LeishMANIAdb
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Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Hypothetical_protein_conserved
Gene product:
hypothetical protein, conserved
Species:
Leishmania donovani
UniProt:
A0A3S7WNZ5_LEIDO
TriTrypDb:
LdBPK_050110.1 , LdCL_050006000 , LDHU3_05.0140
Length:
123

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WNZ5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WNZ5

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_PCSK_SKI1_1 91 95 PF00082 0.535
DEG_APCC_DBOX_1 109 117 PF00400 0.529
DEG_APCC_DBOX_1 40 48 PF00400 0.405
DEG_Nend_UBRbox_3 1 3 PF02207 0.541
DOC_CKS1_1 13 18 PF01111 0.483
DOC_CYCLIN_yCln2_LP_2 13 19 PF00134 0.498
DOC_MAPK_MEF2A_6 46 54 PF00069 0.454
DOC_PP1_RVXF_1 6 12 PF00149 0.468
DOC_USP7_MATH_1 97 101 PF00917 0.521
DOC_WW_Pin1_4 12 17 PF00397 0.453
LIG_AP2alpha_2 118 120 PF02296 0.567
LIG_BRCT_BRCA1_1 116 120 PF00533 0.519
LIG_FHA_1 1 7 PF00498 0.552
LIG_FHA_2 13 19 PF00498 0.554
LIG_NRBOX 8 14 PF00104 0.519
LIG_PTB_Apo_2 11 18 PF02174 0.512
LIG_SH2_STAP1 73 77 PF00017 0.447
LIG_SH3_3 22 28 PF00018 0.508
LIG_WW_3 38 42 PF00397 0.409
MOD_CK1_1 42 48 PF00069 0.548
MOD_CK1_1 83 89 PF00069 0.552
MOD_CK2_1 29 35 PF00069 0.432
MOD_GlcNHglycan 99 102 PF01048 0.435
MOD_PIKK_1 83 89 PF00454 0.476
MOD_PIKK_1 91 97 PF00454 0.488
MOD_PKA_2 80 86 PF00069 0.460
MOD_Plk_1 42 48 PF00069 0.520
MOD_ProDKin_1 12 18 PF00069 0.460
TRG_DiLeu_BaEn_1 49 54 PF01217 0.442
TRG_ER_diArg_1 110 113 PF00400 0.544
TRG_ER_diArg_1 78 81 PF00400 0.435

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P630 Leptomonas seymouri 69% 100%
A0A1X0P3X1 Trypanosomatidae 32% 85%
A0A3R7LAM0 Trypanosoma rangeli 41% 75%
A4H457 Leishmania braziliensis 85% 100%
A4HSE0 Leishmania infantum 100% 100%
C9ZPX2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 41% 100%
E9AKB5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 89% 100%
Q4QJJ2 Leishmania major 92% 100%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS