Monothiol_glutaredoxin_putative/GeneDB:LmjF.05.03 10

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

glutaredoxin-like protein

Species:

Leishmania donovani

UniProt:

A0A3S7WP17_LEIDO

TriTrypDb:

LdBPK_050320.1 , LdCL_050008100 , LDHU3_05.0370

Length:

180

Annotations

Annotations by Jardim et al.

Redox homeostasis, Glutaredoxin-like

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005759	mitochondrial matrix	5	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7WP17

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WP17

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	1
GO:0019725	cellular homeostasis	2	1
GO:0042592	homeostatic process	3	1
GO:0045454	cell redox homeostasis	3	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0065007	biological regulation	1	1
GO:0065008	regulation of biological quality	2	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0005488	binding	1	9
GO:0015035	protein-disulfide reductase activity	3	10
GO:0015036	disulfide oxidoreductase activity	4	10
GO:0016491	oxidoreductase activity	2	10
GO:0016667	oxidoreductase activity, acting on a sulfur group of donors	3	10
GO:0043167	ion binding	2	9
GO:0043169	cation binding	3	9
GO:0046872	metal ion binding	4	9
GO:0051536	iron-sulfur cluster binding	3	9
GO:0051540	metal cluster binding	2	9
GO:0097573	obsolete glutathione oxidoreductase activity	4	10
GO:0140096	catalytic activity, acting on a protein	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	21	23	PF00675	0.575
CLV_PCSK_KEX2_1	21	23	PF00082	0.575
DEG_Nend_UBRbox_1	1	4	PF02207	0.553
DOC_CYCLIN_RxL_1	2	13	PF00134	0.521
DOC_PP1_RVXF_1	88	95	PF00149	0.291
DOC_USP7_MATH_1	42	46	PF00917	0.602
DOC_WW_Pin1_4	95	100	PF00397	0.250
LIG_14-3-3_CanoR_1	103	113	PF00244	0.250
LIG_14-3-3_CanoR_1	21	26	PF00244	0.620
LIG_14-3-3_CanoR_1	56	62	PF00244	0.565
LIG_14-3-3_CanoR_1	6	11	PF00244	0.605
LIG_BRCT_BRCA1_1	57	61	PF00533	0.587
LIG_eIF4E_1	149	155	PF01652	0.273
LIG_FHA_1	105	111	PF00498	0.315
LIG_FHA_1	161	167	PF00498	0.365
LIG_FHA_1	169	175	PF00498	0.344
LIG_FHA_1	62	68	PF00498	0.585
LIG_LIR_Gen_1	122	132	PF02991	0.250
LIG_LIR_LC3C_4	89	93	PF02991	0.406
LIG_LIR_Nem_3	122	126	PF02991	0.250
LIG_LIR_Nem_3	140	145	PF02991	0.250
LIG_LYPXL_yS_3	145	148	PF13949	0.273
LIG_NRBOX	109	115	PF00104	0.345
LIG_SH2_NCK_1	35	39	PF00017	0.487
LIG_SH2_SRC	149	152	PF00017	0.273
LIG_SH2_STAT5	149	152	PF00017	0.273
LIG_SH3_3	140	146	PF00018	0.250
LIG_SH3_3	96	102	PF00018	0.298
LIG_SUMO_SIM_par_1	109	115	PF11976	0.271
LIG_UBA3_1	113	120	PF00899	0.224
MOD_CK1_1	20	26	PF00069	0.518
MOD_CK1_1	44	50	PF00069	0.585
MOD_CK1_1	72	78	PF00069	0.482
MOD_GlcNHglycan	12	15	PF01048	0.540
MOD_GlcNHglycan	36	39	PF01048	0.645
MOD_GlcNHglycan	52	55	PF01048	0.660
MOD_GlcNHglycan	57	60	PF01048	0.635
MOD_GSK3_1	137	144	PF00069	0.250
MOD_GSK3_1	17	24	PF00069	0.469
MOD_GSK3_1	2	9	PF00069	0.483
MOD_GSK3_1	41	48	PF00069	0.556
MOD_GSK3_1	93	100	PF00069	0.349
MOD_NEK2_1	10	15	PF00069	0.600
MOD_NEK2_1	166	171	PF00069	0.391
MOD_NEK2_1	31	36	PF00069	0.574
MOD_NEK2_1	46	51	PF00069	0.454
MOD_NEK2_1	61	66	PF00069	0.523
MOD_PIKK_1	97	103	PF00454	0.249
MOD_PK_1	21	27	PF00069	0.420
MOD_PKA_1	21	27	PF00069	0.509
MOD_PKA_2	104	110	PF00069	0.273
MOD_PKA_2	20	26	PF00069	0.522
MOD_PKA_2	55	61	PF00069	0.574
MOD_Plk_4	119	125	PF00069	0.258
MOD_Plk_4	160	166	PF00069	0.379
MOD_Plk_4	169	175	PF00069	0.361
MOD_ProDKin_1	95	101	PF00069	0.250
TRG_ENDOCYTIC_2	121	124	PF00928	0.253
TRG_ENDOCYTIC_2	145	148	PF00928	0.273
TRG_ER_diArg_1	102	105	PF00400	0.273
TRG_ER_diLys_1	175	180	PF00400	0.340

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0B8	Leptomonas seymouri	64%	100%
A0A0S4J2P4	Bodo saltans	56%	100%
A0A1X0P212	Trypanosomatidae	60%	100%
A0A3S5H4T1	Leishmania donovani	32%	92%
A4H326	Leishmania braziliensis	30%	100%
A4H476	Leishmania braziliensis	76%	100%
A4HRD2	Leishmania infantum	32%	92%
A4HSF1	Leishmania infantum	100%	100%
C9ZXG5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	85%
D0A4I1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	100%
E9AC00	Leishmania major	31%	92%
E9AJ97	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
E9AKD7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q02784	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	34%	100%
Q4QJH1	Leishmania major	93%	100%
Q555C8	Dictyostelium discoideum	27%	100%
Q6YFE4	Lachancea kluyveri	35%	100%
Q84Y95	Arabidopsis thaliana	33%	100%