Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WP10_LEIDO

TriTrypDb:

LdBPK_050370.1 , LdCL_050008700 , LDHU3_05.0420

Length:

328

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WP10

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WP10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	160	164	PF00656	0.588
CLV_C14_Caspase3-7	187	191	PF00656	0.761
CLV_C14_Caspase3-7	296	300	PF00656	0.739
CLV_NRD_NRD_1	246	248	PF00675	0.827
CLV_NRD_NRD_1	38	40	PF00675	0.652
CLV_PCSK_KEX2_1	246	248	PF00082	0.827
CLV_PCSK_KEX2_1	37	39	PF00082	0.653
CLV_PCSK_PC1ET2_1	37	39	PF00082	0.653
CLV_PCSK_PC7_1	33	39	PF00082	0.649
CLV_PCSK_SKI1_1	129	133	PF00082	0.601
CLV_PCSK_SKI1_1	247	251	PF00082	0.748
DEG_SPOP_SBC_1	174	178	PF00917	0.757
DEG_SPOP_SBC_1	180	184	PF00917	0.801
DEG_SPOP_SBC_1	217	221	PF00917	0.722
DEG_SPOP_SBC_1	237	241	PF00917	0.697
DEG_SPOP_SBC_1	254	258	PF00917	0.679
DOC_PP1_RVXF_1	127	134	PF00149	0.644
DOC_PP2B_LxvP_1	242	245	PF13499	0.658
DOC_PP4_FxxP_1	12	15	PF00568	0.791
DOC_PP4_FxxP_1	222	225	PF00568	0.713
DOC_PP4_FxxP_1	52	55	PF00568	0.745
DOC_USP7_MATH_1	174	178	PF00917	0.730
DOC_USP7_MATH_1	180	184	PF00917	0.803
DOC_USP7_MATH_1	216	220	PF00917	0.693
DOC_USP7_MATH_1	237	241	PF00917	0.729
DOC_USP7_MATH_1	255	259	PF00917	0.602
DOC_USP7_MATH_1	268	272	PF00917	0.623
DOC_USP7_MATH_1	98	102	PF00917	0.708
DOC_WW_Pin1_4	181	186	PF00397	0.791
DOC_WW_Pin1_4	309	314	PF00397	0.718
LIG_14-3-3_CanoR_1	252	260	PF00244	0.746
LIG_BRCT_BRCA1_1	218	222	PF00533	0.808
LIG_Clathr_ClatBox_1	132	136	PF01394	0.753
LIG_eIF4E_1	16	22	PF01652	0.665
LIG_FHA_1	17	23	PF00498	0.765
LIG_FHA_1	72	78	PF00498	0.632
LIG_FHA_2	147	153	PF00498	0.623
LIG_FHA_2	310	316	PF00498	0.725
LIG_IBAR_NPY_1	14	16	PF08397	0.775
LIG_Integrin_RGD_1	188	190	PF01839	0.640
LIG_LIR_Apic_2	10	15	PF02991	0.798
LIG_LIR_Apic_2	219	225	PF02991	0.703
LIG_LIR_Nem_3	152	157	PF02991	0.651
LIG_MAD2	129	137	PF02301	0.712
LIG_SH2_CRK	205	209	PF00017	0.777
LIG_SH2_GRB2like	16	19	PF00017	0.626
LIG_SH2_NCK_1	205	209	PF00017	0.675
LIG_SH2_STAP1	75	79	PF00017	0.587
LIG_SH3_3	135	141	PF00018	0.660
LIG_SH3_3	280	286	PF00018	0.762
MOD_CDK_SPxxK_3	181	188	PF00069	0.705
MOD_CK1_1	118	124	PF00069	0.752
MOD_CK1_1	270	276	PF00069	0.744
MOD_CK2_1	309	315	PF00069	0.719
MOD_CK2_1	70	76	PF00069	0.540
MOD_GlcNHglycan	117	120	PF01048	0.776
MOD_GlcNHglycan	270	273	PF01048	0.708
MOD_GlcNHglycan	279	282	PF01048	0.759
MOD_GlcNHglycan	6	10	PF01048	0.804
MOD_GlcNHglycan	90	93	PF01048	0.707
MOD_GlcNHglycan	95	99	PF01048	0.678
MOD_GSK3_1	115	122	PF00069	0.775
MOD_GSK3_1	146	153	PF00069	0.648
MOD_GSK3_1	158	165	PF00069	0.671
MOD_GSK3_1	174	181	PF00069	0.761
MOD_GSK3_1	256	263	PF00069	0.777
MOD_GSK3_1	266	273	PF00069	0.748
MOD_GSK3_1	94	101	PF00069	0.774
MOD_N-GLC_1	17	22	PF02516	0.653
MOD_NEK2_1	104	109	PF00069	0.746
MOD_NEK2_1	204	209	PF00069	0.779
MOD_NEK2_1	260	265	PF00069	0.721
MOD_NEK2_1	267	272	PF00069	0.697
MOD_NEK2_1	70	75	PF00069	0.649
MOD_NEK2_1	83	88	PF00069	0.626
MOD_NEK2_1	94	99	PF00069	0.778
MOD_NEK2_2	218	223	PF00069	0.700
MOD_PIKK_1	83	89	PF00454	0.724
MOD_PKA_2	104	110	PF00069	0.728
MOD_Plk_1	17	23	PF00069	0.684
MOD_Plk_4	17	23	PF00069	0.616
MOD_Plk_4	99	105	PF00069	0.805
MOD_ProDKin_1	181	187	PF00069	0.794
MOD_ProDKin_1	309	315	PF00069	0.719
TRG_ENDOCYTIC_2	154	157	PF00928	0.652
TRG_ENDOCYTIC_2	205	208	PF00928	0.676
TRG_ER_diArg_1	245	247	PF00400	0.741
TRG_ER_diArg_1	289	292	PF00400	0.765
TRG_Pf-PMV_PEXEL_1	202	206	PF00026	0.713

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3H3	Leptomonas seymouri	37%	100%
A4H482	Leishmania braziliensis	66%	99%
A4HSF9	Leishmania infantum	100%	100%
E9AKE3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4QJG5	Leishmania major	91%	100%