Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania donovani

UniProt:

A0A3S7WNW2_LEIDO

TriTrypDb:

LdBPK_040880.1 , LdCL_040014400 , LDHU3_04.1100

Length:

174

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WNW2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WNW2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	54	56	PF00675	0.760
CLV_PCSK_KEX2_1	54	56	PF00082	0.760
CLV_PCSK_SKI1_1	137	141	PF00082	0.696
DEG_Kelch_Keap1_1	152	157	PF01344	0.803
DEG_Nend_UBRbox_1	1	4	PF02207	0.758
DEG_SPOP_SBC_1	12	16	PF00917	0.742
DOC_USP7_MATH_1	12	16	PF00917	0.808
DOC_USP7_MATH_1	72	76	PF00917	0.728
DOC_WW_Pin1_4	1	6	PF00397	0.812
DOC_WW_Pin1_4	32	37	PF00397	0.629
DOC_WW_Pin1_4	62	67	PF00397	0.639
LIG_14-3-3_CanoR_1	13	18	PF00244	0.652
LIG_14-3-3_CanoR_1	131	136	PF00244	0.644
LIG_14-3-3_CanoR_1	137	144	PF00244	0.641
LIG_BRCT_BRCA1_1	95	99	PF00533	0.738
LIG_FHA_1	12	18	PF00498	0.697
LIG_FHA_1	130	136	PF00498	0.628
LIG_FHA_1	138	144	PF00498	0.539
LIG_FHA_2	111	117	PF00498	0.607
LIG_FHA_2	136	142	PF00498	0.561
LIG_FHA_2	44	50	PF00498	0.723
LIG_IBAR_NPY_1	71	73	PF08397	0.621
LIG_LIR_Apic_2	80	86	PF02991	0.709
LIG_LIR_Nem_3	121	127	PF02991	0.695
LIG_MYND_1	8	12	PF01753	0.633
LIG_SH2_CRK	124	128	PF00017	0.687
LIG_SH2_CRK	28	32	PF00017	0.802
LIG_SH2_NCK_1	28	32	PF00017	0.802
LIG_SH2_SRC	26	29	PF00017	0.686
LIG_SH2_STAP1	26	30	PF00017	0.729
LIG_SH2_STAT3	108	111	PF00017	0.701
LIG_SH2_STAT5	108	111	PF00017	0.701
LIG_SH3_1	2	8	PF00018	0.748
LIG_SH3_3	167	173	PF00018	0.680
LIG_SH3_3	2	8	PF00018	0.748
LIG_SUMO_SIM_par_1	126	134	PF11976	0.673
LIG_TYR_ITSM	120	127	PF00017	0.693
MOD_CK1_1	165	171	PF00069	0.813
MOD_CK1_1	75	81	PF00069	0.603
MOD_CK2_1	135	141	PF00069	0.548
MOD_CK2_1	43	49	PF00069	0.763
MOD_CK2_1	79	85	PF00069	0.712
MOD_GlcNHglycan	36	39	PF01048	0.825
MOD_GSK3_1	106	113	PF00069	0.503
MOD_GSK3_1	126	133	PF00069	0.395
MOD_GSK3_1	75	82	PF00069	0.612
MOD_GSK3_1	89	96	PF00069	0.624
MOD_LATS_1	11	17	PF00433	0.740
MOD_N-GLC_1	111	116	PF02516	0.644
MOD_NEK2_2	126	131	PF00069	0.609
MOD_PIKK_1	90	96	PF00454	0.808
MOD_PK_1	13	19	PF00069	0.734
MOD_PKA_2	12	18	PF00069	0.653
MOD_PKA_2	130	136	PF00069	0.597
MOD_Plk_1	165	171	PF00069	0.656
MOD_ProDKin_1	1	7	PF00069	0.809
MOD_ProDKin_1	32	38	PF00069	0.632
MOD_ProDKin_1	62	68	PF00069	0.640
MOD_SUMO_rev_2	96	106	PF00179	0.611
TRG_DiLeu_BaLyEn_6	5	10	PF01217	0.633
TRG_ENDOCYTIC_2	124	127	PF00928	0.688
TRG_Pf-PMV_PEXEL_1	137	141	PF00026	0.696

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4H3Z8	Leishmania braziliensis	62%	100%
A4HS89	Leishmania infantum	98%	100%
O97006	Leishmania major	83%	100%