Serine peptidase, Clan S-, family S54, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

rhomboid-like protein

Species:

Leishmania donovani

UniProt:

A0A3S7WNU2_LEIDO

TriTrypDb:

LdBPK_040850.1 , LdCL_040014100 , LDHU3_04.1070

Length:

396

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

A0A3S7WNU2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WNU2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0004175	endopeptidase activity	4	10
GO:0004252	serine-type endopeptidase activity	5	10
GO:0008233	peptidase activity	3	10
GO:0008236	serine-type peptidase activity	4	10
GO:0016787	hydrolase activity	2	10
GO:0017171	serine hydrolase activity	3	10
GO:0140096	catalytic activity, acting on a protein	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	164	168	PF00656	0.700
CLV_NRD_NRD_1	73	75	PF00675	0.511
CLV_PCSK_SKI1_1	18	22	PF00082	0.511
CLV_PCSK_SKI1_1	357	361	PF00082	0.287
CLV_PCSK_SKI1_1	46	50	PF00082	0.595
DEG_Nend_UBRbox_3	1	3	PF02207	0.698
DEG_SPOP_SBC_1	37	41	PF00917	0.738
DEG_SPOP_SBC_1	66	70	PF00917	0.700
DOC_CYCLIN_RxL_1	382	393	PF00134	0.414
DOC_MAPK_gen_1	87	97	PF00069	0.773
DOC_PP1_RVXF_1	329	336	PF00149	0.344
DOC_PP4_FxxP_1	188	191	PF00568	0.638
DOC_USP7_MATH_1	115	119	PF00917	0.741
DOC_USP7_MATH_1	138	142	PF00917	0.779
DOC_USP7_MATH_1	25	29	PF00917	0.771
DOC_USP7_MATH_1	37	41	PF00917	0.720
DOC_USP7_MATH_1	59	63	PF00917	0.735
DOC_USP7_MATH_1	66	70	PF00917	0.668
DOC_USP7_MATH_1	99	103	PF00917	0.694
DOC_WW_Pin1_4	107	112	PF00397	0.706
DOC_WW_Pin1_4	134	139	PF00397	0.772
DOC_WW_Pin1_4	172	177	PF00397	0.650
DOC_WW_Pin1_4	27	32	PF00397	0.734
LIG_14-3-3_CanoR_1	100	104	PF00244	0.659
LIG_14-3-3_CanoR_1	18	27	PF00244	0.728
LIG_14-3-3_CanoR_1	275	279	PF00244	0.365
LIG_14-3-3_CanoR_1	46	51	PF00244	0.763
LIG_14-3-3_CanoR_1	74	83	PF00244	0.766
LIG_BRCT_BRCA1_1	116	120	PF00533	0.707
LIG_Clathr_ClatBox_1	322	326	PF01394	0.344
LIG_deltaCOP1_diTrp_1	217	222	PF00928	0.419
LIG_deltaCOP1_diTrp_1	232	241	PF00928	0.331
LIG_deltaCOP1_diTrp_1	256	263	PF00928	0.290
LIG_deltaCOP1_diTrp_1	354	359	PF00928	0.344
LIG_EH_1	315	319	PF12763	0.344
LIG_EVH1_1	186	190	PF00568	0.644
LIG_EVH1_2	339	343	PF00568	0.290
LIG_FHA_1	192	198	PF00498	0.490
LIG_FHA_1	345	351	PF00498	0.328
LIG_FHA_1	382	388	PF00498	0.409
LIG_FHA_1	92	98	PF00498	0.718
LIG_FHA_2	359	365	PF00498	0.508
LIG_LIR_Gen_1	232	241	PF02991	0.361
LIG_LIR_Gen_1	277	285	PF02991	0.369
LIG_LIR_Gen_1	347	355	PF02991	0.344
LIG_LIR_Nem_3	217	222	PF02991	0.405
LIG_LIR_Nem_3	232	237	PF02991	0.365
LIG_LIR_Nem_3	277	282	PF02991	0.369
LIG_LIR_Nem_3	347	352	PF02991	0.344
LIG_LIR_Nem_3	354	359	PF02991	0.344
LIG_LYPXL_S_1	237	241	PF13949	0.490
LIG_Pex14_1	234	238	PF04695	0.361
LIG_Pex14_2	188	192	PF04695	0.639
LIG_Pex14_2	241	245	PF04695	0.331
LIG_PTB_Apo_2	240	247	PF02174	0.308
LIG_PTB_Phospho_1	240	246	PF10480	0.308
LIG_REV1ctd_RIR_1	4	14	PF16727	0.685
LIG_SH2_STAT5	185	188	PF00017	0.651
LIG_SH2_STAT5	209	212	PF00017	0.344
LIG_SH2_STAT5	377	380	PF00017	0.344
LIG_SH3_3	184	190	PF00018	0.648
LIG_SH3_3	336	342	PF00018	0.276
LIG_SUMO_SIM_par_1	321	326	PF11976	0.401
LIG_UBA3_1	386	391	PF00899	0.416
MOD_CDC14_SPxK_1	137	140	PF00782	0.766
MOD_CDK_SPK_2	134	139	PF00069	0.772
MOD_CDK_SPxK_1	134	140	PF00069	0.763
MOD_CK1_1	39	45	PF00069	0.749
MOD_CK1_1	69	75	PF00069	0.757
MOD_CK2_1	166	172	PF00069	0.662
MOD_CK2_1	358	364	PF00069	0.508
MOD_CMANNOS	258	261	PF00535	0.490
MOD_GlcNHglycan	167	171	PF01048	0.529
MOD_GlcNHglycan	180	183	PF01048	0.476
MOD_GlcNHglycan	52	55	PF01048	0.544
MOD_GlcNHglycan	61	64	PF01048	0.547
MOD_GlcNHglycan	76	79	PF01048	0.535
MOD_GSK3_1	107	114	PF00069	0.714
MOD_GSK3_1	134	141	PF00069	0.768
MOD_GSK3_1	14	21	PF00069	0.694
MOD_GSK3_1	281	288	PF00069	0.350
MOD_GSK3_1	36	43	PF00069	0.779
MOD_GSK3_1	46	53	PF00069	0.658
MOD_GSK3_1	61	68	PF00069	0.622
MOD_GSK3_1	74	81	PF00069	0.652
MOD_N-GLC_1	232	237	PF02516	0.631
MOD_NEK2_1	263	268	PF00069	0.290
MOD_NEK2_1	271	276	PF00069	0.290
MOD_NEK2_1	281	286	PF00069	0.344
MOD_NEK2_1	344	349	PF00069	0.327
MOD_NEK2_1	38	43	PF00069	0.787
MOD_NEK2_2	115	120	PF00069	0.604
MOD_NEK2_2	85	90	PF00069	0.781
MOD_NEK2_2	99	104	PF00069	0.671
MOD_PIKK_1	69	75	PF00454	0.706
MOD_PKA_1	139	145	PF00069	0.718
MOD_PKA_1	74	80	PF00069	0.706
MOD_PKA_2	129	135	PF00069	0.751
MOD_PKA_2	14	20	PF00069	0.723
MOD_PKA_2	25	31	PF00069	0.622
MOD_PKA_2	274	280	PF00069	0.345
MOD_PKA_2	99	105	PF00069	0.672
MOD_Plk_1	232	238	PF00069	0.398
MOD_Plk_4	115	121	PF00069	0.615
MOD_Plk_4	263	269	PF00069	0.308
MOD_Plk_4	274	280	PF00069	0.344
MOD_Plk_4	285	291	PF00069	0.321
MOD_Plk_4	91	97	PF00069	0.688
MOD_Plk_4	99	105	PF00069	0.634
MOD_ProDKin_1	107	113	PF00069	0.706
MOD_ProDKin_1	134	140	PF00069	0.774
MOD_ProDKin_1	172	178	PF00069	0.646
MOD_ProDKin_1	27	33	PF00069	0.735
TRG_DiLeu_BaLyEn_6	43	48	PF01217	0.632
TRG_ENDOCYTIC_2	185	188	PF00928	0.651
TRG_ENDOCYTIC_2	209	212	PF00928	0.344
TRG_ENDOCYTIC_2	238	241	PF00928	0.281
TRG_ENDOCYTIC_2	300	303	PF00928	0.508
TRG_ER_diArg_1	308	311	PF00400	0.490
TRG_Pf-PMV_PEXEL_1	385	390	PF00026	0.602

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PA30	Leptomonas seymouri	81%	100%
A0A1X0NLI4	Trypanosomatidae	64%	100%
A0A3R7RFZ5	Trypanosoma rangeli	63%	100%
A4H3Z5	Leishmania braziliensis	92%	100%
A4HS82	Leishmania infantum	100%	100%
C9ZY76	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	65%	100%
E9AK68	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	98%
Q9U0Z8	Leishmania major	96%	100%