Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania donovani

UniProt:

A0A3S7WNU3_LEIDO

TriTrypDb:

LdBPK_040920.1 , LdCL_040014800 , LDHU3_04.1150

Length:

595

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WNU3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WNU3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	150	154	PF00656	0.754
CLV_C14_Caspase3-7	250	254	PF00656	0.781
CLV_C14_Caspase3-7	53	57	PF00656	0.832
CLV_NRD_NRD_1	108	110	PF00675	0.732
CLV_NRD_NRD_1	170	172	PF00675	0.745
CLV_NRD_NRD_1	261	263	PF00675	0.793
CLV_NRD_NRD_1	35	37	PF00675	0.801
CLV_NRD_NRD_1	66	68	PF00675	0.823
CLV_PCSK_KEX2_1	170	172	PF00082	0.745
CLV_PCSK_KEX2_1	261	263	PF00082	0.767
CLV_PCSK_KEX2_1	35	37	PF00082	0.801
CLV_PCSK_KEX2_1	66	68	PF00082	0.823
CLV_PCSK_SKI1_1	412	416	PF00082	0.666
CLV_PCSK_SKI1_1	576	580	PF00082	0.615
DEG_Nend_UBRbox_2	1	3	PF02207	0.807
DEG_SCF_FBW7_1	46	51	PF00400	0.724
DEG_SPOP_SBC_1	147	151	PF00917	0.751
DEG_SPOP_SBC_1	394	398	PF00917	0.784
DEG_SPOP_SBC_1	414	418	PF00917	0.564
DEG_SPOP_SBC_1	80	84	PF00917	0.782
DOC_CYCLIN_yCln2_LP_2	313	319	PF00134	0.692
DOC_MAPK_gen_1	376	385	PF00069	0.822
DOC_MAPK_MEF2A_6	35	42	PF00069	0.799
DOC_MAPK_MEF2A_6	376	385	PF00069	0.822
DOC_PP2B_LxvP_1	133	136	PF13499	0.643
DOC_PP2B_LxvP_1	313	316	PF13499	0.611
DOC_PP4_MxPP_1	570	573	PF00568	0.471
DOC_USP7_MATH_1	147	151	PF00917	0.751
DOC_USP7_MATH_1	265	269	PF00917	0.743
DOC_USP7_MATH_1	366	370	PF00917	0.757
DOC_USP7_MATH_1	374	378	PF00917	0.748
DOC_USP7_MATH_1	379	383	PF00917	0.783
DOC_USP7_MATH_1	407	411	PF00917	0.751
DOC_USP7_MATH_1	461	465	PF00917	0.743
DOC_USP7_MATH_1	578	582	PF00917	0.632
DOC_USP7_MATH_1	80	84	PF00917	0.802
DOC_USP7_MATH_2	5	11	PF00917	0.700
DOC_WW_Pin1_4	10	15	PF00397	0.751
DOC_WW_Pin1_4	216	221	PF00397	0.762
DOC_WW_Pin1_4	271	276	PF00397	0.751
DOC_WW_Pin1_4	435	440	PF00397	0.775
DOC_WW_Pin1_4	44	49	PF00397	0.728
DOC_WW_Pin1_4	457	462	PF00397	0.689
DOC_WW_Pin1_4	81	86	PF00397	0.670
LIG_14-3-3_CanoR_1	12	18	PF00244	0.592
LIG_14-3-3_CanoR_1	242	248	PF00244	0.667
LIG_14-3-3_CanoR_1	289	298	PF00244	0.680
LIG_14-3-3_CanoR_1	343	350	PF00244	0.742
LIG_14-3-3_CanoR_1	412	421	PF00244	0.671
LIG_14-3-3_CanoR_1	544	548	PF00244	0.616
LIG_Clathr_ClatBox_1	446	450	PF01394	0.841
LIG_EVH1_1	24	28	PF00568	0.761
LIG_FHA_1	414	420	PF00498	0.851
LIG_FHA_1	49	55	PF00498	0.825
LIG_FHA_1	557	563	PF00498	0.556
LIG_FHA_1	60	66	PF00498	0.644
LIG_FHA_2	235	241	PF00498	0.645
LIG_FHA_2	329	335	PF00498	0.834
LIG_FHA_2	51	57	PF00498	0.831
LIG_GBD_Chelix_1	125	133	PF00786	0.608
LIG_LIR_Gen_1	508	518	PF02991	0.784
LIG_LIR_Nem_3	295	301	PF02991	0.659
LIG_LIR_Nem_3	508	513	PF02991	0.792
LIG_NRBOX	128	134	PF00104	0.619
LIG_PDZ_Class_2	590	595	PF00595	0.581
LIG_Pex14_2	120	124	PF04695	0.621
LIG_SH2_PTP2	93	96	PF00017	0.726
LIG_SH2_STAP1	298	302	PF00017	0.645
LIG_SH2_STAP1	510	514	PF00017	0.795
LIG_SH2_STAT3	301	304	PF00017	0.744
LIG_SH2_STAT5	301	304	PF00017	0.732
LIG_SH2_STAT5	510	513	PF00017	0.694
LIG_SH2_STAT5	93	96	PF00017	0.726
LIG_SH3_3	109	115	PF00018	0.739
LIG_SH3_3	22	28	PF00018	0.760
LIG_SH3_3	353	359	PF00018	0.731
LIG_SH3_3	43	49	PF00018	0.727
LIG_SH3_3	434	440	PF00018	0.724
LIG_SH3_3	519	525	PF00018	0.686
LIG_SH3_3	82	88	PF00018	0.695
LIG_SUMO_SIM_par_1	50	56	PF11976	0.829
LIG_TRAF2_1	4	7	PF00917	0.580
LIG_TRAF2_1	465	468	PF00917	0.827
LIG_TYR_ITIM	91	96	PF00017	0.630
MOD_CDK_SPxxK_3	435	442	PF00069	0.776
MOD_CDK_SPxxK_3	459	466	PF00069	0.848
MOD_CK1_1	10	16	PF00069	0.714
MOD_CK1_1	146	152	PF00069	0.834
MOD_CK1_1	160	166	PF00069	0.544
MOD_CK1_1	181	187	PF00069	0.724
MOD_CK1_1	227	233	PF00069	0.848
MOD_CK1_1	234	240	PF00069	0.820
MOD_CK1_1	369	375	PF00069	0.757
MOD_CK1_1	410	416	PF00069	0.842
MOD_CK1_1	508	514	PF00069	0.795
MOD_CK2_1	183	189	PF00069	0.842
MOD_CK2_1	234	240	PF00069	0.659
MOD_CK2_1	243	249	PF00069	0.689
MOD_CK2_1	435	441	PF00069	0.755
MOD_CK2_1	461	467	PF00069	0.832
MOD_Cter_Amidation	107	110	PF01082	0.649
MOD_DYRK1A_RPxSP_1	216	220	PF00069	0.759
MOD_GlcNHglycan	139	142	PF01048	0.763
MOD_GlcNHglycan	145	148	PF01048	0.753
MOD_GlcNHglycan	150	153	PF01048	0.683
MOD_GlcNHglycan	159	162	PF01048	0.546
MOD_GlcNHglycan	17	20	PF01048	0.793
MOD_GlcNHglycan	174	177	PF01048	0.695
MOD_GlcNHglycan	181	184	PF01048	0.636
MOD_GlcNHglycan	216	219	PF01048	0.758
MOD_GlcNHglycan	258	261	PF01048	0.732
MOD_GlcNHglycan	29	32	PF01048	0.629
MOD_GlcNHglycan	345	348	PF01048	0.772
MOD_GlcNHglycan	368	371	PF01048	0.728
MOD_GlcNHglycan	402	405	PF01048	0.686
MOD_GlcNHglycan	429	432	PF01048	0.751
MOD_GSK3_1	143	150	PF00069	0.800
MOD_GSK3_1	178	185	PF00069	0.706
MOD_GSK3_1	210	217	PF00069	0.801
MOD_GSK3_1	224	231	PF00069	0.733
MOD_GSK3_1	236	243	PF00069	0.790
MOD_GSK3_1	281	288	PF00069	0.812
MOD_GSK3_1	379	386	PF00069	0.754
MOD_GSK3_1	394	401	PF00069	0.754
MOD_GSK3_1	410	417	PF00069	0.588
MOD_GSK3_1	425	432	PF00069	0.620
MOD_GSK3_1	44	51	PF00069	0.763
MOD_GSK3_1	457	464	PF00069	0.800
MOD_GSK3_1	474	481	PF00069	0.848
MOD_GSK3_1	508	515	PF00069	0.665
MOD_N-GLC_1	457	462	PF02516	0.849
MOD_NEK2_1	120	125	PF00069	0.620
MOD_NEK2_1	143	148	PF00069	0.820
MOD_NEK2_1	15	20	PF00069	0.618
MOD_NEK2_1	179	184	PF00069	0.714
MOD_NEK2_1	228	233	PF00069	0.853
MOD_NEK2_2	379	384	PF00069	0.739
MOD_PIKK_1	281	287	PF00454	0.815
MOD_PIKK_1	328	334	PF00454	0.835
MOD_PKA_2	496	502	PF00069	0.796
MOD_PKA_2	508	514	PF00069	0.628
MOD_PKA_2	543	549	PF00069	0.618
MOD_Plk_1	120	126	PF00069	0.613
MOD_Plk_1	224	230	PF00069	0.809
MOD_Plk_1	410	416	PF00069	0.849
MOD_Plk_1	493	499	PF00069	0.795
MOD_Plk_4	120	126	PF00069	0.613
MOD_Plk_4	379	385	PF00069	0.823
MOD_ProDKin_1	10	16	PF00069	0.750
MOD_ProDKin_1	216	222	PF00069	0.761
MOD_ProDKin_1	271	277	PF00069	0.751
MOD_ProDKin_1	435	441	PF00069	0.774
MOD_ProDKin_1	44	50	PF00069	0.728
MOD_ProDKin_1	457	463	PF00069	0.686
MOD_ProDKin_1	81	87	PF00069	0.667
TRG_DiLeu_BaEn_2	587	593	PF01217	0.559
TRG_DiLeu_BaEn_4	337	343	PF01217	0.828
TRG_DiLeu_BaEn_4	469	475	PF01217	0.774
TRG_ENDOCYTIC_2	510	513	PF00928	0.694
TRG_ENDOCYTIC_2	93	96	PF00928	0.625
TRG_ER_diArg_1	34	36	PF00400	0.809
TRG_ER_diArg_1	65	67	PF00400	0.832
TRG_Pf-PMV_PEXEL_1	245	249	PF00026	0.666
TRG_Pf-PMV_PEXEL_1	569	574	PF00026	0.707

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3V5	Leptomonas seymouri	39%	100%
A4H3Y5	Leishmania braziliensis	75%	99%
E9AK73	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
O97009	Leishmania major	91%	100%