Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

basal body component, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WNZ4_LEIDO

TriTrypDb:

LdBPK_050170.1 , LdCL_050006600 , LDHU3_05.0210

Length:

759

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005815	microtubule organizing center	2	1
GO:0036064	ciliary basal body	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7WNZ4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WNZ4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	713	717	PF00656	0.638
CLV_NRD_NRD_1	139	141	PF00675	0.515
CLV_NRD_NRD_1	15	17	PF00675	0.556
CLV_NRD_NRD_1	219	221	PF00675	0.663
CLV_NRD_NRD_1	369	371	PF00675	0.732
CLV_NRD_NRD_1	414	416	PF00675	0.756
CLV_NRD_NRD_1	645	647	PF00675	0.730
CLV_NRD_NRD_1	675	677	PF00675	0.737
CLV_PCSK_FUR_1	673	677	PF00082	0.660
CLV_PCSK_KEX2_1	139	141	PF00082	0.583
CLV_PCSK_KEX2_1	15	17	PF00082	0.546
CLV_PCSK_KEX2_1	219	221	PF00082	0.662
CLV_PCSK_KEX2_1	369	371	PF00082	0.732
CLV_PCSK_KEX2_1	414	416	PF00082	0.756
CLV_PCSK_KEX2_1	42	44	PF00082	0.449
CLV_PCSK_KEX2_1	645	647	PF00082	0.730
CLV_PCSK_KEX2_1	675	677	PF00082	0.733
CLV_PCSK_PC1ET2_1	42	44	PF00082	0.449
CLV_PCSK_SKI1_1	395	399	PF00082	0.681
CLV_PCSK_SKI1_1	423	427	PF00082	0.642
CLV_PCSK_SKI1_1	576	580	PF00082	0.603
CLV_PCSK_SKI1_1	645	649	PF00082	0.792
CLV_PCSK_SKI1_1	676	680	PF00082	0.730
CLV_PCSK_SKI1_1	744	748	PF00082	0.490
CLV_Separin_Metazoa	193	197	PF03568	0.559
CLV_Separin_Metazoa	411	415	PF03568	0.677
CLV_Separin_Metazoa	420	424	PF03568	0.576
DEG_APCC_DBOX_1	188	196	PF00400	0.642
DEG_APCC_DBOX_1	314	322	PF00400	0.641
DEG_APCC_DBOX_1	414	422	PF00400	0.737
DEG_SPOP_SBC_1	717	721	PF00917	0.649
DOC_CDC14_PxL_1	398	406	PF14671	0.663
DOC_CKS1_1	374	379	PF01111	0.692
DOC_CKS1_1	444	449	PF01111	0.745
DOC_CKS1_1	588	593	PF01111	0.745
DOC_CYCLIN_RxL_1	485	496	PF00134	0.752
DOC_CYCLIN_yCln2_LP_2	421	427	PF00134	0.588
DOC_MAPK_DCC_7	478	487	PF00069	0.685
DOC_MAPK_gen_1	139	145	PF00069	0.621
DOC_MAPK_gen_1	478	487	PF00069	0.685
DOC_MAPK_MEF2A_6	478	487	PF00069	0.685
DOC_PP2B_LxvP_1	526	529	PF13499	0.761
DOC_PP2B_LxvP_1	559	562	PF13499	0.638
DOC_PP2B_LxvP_1	639	642	PF13499	0.686
DOC_USP7_MATH_1	181	185	PF00917	0.724
DOC_USP7_MATH_1	473	477	PF00917	0.692
DOC_USP7_MATH_1	516	520	PF00917	0.744
DOC_USP7_MATH_1	533	537	PF00917	0.609
DOC_USP7_MATH_1	540	544	PF00917	0.630
DOC_USP7_MATH_1	548	552	PF00917	0.802
DOC_USP7_MATH_1	656	660	PF00917	0.744
DOC_USP7_MATH_1	698	702	PF00917	0.687
DOC_USP7_MATH_1	717	721	PF00917	0.704
DOC_WW_Pin1_4	213	218	PF00397	0.723
DOC_WW_Pin1_4	360	365	PF00397	0.649
DOC_WW_Pin1_4	373	378	PF00397	0.613
DOC_WW_Pin1_4	440	445	PF00397	0.670
DOC_WW_Pin1_4	457	462	PF00397	0.604
DOC_WW_Pin1_4	512	517	PF00397	0.695
DOC_WW_Pin1_4	552	557	PF00397	0.744
DOC_WW_Pin1_4	568	573	PF00397	0.698
DOC_WW_Pin1_4	584	589	PF00397	0.550
DOC_WW_Pin1_4	600	605	PF00397	0.655
DOC_WW_Pin1_4	654	659	PF00397	0.713
DOC_WW_Pin1_4	665	670	PF00397	0.582
DOC_WW_Pin1_4	676	681	PF00397	0.746
DOC_WW_Pin1_4	685	690	PF00397	0.585
DOC_WW_Pin1_4	700	705	PF00397	0.688
LIG_14-3-3_CanoR_1	123	132	PF00244	0.468
LIG_14-3-3_CanoR_1	139	145	PF00244	0.505
LIG_14-3-3_CanoR_1	182	186	PF00244	0.705
LIG_14-3-3_CanoR_1	220	230	PF00244	0.636
LIG_14-3-3_CanoR_1	292	297	PF00244	0.625
LIG_14-3-3_CanoR_1	415	425	PF00244	0.709
LIG_14-3-3_CanoR_1	510	516	PF00244	0.662
LIG_14-3-3_CanoR_1	541	545	PF00244	0.612
LIG_14-3-3_CanoR_1	645	655	PF00244	0.676
LIG_14-3-3_CanoR_1	673	681	PF00244	0.728
LIG_APCC_ABBA_1	232	237	PF00400	0.668
LIG_BIR_III_2	209	213	PF00653	0.602
LIG_BIR_III_2	258	262	PF00653	0.645
LIG_BRCT_BRCA1_1	459	463	PF00533	0.770
LIG_EVH1_1	526	530	PF00568	0.713
LIG_FHA_1	144	150	PF00498	0.575
LIG_FHA_1	237	243	PF00498	0.671
LIG_FHA_1	464	470	PF00498	0.658
LIG_FHA_1	512	518	PF00498	0.606
LIG_FHA_2	241	247	PF00498	0.678
LIG_FHA_2	311	317	PF00498	0.465
LIG_FHA_2	555	561	PF00498	0.545
LIG_FHA_2	577	583	PF00498	0.600
LIG_FHA_2	688	694	PF00498	0.791
LIG_LIR_Apic_2	323	328	PF02991	0.533
LIG_LIR_Nem_3	719	725	PF02991	0.535
LIG_MYND_1	190	194	PF01753	0.561
LIG_Pex14_2	394	398	PF04695	0.559
LIG_SH2_CRK	722	726	PF00017	0.537
LIG_SH2_NCK_1	432	436	PF00017	0.642
LIG_SH2_NCK_1	722	726	PF00017	0.680
LIG_SH2_STAP1	89	93	PF00017	0.591
LIG_SH2_STAT3	38	41	PF00017	0.466
LIG_SH2_STAT3	634	637	PF00017	0.793
LIG_SH2_STAT5	121	124	PF00017	0.505
LIG_SH2_STAT5	387	390	PF00017	0.650
LIG_SH3_1	480	486	PF00018	0.628
LIG_SH3_2	483	488	PF14604	0.628
LIG_SH3_3	182	188	PF00018	0.627
LIG_SH3_3	396	402	PF00018	0.619
LIG_SH3_3	436	442	PF00018	0.662
LIG_SH3_3	458	464	PF00018	0.737
LIG_SH3_3	480	486	PF00018	0.628
LIG_SH3_3	524	530	PF00018	0.666
LIG_SH3_3	585	591	PF00018	0.643
LIG_SH3_3	598	604	PF00018	0.661
LIG_SH3_3	652	658	PF00018	0.665
LIG_SH3_4	131	138	PF00018	0.467
LIG_SH3_CIN85_PxpxPR_1	529	534	PF14604	0.761
LIG_SUMO_SIM_par_1	581	587	PF11976	0.773
LIG_TRAF2_1	244	247	PF00917	0.732
LIG_TRAF2_1	328	331	PF00917	0.765
LIG_TRAF2_1	519	522	PF00917	0.699
LIG_TRAF2_1	579	582	PF00917	0.645
LIG_TRAF2_1	97	100	PF00917	0.583
LIG_WW_3	411	415	PF00397	0.665
MOD_CDC14_SPxK_1	216	219	PF00782	0.706
MOD_CDC14_SPxK_1	555	558	PF00782	0.773
MOD_CDC14_SPxK_1	573	576	PF00782	0.752
MOD_CDK_SPxK_1	213	219	PF00069	0.705
MOD_CDK_SPxK_1	373	379	PF00069	0.681
MOD_CDK_SPxK_1	552	558	PF00069	0.769
MOD_CDK_SPxK_1	570	576	PF00069	0.757
MOD_CDK_SPxxK_3	213	220	PF00069	0.706
MOD_CK1_1	163	169	PF00069	0.666
MOD_CK1_1	248	254	PF00069	0.492
MOD_CK1_1	357	363	PF00069	0.716
MOD_CK1_1	564	570	PF00069	0.644
MOD_CK1_1	587	593	PF00069	0.747
MOD_CK1_1	628	634	PF00069	0.748
MOD_CK1_1	659	665	PF00069	0.676
MOD_CK1_1	682	688	PF00069	0.738
MOD_CK1_1	699	705	PF00069	0.576
MOD_CK1_1	710	716	PF00069	0.618
MOD_CK1_1	718	724	PF00069	0.715
MOD_CK1_1	728	734	PF00069	0.601
MOD_CK2_1	240	246	PF00069	0.682
MOD_CK2_1	310	316	PF00069	0.462
MOD_CK2_1	502	508	PF00069	0.728
MOD_CK2_1	515	521	PF00069	0.655
MOD_CK2_1	576	582	PF00069	0.630
MOD_CK2_1	646	652	PF00069	0.665
MOD_CK2_1	660	666	PF00069	0.718
MOD_CK2_1	687	693	PF00069	0.791
MOD_Cter_Amidation	336	339	PF01082	0.634
MOD_Cter_Amidation	643	646	PF01082	0.731
MOD_DYRK1A_RPxSP_1	568	572	PF00069	0.664
MOD_DYRK1A_RPxSP_1	676	680	PF00069	0.730
MOD_GlcNHglycan	249	253	PF01048	0.607
MOD_GlcNHglycan	262	265	PF01048	0.591
MOD_GlcNHglycan	334	337	PF01048	0.770
MOD_GlcNHglycan	357	360	PF01048	0.696
MOD_GlcNHglycan	452	455	PF01048	0.713
MOD_GlcNHglycan	471	474	PF01048	0.584
MOD_GlcNHglycan	475	478	PF01048	0.656
MOD_GlcNHglycan	496	499	PF01048	0.736
MOD_GlcNHglycan	504	507	PF01048	0.733
MOD_GlcNHglycan	518	521	PF01048	0.578
MOD_GlcNHglycan	536	539	PF01048	0.781
MOD_GlcNHglycan	546	549	PF01048	0.553
MOD_GlcNHglycan	648	651	PF01048	0.769
MOD_GlcNHglycan	658	661	PF01048	0.614
MOD_GlcNHglycan	676	679	PF01048	0.816
MOD_GlcNHglycan	698	701	PF01048	0.651
MOD_GlcNHglycan	712	715	PF01048	0.653
MOD_GlcNHglycan	727	730	PF01048	0.582
MOD_GlcNHglycan	755	758	PF01048	0.612
MOD_GSK3_1	119	126	PF00069	0.437
MOD_GSK3_1	163	170	PF00069	0.605
MOD_GSK3_1	236	243	PF00069	0.670
MOD_GSK3_1	344	351	PF00069	0.673
MOD_GSK3_1	353	360	PF00069	0.654
MOD_GSK3_1	430	437	PF00069	0.592
MOD_GSK3_1	459	466	PF00069	0.719
MOD_GSK3_1	469	476	PF00069	0.640
MOD_GSK3_1	511	518	PF00069	0.756
MOD_GSK3_1	540	547	PF00069	0.709
MOD_GSK3_1	548	555	PF00069	0.754
MOD_GSK3_1	564	571	PF00069	0.682
MOD_GSK3_1	656	663	PF00069	0.674
MOD_GSK3_1	676	683	PF00069	0.851
MOD_GSK3_1	684	691	PF00069	0.740
MOD_GSK3_1	696	703	PF00069	0.700
MOD_GSK3_1	708	715	PF00069	0.643
MOD_GSK3_1	717	724	PF00069	0.592
MOD_GSK3_1	749	756	PF00069	0.519
MOD_N-GLC_1	360	365	PF02516	0.785
MOD_NEK2_1	162	167	PF00069	0.730
MOD_NEK2_1	430	435	PF00069	0.570
MOD_NEK2_1	618	623	PF00069	0.645
MOD_NEK2_1	684	689	PF00069	0.670
MOD_NEK2_2	540	545	PF00069	0.605
MOD_PIKK_1	121	127	PF00454	0.526
MOD_PIKK_1	310	316	PF00454	0.456
MOD_PKA_1	645	651	PF00069	0.728
MOD_PKA_2	138	144	PF00069	0.583
MOD_PKA_2	181	187	PF00069	0.702
MOD_PKA_2	221	227	PF00069	0.626
MOD_PKA_2	240	246	PF00069	0.714
MOD_PKA_2	494	500	PF00069	0.712
MOD_PKA_2	533	539	PF00069	0.718
MOD_PKA_2	540	546	PF00069	0.644
MOD_PKA_2	564	570	PF00069	0.722
MOD_PKA_2	645	651	PF00069	0.737
MOD_PKA_2	674	680	PF00069	0.675
MOD_PKA_2	73	79	PF00069	0.515
MOD_PKB_1	751	759	PF00069	0.549
MOD_Plk_1	248	254	PF00069	0.618
MOD_Plk_1	628	634	PF00069	0.748
MOD_Plk_4	163	169	PF00069	0.707
MOD_Plk_4	292	298	PF00069	0.632
MOD_Plk_4	660	666	PF00069	0.721
MOD_ProDKin_1	213	219	PF00069	0.725
MOD_ProDKin_1	360	366	PF00069	0.649
MOD_ProDKin_1	373	379	PF00069	0.611
MOD_ProDKin_1	440	446	PF00069	0.674
MOD_ProDKin_1	457	463	PF00069	0.603
MOD_ProDKin_1	512	518	PF00069	0.695
MOD_ProDKin_1	552	558	PF00069	0.748
MOD_ProDKin_1	568	574	PF00069	0.692
MOD_ProDKin_1	584	590	PF00069	0.545
MOD_ProDKin_1	600	606	PF00069	0.648
MOD_ProDKin_1	654	660	PF00069	0.715
MOD_ProDKin_1	665	671	PF00069	0.583
MOD_ProDKin_1	676	682	PF00069	0.747
MOD_ProDKin_1	685	691	PF00069	0.585
MOD_ProDKin_1	700	706	PF00069	0.687
MOD_SUMO_for_1	388	391	PF00179	0.643
MOD_SUMO_for_1	501	504	PF00179	0.615
TRG_DiLeu_BaEn_4	521	527	PF01217	0.697
TRG_DiLeu_BaEn_4	581	587	PF01217	0.776
TRG_ENDOCYTIC_2	722	725	PF00928	0.537
TRG_ER_diArg_1	114	117	PF00400	0.483
TRG_ER_diArg_1	218	220	PF00400	0.752
TRG_ER_diArg_1	369	371	PF00400	0.732
TRG_ER_diArg_1	413	415	PF00400	0.762
TRG_ER_diArg_1	478	481	PF00400	0.692
TRG_ER_diArg_1	673	676	PF00400	0.789
TRG_ER_diArg_1	748	751	PF00400	0.503
TRG_NES_CRM1_1	429	441	PF08389	0.653
TRG_Pf-PMV_PEXEL_1	108	112	PF00026	0.524
TRG_Pf-PMV_PEXEL_1	303	307	PF00026	0.572
TRG_Pf-PMV_PEXEL_1	488	493	PF00026	0.751
TRG_Pf-PMV_PEXEL_1	54	59	PF00026	0.572
TRG_Pf-PMV_PEXEL_1	616	620	PF00026	0.706

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HWW2	Leptomonas seymouri	45%	100%
A4H463	Leishmania braziliensis	67%	98%
A4HSD2	Leishmania infantum	99%	100%
E9AKC1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4QJI6	Leishmania major	87%	99%