0.582
LIG_SH3_2	303	308	PF14604	0.516
LIG_SH3_3	165	171	PF00018	0.619
LIG_SH3_3	22	28	PF00018	0.662
LIG_SH3_3	297	303	PF00018	0.412
LIG_SH3_3	4	10	PF00018	0.557
LIG_SH3_3	466	472	PF00018	0.612
LIG_SH3_3	681	687	PF00018	0.734
LIG_SH3_3	775	781	PF00018	0.697
LIG_SH3_3	890	896	PF00018	0.609
LIG_SH3_3	906	912	PF00018	0.636
LIG_SUMO_SIM_anti_2	221	229	PF11976	0.381
LIG_TRAF2_1	237	240	PF00917	0.473
LIG_TRAF2_1	342	345	PF00917	0.633
LIG_TYR_ITIM	591	596	PF00017	0.428
LIG_UBA3_1	872	877	PF00899	0.478
LIG_WW_1	138	141	PF00397	0.653
MOD_CDK_SPK_2	707	712	PF00069	0.639
MOD_CDK_SPxxK_3	707	714	PF00069	0.648
MOD_CDK_SPxxK_3	721	728	PF00069	0.524
MOD_CK1_1	161	167	PF00069	0.568
MOD_CK1_1	175	181	PF00069	0.624
MOD_CK1_1	18	24	PF00069	0.609
MOD_CK1_1	284	290	PF00069	0.494
MOD_CK1_1	391	397	PF00069	0.656
MOD_CK1_1	398	404	PF00069	0.626
MOD_CK1_1	405	411	PF00069	0.634
MOD_CK1_1	611	617	PF00069	0.698
MOD_CK1_1	639	645	PF00069	0.635
MOD_CK1_1	656	662	PF00069	0.484
MOD_CK1_1	694	700	PF00069	0.623
MOD_CK1_1	702	708	PF00069	0.662
MOD_CK1_1	71	77	PF00069	0.669
MOD_CK1_1	793	799	PF00069	0.644
MOD_CK1_1	800	806	PF00069	0.653
MOD_CK1_1	84	90	PF00069	0.537
MOD_CK1_1	841	847	PF00069	0.736
MOD_CK1_1	848	854	PF00069	0.657
MOD_CK1_1	863	869	PF00069	0.517
MOD_CK2_1	160	166	PF00069	0.644
MOD_CK2_1	179	185	PF00069	0.555
MOD_CK2_1	234	240	PF00069	0.473
MOD_CK2_1	374	380	PF00069	0.651
MOD_CK2_1	406	412	PF00069	0.737
MOD_CK2_1	450	456	PF00069	0.705
MOD_CK2_1	721	727	PF00069	0.592
MOD_CK2_1	736	742	PF00069	0.482
MOD_CK2_1	793	799	PF00069	0.627
MOD_CK2_1	84	90	PF00069	0.578
MOD_GlcNHglycan	145	148	PF01048	0.608
MOD_GlcNHglycan	160	163	PF01048	0.530
MOD_GlcNHglycan	168	171	PF01048	0.638
MOD_GlcNHglycan	17	20	PF01048	0.692
MOD_GlcNHglycan	172	175	PF01048	0.603
MOD_GlcNHglycan	185	188	PF01048	0.510
MOD_GlcNHglycan	330	333	PF01048	0.655
MOD_GlcNHglycan	366	369	PF01048	0.652
MOD_GlcNHglycan	391	394	PF01048	0.620
MOD_GlcNHglycan	400	403	PF01048	0.604
MOD_GlcNHglycan	43	46	PF01048	0.645
MOD_GlcNHglycan	453	456	PF01048	0.670
MOD_GlcNHglycan	474	477	PF01048	0.548
MOD_GlcNHglycan	57	60	PF01048	0.561
MOD_GlcNHglycan	609	613	PF01048	0.670
MOD_GlcNHglycan	638	641	PF01048	0.657
MOD_GlcNHglycan	694	697	PF01048	0.688
MOD_GlcNHglycan	70	73	PF01048	0.688
MOD_GlcNHglycan	704	707	PF01048	0.665
MOD_GlcNHglycan	76	79	PF01048	0.579
MOD_GlcNHglycan	799	802	PF01048	0.777
MOD_GlcNHglycan	843	846	PF01048	0.661
MOD_GlcNHglycan	847	850	PF01048	0.692
MOD_GlcNHglycan	851	854	PF01048	0.742
MOD_GlcNHglycan	865	868	PF01048	0.536
MOD_GlcNHglycan	898	901	PF01048	0.665
MOD_GlcNHglycan	962	965	PF01048	0.523
MOD_GSK3_1	11	18	PF00069	0.643
MOD_GSK3_1	166	173	PF00069	0.644
MOD_GSK3_1	175	182	PF00069	0.614
MOD_GSK3_1	20	27	PF00069	0.583
MOD_GSK3_1	388	395	PF00069	0.677
MOD_GSK3_1	396	403	PF00069	0.531
MOD_GSK3_1	404	411	PF00069	0.704
MOD_GSK3_1	436	443	PF00069	0.790
MOD_GSK3_1	446	453	PF00069	0.591
MOD_GSK3_1	477	484	PF00069	0.603
MOD_GSK3_1	604	611	PF00069	0.623
MOD_GSK3_1	679	686	PF00069	0.604
MOD_GSK3_1	68	75	PF00069	0.733
MOD_GSK3_1	690	697	PF00069	0.772
MOD_GSK3_1	702	709	PF00069	0.641
MOD_GSK3_1	793	800	PF00069	0.634
MOD_GSK3_1	801	808	PF00069	0.620
MOD_GSK3_1	826	833	PF00069	0.664
MOD_GSK3_1	834	841	PF00069	0.580
MOD_GSK3_1	845	852	PF00069	0.524
MOD_GSK3_1	856	863	PF00069	0.790
MOD_GSK3_1	892	899	PF00069	0.621
MOD_LATS_1	362	368	PF00433	0.649
MOD_N-GLC_1	388	393	PF02516	0.634
MOD_N-GLC_1	41	46	PF02516	0.577
MOD_N-GLC_1	602	607	PF02516	0.505
MOD_N-GLC_1	620	625	PF02516	0.625
MOD_N-GLC_1	797	802	PF02516	0.559
MOD_N-GLC_1	938	943	PF02516	0.492
MOD_NEK2_1	1	6	PF00069	0.570
MOD_NEK2_1	11	16	PF00069	0.560
MOD_NEK2_1	218	223	PF00069	0.419
MOD_NEK2_1	226	231	PF00069	0.473
MOD_NEK2_1	48	53	PF00069	0.604
MOD_NEK2_1	55	60	PF00069	0.579
MOD_NEK2_1	602	607	PF00069	0.505
MOD_NEK2_1	802	807	PF00069	0.640
MOD_NEK2_2	117	122	PF00069	0.559
MOD_NEK2_2	815	820	PF00069	0.594
MOD_PIKK_1	127	133	PF00454	0.676
MOD_PIKK_1	284	290	PF00454	0.494
MOD_PIKK_1	440	446	PF00454	0.664
MOD_PIKK_1	757	763	PF00454	0.616
MOD_PIKK_1	946	952	PF00454	0.648
MOD_PKA_1	15	21	PF00069	0.593
MOD_PKA_2	389	395	PF00069	0.637
MOD_PKA_2	972	978	PF00069	0.520
MOD_PKB_1	209	217	PF00069	0.412
MOD_PKB_1	270	278	PF00069	0.473
MOD_Plk_1	125	131	PF00069	0.626
MOD_Plk_1	218	224	PF00069	0.410
MOD_Plk_1	48	54	PF00069	0.620
MOD_Plk_1	797	803	PF00069	0.520
MOD_Plk_1	927	933	PF00069	0.566
MOD_Plk_1	938	944	PF00069	0.527
MOD_Plk_2-3	219	225	PF00069	0.398
MOD_Plk_4	100	106	PF00069	0.605
MOD_Plk_4	117	123	PF00069	0.493
MOD_Plk_4	219	225	PF00069	0.398
MOD_Plk_4	272	278	PF00069	0.473
MOD_Plk_4	49	55	PF00069	0.574
MOD_Plk_4	550	556	PF00069	0.406
MOD_Plk_4	736	742	PF00069	0.482
MOD_Plk_4	84	90	PF00069	0.599
MOD_Plk_4	911	917	PF00069	0.630
MOD_Plk_4	938	944	PF00069	0.613
MOD_Plk_4	972	978	PF00069	0.520
MOD_ProDKin_1	175	181	PF00069	0.680
MOD_ProDKin_1	2	8	PF00069	0.572
MOD_ProDKin_1	20	26	PF00069	0.606
MOD_ProDKin_1	446	452	PF00069	0.642
MOD_ProDKin_1	604	610	PF00069	0.757
MOD_ProDKin_1	656	662	PF00069	0.542
MOD_ProDKin_1	680	686	PF00069	0.748
MOD_ProDKin_1	699	705	PF00069	0.694
MOD_ProDKin_1	707	713	PF00069	0.609
MOD_ProDKin_1	721	727	PF00069	0.527
MOD_ProDKin_1	81	87	PF00069	0.604
MOD_ProDKin_1	830	836	PF00069	0.620
MOD_ProDKin_1	839	845	PF00069	0.721
MOD_ProDKin_1	892	898	PF00069	0.660
MOD_SUMO_for_1	243	246	PF00179	0.473
MOD_SUMO_rev_2	103	111	PF00179	0.615
TRG_DiLeu_BaEn_1	219	224	PF01217	0.402
TRG_DiLeu_BaLyEn_6	132	137	PF01217	0.672
TRG_DiLeu_BaLyEn_6	957	962	PF01217	0.565
TRG_ENDOCYTIC_2	274	277	PF00928	0.508
TRG_ENDOCYTIC_2	299	302	PF00928	0.398
TRG_ENDOCYTIC_2	593	596	PF00928	0.426
TRG_ENDOCYTIC_2	667	670	PF00928	0.590
TRG_ENDOCYTIC_2	86	89	PF00928	0.607
TRG_ENDOCYTIC_2	974	977	PF00928	0.512
TRG_ER_diArg_1	208	211	PF00400	0.444
TRG_ER_diArg_1	356	359	PF00400	0.623
TRG_ER_diArg_1	529	531	PF00400	0.504
TRG_ER_diArg_1	670	672	PF00400	0.468
TRG_ER_diArg_1	711	714	PF00400	0.645
TRG_ER_diArg_1	715	718	PF00400	0.647
TRG_NES_CRM1_1	546	557	PF08389	0.436
TRG_NLS_Bipartite_1	358	379	PF00514	0.609
TRG_NLS_MonoExtC_3	374	380	PF00514	0.628
TRG_Pf-PMV_PEXEL_1	527	532	PF00026	0.482

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAE1	Leptomonas seymouri	41%	100%
A4HD48	Leishmania braziliensis	73%	99%
A4HSI3	Leishmania infantum	99%	100%
E9AKG7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	99%
Q4QJE1	Leishmania major	91%	99%