Methyltransf_21 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania donovani

UniProt:

A0A3S7WNZ2_LEIDO

TriTrypDb:

LdCL_040017400 , LDHU3_04.1430

Length:

317

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

A0A3S7WNZ2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WNZ2

Function

Biological processes
Term	Name	Level	Count
GO:0008152	metabolic process	1	3
GO:0032259	methylation	2	3

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0008168	methyltransferase activity	4	3
GO:0016740	transferase activity	2	3
GO:0016741	transferase activity, transferring one-carbon groups	3	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	260	264	PF00656	0.393
CLV_NRD_NRD_1	134	136	PF00675	0.623
CLV_NRD_NRD_1	152	154	PF00675	0.470
CLV_NRD_NRD_1	161	163	PF00675	0.643
CLV_NRD_NRD_1	192	194	PF00675	0.611
CLV_NRD_NRD_1	232	234	PF00675	0.658
CLV_NRD_NRD_1	247	249	PF00675	0.611
CLV_NRD_NRD_1	251	253	PF00675	0.620
CLV_NRD_NRD_1	85	87	PF00675	0.527
CLV_PCSK_FUR_1	248	252	PF00082	0.530
CLV_PCSK_FUR_1	83	87	PF00082	0.372
CLV_PCSK_KEX2_1	133	135	PF00082	0.617
CLV_PCSK_KEX2_1	161	163	PF00082	0.653
CLV_PCSK_KEX2_1	192	194	PF00082	0.611
CLV_PCSK_KEX2_1	247	249	PF00082	0.660
CLV_PCSK_KEX2_1	250	252	PF00082	0.673
CLV_PCSK_KEX2_1	85	87	PF00082	0.377
CLV_PCSK_PC1ET2_1	250	252	PF00082	0.538
CLV_PCSK_PC7_1	247	253	PF00082	0.533
CLV_PCSK_SKI1_1	112	116	PF00082	0.462
CLV_PCSK_SKI1_1	161	165	PF00082	0.628
DEG_APCC_KENBOX_2	34	38	PF00400	0.603
DEG_Nend_UBRbox_2	1	3	PF02207	0.526
DEG_ODPH_VHL_1	225	238	PF01847	0.294
DOC_CYCLIN_yCln2_LP_2	114	120	PF00134	0.441
DOC_MAPK_gen_1	192	199	PF00069	0.402
DOC_MAPK_gen_1	216	225	PF00069	0.429
DOC_MAPK_gen_1	233	243	PF00069	0.262
DOC_MAPK_gen_1	40	47	PF00069	0.528
DOC_MAPK_HePTP_8	109	121	PF00069	0.208
DOC_MAPK_MEF2A_6	112	121	PF00069	0.208
DOC_MAPK_MEF2A_6	192	201	PF00069	0.332
DOC_PP2B_LxvP_1	114	117	PF13499	0.374
DOC_PP2B_LxvP_1	243	246	PF13499	0.270
DOC_USP7_MATH_1	128	132	PF00917	0.285
DOC_USP7_MATH_2	227	233	PF00917	0.303
DOC_WW_Pin1_4	126	131	PF00397	0.574
DOC_WW_Pin1_4	258	263	PF00397	0.387
LIG_14-3-3_CanoR_1	149	157	PF00244	0.454
LIG_14-3-3_CanoR_1	267	272	PF00244	0.373
LIG_CtBP_PxDLS_1	268	272	PF00389	0.368
LIG_DLG_GKlike_1	267	275	PF00625	0.358
LIG_FHA_1	280	286	PF00498	0.208
LIG_FHA_2	258	264	PF00498	0.437
LIG_FHA_2	92	98	PF00498	0.571
LIG_GBD_Chelix_1	119	127	PF00786	0.208
LIG_IRF3_LxIS_1	285	292	PF10401	0.208
LIG_LIR_Gen_1	142	147	PF02991	0.235
LIG_LIR_Gen_1	178	187	PF02991	0.340
LIG_LIR_LC3C_4	195	199	PF02991	0.230
LIG_LIR_Nem_3	142	146	PF02991	0.237
LIG_LIR_Nem_3	178	183	PF02991	0.354
LIG_LIR_Nem_3	188	194	PF02991	0.318
LIG_NRBOX	279	285	PF00104	0.208
LIG_SH3_2	167	172	PF14604	0.260
LIG_SH3_3	164	170	PF00018	0.273
LIG_SUMO_SIM_anti_2	9	14	PF11976	0.429
LIG_SUMO_SIM_par_1	287	293	PF11976	0.208
LIG_SUMO_SIM_par_1	9	14	PF11976	0.554
LIG_UBA3_1	27	35	PF00899	0.263
MOD_CDK_SPK_2	262	267	PF00069	0.488
MOD_CDK_SPxxK_3	126	133	PF00069	0.569
MOD_CK1_1	53	59	PF00069	0.495
MOD_CK2_1	229	235	PF00069	0.460
MOD_GlcNHglycan	106	109	PF01048	0.308
MOD_GlcNHglycan	52	55	PF01048	0.464
MOD_GSK3_1	257	264	PF00069	0.479
MOD_NEK2_1	147	152	PF00069	0.494
MOD_PIKK_1	128	134	PF00454	0.392
MOD_PKA_1	161	167	PF00069	0.576
MOD_PKA_2	102	108	PF00069	0.417
MOD_PKA_2	148	154	PF00069	0.559
MOD_PKA_2	161	167	PF00069	0.386
MOD_PKA_2	70	76	PF00069	0.515
MOD_Plk_4	279	285	PF00069	0.208
MOD_Plk_4	6	12	PF00069	0.264
MOD_ProDKin_1	126	132	PF00069	0.573
MOD_ProDKin_1	258	264	PF00069	0.482
TRG_DiLeu_BaLyEn_6	109	114	PF01217	0.399
TRG_DiLeu_BaLyEn_6	284	289	PF01217	0.208
TRG_ER_diArg_1	133	135	PF00400	0.324
TRG_ER_diArg_1	191	193	PF00400	0.516
TRG_ER_diArg_1	246	248	PF00400	0.456
TRG_ER_diArg_1	313	316	PF00400	0.429
TRG_ER_diArg_1	41	44	PF00400	0.308
TRG_ER_diArg_1	82	85	PF00400	0.460
TRG_NLS_Bipartite_1	233	254	PF00514	0.355
TRG_NLS_MonoCore_2	249	254	PF00514	0.412
TRG_NLS_MonoExtN_4	247	254	PF00514	0.410
TRG_Pf-PMV_PEXEL_1	192	196	PF00026	0.502
TRG_Pf-PMV_PEXEL_1	207	212	PF00026	0.278
TRG_Pf-PMV_PEXEL_1	85	89	PF00026	0.470

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBS3	Leptomonas seymouri	39%	89%
A0A0S4JIM3	Bodo saltans	28%	85%
A4H431	Leishmania braziliensis	56%	100%