Peptide deformylase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Peptide deformylase

Gene product:

Peptide deformylase 2, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WNT3_LEIDO

TriTrypDb:

LdBPK_040820.1 , LdCL_040013800 , LDHU3_04.1040

Length:

408

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7WNT3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WNT3

Function

Biological processes
Term	Name	Level	Count
GO:0006412	translation	4	11
GO:0006518	peptide metabolic process	4	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009058	biosynthetic process	2	11
GO:0009059	macromolecule biosynthetic process	4	11
GO:0009987	cellular process	1	11
GO:0019538	protein metabolic process	3	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	11
GO:0043043	peptide biosynthetic process	5	11
GO:0043170	macromolecule metabolic process	3	11
GO:0043603	amide metabolic process	3	11
GO:0043604	amide biosynthetic process	4	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044249	cellular biosynthetic process	3	11
GO:0044260	obsolete cellular macromolecule metabolic process	3	11
GO:0044271	cellular nitrogen compound biosynthetic process	4	11
GO:0071704	organic substance metabolic process	2	11
GO:1901564	organonitrogen compound metabolic process	3	11
GO:1901566	organonitrogen compound biosynthetic process	4	11
GO:1901576	organic substance biosynthetic process	3	11
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018206	peptidyl-methionine modification	6	1
GO:0036211	protein modification process	4	1
GO:0043412	macromolecule modification	4	1
GO:0006508	proteolysis	4	5

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0005488	binding	1	11
GO:0016787	hydrolase activity	2	11
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	3	11
GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	4	11
GO:0042586	peptide deformylase activity	5	11
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11
GO:0008233	peptidase activity	3	5
GO:0008237	metallopeptidase activity	4	5
GO:0140096	catalytic activity, acting on a protein	2	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	102	106	PF00656	0.686
CLV_NRD_NRD_1	140	142	PF00675	0.375
CLV_NRD_NRD_1	286	288	PF00675	0.323
CLV_NRD_NRD_1	342	344	PF00675	0.538
CLV_NRD_NRD_1	374	376	PF00675	0.595
CLV_NRD_NRD_1	380	382	PF00675	0.658
CLV_PCSK_KEX2_1	140	142	PF00082	0.383
CLV_PCSK_KEX2_1	286	288	PF00082	0.338
CLV_PCSK_KEX2_1	380	382	PF00082	0.663
CLV_PCSK_PC1ET2_1	380	382	PF00082	0.669
CLV_PCSK_SKI1_1	244	248	PF00082	0.357
CLV_PCSK_SKI1_1	258	262	PF00082	0.295
CLV_PCSK_SKI1_1	270	274	PF00082	0.242
DEG_APCC_DBOX_1	269	277	PF00400	0.338
DEG_APCC_DBOX_1	359	367	PF00400	0.651
DEG_Nend_UBRbox_1	1	4	PF02207	0.692
DOC_ANK_TNKS_1	107	114	PF00023	0.665
DOC_CKS1_1	323	328	PF01111	0.540
DOC_MAPK_gen_1	266	273	PF00069	0.325
DOC_MAPK_RevD_3	271	287	PF00069	0.338
DOC_PP2B_LxvP_1	53	56	PF13499	0.733
DOC_PP4_FxxP_1	186	189	PF00568	0.338
DOC_PP4_FxxP_1	324	327	PF00568	0.449
DOC_USP7_MATH_1	104	108	PF00917	0.673
DOC_USP7_MATH_1	126	130	PF00917	0.406
DOC_USP7_MATH_1	164	168	PF00917	0.466
DOC_USP7_MATH_1	231	235	PF00917	0.328
DOC_USP7_MATH_1	26	30	PF00917	0.634
DOC_USP7_UBL2_3	376	380	PF12436	0.617
DOC_WW_Pin1_4	30	35	PF00397	0.718
DOC_WW_Pin1_4	322	327	PF00397	0.390
LIG_14-3-3_CanoR_1	17	25	PF00244	0.728
LIG_14-3-3_CanoR_1	2	9	PF00244	0.714
LIG_14-3-3_CanoR_1	244	249	PF00244	0.338
LIG_14-3-3_CanoR_1	316	320	PF00244	0.409
LIG_14-3-3_CanoR_1	60	68	PF00244	0.659
LIG_14-3-3_CanoR_1	71	76	PF00244	0.547
LIG_BIR_III_2	333	337	PF00653	0.606
LIG_BRCT_BRCA1_1	233	237	PF00533	0.322
LIG_BRCT_BRCA1_1	64	68	PF00533	0.720
LIG_EVH1_2	326	330	PF00568	0.471
LIG_FHA_1	117	123	PF00498	0.502
LIG_FHA_1	219	225	PF00498	0.279
LIG_FHA_1	245	251	PF00498	0.297
LIG_FHA_1	259	265	PF00498	0.373
LIG_FHA_1	283	289	PF00498	0.322
LIG_FHA_2	177	183	PF00498	0.338
LIG_FHA_2	300	306	PF00498	0.478
LIG_FHA_2	393	399	PF00498	0.713
LIG_Integrin_RGD_1	390	392	PF01839	0.768
LIG_LIR_Apic_2	184	189	PF02991	0.321
LIG_LIR_Apic_2	322	327	PF02991	0.390
LIG_LIR_Gen_1	207	216	PF02991	0.472
LIG_LIR_Gen_1	298	305	PF02991	0.486
LIG_LIR_Gen_1	318	328	PF02991	0.467
LIG_LIR_Nem_3	118	123	PF02991	0.526
LIG_LIR_Nem_3	146	150	PF02991	0.437
LIG_LIR_Nem_3	207	211	PF02991	0.472
LIG_LIR_Nem_3	307	313	PF02991	0.439
LIG_LIR_Nem_3	318	324	PF02991	0.397
LIG_LIR_Nem_3	325	331	PF02991	0.376
LIG_LYPXL_yS_3	120	123	PF13949	0.527
LIG_LYPXL_yS_3	163	166	PF13949	0.322
LIG_LYPXL_yS_3	310	313	PF13949	0.412
LIG_Pex14_1	131	135	PF04695	0.415
LIG_Pex14_1	306	310	PF04695	0.462
LIG_PTB_Apo_2	180	187	PF02174	0.440
LIG_Rb_pABgroove_1	175	183	PF01858	0.322
LIG_REV1ctd_RIR_1	55	64	PF16727	0.660
LIG_SH2_CRK	147	151	PF00017	0.414
LIG_SH2_CRK	161	165	PF00017	0.226
LIG_SH2_CRK	328	332	PF00017	0.489
LIG_SH2_SRC	110	113	PF00017	0.637
LIG_SH2_SRC	161	164	PF00017	0.322
LIG_SH2_STAP1	135	139	PF00017	0.440
LIG_SH2_STAP1	80	84	PF00017	0.734
LIG_SH2_STAT5	110	113	PF00017	0.619
LIG_SH2_STAT5	241	244	PF00017	0.338
LIG_SH2_STAT5	321	324	PF00017	0.432
LIG_SH3_3	106	112	PF00018	0.599
LIG_SH3_3	42	48	PF00018	0.680
LIG_SUMO_SIM_par_1	260	265	PF11976	0.447
LIG_TRAF2_1	115	118	PF00917	0.634
LIG_TRAF2_1	210	213	PF00917	0.443
LIG_TRAF2_1	365	368	PF00917	0.492
MOD_CK1_1	29	35	PF00069	0.704
MOD_CK1_1	304	310	PF00069	0.485
MOD_CK1_1	51	57	PF00069	0.699
MOD_CK1_1	97	103	PF00069	0.632
MOD_GlcNHglycan	166	169	PF01048	0.406
MOD_GlcNHglycan	234	237	PF01048	0.412
MOD_GlcNHglycan	3	6	PF01048	0.715
MOD_GlcNHglycan	39	42	PF01048	0.738
MOD_GlcNHglycan	398	404	PF01048	0.769
MOD_GlcNHglycan	50	53	PF01048	0.686
MOD_GlcNHglycan	64	67	PF01048	0.634
MOD_GlcNHglycan	99	102	PF01048	0.666
MOD_GSK3_1	164	171	PF00069	0.443
MOD_GSK3_1	218	225	PF00069	0.279
MOD_GSK3_1	26	33	PF00069	0.730
MOD_GSK3_1	315	322	PF00069	0.411
MOD_GSK3_1	401	408	PF00069	0.663
MOD_GSK3_1	62	69	PF00069	0.729
MOD_GSK3_1	96	103	PF00069	0.644
MOD_LATS_1	256	262	PF00433	0.443
MOD_N-GLC_1	97	102	PF02516	0.637
MOD_N-GLC_2	28	30	PF02516	0.719
MOD_NEK2_1	1	6	PF00069	0.653
MOD_NEK2_1	181	186	PF00069	0.332
MOD_NEK2_1	319	324	PF00069	0.406
MOD_NEK2_1	89	94	PF00069	0.603
MOD_PIKK_1	149	155	PF00454	0.443
MOD_PK_1	71	77	PF00069	0.685
MOD_PKA_2	1	7	PF00069	0.706
MOD_PKA_2	315	321	PF00069	0.401
MOD_Plk_1	181	187	PF00069	0.429
MOD_Plk_2-3	309	315	PF00069	0.428
MOD_Plk_2-3	392	398	PF00069	0.674
MOD_Plk_4	181	187	PF00069	0.318
MOD_Plk_4	204	210	PF00069	0.429
MOD_Plk_4	315	321	PF00069	0.428
MOD_ProDKin_1	30	36	PF00069	0.719
MOD_ProDKin_1	322	328	PF00069	0.403
MOD_SUMO_rev_2	207	216	PF00179	0.481
MOD_SUMO_rev_2	337	345	PF00179	0.530
TRG_DiLeu_BaEn_1	146	151	PF01217	0.443
TRG_ENDOCYTIC_2	120	123	PF00928	0.503
TRG_ENDOCYTIC_2	147	150	PF00928	0.384
TRG_ENDOCYTIC_2	163	166	PF00928	0.219
TRG_ENDOCYTIC_2	310	313	PF00928	0.412
TRG_ENDOCYTIC_2	321	324	PF00928	0.409
TRG_ENDOCYTIC_2	328	331	PF00928	0.473
TRG_ER_diArg_1	140	142	PF00400	0.380
TRG_ER_diArg_1	248	251	PF00400	0.332
TRG_ER_diArg_1	267	270	PF00400	0.403
TRG_ER_diArg_1	286	288	PF00400	0.338
TRG_Pf-PMV_PEXEL_1	217	222	PF00026	0.443
TRG_Pf-PMV_PEXEL_1	251	255	PF00026	0.403

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P349	Leptomonas seymouri	79%	98%
A0A0S4JJP7	Bodo saltans	46%	100%
A0A1X0NLE7	Trypanosomatidae	59%	100%
A0A3S5IQR8	Trypanosoma rangeli	64%	100%
A4HS79	Leishmania infantum	100%	100%
C9ZY73	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	63%	100%
E9AK65	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	98%
Q9U112	Leishmania major	92%	100%
V5BDN2	Trypanosoma cruzi	62%	100%