LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania donovani
UniProt:
A0A3S7WP32_LEIDO
TriTrypDb:
LdBPK_050580.1 * , LdCL_050010900 , LDHU3_05.0660
Length:
779

Annotations

LeishMANIAdb annotations

This Kinetoplastid-unique protein has a 4TM central helical bundle and long cytoplasmic termini with strikingly low complexity. Its function is unknown.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 3
Silverman et al. no yes: 0
Pissara et al. no yes: 4
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 6
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0016020 membrane 2 6
GO:0110165 cellular anatomical entity 1 6
GO:0000123 histone acetyltransferase complex 4 1
GO:0000124 SAGA complex 4 1
GO:0005815 microtubule organizing center 2 1
GO:0031248 protein acetyltransferase complex 3 1
GO:0032991 protein-containing complex 1 1
GO:0036064 ciliary basal body 3 1
GO:0070461 SAGA-type complex 5 1
GO:0140535 intracellular protein-containing complex 2 1
GO:1902493 acetyltransferase complex 4 1
GO:1902494 catalytic complex 2 1
GO:1905368 peptidase complex 3 1
GO:1990234 transferase complex 3 1

Expansion

Sequence features

A0A3S7WP32
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WP32

Function

Biological processes
Term Name Level Count
GO:0006355 regulation of DNA-templated transcription 6 1
GO:0006357 regulation of transcription by RNA polymerase II 7 1
GO:0009889 regulation of biosynthetic process 4 1
GO:0010468 regulation of gene expression 5 1
GO:0010556 regulation of macromolecule biosynthetic process 5 1
GO:0019219 regulation of nucleobase-containing compound metabolic process 5 1
GO:0019222 regulation of metabolic process 3 1
GO:0031323 regulation of cellular metabolic process 4 1
GO:0031326 regulation of cellular biosynthetic process 5 1
GO:0050789 regulation of biological process 2 1
GO:0050794 regulation of cellular process 3 1
GO:0051171 regulation of nitrogen compound metabolic process 4 1
GO:0051252 regulation of RNA metabolic process 5 1
GO:0060255 regulation of macromolecule metabolic process 4 1
GO:0065007 biological regulation 1 1
GO:0080090 regulation of primary metabolic process 4 1
GO:1903506 regulation of nucleic acid-templated transcription 7 1
GO:2001141 regulation of RNA biosynthetic process 6 1
Molecular functions
Term Name Level Count
GO:0003712 transcription coregulator activity 2 4
GO:0003713 transcription coactivator activity 3 4
GO:0140110 transcription regulator activity 1 4

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 190 194 PF00656 0.287
CLV_C14_Caspase3-7 757 761 PF00656 0.720
CLV_NRD_NRD_1 134 136 PF00675 0.495
CLV_NRD_NRD_1 260 262 PF00675 0.606
CLV_NRD_NRD_1 315 317 PF00675 0.402
CLV_NRD_NRD_1 448 450 PF00675 0.522
CLV_NRD_NRD_1 641 643 PF00675 0.512
CLV_NRD_NRD_1 649 651 PF00675 0.510
CLV_NRD_NRD_1 681 683 PF00675 0.534
CLV_NRD_NRD_1 728 730 PF00675 0.520
CLV_NRD_NRD_1 731 733 PF00675 0.504
CLV_PCSK_FUR_1 679 683 PF00082 0.531
CLV_PCSK_FUR_1 729 733 PF00082 0.509
CLV_PCSK_KEX2_1 134 136 PF00082 0.495
CLV_PCSK_KEX2_1 259 261 PF00082 0.567
CLV_PCSK_KEX2_1 315 317 PF00082 0.424
CLV_PCSK_KEX2_1 491 493 PF00082 0.431
CLV_PCSK_KEX2_1 523 525 PF00082 0.365
CLV_PCSK_KEX2_1 639 641 PF00082 0.520
CLV_PCSK_KEX2_1 649 651 PF00082 0.504
CLV_PCSK_KEX2_1 681 683 PF00082 0.529
CLV_PCSK_KEX2_1 727 729 PF00082 0.503
CLV_PCSK_KEX2_1 731 733 PF00082 0.512
CLV_PCSK_PC1ET2_1 491 493 PF00082 0.399
CLV_PCSK_PC1ET2_1 523 525 PF00082 0.365
CLV_PCSK_PC1ET2_1 639 641 PF00082 0.560
CLV_PCSK_PC7_1 487 493 PF00082 0.380
CLV_PCSK_PC7_1 636 642 PF00082 0.559
CLV_PCSK_PC7_1 677 683 PF00082 0.556
CLV_PCSK_PC7_1 727 733 PF00082 0.509
CLV_PCSK_SKI1_1 260 264 PF00082 0.582
CLV_PCSK_SKI1_1 498 502 PF00082 0.404
CLV_PCSK_SKI1_1 540 544 PF00082 0.399
CLV_PCSK_SKI1_1 697 701 PF00082 0.507
DEG_APCC_DBOX_1 290 298 PF00400 0.269
DEG_APCC_KENBOX_2 671 675 PF00400 0.756
DEG_Nend_UBRbox_2 1 3 PF02207 0.754
DOC_AGCK_PIF_1 425 430 PF00069 0.359
DOC_CKS1_1 395 400 PF01111 0.578
DOC_CKS1_1 99 104 PF01111 0.687
DOC_CYCLIN_RxL_1 255 265 PF00134 0.380
DOC_CYCLIN_yCln2_LP_2 479 485 PF00134 0.369
DOC_MAPK_gen_1 449 457 PF00069 0.325
DOC_PP1_RVXF_1 388 395 PF00149 0.638
DOC_PP1_RVXF_1 521 528 PF00149 0.575
DOC_PP2B_LxvP_1 479 482 PF13499 0.369
DOC_PP2B_PxIxI_1 206 212 PF00149 0.421
DOC_PP4_FxxP_1 331 334 PF00568 0.649
DOC_PP4_MxPP_1 574 577 PF00568 0.623
DOC_USP7_MATH_1 239 243 PF00917 0.442
DOC_USP7_MATH_1 326 330 PF00917 0.679
DOC_USP7_MATH_1 617 621 PF00917 0.716
DOC_WW_Pin1_4 129 134 PF00397 0.707
DOC_WW_Pin1_4 32 37 PF00397 0.719
DOC_WW_Pin1_4 334 339 PF00397 0.605
DOC_WW_Pin1_4 345 350 PF00397 0.608
DOC_WW_Pin1_4 39 44 PF00397 0.697
DOC_WW_Pin1_4 394 399 PF00397 0.582
DOC_WW_Pin1_4 586 591 PF00397 0.675
DOC_WW_Pin1_4 6 11 PF00397 0.742
DOC_WW_Pin1_4 612 617 PF00397 0.788
DOC_WW_Pin1_4 621 626 PF00397 0.842
DOC_WW_Pin1_4 85 90 PF00397 0.647
DOC_WW_Pin1_4 98 103 PF00397 0.642
LIG_14-3-3_CanoR_1 25 34 PF00244 0.714
LIG_14-3-3_CanoR_1 315 323 PF00244 0.601
LIG_14-3-3_CanoR_1 327 332 PF00244 0.685
LIG_14-3-3_CanoR_1 487 491 PF00244 0.593
LIG_AP2alpha_2 127 129 PF02296 0.641
LIG_BRCT_BRCA1_1 371 375 PF00533 0.655
LIG_deltaCOP1_diTrp_1 151 155 PF00928 0.304
LIG_FHA_1 151 157 PF00498 0.304
LIG_FHA_1 206 212 PF00498 0.434
LIG_FHA_1 225 231 PF00498 0.408
LIG_FHA_1 277 283 PF00498 0.326
LIG_FHA_1 291 297 PF00498 0.269
LIG_FHA_1 40 46 PF00498 0.735
LIG_FHA_1 416 422 PF00498 0.340
LIG_FHA_1 435 441 PF00498 0.230
LIG_FHA_1 452 458 PF00498 0.207
LIG_FHA_2 188 194 PF00498 0.409
LIG_FHA_2 238 244 PF00498 0.458
LIG_FHA_2 534 540 PF00498 0.599
LIG_LIR_Apic_2 329 334 PF02991 0.650
LIG_LIR_Apic_2 393 398 PF02991 0.586
LIG_LIR_Gen_1 151 160 PF02991 0.334
LIG_LIR_Gen_1 178 189 PF02991 0.377
LIG_LIR_Gen_1 302 311 PF02991 0.350
LIG_LIR_Gen_1 342 349 PF02991 0.605
LIG_LIR_Gen_1 397 408 PF02991 0.552
LIG_LIR_Gen_1 427 433 PF02991 0.351
LIG_LIR_Gen_1 513 522 PF02991 0.576
LIG_LIR_LC3C_4 472 475 PF02991 0.270
LIG_LIR_LC3C_4 748 752 PF02991 0.706
LIG_LIR_Nem_3 144 150 PF02991 0.591
LIG_LIR_Nem_3 151 155 PF02991 0.298
LIG_LIR_Nem_3 178 184 PF02991 0.326
LIG_LIR_Nem_3 265 269 PF02991 0.405
LIG_LIR_Nem_3 302 306 PF02991 0.300
LIG_LIR_Nem_3 396 402 PF02991 0.600
LIG_LIR_Nem_3 424 428 PF02991 0.391
LIG_LIR_Nem_3 429 433 PF02991 0.335
LIG_LIR_Nem_3 513 519 PF02991 0.577
LIG_MYND_1 249 253 PF01753 0.394
LIG_MYND_1 499 503 PF01753 0.619
LIG_Pex14_1 143 147 PF04695 0.630
LIG_Pex14_1 426 430 PF04695 0.329
LIG_Pex14_2 150 154 PF04695 0.469
LIG_Pex14_2 355 359 PF04695 0.620
LIG_Pex14_2 405 409 PF04695 0.495
LIG_Pex14_2 422 426 PF04695 0.227
LIG_Pex14_2 515 519 PF04695 0.578
LIG_SH2_CRK 301 305 PF00017 0.304
LIG_SH2_CRK 308 312 PF00017 0.304
LIG_SH2_GRB2like 276 279 PF00017 0.331
LIG_SH2_NCK_1 395 399 PF00017 0.586
LIG_SH2_STAP1 235 239 PF00017 0.418
LIG_SH2_STAP1 276 280 PF00017 0.326
LIG_SH2_STAP1 308 312 PF00017 0.284
LIG_SH2_STAP1 447 451 PF00017 0.305
LIG_SH2_STAT3 100 103 PF00017 0.686
LIG_SH2_STAT3 15 18 PF00017 0.746
LIG_SH2_STAT5 100 103 PF00017 0.686
LIG_SH2_STAT5 149 152 PF00017 0.599
LIG_SH2_STAT5 199 202 PF00017 0.311
LIG_SH2_STAT5 430 433 PF00017 0.315
LIG_SH2_STAT5 447 450 PF00017 0.290
LIG_SH2_STAT5 509 512 PF00017 0.580
LIG_SH3_3 119 125 PF00018 0.638
LIG_SH3_3 130 136 PF00018 0.658
LIG_SH3_3 496 502 PF00018 0.636
LIG_SH3_3 584 590 PF00018 0.690
LIG_SH3_3 592 598 PF00018 0.641
LIG_SH3_3 701 707 PF00018 0.709
LIG_SH3_3 749 755 PF00018 0.751
LIG_SUMO_SIM_anti_2 302 308 PF11976 0.304
LIG_SUMO_SIM_anti_2 454 459 PF11976 0.316
LIG_SUMO_SIM_anti_2 472 478 PF11976 0.201
LIG_SUMO_SIM_par_1 169 174 PF11976 0.464
LIG_SUMO_SIM_par_1 207 212 PF11976 0.405
LIG_TYR_ITIM 306 311 PF00017 0.304
LIG_WRC_WIRS_1 263 268 PF05994 0.396
LIG_WRC_WIRS_1 300 305 PF05994 0.272
LIG_WRC_WIRS_1 412 417 PF05994 0.362
LIG_WRC_WIRS_1 422 427 PF05994 0.269
MOD_CDK_SPK_2 129 134 PF00069 0.707
MOD_CDK_SPxK_1 129 135 PF00069 0.707
MOD_CK1_1 242 248 PF00069 0.444
MOD_CK1_1 302 308 PF00069 0.435
MOD_CK1_1 319 325 PF00069 0.663
MOD_CK1_1 35 41 PF00069 0.738
MOD_CK1_1 4 10 PF00069 0.741
MOD_CK1_1 410 416 PF00069 0.304
MOD_CK1_1 424 430 PF00069 0.362
MOD_CK1_1 586 592 PF00069 0.657
MOD_CK1_1 71 77 PF00069 0.675
MOD_CK1_1 85 91 PF00069 0.615
MOD_CK1_1 98 104 PF00069 0.622
MOD_CK2_1 237 243 PF00069 0.430
MOD_CK2_1 262 268 PF00069 0.404
MOD_CK2_1 533 539 PF00069 0.609
MOD_GlcNHglycan 10 13 PF01048 0.546
MOD_GlcNHglycan 214 217 PF01048 0.589
MOD_GlcNHglycan 246 249 PF01048 0.564
MOD_GlcNHglycan 37 40 PF01048 0.575
MOD_GlcNHglycan 371 374 PF01048 0.584
MOD_GlcNHglycan 409 412 PF01048 0.352
MOD_GlcNHglycan 60 63 PF01048 0.526
MOD_GlcNHglycan 609 613 PF01048 0.511
MOD_GlcNHglycan 66 69 PF01048 0.551
MOD_GlcNHglycan 663 666 PF01048 0.534
MOD_GlcNHglycan 71 74 PF01048 0.430
MOD_GlcNHglycan 745 750 PF01048 0.522
MOD_GlcNHglycan 84 87 PF01048 0.411
MOD_GSK3_1 110 117 PF00069 0.665
MOD_GSK3_1 212 219 PF00069 0.423
MOD_GSK3_1 237 244 PF00069 0.455
MOD_GSK3_1 35 42 PF00069 0.737
MOD_GSK3_1 4 11 PF00069 0.741
MOD_GSK3_1 407 414 PF00069 0.303
MOD_GSK3_1 608 615 PF00069 0.753
MOD_GSK3_1 617 624 PF00069 0.648
MOD_GSK3_1 64 71 PF00069 0.698
MOD_GSK3_1 656 663 PF00069 0.790
MOD_GSK3_1 681 688 PF00069 0.768
MOD_GSK3_1 689 696 PF00069 0.692
MOD_GSK3_1 730 737 PF00069 0.728
MOD_LATS_1 685 691 PF00433 0.759
MOD_LATS_1 730 736 PF00433 0.716
MOD_N-GLC_1 187 192 PF02516 0.657
MOD_N-GLC_1 25 30 PF02516 0.512
MOD_N-GLC_1 255 260 PF02516 0.517
MOD_N-GLC_1 673 678 PF02516 0.554
MOD_N-GLC_2 76 78 PF02516 0.488
MOD_NEK2_1 1 6 PF00069 0.746
MOD_NEK2_1 150 155 PF00069 0.469
MOD_NEK2_1 262 267 PF00069 0.394
MOD_NEK2_1 299 304 PF00069 0.307
MOD_NEK2_1 415 420 PF00069 0.304
MOD_NEK2_1 421 426 PF00069 0.304
MOD_NEK2_1 451 456 PF00069 0.341
MOD_NEK2_1 525 530 PF00069 0.586
MOD_NEK2_1 570 575 PF00069 0.666
MOD_NEK2_1 608 613 PF00069 0.726
MOD_NEK2_1 64 69 PF00069 0.693
MOD_NEK2_1 660 665 PF00069 0.742
MOD_NEK2_2 142 147 PF00069 0.589
MOD_NEK2_2 442 447 PF00069 0.318
MOD_PIKK_1 101 107 PF00454 0.688
MOD_PIKK_1 110 116 PF00454 0.622
MOD_PIKK_1 25 31 PF00454 0.714
MOD_PIKK_1 374 380 PF00454 0.662
MOD_PIKK_1 501 507 PF00454 0.580
MOD_PIKK_1 555 561 PF00454 0.640
MOD_PIKK_1 600 606 PF00454 0.654
MOD_PIKK_1 702 708 PF00454 0.712
MOD_PKA_1 681 687 PF00069 0.757
MOD_PKA_2 290 296 PF00069 0.269
MOD_PKA_2 326 332 PF00069 0.696
MOD_PKA_2 433 439 PF00069 0.365
MOD_PKA_2 486 492 PF00069 0.573
MOD_PKA_2 681 687 PF00069 0.757
MOD_PKA_2 730 736 PF00069 0.729
MOD_PKA_2 755 761 PF00069 0.716
MOD_PKB_1 640 648 PF00069 0.714
MOD_PKB_1 679 687 PF00069 0.742
MOD_PKB_1 691 699 PF00069 0.675
MOD_Plk_1 1 7 PF00069 0.744
MOD_Plk_1 114 120 PF00069 0.665
MOD_Plk_1 150 156 PF00069 0.469
MOD_Plk_1 187 193 PF00069 0.433
MOD_Plk_1 242 248 PF00069 0.559
MOD_Plk_1 451 457 PF00069 0.361
MOD_Plk_2-3 547 553 PF00069 0.654
MOD_Plk_4 142 148 PF00069 0.591
MOD_Plk_4 161 167 PF00069 0.304
MOD_Plk_4 205 211 PF00069 0.386
MOD_Plk_4 282 288 PF00069 0.346
MOD_Plk_4 290 296 PF00069 0.238
MOD_Plk_4 299 305 PF00069 0.249
MOD_Plk_4 327 333 PF00069 0.658
MOD_Plk_4 451 457 PF00069 0.299
MOD_Plk_4 570 576 PF00069 0.618
MOD_Plk_4 583 589 PF00069 0.669
MOD_Plk_4 617 623 PF00069 0.681
MOD_Plk_4 95 101 PF00069 0.686
MOD_ProDKin_1 129 135 PF00069 0.707
MOD_ProDKin_1 32 38 PF00069 0.718
MOD_ProDKin_1 334 340 PF00069 0.602
MOD_ProDKin_1 345 351 PF00069 0.604
MOD_ProDKin_1 39 45 PF00069 0.697
MOD_ProDKin_1 394 400 PF00069 0.576
MOD_ProDKin_1 586 592 PF00069 0.677
MOD_ProDKin_1 6 12 PF00069 0.743
MOD_ProDKin_1 612 618 PF00069 0.788
MOD_ProDKin_1 621 627 PF00069 0.843
MOD_ProDKin_1 85 91 PF00069 0.645
MOD_ProDKin_1 98 104 PF00069 0.641
MOD_SUMO_rev_2 518 525 PF00179 0.579
TRG_DiLeu_BaEn_1 472 477 PF01217 0.369
TRG_ENDOCYTIC_2 147 150 PF00928 0.608
TRG_ENDOCYTIC_2 301 304 PF00928 0.304
TRG_ENDOCYTIC_2 308 311 PF00928 0.304
TRG_ENDOCYTIC_2 400 403 PF00928 0.575
TRG_ENDOCYTIC_2 430 433 PF00928 0.326
TRG_ER_diArg_1 133 135 PF00400 0.705
TRG_ER_diArg_1 259 261 PF00400 0.367
TRG_ER_diArg_1 314 316 PF00400 0.596
TRG_ER_diArg_1 640 642 PF00400 0.716
TRG_ER_diArg_1 679 682 PF00400 0.732
TRG_ER_diArg_1 727 729 PF00400 0.703
TRG_NLS_MonoCore_2 638 643 PF00514 0.758
TRG_NLS_MonoExtN_4 636 643 PF00514 0.757

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I288 Leptomonas seymouri 50% 90%
A4H4A9 Leishmania braziliensis 67% 98%
A4HSI0 Leishmania infantum 100% 100%
E9AKG4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 87% 100%
Q4QJE4 Leishmania major 93% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS