Heat shock protein, putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

heat shock protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WNV0_LEIDO

TriTrypDb:

LdBPK_040780.1 , LdCL_040013400 , LDHU3_04.1000

Length:

576

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8
GO:0020016	ciliary pocket	2	1

Expansion

Sequence features

A0A3S7WNV0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WNV0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	158	160	PF00675	0.339
CLV_NRD_NRD_1	30	32	PF00675	0.297
CLV_NRD_NRD_1	314	316	PF00675	0.487
CLV_PCSK_KEX2_1	158	160	PF00082	0.298
CLV_PCSK_KEX2_1	30	32	PF00082	0.295
CLV_PCSK_KEX2_1	314	316	PF00082	0.487
CLV_PCSK_KEX2_1	450	452	PF00082	0.658
CLV_PCSK_PC1ET2_1	450	452	PF00082	0.658
CLV_PCSK_SKI1_1	170	174	PF00082	0.406
CLV_PCSK_SKI1_1	31	35	PF00082	0.278
DEG_APCC_DBOX_1	169	177	PF00400	0.406
DEG_APCC_DBOX_1	72	80	PF00400	0.640
DEG_ODPH_VHL_1	353	366	PF01847	0.386
DEG_SPOP_SBC_1	152	156	PF00917	0.257
DEG_SPOP_SBC_1	391	395	PF00917	0.738
DEG_SPOP_SBC_1	400	404	PF00917	0.665
DOC_CDC14_PxL_1	461	469	PF14671	0.406
DOC_MAPK_DCC_7	339	349	PF00069	0.253
DOC_MAPK_gen_1	158	166	PF00069	0.536
DOC_MAPK_gen_1	290	300	PF00069	0.536
DOC_MAPK_gen_1	417	425	PF00069	0.555
DOC_MAPK_MEF2A_6	158	165	PF00069	0.518
DOC_MAPK_MEF2A_6	170	177	PF00069	0.301
DOC_PP1_RVXF_1	100	107	PF00149	0.213
DOC_PP2B_LxvP_1	164	167	PF13499	0.406
DOC_PP4_FxxP_1	248	251	PF00568	0.536
DOC_USP7_MATH_1	266	270	PF00917	0.549
DOC_USP7_MATH_1	399	403	PF00917	0.770
DOC_USP7_MATH_1	427	431	PF00917	0.482
DOC_USP7_MATH_1	455	459	PF00917	0.455
DOC_USP7_MATH_1	498	502	PF00917	0.727
DOC_USP7_MATH_1	504	508	PF00917	0.688
DOC_USP7_MATH_2	125	131	PF00917	0.355
DOC_WW_Pin1_4	220	225	PF00397	0.555
DOC_WW_Pin1_4	378	383	PF00397	0.771
DOC_WW_Pin1_4	385	390	PF00397	0.762
DOC_WW_Pin1_4	528	533	PF00397	0.742
LIG_14-3-3_CanoR_1	239	245	PF00244	0.453
LIG_14-3-3_CanoR_1	392	401	PF00244	0.737
LIG_14-3-3_CanoR_1	524	528	PF00244	0.753
LIG_14-3-3_CanoR_1	540	547	PF00244	0.767
LIG_AP2alpha_2	246	248	PF02296	0.555
LIG_APCC_ABBAyCdc20_2	222	228	PF00400	0.430
LIG_deltaCOP1_diTrp_1	127	131	PF00928	0.341
LIG_EH1_1	359	367	PF00400	0.369
LIG_FHA_1	106	112	PF00498	0.490
LIG_FHA_1	152	158	PF00498	0.372
LIG_FHA_1	191	197	PF00498	0.403
LIG_FHA_1	20	26	PF00498	0.532
LIG_FHA_2	19	25	PF00498	0.473
LIG_FHA_2	204	210	PF00498	0.406
LIG_FHA_2	240	246	PF00498	0.510
LIG_GBD_Chelix_1	483	491	PF00786	0.300
LIG_Integrin_isoDGR_2	517	519	PF01839	0.446
LIG_IRF3_LxIS_1	111	118	PF10401	0.432
LIG_LIR_Apic_2	245	251	PF02991	0.555
LIG_LIR_Apic_2	325	330	PF02991	0.230
LIG_LIR_Gen_1	297	308	PF02991	0.406
LIG_LIR_Gen_1	348	357	PF02991	0.314
LIG_LIR_Gen_1	458	468	PF02991	0.336
LIG_LIR_Gen_1	47	55	PF02991	0.447
LIG_LIR_Gen_1	9	18	PF02991	0.488
LIG_LIR_Nem_3	130	134	PF02991	0.279
LIG_LIR_Nem_3	26	32	PF02991	0.415
LIG_LIR_Nem_3	297	303	PF02991	0.445
LIG_LIR_Nem_3	348	353	PF02991	0.314
LIG_LIR_Nem_3	358	362	PF02991	0.314
LIG_LIR_Nem_3	458	463	PF02991	0.433
LIG_LIR_Nem_3	47	52	PF02991	0.447
LIG_LIR_Nem_3	9	14	PF02991	0.522
LIG_MYND_1	247	251	PF01753	0.555
LIG_NRBOX	86	92	PF00104	0.603
LIG_Pex14_1	198	202	PF04695	0.406
LIG_PTB_Apo_2	275	282	PF02174	0.487
LIG_SH2_CRK	29	33	PF00017	0.463
LIG_SH2_CRK	306	310	PF00017	0.432
LIG_SH2_CRK	327	331	PF00017	0.230
LIG_SH2_CRK	68	72	PF00017	0.588
LIG_SH2_NCK_1	327	331	PF00017	0.230
LIG_SH2_NCK_1	68	72	PF00017	0.608
LIG_SH2_PTP2	162	165	PF00017	0.432
LIG_SH2_STAP1	306	310	PF00017	0.432
LIG_SH2_STAT5	162	165	PF00017	0.432
LIG_SH2_STAT5	202	205	PF00017	0.421
LIG_SH2_STAT5	359	362	PF00017	0.411
LIG_SH3_3	131	137	PF00018	0.296
LIG_SH3_3	241	247	PF00018	0.597
LIG_SH3_3	379	385	PF00018	0.756
LIG_SUMO_SIM_anti_2	149	156	PF11976	0.406
LIG_SUMO_SIM_par_1	12	17	PF11976	0.512
LIG_SUMO_SIM_par_1	143	149	PF11976	0.431
LIG_SUMO_SIM_par_1	162	168	PF11976	0.249
LIG_TRAF2_1	384	387	PF00917	0.732
LIG_WRC_WIRS_1	346	351	PF05994	0.350
MOD_CDK_SPxxK_3	385	392	PF00069	0.575
MOD_CK1_1	264	270	PF00069	0.440
MOD_CK1_1	280	286	PF00069	0.314
MOD_CK1_1	325	331	PF00069	0.404
MOD_CK1_1	393	399	PF00069	0.674
MOD_CK1_1	507	513	PF00069	0.694
MOD_CK1_1	525	531	PF00069	0.736
MOD_CK1_1	534	540	PF00069	0.784
MOD_CK1_1	545	551	PF00069	0.469
MOD_CK2_1	18	24	PF00069	0.318
MOD_CK2_1	239	245	PF00069	0.385
MOD_CK2_1	257	263	PF00069	0.214
MOD_CK2_1	267	273	PF00069	0.329
MOD_CK2_1	364	370	PF00069	0.440
MOD_CK2_1	381	387	PF00069	0.735
MOD_CK2_1	412	418	PF00069	0.616
MOD_CMANNOS	128	131	PF00535	0.406
MOD_CMANNOS	198	201	PF00535	0.406
MOD_GlcNHglycan	167	170	PF01048	0.474
MOD_GlcNHglycan	252	255	PF01048	0.389
MOD_GlcNHglycan	269	272	PF01048	0.434
MOD_GlcNHglycan	429	432	PF01048	0.434
MOD_GlcNHglycan	456	460	PF01048	0.448
MOD_GlcNHglycan	500	503	PF01048	0.622
MOD_GlcNHglycan	506	509	PF01048	0.672
MOD_GlcNHglycan	512	515	PF01048	0.624
MOD_GlcNHglycan	536	539	PF01048	0.690
MOD_GlcNHglycan	565	568	PF01048	0.618
MOD_GlcNHglycan	6	9	PF01048	0.431
MOD_GSK3_1	111	118	PF00069	0.443
MOD_GSK3_1	148	155	PF00069	0.416
MOD_GSK3_1	19	26	PF00069	0.496
MOD_GSK3_1	216	223	PF00069	0.392
MOD_GSK3_1	257	264	PF00069	0.374
MOD_GSK3_1	325	332	PF00069	0.475
MOD_GSK3_1	369	376	PF00069	0.442
MOD_GSK3_1	377	384	PF00069	0.665
MOD_GSK3_1	518	525	PF00069	0.666
MOD_GSK3_1	528	535	PF00069	0.671
MOD_GSK3_1	538	545	PF00069	0.733
MOD_GSK3_1	551	558	PF00069	0.709
MOD_N-GLC_1	240	245	PF02516	0.369
MOD_N-GLC_1	277	282	PF02516	0.386
MOD_N-GLC_1	538	543	PF02516	0.667
MOD_NEK2_1	111	116	PF00069	0.402
MOD_NEK2_1	146	151	PF00069	0.435
MOD_NEK2_1	153	158	PF00069	0.368
MOD_NEK2_1	369	374	PF00069	0.415
MOD_NEK2_1	434	439	PF00069	0.401
MOD_NEK2_1	67	72	PF00069	0.508
MOD_NEK2_1	86	91	PF00069	0.611
MOD_NEK2_2	412	417	PF00069	0.471
MOD_OFUCOSY	432	438	PF10250	0.369
MOD_PIKK_1	23	29	PF00454	0.433
MOD_PIKK_1	280	286	PF00454	0.369
MOD_PIKK_1	401	407	PF00454	0.583
MOD_PIKK_1	545	551	PF00454	0.739
MOD_PKA_2	391	397	PF00069	0.694
MOD_PKA_2	518	524	PF00069	0.667
MOD_PKA_2	545	551	PF00069	0.739
MOD_Plk_1	240	246	PF00069	0.447
MOD_Plk_1	256	262	PF00069	0.269
MOD_Plk_1	277	283	PF00069	0.500
MOD_Plk_1	374	380	PF00069	0.583
MOD_Plk_2-3	257	263	PF00069	0.369
MOD_Plk_4	111	117	PF00069	0.319
MOD_Plk_4	148	154	PF00069	0.348
MOD_Plk_4	213	219	PF00069	0.410
MOD_Plk_4	277	283	PF00069	0.364
MOD_Plk_4	322	328	PF00069	0.266
MOD_Plk_4	345	351	PF00069	0.348
MOD_Plk_4	355	361	PF00069	0.311
MOD_Plk_4	369	375	PF00069	0.386
MOD_Plk_4	86	92	PF00069	0.553
MOD_ProDKin_1	220	226	PF00069	0.432
MOD_ProDKin_1	378	384	PF00069	0.738
MOD_ProDKin_1	385	391	PF00069	0.721
MOD_ProDKin_1	528	534	PF00069	0.694
MOD_SUMO_for_1	442	445	PF00179	0.439
TRG_DiLeu_BaLyEn_6	167	172	PF01217	0.406
TRG_DiLeu_BaLyEn_6	99	104	PF01217	0.178
TRG_ENDOCYTIC_2	11	14	PF00928	0.304
TRG_ENDOCYTIC_2	162	165	PF00928	0.406
TRG_ENDOCYTIC_2	29	32	PF00928	0.304
TRG_ENDOCYTIC_2	306	309	PF00928	0.374
TRG_ENDOCYTIC_2	359	362	PF00928	0.369
TRG_ENDOCYTIC_2	68	71	PF00928	0.437
TRG_ER_diArg_1	157	159	PF00400	0.432
TRG_ER_diArg_1	29	31	PF00400	0.397
TRG_ER_diArg_1	313	315	PF00400	0.337
TRG_ER_diArg_1	62	65	PF00400	0.397
TRG_Pf-PMV_PEXEL_1	57	61	PF00026	0.397
TRG_Pf-PMV_PEXEL_1	65	69	PF00026	0.397

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2R3	Leptomonas seymouri	51%	100%
A4H3Z0	Leishmania braziliensis	72%	99%
A4HS75	Leishmania infantum	100%	100%
C9ZY69	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	100%
E9AK61	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
O97211	Leishmania major	90%	99%
V5BMT5	Trypanosoma cruzi	27%	100%