Ankyrin repeat, putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WP15_LEIDO

TriTrypDb:

LdBPK_050260.1 , LdCL_050007500 , LDHU3_05.0300

Length:

386

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WP15

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WP15

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	366	370	PF00656	0.655
CLV_C14_Caspase3-7	382	386	PF00656	0.553
CLV_NRD_NRD_1	138	140	PF00675	0.404
CLV_NRD_NRD_1	306	308	PF00675	0.442
CLV_NRD_NRD_1	324	326	PF00675	0.442
CLV_NRD_NRD_1	330	332	PF00675	0.463
CLV_NRD_NRD_1	347	349	PF00675	0.561
CLV_PCSK_FUR_1	320	324	PF00082	0.391
CLV_PCSK_KEX2_1	138	140	PF00082	0.460
CLV_PCSK_KEX2_1	149	151	PF00082	0.417
CLV_PCSK_KEX2_1	218	220	PF00082	0.439
CLV_PCSK_KEX2_1	306	308	PF00082	0.587
CLV_PCSK_KEX2_1	319	321	PF00082	0.361
CLV_PCSK_KEX2_1	322	324	PF00082	0.354
CLV_PCSK_KEX2_1	330	332	PF00082	0.432
CLV_PCSK_KEX2_1	347	349	PF00082	0.561
CLV_PCSK_PC1ET2_1	149	151	PF00082	0.459
CLV_PCSK_PC1ET2_1	218	220	PF00082	0.439
CLV_PCSK_PC1ET2_1	319	321	PF00082	0.440
CLV_PCSK_PC7_1	320	326	PF00082	0.427
CLV_PCSK_SKI1_1	149	153	PF00082	0.374
CLV_PCSK_SKI1_1	47	51	PF00082	0.433
DEG_Kelch_Keap1_1	374	379	PF01344	0.571
DOC_MAPK_MEF2A_6	172	181	PF00069	0.546
DOC_SPAK_OSR1_1	240	244	PF12202	0.451
DOC_USP7_MATH_1	200	204	PF00917	0.564
DOC_USP7_MATH_1	247	251	PF00917	0.479
DOC_USP7_MATH_1	357	361	PF00917	0.609
DOC_WW_Pin1_4	173	178	PF00397	0.522
DOC_WW_Pin1_4	222	227	PF00397	0.368
DOC_WW_Pin1_4	276	281	PF00397	0.420
DOC_WW_Pin1_4	33	38	PF00397	0.537
LIG_14-3-3_CanoR_1	172	177	PF00244	0.609
LIG_Actin_WH2_2	77	93	PF00022	0.408
LIG_BIR_II_1	1	5	PF00653	0.453
LIG_CtBP_PxDLS_1	178	182	PF00389	0.456
LIG_FHA_1	15	21	PF00498	0.408
LIG_FHA_1	174	180	PF00498	0.479
LIG_FHA_1	193	199	PF00498	0.509
LIG_FHA_1	290	296	PF00498	0.425
LIG_FHA_2	375	381	PF00498	0.566
LIG_LIR_Apic_2	31	37	PF02991	0.488
LIG_LIR_Gen_1	311	321	PF02991	0.481
LIG_LIR_Nem_3	182	187	PF02991	0.396
LIG_LIR_Nem_3	311	317	PF02991	0.482
LIG_Pex14_1	34	38	PF04695	0.513
LIG_SH2_CRK	148	152	PF00017	0.377
LIG_SH2_CRK	184	188	PF00017	0.382
LIG_SH2_STAT5	328	331	PF00017	0.534
LIG_SUMO_SIM_anti_2	292	297	PF11976	0.419
LIG_SUMO_SIM_par_1	291	297	PF11976	0.408
LIG_TRAF2_1	301	304	PF00917	0.437
LIG_TRAF2_1	308	311	PF00917	0.423
LIG_TRAF2_1	377	380	PF00917	0.655
LIG_TYR_ITIM	146	151	PF00017	0.385
MOD_CDK_SPxK_1	276	282	PF00069	0.499
MOD_CK1_1	203	209	PF00069	0.611
MOD_CK1_1	217	223	PF00069	0.343
MOD_CK1_1	289	295	PF00069	0.425
MOD_CK1_1	360	366	PF00069	0.632
MOD_CK2_1	157	163	PF00069	0.451
MOD_CK2_1	186	192	PF00069	0.475
MOD_CK2_1	367	373	PF00069	0.650
MOD_CK2_1	374	380	PF00069	0.596
MOD_CK2_1	95	101	PF00069	0.475
MOD_GlcNHglycan	248	252	PF01048	0.393
MOD_GlcNHglycan	30	33	PF01048	0.616
MOD_GlcNHglycan	361	365	PF01048	0.664
MOD_GlcNHglycan	369	372	PF01048	0.610
MOD_GlcNHglycan	41	45	PF01048	0.440
MOD_GSK3_1	200	207	PF00069	0.546
MOD_N-GLC_1	286	291	PF02516	0.436
MOD_N-GLC_1	367	372	PF02516	0.632
MOD_NEK2_1	171	176	PF00069	0.447
MOD_NEK2_2	235	240	PF00069	0.388
MOD_PKA_2	157	163	PF00069	0.404
MOD_PKA_2	171	177	PF00069	0.492
MOD_Plk_1	179	185	PF00069	0.488
MOD_Plk_1	203	209	PF00069	0.579
MOD_Plk_4	179	185	PF00069	0.488
MOD_ProDKin_1	173	179	PF00069	0.525
MOD_ProDKin_1	222	228	PF00069	0.366
MOD_ProDKin_1	276	282	PF00069	0.426
MOD_ProDKin_1	33	39	PF00069	0.537
TRG_DiLeu_BaEn_2	309	315	PF01217	0.487
TRG_DiLeu_BaEn_3	310	316	PF01217	0.445
TRG_DiLeu_BaEn_4	79	85	PF01217	0.450
TRG_DiLeu_BaLyEn_6	147	152	PF01217	0.453
TRG_ENDOCYTIC_2	148	151	PF00928	0.408
TRG_ENDOCYTIC_2	184	187	PF00928	0.373
TRG_ER_diArg_1	219	222	PF00400	0.425
TRG_ER_diArg_1	320	323	PF00400	0.448
TRG_ER_diArg_1	329	331	PF00400	0.434
TRG_NLS_MonoExtN_4	216	222	PF00514	0.424
TRG_Pf-PMV_PEXEL_1	150	155	PF00026	0.391
TRG_Pf-PMV_PEXEL_1	240	244	PF00026	0.350

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHU8	Leptomonas seymouri	45%	93%
A4H470	Leishmania braziliensis	81%	100%
A4HSE5	Leishmania infantum	99%	100%
E9AKD1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	99%
Q4QJH7	Leishmania major	88%	100%