Protein kinase, putative

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein kinase, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WP16_LEIDO

TriTrypDb:

LdBPK_050390.1 , LdCL_050008900 , LDHU3_05.0450

Length:

789

Annotations

LeishMANIAdb annotations

A large and apprently artificial collection of diverse kinetoplastid protein kinases. A subfamily has 2TM regions, but the majority is cytoplasmic.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

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Expansion

Sequence features

A0A3S7WP16

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WP16

Function

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Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	12
GO:0006793	phosphorus metabolic process	3	12
GO:0006796	phosphate-containing compound metabolic process	4	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016310	phosphorylation	5	12
GO:0019538	protein metabolic process	3	12
GO:0036211	protein modification process	4	12
GO:0043170	macromolecule metabolic process	3	12

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	12
GO:0004672	protein kinase activity	3	12
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0016301	kinase activity	4	12
GO:0016740	transferase activity	2	12
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	12
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	12
GO:0017076	purine nucleotide binding	4	12

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	149	153	PF00656	0.689
CLV_C14_Caspase3-7	224	228	PF00656	0.350
CLV_C14_Caspase3-7	245	249	PF00656	0.473
CLV_C14_Caspase3-7	316	320	PF00656	0.449
CLV_C14_Caspase3-7	377	381	PF00656	0.661
CLV_C14_Caspase3-7	394	398	PF00656	0.456
CLV_NRD_NRD_1	438	440	PF00675	0.684
CLV_NRD_NRD_1	465	467	PF00675	0.742
CLV_NRD_NRD_1	562	564	PF00675	0.452
CLV_NRD_NRD_1	787	789	PF00675	0.596

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZR8	Leptomonas seymouri	64%	99%
A0A0S4J7Q1	Bodo saltans	54%	100%
A0A1X0P0R3	Trypanosomatidae	64%	100%
A0A422N0Q9	Trypanosoma rangeli	61%	100%
A4H485	Leishmania braziliensis	84%	100%
A4HSG1	Leishmania infantum	100%	100%
D0A4H1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	100%
E9AKE5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4QJG3	Leishmania major	95%	100%
V5D179	Trypanosoma cruzi	62%	100%

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