Hydrogenase_putative/GeneDB:LmjF.05.0230

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hydrogenase, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WP18_LEIDO

TriTrypDb:

LdBPK_050230.1 , LdCL_050007200 , LDHU3_05.0270

Length:

633

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7WP18

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WP18

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0051536	iron-sulfur cluster binding	3	1
GO:0051539	4 iron, 4 sulfur cluster binding	4	1
GO:0051540	metal cluster binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	602	606	PF00656	0.555
CLV_NRD_NRD_1	228	230	PF00675	0.279
CLV_NRD_NRD_1	296	298	PF00675	0.231
CLV_NRD_NRD_1	582	584	PF00675	0.656
CLV_PCSK_FUR_1	226	230	PF00082	0.316
CLV_PCSK_KEX2_1	226	228	PF00082	0.274
CLV_PCSK_KEX2_1	279	281	PF00082	0.249
CLV_PCSK_KEX2_1	40	42	PF00082	0.760
CLV_PCSK_KEX2_1	447	449	PF00082	0.231
CLV_PCSK_KEX2_1	483	485	PF00082	0.245
CLV_PCSK_KEX2_1	581	583	PF00082	0.706
CLV_PCSK_PC1ET2_1	279	281	PF00082	0.249
CLV_PCSK_PC1ET2_1	40	42	PF00082	0.767
CLV_PCSK_PC1ET2_1	447	449	PF00082	0.226
CLV_PCSK_PC1ET2_1	483	485	PF00082	0.245
CLV_PCSK_PC7_1	479	485	PF00082	0.328
CLV_PCSK_SKI1_1	479	483	PF00082	0.243
DEG_APCC_DBOX_1	114	122	PF00400	0.384
DEG_Nend_UBRbox_2	1	3	PF02207	0.551
DEG_SPOP_SBC_1	100	104	PF00917	0.643
DEG_SPOP_SBC_1	383	387	PF00917	0.404
DEG_SPOP_SBC_1	429	433	PF00917	0.539
DOC_ANK_TNKS_1	418	425	PF00023	0.470
DOC_CKS1_1	436	441	PF01111	0.569
DOC_USP7_MATH_1	101	105	PF00917	0.636
DOC_USP7_MATH_1	266	270	PF00917	0.528
DOC_USP7_MATH_1	29	33	PF00917	0.673
DOC_USP7_MATH_1	302	306	PF00917	0.534
DOC_USP7_MATH_1	390	394	PF00917	0.532
DOC_USP7_MATH_1	427	431	PF00917	0.543
DOC_USP7_MATH_1	546	550	PF00917	0.653
DOC_USP7_MATH_1	563	567	PF00917	0.705
DOC_WW_Pin1_4	168	173	PF00397	0.563
DOC_WW_Pin1_4	386	391	PF00397	0.462
DOC_WW_Pin1_4	430	435	PF00397	0.537
DOC_WW_Pin1_4	96	101	PF00397	0.618
LIG_14-3-3_CanoR_1	149	157	PF00244	0.505
LIG_14-3-3_CanoR_1	489	494	PF00244	0.450
LIG_14-3-3_CanoR_1	609	613	PF00244	0.518
LIG_BRCT_BRCA1_1	392	396	PF00533	0.470
LIG_deltaCOP1_diTrp_1	585	591	PF00928	0.477
LIG_deltaCOP1_diTrp_1	605	612	PF00928	0.439
LIG_eIF4E_1	491	497	PF01652	0.431
LIG_FHA_1	108	114	PF00498	0.472
LIG_FHA_1	152	158	PF00498	0.540
LIG_FHA_1	231	237	PF00498	0.391
LIG_FHA_1	323	329	PF00498	0.420
LIG_FHA_1	593	599	PF00498	0.547
LIG_FHA_1	79	85	PF00498	0.433
LIG_FHA_2	218	224	PF00498	0.431
LIG_FHA_2	490	496	PF00498	0.431
LIG_FHA_2	609	615	PF00498	0.529
LIG_FHA_2	63	69	PF00498	0.429
LIG_FHA_2	75	81	PF00498	0.383
LIG_GBD_Chelix_1	129	137	PF00786	0.361
LIG_LIR_Apic_2	2	6	PF02991	0.501
LIG_LIR_Gen_1	492	500	PF02991	0.434
LIG_LIR_Gen_1	616	623	PF02991	0.528
LIG_LIR_Nem_3	492	496	PF02991	0.434
LIG_LIR_Nem_3	585	591	PF02991	0.573
LIG_MYND_1	262	266	PF01753	0.447
LIG_MYND_1	46	50	PF01753	0.618
LIG_Pex14_1	608	612	PF04695	0.407
LIG_RPA_C_Fungi	414	426	PF08784	0.282
LIG_SH2_NCK_1	141	145	PF00017	0.407
LIG_SH2_PTP2	3	6	PF00017	0.509
LIG_SH2_STAP1	141	145	PF00017	0.450
LIG_SH2_STAP1	277	281	PF00017	0.254
LIG_SH2_STAP1	324	328	PF00017	0.275
LIG_SH2_STAP1	528	532	PF00017	0.512
LIG_SH2_STAT3	469	472	PF00017	0.275
LIG_SH2_STAT5	205	208	PF00017	0.260
LIG_SH2_STAT5	252	255	PF00017	0.290
LIG_SH2_STAT5	3	6	PF00017	0.511
LIG_SH2_STAT5	324	327	PF00017	0.275
LIG_SH2_STAT5	491	494	PF00017	0.275
LIG_SH3_2	343	348	PF14604	0.393
LIG_SH3_3	110	116	PF00018	0.541
LIG_SH3_3	23	29	PF00018	0.583
LIG_SH3_3	340	346	PF00018	0.410
LIG_SH3_3	433	439	PF00018	0.396
LIG_SH3_3	44	50	PF00018	0.641
LIG_SH3_3	595	601	PF00018	0.503
LIG_SUMO_SIM_anti_2	492	498	PF11976	0.275
LIG_SUMO_SIM_par_1	117	123	PF11976	0.340
LIG_SUMO_SIM_par_1	205	210	PF11976	0.410
LIG_SUMO_SIM_par_1	239	245	PF11976	0.410
LIG_SUMO_SIM_par_1	593	599	PF11976	0.404
LIG_TRAF2_1	220	223	PF00917	0.280
LIG_UBA3_1	334	339	PF00899	0.404
LIG_WRPW_2	588	591	PF00400	0.318
LIG_WW_1	202	205	PF00397	0.329
MOD_CDK_SPK_2	168	173	PF00069	0.266
MOD_CK1_1	120	126	PF00069	0.340
MOD_CK1_1	182	188	PF00069	0.454
MOD_CK1_1	305	311	PF00069	0.346
MOD_CK1_1	386	392	PF00069	0.250
MOD_CK1_1	430	436	PF00069	0.432
MOD_CK1_1	549	555	PF00069	0.706
MOD_CK1_1	99	105	PF00069	0.657
MOD_CK2_1	195	201	PF00069	0.329
MOD_CK2_1	217	223	PF00069	0.275
MOD_CK2_1	327	333	PF00069	0.291
MOD_CK2_1	489	495	PF00069	0.275
MOD_CK2_1	74	80	PF00069	0.461
MOD_CK2_1	85	91	PF00069	0.375
MOD_GlcNHglycan	17	20	PF01048	0.622
MOD_GlcNHglycan	179	184	PF01048	0.412
MOD_GlcNHglycan	215	218	PF01048	0.410
MOD_GlcNHglycan	257	260	PF01048	0.354
MOD_GlcNHglycan	268	271	PF01048	0.401
MOD_GlcNHglycan	31	34	PF01048	0.650
MOD_GlcNHglycan	392	395	PF01048	0.370
MOD_GlcNHglycan	407	410	PF01048	0.193
MOD_GlcNHglycan	549	552	PF01048	0.678
MOD_GlcNHglycan	559	562	PF01048	0.734
MOD_GlcNHglycan	7	10	PF01048	0.635
MOD_GlcNHglycan	72	75	PF01048	0.484
MOD_GlcNHglycan	93	96	PF01048	0.555
MOD_GSK3_1	107	114	PF00069	0.699
MOD_GSK3_1	11	18	PF00069	0.573
MOD_GSK3_1	179	186	PF00069	0.451
MOD_GSK3_1	213	220	PF00069	0.286
MOD_GSK3_1	27	34	PF00069	0.538
MOD_GSK3_1	302	309	PF00069	0.429
MOD_GSK3_1	382	389	PF00069	0.405
MOD_GSK3_1	428	435	PF00069	0.380
MOD_GSK3_1	528	535	PF00069	0.545
MOD_GSK3_1	542	549	PF00069	0.688
MOD_GSK3_1	592	599	PF00069	0.515
MOD_GSK3_1	70	77	PF00069	0.415
MOD_GSK3_1	91	98	PF00069	0.491
MOD_GSK3_1	99	106	PF00069	0.636
MOD_N-GLC_1	353	358	PF02516	0.382
MOD_NEK2_1	133	138	PF00069	0.405
MOD_NEK2_1	148	153	PF00069	0.374
MOD_NEK2_1	15	20	PF00069	0.617
MOD_NEK2_1	241	246	PF00069	0.275
MOD_NEK2_1	306	311	PF00069	0.218
MOD_NEK2_1	405	410	PF00069	0.275
MOD_NEK2_1	554	559	PF00069	0.649
MOD_NEK2_1	70	75	PF00069	0.429
MOD_NEK2_2	608	613	PF00069	0.572
MOD_PIKK_1	120	126	PF00454	0.432
MOD_PIKK_1	373	379	PF00454	0.377
MOD_PK_1	117	123	PF00069	0.459
MOD_PKA_2	148	154	PF00069	0.462
MOD_PKA_2	302	308	PF00069	0.358
MOD_PKA_2	608	614	PF00069	0.506
MOD_PKB_1	115	123	PF00069	0.472
MOD_PKB_1	348	356	PF00069	0.298
MOD_Plk_1	592	598	PF00069	0.498
MOD_Plk_4	11	17	PF00069	0.637
MOD_Plk_4	489	495	PF00069	0.275
MOD_Plk_4	78	84	PF00069	0.428
MOD_ProDKin_1	168	174	PF00069	0.459
MOD_ProDKin_1	386	392	PF00069	0.318
MOD_ProDKin_1	430	436	PF00069	0.423
MOD_ProDKin_1	96	102	PF00069	0.627
MOD_SUMO_for_1	176	179	PF00179	0.298
MOD_SUMO_rev_2	290	299	PF00179	0.275
TRG_DiLeu_BaLyEn_6	237	242	PF01217	0.393
TRG_ENDOCYTIC_2	141	144	PF00928	0.390
TRG_ENDOCYTIC_2	491	494	PF00928	0.275
TRG_ER_diArg_1	115	118	PF00400	0.493
TRG_ER_diArg_1	226	229	PF00400	0.335
TRG_ER_diArg_1	347	350	PF00400	0.298
TRG_ER_diArg_1	419	422	PF00400	0.250
TRG_ER_diArg_1	581	583	PF00400	0.641
TRG_NLS_MonoExtC_3	481	486	PF00514	0.404
TRG_NLS_MonoExtN_4	479	486	PF00514	0.275

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2B2	Leptomonas seymouri	54%	98%
A0A0S4J2N1	Bodo saltans	35%	100%
A0A1X0P0T4	Trypanosomatidae	38%	100%
A0A422NE31	Trypanosoma rangeli	37%	100%
A1CWD8	Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)	28%	100%
A2Q9A9	Aspergillus niger (strain CBS 513.88 / FGSC A1513)	28%	100%
A3LYR2	Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545)	25%	100%
A4FV58	Bos taurus	28%	100%
A4H468	Leishmania braziliensis	76%	100%
A4HSF5	Leishmania infantum	100%	100%
A5DKC0	Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324)	25%	100%
A5DSI2	Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239)	27%	100%
A6ZRK3	Saccharomyces cerevisiae (strain YJM789)	22%	100%
A7E7C4	Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1)	27%	100%
A7SDA8	Nematostella vectensis	26%	100%
A7TQP0	Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17)	22%	100%
B0WU52	Culex quinquefasciatus	27%	100%
B3N018	Drosophila ananassae	27%	100%
B3NKH7	Drosophila erecta	27%	100%
B4GXC8	Drosophila persimilis	27%	100%
B4IMH3	Drosophila sechellia	25%	100%
B4ISL0	Drosophila yakuba	28%	100%
B4JBE6	Drosophila grimshawi	28%	100%
B4KFU7	Drosophila mojavensis	28%	100%
B4LQR5	Drosophila virilis	28%	100%
B4MUM8	Drosophila willistoni	27%	100%
B4NSS7	Drosophila simulans	26%	100%
B5DK31	Drosophila pseudoobscura pseudoobscura	27%	100%
B6HUC4	Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255)	26%	100%
B6K2N0	Schizosaccharomyces japonicus (strain yFS275 / FY16936)	26%	100%
B6QQH9	Talaromyces marneffei (strain ATCC 18224 / CBS 334.59 / QM 7333)	27%	100%
B8N122	Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / IAM 13836 / NRRL 3357 / JCM 12722 / SRRC 167)	26%	100%
B9W8S4	Candida dubliniensis (strain CD36 / ATCC MYA-646 / CBS 7987 / NCPF 3949 / NRRL Y-17841)	24%	100%
D0A4K1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9AKC7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
P23503	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	22%	100%
P53998	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	24%	100%
Q0UM75	Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173)	29%	100%
Q16ML2	Aedes aegypti	26%	100%
Q1E736	Coccidioides immitis (strain RS)	26%	100%
Q2HEF1	Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)	28%	100%
Q2UJY8	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	26%	100%
Q2YDU6	Rattus norvegicus	27%	100%
Q4QJI0	Leishmania major	89%	100%
Q5APK7	Candida albicans (strain SC5314 / ATCC MYA-2876)	26%	100%
Q5B748	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	26%	100%
Q5BK18	Rattus norvegicus	27%	100%
Q5RF36	Pongo abelii	28%	100%
Q6BUI4	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	24%	100%
Q6CFR3	Yarrowia lipolytica (strain CLIB 122 / E 150)	27%	100%
Q6DHP6	Danio rerio	25%	100%
Q6GP25	Xenopus laevis	26%	100%
Q75E78	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	23%	100%
Q7PWB8	Anopheles gambiae	26%	100%
Q7SGW5	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	29%	100%
Q8SYS7	Drosophila melanogaster	26%	100%
Q94CL6	Arabidopsis thaliana	28%	100%
Q9CYQ7	Mus musculus	27%	100%
Q9H6Q4	Homo sapiens	28%	100%
Q9N392	Caenorhabditis elegans	26%	100%
Q9UHQ1	Homo sapiens	27%	100%
Q9Y7N7	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	100%
V5DC01	Trypanosoma cruzi	39%	100%