LeishMANIAdb
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Protein kinase, putative

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Protein kinase, putative
Gene product:
protein kinase, putative
Species:
Leishmania donovani
UniProt:
A0A3S7WP16_LEIDO
TriTrypDb:
LdBPK_050390.1 * , LdCL_050008900 , LDHU3_05.0450
Length:
789

Annotations

LeishMANIAdb annotations

A large and apprently artificial collection of diverse kinetoplastid protein kinases. A subfamily has 2TM regions, but the majority is cytoplasmic.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A0A3S7WP16
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WP16

Function

Biological processes
Term Name Level Count
GO:0006468 protein phosphorylation 5 12
GO:0006793 phosphorus metabolic process 3 12
GO:0006796 phosphate-containing compound metabolic process 4 12
GO:0006807 nitrogen compound metabolic process 2 12
GO:0008152 metabolic process 1 12
GO:0009987 cellular process 1 12
GO:0016310 phosphorylation 5 12
GO:0019538 protein metabolic process 3 12
GO:0036211 protein modification process 4 12
GO:0043170 macromolecule metabolic process 3 12
GO:0043412 macromolecule modification 4 12
GO:0044237 cellular metabolic process 2 12
GO:0044238 primary metabolic process 2 12
GO:0071704 organic substance metabolic process 2 12
GO:1901564 organonitrogen compound metabolic process 3 12
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 12
GO:0003824 catalytic activity 1 12
GO:0004672 protein kinase activity 3 12
GO:0005488 binding 1 12
GO:0005524 ATP binding 5 12
GO:0016301 kinase activity 4 12
GO:0016740 transferase activity 2 12
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 12
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 12
GO:0017076 purine nucleotide binding 4 12
GO:0030554 adenyl nucleotide binding 5 12
GO:0032553 ribonucleotide binding 3 12
GO:0032555 purine ribonucleotide binding 4 12
GO:0032559 adenyl ribonucleotide binding 5 12
GO:0035639 purine ribonucleoside triphosphate binding 4 12
GO:0036094 small molecule binding 2 12
GO:0043167 ion binding 2 12
GO:0043168 anion binding 3 12
GO:0097159 organic cyclic compound binding 2 12
GO:0097367 carbohydrate derivative binding 2 12
GO:0140096 catalytic activity, acting on a protein 2 12
GO:1901265 nucleoside phosphate binding 3 12
GO:1901363 heterocyclic compound binding 2 12

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 149 153 PF00656 0.689
CLV_C14_Caspase3-7 224 228 PF00656 0.350
CLV_C14_Caspase3-7 245 249 PF00656 0.473
CLV_C14_Caspase3-7 316 320 PF00656 0.449
CLV_C14_Caspase3-7 377 381 PF00656 0.661
CLV_C14_Caspase3-7 394 398 PF00656 0.456
CLV_NRD_NRD_1 438 440 PF00675 0.684
CLV_NRD_NRD_1 465 467 PF00675 0.742
CLV_NRD_NRD_1 562 564 PF00675 0.452
CLV_NRD_NRD_1 787 789 PF00675 0.596
CLV_PCSK_KEX2_1 438 440 PF00082 0.684
CLV_PCSK_KEX2_1 562 564 PF00082 0.328
CLV_PCSK_SKI1_1 247 251 PF00082 0.383
CLV_PCSK_SKI1_1 633 637 PF00082 0.328
DEG_SCF_FBW7_1 390 396 PF00400 0.706
DOC_CKS1_1 390 395 PF01111 0.705
DOC_CKS1_1 673 678 PF01111 0.328
DOC_CYCLIN_yCln2_LP_2 291 297 PF00134 0.598
DOC_CYCLIN_yCln2_LP_2 767 773 PF00134 0.385
DOC_MAPK_gen_1 553 560 PF00069 0.328
DOC_MAPK_gen_1 633 642 PF00069 0.328
DOC_MAPK_HePTP_8 576 588 PF00069 0.413
DOC_MAPK_MEF2A_6 579 588 PF00069 0.328
DOC_MAPK_MEF2A_6 636 644 PF00069 0.328
DOC_PP2B_LxvP_1 495 498 PF13499 0.665
DOC_PP4_FxxP_1 476 479 PF00568 0.564
DOC_USP7_MATH_1 393 397 PF00917 0.710
DOC_USP7_MATH_1 411 415 PF00917 0.687
DOC_USP7_MATH_1 457 461 PF00917 0.743
DOC_USP7_MATH_1 53 57 PF00917 0.739
DOC_USP7_MATH_1 79 83 PF00917 0.751
DOC_USP7_MATH_1 95 99 PF00917 0.777
DOC_USP7_UBL2_3 351 355 PF12436 0.413
DOC_USP7_UBL2_3 514 518 PF12436 0.328
DOC_USP7_UBL2_3 785 789 PF12436 0.557
DOC_WW_Pin1_4 25 30 PF00397 0.762
DOC_WW_Pin1_4 389 394 PF00397 0.706
DOC_WW_Pin1_4 486 491 PF00397 0.550
DOC_WW_Pin1_4 508 513 PF00397 0.568
DOC_WW_Pin1_4 672 677 PF00397 0.328
DOC_WW_Pin1_4 778 783 PF00397 0.632
LIG_14-3-3_CanoR_1 115 123 PF00244 0.783
LIG_14-3-3_CanoR_1 385 391 PF00244 0.578
LIG_14-3-3_CanoR_1 462 466 PF00244 0.694
LIG_14-3-3_CanoR_1 530 536 PF00244 0.449
LIG_Actin_WH2_2 446 464 PF00022 0.548
LIG_Actin_WH2_2 517 532 PF00022 0.449
LIG_APCC_ABBA_1 347 352 PF00400 0.449
LIG_APCC_ABBA_1 584 589 PF00400 0.328
LIG_BIR_II_1 1 5 PF00653 0.715
LIG_BIR_III_4 248 252 PF00653 0.385
LIG_BIR_III_4 397 401 PF00653 0.703
LIG_BRCT_BRCA1_1 487 491 PF00533 0.601
LIG_BRCT_BRCA1_1 767 771 PF00533 0.398
LIG_Clathr_ClatBox_1 641 645 PF01394 0.328
LIG_deltaCOP1_diTrp_1 361 368 PF00928 0.331
LIG_eIF4E_1 165 171 PF01652 0.570
LIG_FHA_1 10 16 PF00498 0.629
LIG_FHA_1 17 23 PF00498 0.787
LIG_FHA_1 52 58 PF00498 0.805
LIG_FHA_1 524 530 PF00498 0.441
LIG_FHA_1 581 587 PF00498 0.341
LIG_FHA_1 595 601 PF00498 0.328
LIG_FHA_1 774 780 PF00498 0.657
LIG_FHA_2 143 149 PF00498 0.722
LIG_FHA_2 185 191 PF00498 0.381
LIG_FHA_2 222 228 PF00498 0.363
LIG_FHA_2 314 320 PF00498 0.363
LIG_FHA_2 481 487 PF00498 0.745
LIG_FHA_2 701 707 PF00498 0.328
LIG_FHA_2 760 766 PF00498 0.378
LIG_Integrin_isoDGR_2 333 335 PF01839 0.449
LIG_Integrin_isoDGR_2 531 533 PF01839 0.413
LIG_LIR_Apic_2 475 479 PF02991 0.565
LIG_LIR_Apic_2 675 681 PF02991 0.328
LIG_LIR_Gen_1 470 479 PF02991 0.700
LIG_LIR_Gen_1 719 728 PF02991 0.328
LIG_LIR_Nem_3 164 168 PF02991 0.585
LIG_LIR_Nem_3 470 476 PF02991 0.753
LIG_LIR_Nem_3 508 513 PF02991 0.457
LIG_LIR_Nem_3 520 524 PF02991 0.309
LIG_LIR_Nem_3 719 724 PF02991 0.328
LIG_MYND_1 757 761 PF01753 0.449
LIG_NRBOX 744 750 PF00104 0.449
LIG_Pex14_1 721 725 PF04695 0.328
LIG_Pex14_2 599 603 PF04695 0.328
LIG_PTB_Apo_2 104 111 PF02174 0.666
LIG_SH2_CRK 165 169 PF00017 0.578
LIG_SH2_CRK 525 529 PF00017 0.420
LIG_SH2_CRK 616 620 PF00017 0.385
LIG_SH2_STAP1 525 529 PF00017 0.328
LIG_SH2_STAT5 165 168 PF00017 0.540
LIG_SH2_STAT5 184 187 PF00017 0.166
LIG_SH2_STAT5 223 226 PF00017 0.396
LIG_SH2_STAT5 235 238 PF00017 0.328
LIG_SH2_STAT5 253 256 PF00017 0.218
LIG_SH2_STAT5 338 341 PF00017 0.344
LIG_SH2_STAT5 346 349 PF00017 0.344
LIG_SH2_STAT5 525 528 PF00017 0.449
LIG_SH2_STAT5 590 593 PF00017 0.445
LIG_SH2_STAT5 624 627 PF00017 0.328
LIG_SH3_3 132 138 PF00018 0.800
LIG_SH3_3 156 162 PF00018 0.655
LIG_SH3_3 387 393 PF00018 0.694
LIG_SH3_3 425 431 PF00018 0.684
LIG_SH3_3 441 447 PF00018 0.745
LIG_SH3_3 670 676 PF00018 0.328
LIG_SH3_3 709 715 PF00018 0.328
LIG_SH3_3 776 782 PF00018 0.607
LIG_SUMO_SIM_anti_2 557 562 PF11976 0.319
LIG_SUMO_SIM_par_1 18 24 PF11976 0.579
LIG_SUMO_SIM_par_1 538 544 PF11976 0.328
LIG_SUMO_SIM_par_1 640 645 PF11976 0.344
LIG_TRAF2_1 483 486 PF00917 0.632
LIG_TRAF2_1 547 550 PF00917 0.447
LIG_TYR_ITIM 163 168 PF00017 0.591
LIG_WRC_WIRS_1 596 601 PF05994 0.344
MOD_CDK_SPxK_1 508 514 PF00069 0.571
MOD_CDK_SPxxK_3 486 493 PF00069 0.587
MOD_CDK_SPxxK_3 778 785 PF00069 0.525
MOD_CK1_1 10 16 PF00069 0.554
MOD_CK1_1 117 123 PF00069 0.800
MOD_CK1_1 136 142 PF00069 0.762
MOD_CK1_1 2 8 PF00069 0.626
MOD_CK1_1 204 210 PF00069 0.376
MOD_CK1_1 21 27 PF00069 0.483
MOD_CK1_1 34 40 PF00069 0.816
MOD_CK1_1 381 387 PF00069 0.718
MOD_CK1_1 414 420 PF00069 0.737
MOD_CK1_1 421 427 PF00069 0.684
MOD_CK1_1 460 466 PF00069 0.696
MOD_CK1_1 592 598 PF00069 0.337
MOD_CK1_1 60 66 PF00069 0.772
MOD_CK2_1 184 190 PF00069 0.344
MOD_CK2_1 20 26 PF00069 0.651
MOD_CK2_1 32 38 PF00069 0.824
MOD_CK2_1 480 486 PF00069 0.658
MOD_CK2_1 502 508 PF00069 0.568
MOD_CK2_1 544 550 PF00069 0.348
MOD_CK2_1 700 706 PF00069 0.328
MOD_CK2_1 778 784 PF00069 0.746
MOD_CK2_1 95 101 PF00069 0.627
MOD_Cter_Amidation 786 789 PF01082 0.555
MOD_GlcNHglycan 117 120 PF01048 0.582
MOD_GlcNHglycan 203 206 PF01048 0.395
MOD_GlcNHglycan 287 290 PF01048 0.452
MOD_GlcNHglycan 453 456 PF01048 0.744
MOD_GlcNHglycan 475 479 PF01048 0.683
MOD_GlcNHglycan 591 594 PF01048 0.328
MOD_GlcNHglycan 663 666 PF01048 0.449
MOD_GlcNHglycan 7 10 PF01048 0.728
MOD_GlcNHglycan 70 73 PF01048 0.782
MOD_GlcNHglycan 784 788 PF01048 0.552
MOD_GlcNHglycan 97 100 PF01048 0.782
MOD_GSK3_1 16 23 PF00069 0.675
MOD_GSK3_1 247 254 PF00069 0.344
MOD_GSK3_1 27 34 PF00069 0.757
MOD_GSK3_1 389 396 PF00069 0.759
MOD_GSK3_1 414 421 PF00069 0.747
MOD_GSK3_1 447 454 PF00069 0.677
MOD_GSK3_1 457 464 PF00069 0.655
MOD_GSK3_1 5 12 PF00069 0.751
MOD_GSK3_1 508 515 PF00069 0.559
MOD_GSK3_1 53 60 PF00069 0.756
MOD_GSK3_1 663 670 PF00069 0.348
MOD_GSK3_1 692 699 PF00069 0.328
MOD_GSK3_1 728 735 PF00069 0.328
MOD_N-GLC_1 115 120 PF02516 0.763
MOD_N-GLC_1 451 456 PF02516 0.676
MOD_N-GLC_1 467 472 PF02516 0.695
MOD_N-GLC_1 61 66 PF02516 0.768
MOD_N-GLC_1 728 733 PF02516 0.413
MOD_NEK2_1 114 119 PF00069 0.604
MOD_NEK2_1 420 425 PF00069 0.701
MOD_NEK2_1 451 456 PF00069 0.739
MOD_NEK2_1 461 466 PF00069 0.663
MOD_NEK2_1 491 496 PF00069 0.600
MOD_NEK2_1 61 66 PF00069 0.766
MOD_NEK2_1 653 658 PF00069 0.328
MOD_NEK2_1 783 788 PF00069 0.762
MOD_NEK2_2 457 462 PF00069 0.754
MOD_NEK2_2 607 612 PF00069 0.449
MOD_PIKK_1 27 33 PF00454 0.654
MOD_PIKK_1 378 384 PF00454 0.643
MOD_PK_1 602 608 PF00069 0.449
MOD_PKA_1 466 472 PF00069 0.697
MOD_PKA_2 114 120 PF00069 0.796
MOD_PKA_2 334 340 PF00069 0.449
MOD_PKA_2 414 420 PF00069 0.735
MOD_PKA_2 461 467 PF00069 0.745
MOD_PKA_2 759 765 PF00069 0.344
MOD_Plk_1 46 52 PF00069 0.748
MOD_Plk_1 61 67 PF00069 0.760
MOD_Plk_2-3 399 405 PF00069 0.727
MOD_Plk_2-3 541 547 PF00069 0.376
MOD_Plk_4 136 142 PF00069 0.706
MOD_Plk_4 334 340 PF00069 0.363
MOD_Plk_4 386 392 PF00069 0.752
MOD_Plk_4 595 601 PF00069 0.344
MOD_Plk_4 668 674 PF00069 0.328
MOD_Plk_4 700 706 PF00069 0.328
MOD_Plk_4 716 722 PF00069 0.328
MOD_ProDKin_1 25 31 PF00069 0.764
MOD_ProDKin_1 389 395 PF00069 0.704
MOD_ProDKin_1 486 492 PF00069 0.547
MOD_ProDKin_1 508 514 PF00069 0.571
MOD_ProDKin_1 672 678 PF00069 0.328
MOD_ProDKin_1 778 784 PF00069 0.636
MOD_SUMO_for_1 684 687 PF00179 0.344
MOD_SUMO_rev_2 241 249 PF00179 0.449
MOD_SUMO_rev_2 575 580 PF00179 0.437
TRG_DiLeu_BaEn_1 744 749 PF01217 0.428
TRG_DiLeu_BaEn_4 549 555 PF01217 0.385
TRG_DiLeu_BaLyEn_6 166 171 PF01217 0.484
TRG_ENDOCYTIC_2 165 168 PF00928 0.577
TRG_ENDOCYTIC_2 265 268 PF00928 0.437
TRG_ENDOCYTIC_2 346 349 PF00928 0.449
TRG_ENDOCYTIC_2 473 476 PF00928 0.755
TRG_ENDOCYTIC_2 525 528 PF00928 0.348
TRG_ENDOCYTIC_2 573 576 PF00928 0.413
TRG_ENDOCYTIC_2 616 619 PF00928 0.385
TRG_ER_diArg_1 236 239 PF00400 0.475
TRG_ER_diArg_1 437 439 PF00400 0.684
TRG_ER_diArg_1 561 563 PF00400 0.398
TRG_Pf-PMV_PEXEL_1 438 442 PF00026 0.599
TRG_Pf-PMV_PEXEL_1 623 627 PF00026 0.475

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HZR8 Leptomonas seymouri 64% 99%
A0A0S4J7Q1 Bodo saltans 54% 100%
A0A1X0P0R3 Trypanosomatidae 64% 100%
A0A422N0Q9 Trypanosoma rangeli 61% 100%
A4H485 Leishmania braziliensis 84% 100%
A4HSG1 Leishmania infantum 100% 100%
D0A4H1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 58% 100%
E9AKE5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
Q4QJG3 Leishmania major 95% 100%
V5D179 Trypanosoma cruzi 62% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS