Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WP37_LEIDO

TriTrypDb:

LdBPK_050440.1 , LdCL_050009400 , LDHU3_05.0510

Length:

846

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7WP37

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WP37

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	453	457	PF00656	0.779
CLV_C14_Caspase3-7	656	660	PF00656	0.627
CLV_C14_Caspase3-7	786	790	PF00656	0.538
CLV_NRD_NRD_1	109	111	PF00675	0.747
CLV_NRD_NRD_1	264	266	PF00675	0.561
CLV_NRD_NRD_1	339	341	PF00675	0.540
CLV_NRD_NRD_1	625	627	PF00675	0.496
CLV_NRD_NRD_1	748	750	PF00675	0.583
CLV_PCSK_FUR_1	337	341	PF00082	0.556
CLV_PCSK_FUR_1	498	502	PF00082	0.567
CLV_PCSK_FUR_1	745	749	PF00082	0.552
CLV_PCSK_KEX2_1	264	266	PF00082	0.561
CLV_PCSK_KEX2_1	339	341	PF00082	0.591
CLV_PCSK_KEX2_1	500	502	PF00082	0.571
CLV_PCSK_KEX2_1	625	627	PF00082	0.496
CLV_PCSK_KEX2_1	745	747	PF00082	0.534
CLV_PCSK_KEX2_1	748	750	PF00082	0.579
CLV_PCSK_PC1ET2_1	500	502	PF00082	0.571
CLV_PCSK_SKI1_1	301	305	PF00082	0.511
DEG_APCC_DBOX_1	300	308	PF00400	0.485
DEG_APCC_DBOX_1	675	683	PF00400	0.609
DEG_APCC_KENBOX_2	766	770	PF00400	0.659
DEG_SCF_FBW7_2	750	757	PF00400	0.661
DEG_SPOP_SBC_1	211	215	PF00917	0.762
DOC_CDC14_PxL_1	526	534	PF14671	0.524
DOC_CKS1_1	601	606	PF01111	0.662
DOC_CKS1_1	751	756	PF01111	0.669
DOC_CYCLIN_RxL_1	676	686	PF00134	0.583
DOC_MAPK_gen_1	337	344	PF00069	0.423
DOC_MAPK_gen_1	479	489	PF00069	0.593
DOC_MAPK_gen_1	625	633	PF00069	0.601
DOC_MAPK_MEF2A_6	527	534	PF00069	0.528
DOC_MAPK_MEF2A_6	729	738	PF00069	0.502
DOC_MAPK_MEF2A_6	806	815	PF00069	0.373
DOC_MAPK_RevD_3	734	748	PF00069	0.474
DOC_PP1_SILK_1	423	428	PF00149	0.480
DOC_PP4_FxxP_1	546	549	PF00568	0.520
DOC_USP7_MATH_1	131	135	PF00917	0.726
DOC_USP7_MATH_1	166	170	PF00917	0.523
DOC_USP7_MATH_1	211	215	PF00917	0.762
DOC_USP7_MATH_1	639	643	PF00917	0.605
DOC_USP7_MATH_1	653	657	PF00917	0.383
DOC_USP7_MATH_1	82	86	PF00917	0.510
DOC_USP7_MATH_1	829	833	PF00917	0.532
DOC_USP7_MATH_1	93	97	PF00917	0.692
DOC_USP7_UBL2_3	111	115	PF12436	0.705
DOC_WW_Pin1_4	16	21	PF00397	0.578
DOC_WW_Pin1_4	181	186	PF00397	0.511
DOC_WW_Pin1_4	188	193	PF00397	0.540
DOC_WW_Pin1_4	207	212	PF00397	0.655
DOC_WW_Pin1_4	600	605	PF00397	0.676
DOC_WW_Pin1_4	750	755	PF00397	0.662
DOC_WW_Pin1_4	95	100	PF00397	0.701
LIG_14-3-3_CanoR_1	119	124	PF00244	0.714
LIG_14-3-3_CanoR_1	361	371	PF00244	0.643
LIG_14-3-3_CanoR_1	462	470	PF00244	0.639
LIG_14-3-3_CanoR_1	486	490	PF00244	0.613
LIG_14-3-3_CanoR_1	58	62	PF00244	0.616
LIG_14-3-3_CanoR_1	676	680	PF00244	0.606
LIG_14-3-3_CanoR_1	818	828	PF00244	0.539
LIG_APCC_ABBAyCdc20_2	708	714	PF00400	0.614
LIG_BIR_II_1	1	5	PF00653	0.603
LIG_BIR_III_2	276	280	PF00653	0.628
LIG_BIR_III_2	398	402	PF00653	0.513
LIG_BIR_III_2	49	53	PF00653	0.554
LIG_BIR_III_4	385	389	PF00653	0.594
LIG_Clathr_ClatBox_1	196	200	PF01394	0.452
LIG_deltaCOP1_diTrp_1	266	272	PF00928	0.508
LIG_deltaCOP1_diTrp_1	430	439	PF00928	0.560
LIG_FHA_1	118	124	PF00498	0.729
LIG_FHA_1	292	298	PF00498	0.571
LIG_FHA_1	417	423	PF00498	0.399
LIG_FHA_1	489	495	PF00498	0.543
LIG_FHA_1	526	532	PF00498	0.531
LIG_FHA_1	628	634	PF00498	0.493
LIG_FHA_1	772	778	PF00498	0.490
LIG_FHA_2	64	70	PF00498	0.544
LIG_FHA_2	676	682	PF00498	0.500
LIG_FHA_2	751	757	PF00498	0.663
LIG_LIR_Gen_1	372	380	PF02991	0.506
LIG_LIR_Gen_1	430	440	PF02991	0.558
LIG_LIR_Gen_1	538	547	PF02991	0.565
LIG_LIR_Gen_1	56	64	PF02991	0.528
LIG_LIR_Gen_1	642	651	PF02991	0.444
LIG_LIR_Gen_1	710	720	PF02991	0.490
LIG_LIR_Nem_3	251	256	PF02991	0.557
LIG_LIR_Nem_3	372	377	PF02991	0.502
LIG_LIR_Nem_3	430	436	PF02991	0.568
LIG_LIR_Nem_3	538	543	PF02991	0.449
LIG_LIR_Nem_3	56	62	PF02991	0.515
LIG_LIR_Nem_3	642	647	PF02991	0.454
LIG_LIR_Nem_3	710	715	PF02991	0.496
LIG_NRBOX	151	157	PF00104	0.600
LIG_NRBOX	646	652	PF00104	0.476
LIG_PCNA_TLS_4	368	375	PF02747	0.506
LIG_PCNA_yPIPBox_3	725	734	PF02747	0.511
LIG_Pex14_2	692	696	PF04695	0.639
LIG_SH2_CRK	178	182	PF00017	0.489
LIG_SH2_CRK	526	530	PF00017	0.489
LIG_SH2_CRK	90	94	PF00017	0.653
LIG_SH2_NCK_1	81	85	PF00017	0.601
LIG_SH2_NCK_1	90	94	PF00017	0.599
LIG_SH2_STAP1	644	648	PF00017	0.482
LIG_SH2_STAP1	740	744	PF00017	0.581
LIG_SH2_STAP1	784	788	PF00017	0.681
LIG_SH2_STAT5	374	377	PF00017	0.498
LIG_SH2_STAT5	537	540	PF00017	0.442
LIG_SH3_1	748	754	PF00018	0.570
LIG_SH3_2	601	606	PF14604	0.662
LIG_SH3_3	189	195	PF00018	0.479
LIG_SH3_3	598	604	PF00018	0.716
LIG_SH3_3	691	697	PF00018	0.546
LIG_SH3_3	748	754	PF00018	0.570
LIG_SUMO_SIM_par_1	193	201	PF11976	0.510
LIG_SUMO_SIM_par_1	340	346	PF11976	0.441
LIG_SUMO_SIM_par_1	646	652	PF11976	0.553
LIG_SUMO_SIM_par_1	811	817	PF11976	0.364
LIG_SxIP_EBH_1	167	177	PF03271	0.522
LIG_UBA3_1	341	347	PF00899	0.448
LIG_UBA3_1	422	427	PF00899	0.470
LIG_WRC_WIRS_1	689	694	PF05994	0.582
MOD_CDK_SPxK_1	600	606	PF00069	0.671
MOD_CK1_1	117	123	PF00069	0.691
MOD_CK1_1	134	140	PF00069	0.569
MOD_CK1_1	147	153	PF00069	0.620
MOD_CK1_1	210	216	PF00069	0.771
MOD_CK1_1	450	456	PF00069	0.649
MOD_CK1_1	466	472	PF00069	0.553
MOD_CK1_1	683	689	PF00069	0.492
MOD_CK1_1	790	796	PF00069	0.621
MOD_CK2_1	576	582	PF00069	0.485
MOD_CK2_1	675	681	PF00069	0.523
MOD_CK2_1	811	817	PF00069	0.539
MOD_Cter_Amidation	113	116	PF01082	0.664
MOD_GlcNHglycan	102	105	PF01048	0.762
MOD_GlcNHglycan	136	139	PF01048	0.695
MOD_GlcNHglycan	173	176	PF01048	0.625
MOD_GlcNHglycan	215	218	PF01048	0.731
MOD_GlcNHglycan	248	253	PF01048	0.552
MOD_GlcNHglycan	322	325	PF01048	0.612
MOD_GlcNHglycan	362	365	PF01048	0.619
MOD_GlcNHglycan	42	45	PF01048	0.620
MOD_GlcNHglycan	450	453	PF01048	0.597
MOD_GlcNHglycan	556	559	PF01048	0.651
MOD_GlcNHglycan	596	599	PF01048	0.752
MOD_GlcNHglycan	651	654	PF01048	0.564
MOD_GlcNHglycan	661	664	PF01048	0.460
MOD_GlcNHglycan	789	792	PF01048	0.670
MOD_GlcNHglycan	821	824	PF01048	0.544
MOD_GlcNHglycan	831	834	PF01048	0.488
MOD_GSK3_1	115	122	PF00069	0.747
MOD_GSK3_1	200	207	PF00069	0.615
MOD_GSK3_1	209	216	PF00069	0.645
MOD_GSK3_1	450	457	PF00069	0.747
MOD_GSK3_1	513	520	PF00069	0.608
MOD_GSK3_1	550	557	PF00069	0.678
MOD_GSK3_1	576	583	PF00069	0.640
MOD_GSK3_1	649	656	PF00069	0.534
MOD_GSK3_1	783	790	PF00069	0.584
MOD_GSK3_1	91	98	PF00069	0.717
MOD_N-GLC_1	16	21	PF02516	0.656
MOD_N-GLC_1	454	459	PF02516	0.745
MOD_N-GLC_1	594	599	PF02516	0.684
MOD_N-GLC_2	411	413	PF02516	0.684
MOD_N-GLC_2	566	568	PF02516	0.518
MOD_NEK2_1	1	6	PF00069	0.597
MOD_NEK2_1	186	191	PF00069	0.627
MOD_NEK2_1	204	209	PF00069	0.400
MOD_NEK2_1	513	518	PF00069	0.499
MOD_NEK2_1	525	530	PF00069	0.483
MOD_NEK2_1	633	638	PF00069	0.468
MOD_NEK2_2	675	680	PF00069	0.634
MOD_NEK2_2	740	745	PF00069	0.585
MOD_PIKK_1	587	593	PF00454	0.725
MOD_PIKK_1	723	729	PF00454	0.622
MOD_PK_1	421	427	PF00069	0.516
MOD_PKA_1	115	121	PF00069	0.733
MOD_PKA_2	360	366	PF00069	0.669
MOD_PKA_2	485	491	PF00069	0.625
MOD_PKA_2	550	556	PF00069	0.682
MOD_PKA_2	559	565	PF00069	0.474
MOD_PKA_2	57	63	PF00069	0.623
MOD_PKA_2	576	582	PF00069	0.379
MOD_PKA_2	605	611	PF00069	0.598
MOD_PKA_2	675	681	PF00069	0.523
MOD_Plk_1	147	153	PF00069	0.637
MOD_Plk_1	200	206	PF00069	0.426
MOD_Plk_1	466	472	PF00069	0.613
MOD_Plk_1	680	686	PF00069	0.565
MOD_Plk_2-3	627	633	PF00069	0.599
MOD_Plk_4	1	7	PF00069	0.598
MOD_Plk_4	136	142	PF00069	0.733
MOD_Plk_4	147	153	PF00069	0.485
MOD_Plk_4	19	25	PF00069	0.546
MOD_Plk_4	370	376	PF00069	0.600
MOD_Plk_4	421	427	PF00069	0.545
MOD_Plk_4	490	496	PF00069	0.597
MOD_Plk_4	614	620	PF00069	0.547
MOD_Plk_4	688	694	PF00069	0.578
MOD_ProDKin_1	16	22	PF00069	0.571
MOD_ProDKin_1	181	187	PF00069	0.509
MOD_ProDKin_1	188	194	PF00069	0.533
MOD_ProDKin_1	207	213	PF00069	0.661
MOD_ProDKin_1	600	606	PF00069	0.678
MOD_ProDKin_1	750	756	PF00069	0.658
MOD_ProDKin_1	95	101	PF00069	0.702
MOD_SUMO_for_1	472	475	PF00179	0.518
TRG_DiLeu_BaEn_1	193	198	PF01217	0.504
TRG_DiLeu_BaEn_1	732	737	PF01217	0.453
TRG_DiLeu_BaLyEn_6	182	187	PF01217	0.513
TRG_DiLeu_BaLyEn_6	192	197	PF01217	0.516
TRG_DiLeu_BaLyEn_6	337	342	PF01217	0.631
TRG_DiLeu_BaLyEn_6	365	370	PF01217	0.635
TRG_ENDOCYTIC_2	374	377	PF00928	0.498
TRG_ENDOCYTIC_2	526	529	PF00928	0.484
TRG_ENDOCYTIC_2	644	647	PF00928	0.439
TRG_ER_diArg_1	26	29	PF00400	0.473
TRG_ER_diArg_1	263	265	PF00400	0.570
TRG_ER_diArg_1	309	312	PF00400	0.545
TRG_ER_diArg_1	337	340	PF00400	0.625
TRG_ER_diArg_1	624	626	PF00400	0.489
TRG_ER_diArg_1	744	747	PF00400	0.517
TRG_ER_diArg_1	748	750	PF00400	0.579
TRG_NES_CRM1_1	148	158	PF08389	0.612
TRG_NES_CRM1_1	193	205	PF08389	0.404
TRG_Pf-PMV_PEXEL_1	121	125	PF00026	0.727
TRG_Pf-PMV_PEXEL_1	282	286	PF00026	0.654
TRG_Pf-PMV_PEXEL_1	368	372	PF00026	0.616

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I264	Leptomonas seymouri	45%	95%
A4H490	Leishmania braziliensis	79%	98%
A4HSG6	Leishmania infantum	99%	100%
E9AKF0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4QJF8	Leishmania major	92%	100%