Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WNS9_LEIDO

TriTrypDb:

LdBPK_040700.1 , LdCL_040012600 , LDHU3_04.0920

Length:

1091

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WNS9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WNS9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1050	1054	PF00656	0.634
CLV_C14_Caspase3-7	208	212	PF00656	0.643
CLV_C14_Caspase3-7	868	872	PF00656	0.560
CLV_C14_Caspase3-7	954	958	PF00656	0.559
CLV_NRD_NRD_1	1074	1076	PF00675	0.648
CLV_NRD_NRD_1	1089	1091	PF00675	0.510
CLV_NRD_NRD_1	298	300	PF00675	0.659
CLV_NRD_NRD_1	497	499	PF00675	0.610
CLV_NRD_NRD_1	611	613	PF00675	0.621
CLV_NRD_NRD_1	621	623	PF00675	0.549
CLV_NRD_NRD_1	629	631	PF00675	0.496
CLV_NRD_NRD_1	633	635	PF00675	0.634
CLV_NRD_NRD_1	79	81	PF00675	0.674
CLV_NRD_NRD_1	864	866	PF00675	0.614
CLV_PCSK_FUR_1	618	622	PF00082	0.600
CLV_PCSK_FUR_1	862	866	PF00082	0.606
CLV_PCSK_KEX2_1	1074	1076	PF00082	0.648
CLV_PCSK_KEX2_1	1089	1091	PF00082	0.510
CLV_PCSK_KEX2_1	199	201	PF00082	0.648
CLV_PCSK_KEX2_1	298	300	PF00082	0.659
CLV_PCSK_KEX2_1	497	499	PF00082	0.610
CLV_PCSK_KEX2_1	611	613	PF00082	0.614
CLV_PCSK_KEX2_1	620	622	PF00082	0.553
CLV_PCSK_KEX2_1	629	631	PF00082	0.500
CLV_PCSK_KEX2_1	633	635	PF00082	0.638
CLV_PCSK_KEX2_1	78	80	PF00082	0.683
CLV_PCSK_KEX2_1	864	866	PF00082	0.622
CLV_PCSK_PC1ET2_1	199	201	PF00082	0.648
CLV_PCSK_PC7_1	1085	1091	PF00082	0.628
CLV_PCSK_PC7_1	629	635	PF00082	0.565
CLV_PCSK_PC7_1	75	81	PF00082	0.642
CLV_PCSK_SKI1_1	520	524	PF00082	0.737
CLV_PCSK_SKI1_1	786	790	PF00082	0.574
CLV_PCSK_SKI1_1	904	908	PF00082	0.475
DEG_APCC_DBOX_1	785	793	PF00400	0.559
DEG_APCC_DBOX_1	997	1005	PF00400	0.602
DEG_SCF_FBW7_1	250	257	PF00400	0.618
DEG_SPOP_SBC_1	745	749	PF00917	0.548
DOC_ANK_TNKS_1	298	305	PF00023	0.628
DOC_ANK_TNKS_1	771	778	PF00023	0.514
DOC_CKS1_1	1055	1060	PF01111	0.506
DOC_CKS1_1	438	443	PF01111	0.632
DOC_CKS1_1	93	98	PF01111	0.613
DOC_CYCLIN_yCln2_LP_2	474	480	PF00134	0.592
DOC_MAPK_DCC_7	404	413	PF00069	0.640
DOC_MAPK_gen_1	791	799	PF00069	0.597
DOC_MAPK_MEF2A_6	404	413	PF00069	0.640
DOC_MAPK_MEF2A_6	84	93	PF00069	0.639
DOC_PP2B_LxvP_1	797	800	PF13499	0.597
DOC_PP2B_LxvP_1	91	94	PF13499	0.641
DOC_PP4_FxxP_1	531	534	PF00568	0.725
DOC_USP7_MATH_1	128	132	PF00917	0.739
DOC_USP7_MATH_1	153	157	PF00917	0.611
DOC_USP7_MATH_1	24	28	PF00917	0.656
DOC_USP7_MATH_1	308	312	PF00917	0.667
DOC_USP7_MATH_1	334	338	PF00917	0.705
DOC_USP7_MATH_1	35	39	PF00917	0.611
DOC_USP7_MATH_1	366	370	PF00917	0.599
DOC_USP7_MATH_1	506	510	PF00917	0.739
DOC_USP7_MATH_1	610	614	PF00917	0.681
DOC_USP7_MATH_1	734	738	PF00917	0.711
DOC_USP7_MATH_1	764	768	PF00917	0.684
DOC_USP7_MATH_2	301	307	PF00917	0.642
DOC_WW_Pin1_4	1054	1059	PF00397	0.505
DOC_WW_Pin1_4	12	17	PF00397	0.628
DOC_WW_Pin1_4	142	147	PF00397	0.638
DOC_WW_Pin1_4	215	220	PF00397	0.689
DOC_WW_Pin1_4	250	255	PF00397	0.619
DOC_WW_Pin1_4	292	297	PF00397	0.672
DOC_WW_Pin1_4	310	315	PF00397	0.562
DOC_WW_Pin1_4	326	331	PF00397	0.759
DOC_WW_Pin1_4	437	442	PF00397	0.654
DOC_WW_Pin1_4	49	54	PF00397	0.676
DOC_WW_Pin1_4	569	574	PF00397	0.676
DOC_WW_Pin1_4	585	590	PF00397	0.698
DOC_WW_Pin1_4	756	761	PF00397	0.600
DOC_WW_Pin1_4	915	920	PF00397	0.693
DOC_WW_Pin1_4	92	97	PF00397	0.622
DOC_WW_Pin1_4	968	973	PF00397	0.713
LIG_14-3-3_CanoR_1	132	139	PF00244	0.623
LIG_14-3-3_CanoR_1	205	214	PF00244	0.645
LIG_14-3-3_CanoR_1	225	229	PF00244	0.682
LIG_14-3-3_CanoR_1	232	237	PF00244	0.613
LIG_14-3-3_CanoR_1	325	330	PF00244	0.688
LIG_14-3-3_CanoR_1	352	360	PF00244	0.609
LIG_14-3-3_CanoR_1	633	640	PF00244	0.730
LIG_14-3-3_CanoR_1	668	674	PF00244	0.697
LIG_14-3-3_CanoR_1	754	761	PF00244	0.634
LIG_14-3-3_CanoR_1	763	769	PF00244	0.749
LIG_14-3-3_CanoR_1	772	776	PF00244	0.501
LIG_14-3-3_CanoR_1	795	800	PF00244	0.611
LIG_14-3-3_CanoR_1	82	91	PF00244	0.635
LIG_14-3-3_CanoR_1	904	909	PF00244	0.549
LIG_14-3-3_CanoR_1	941	945	PF00244	0.743
LIG_Actin_WH2_2	1069	1087	PF00022	0.527
LIG_APCC_ABBA_1	848	853	PF00400	0.472
LIG_BRCT_BRCA1_1	961	965	PF00533	0.650
LIG_Clathr_ClatBox_1	819	823	PF01394	0.458
LIG_EVH1_1	1037	1041	PF00568	0.538
LIG_EVH1_1	93	97	PF00568	0.618
LIG_FHA_1	1032	1038	PF00498	0.549
LIG_FHA_1	233	239	PF00498	0.642
LIG_FHA_1	251	257	PF00498	0.620
LIG_FHA_1	273	279	PF00498	0.638
LIG_FHA_1	588	594	PF00498	0.653
LIG_FHA_1	698	704	PF00498	0.537
LIG_FHA_1	722	728	PF00498	0.613
LIG_FHA_1	916	922	PF00498	0.588
LIG_FHA_2	298	304	PF00498	0.569
LIG_FHA_2	421	427	PF00498	0.607
LIG_FHA_2	558	564	PF00498	0.693
LIG_FHA_2	771	777	PF00498	0.577
LIG_GBD_Chelix_1	1076	1084	PF00786	0.524
LIG_GBD_Chelix_1	242	250	PF00786	0.633
LIG_Integrin_RGD_1	498	500	PF01839	0.673
LIG_LIR_Apic_2	1053	1058	PF02991	0.504
LIG_LIR_Apic_2	235	239	PF02991	0.585
LIG_LIR_Apic_2	435	441	PF02991	0.601
LIG_LIR_Apic_2	553	558	PF02991	0.664
LIG_LIR_Gen_1	275	285	PF02991	0.569
LIG_LIR_Gen_1	373	383	PF02991	0.576
LIG_LIR_Gen_1	691	699	PF02991	0.613
LIG_LIR_Gen_1	701	712	PF02991	0.458
LIG_LIR_Nem_3	275	280	PF02991	0.633
LIG_LIR_Nem_3	373	379	PF02991	0.580
LIG_LIR_Nem_3	602	607	PF02991	0.576
LIG_LIR_Nem_3	691	696	PF02991	0.548
LIG_MYND_1	254	258	PF01753	0.676
LIG_MYND_3	727	731	PF01753	0.650
LIG_NRBOX	1075	1081	PF00104	0.597
LIG_NRBOX	241	247	PF00104	0.623
LIG_NRBOX	374	380	PF00104	0.537
LIG_PCNA_yPIPBox_3	1070	1082	PF02747	0.549
LIG_Pex14_1	887	891	PF04695	0.461
LIG_SH2_CRK	236	240	PF00017	0.579
LIG_SH2_CRK	493	497	PF00017	0.693
LIG_SH2_CRK	546	550	PF00017	0.595
LIG_SH2_NCK_1	236	240	PF00017	0.579
LIG_SH2_SRC	236	239	PF00017	0.582
LIG_SH2_STAP1	234	238	PF00017	0.598
LIG_SH2_STAT3	851	854	PF00017	0.555
LIG_SH2_STAT5	234	237	PF00017	0.606
LIG_SH2_STAT5	249	252	PF00017	0.710
LIG_SH2_STAT5	851	854	PF00017	0.555
LIG_SH3_1	213	219	PF00018	0.676
LIG_SH3_1	252	258	PF00018	0.625
LIG_SH3_1	317	323	PF00018	0.655
LIG_SH3_1	538	544	PF00018	0.633
LIG_SH3_1	545	551	PF00018	0.618
LIG_SH3_2	320	325	PF14604	0.697
LIG_SH3_2	330	335	PF14604	0.586
LIG_SH3_2	930	935	PF14604	0.641
LIG_SH3_3	1032	1038	PF00018	0.661
LIG_SH3_3	13	19	PF00018	0.626
LIG_SH3_3	141	147	PF00018	0.577
LIG_SH3_3	213	219	PF00018	0.827
LIG_SH3_3	252	258	PF00018	0.630
LIG_SH3_3	262	268	PF00018	0.676
LIG_SH3_3	284	290	PF00018	0.541
LIG_SH3_3	316	322	PF00018	0.684
LIG_SH3_3	327	333	PF00018	0.587
LIG_SH3_3	406	412	PF00018	0.640
LIG_SH3_3	538	544	PF00018	0.684
LIG_SH3_3	545	551	PF00018	0.733
LIG_SH3_3	570	576	PF00018	0.751
LIG_SH3_3	588	594	PF00018	0.616
LIG_SH3_3	60	66	PF00018	0.691
LIG_SH3_3	645	651	PF00018	0.641
LIG_SH3_3	722	728	PF00018	0.688
LIG_SH3_3	797	803	PF00018	0.599
LIG_SH3_3	91	97	PF00018	0.626
LIG_SH3_3	926	932	PF00018	0.578
LIG_SH3_3	969	975	PF00018	0.663
LIG_SH3_3	977	983	PF00018	0.598
LIG_SH3_CIN85_PxpxPR_1	330	335	PF14604	0.638
LIG_SUMO_SIM_anti_2	38	45	PF11976	0.676
LIG_SUMO_SIM_anti_2	722	727	PF11976	0.632
LIG_SUMO_SIM_par_1	594	600	PF11976	0.535
LIG_SUMO_SIM_par_1	897	903	PF11976	0.492
LIG_TRAF2_1	37	40	PF00917	0.659
LIG_TRAF2_1	433	436	PF00917	0.614
LIG_TRAF2_1	522	525	PF00917	0.686
LIG_TRAF2_1	866	869	PF00917	0.650
LIG_WRC_WIRS_1	822	827	PF05994	0.471
LIG_WW_2	1038	1041	PF00397	0.621
LIG_WW_2	648	651	PF00397	0.573
LIG_WW_3	318	322	PF00397	0.688
LIG_WW_3	332	336	PF00397	0.546
LIG_WW_3	539	543	PF00397	0.623
LIG_WW_3	799	803	PF00397	0.603
MOD_CDC14_SPxK_1	295	298	PF00782	0.644
MOD_CDK_SPxK_1	292	298	PF00069	0.644
MOD_CDK_SPxK_1	437	443	PF00069	0.541
MOD_CDK_SPxxK_3	292	299	PF00069	0.647
MOD_CDK_SPxxK_3	310	317	PF00069	0.526
MOD_CDK_SPxxK_3	328	335	PF00069	0.528
MOD_CDK_SPxxK_3	756	763	PF00069	0.648
MOD_CK1_1	1031	1037	PF00069	0.599
MOD_CK1_1	122	128	PF00069	0.673
MOD_CK1_1	133	139	PF00069	0.578
MOD_CK1_1	15	21	PF00069	0.619
MOD_CK1_1	173	179	PF00069	0.630
MOD_CK1_1	27	33	PF00069	0.557
MOD_CK1_1	292	298	PF00069	0.693
MOD_CK1_1	328	334	PF00069	0.621
MOD_CK1_1	356	362	PF00069	0.648
MOD_CK1_1	446	452	PF00069	0.649
MOD_CK1_1	45	51	PF00069	0.569
MOD_CK1_1	462	468	PF00069	0.490
MOD_CK1_1	509	515	PF00069	0.634
MOD_CK1_1	614	620	PF00069	0.732
MOD_CK1_1	642	648	PF00069	0.705
MOD_CK1_1	667	673	PF00069	0.736
MOD_CK1_1	737	743	PF00069	0.659
MOD_CK1_1	753	759	PF00069	0.527
MOD_CK1_1	92	98	PF00069	0.617
MOD_CK1_1	985	991	PF00069	0.587
MOD_CK2_1	297	303	PF00069	0.600
MOD_CK2_1	420	426	PF00069	0.609
MOD_CK2_1	48	54	PF00069	0.643
MOD_CK2_1	557	563	PF00069	0.690
MOD_CK2_1	770	776	PF00069	0.636
MOD_CK2_1	84	90	PF00069	0.685
MOD_GlcNHglycan	1047	1050	PF01048	0.688
MOD_GlcNHglycan	156	159	PF01048	0.725
MOD_GlcNHglycan	160	163	PF01048	0.699
MOD_GlcNHglycan	207	210	PF01048	0.733
MOD_GlcNHglycan	314	317	PF01048	0.642
MOD_GlcNHglycan	336	339	PF01048	0.763
MOD_GlcNHglycan	355	358	PF01048	0.561
MOD_GlcNHglycan	385	389	PF01048	0.543
MOD_GlcNHglycan	44	47	PF01048	0.666
MOD_GlcNHglycan	508	511	PF01048	0.627
MOD_GlcNHglycan	613	616	PF01048	0.614
MOD_GlcNHglycan	635	638	PF01048	0.704
MOD_GlcNHglycan	654	657	PF01048	0.592
MOD_GlcNHglycan	755	758	PF01048	0.569
MOD_GlcNHglycan	84	87	PF01048	0.686
MOD_GlcNHglycan	891	894	PF01048	0.445
MOD_GlcNHglycan	984	987	PF01048	0.595
MOD_GSK3_1	1064	1071	PF00069	0.456
MOD_GSK3_1	115	122	PF00069	0.682
MOD_GSK3_1	124	131	PF00069	0.592
MOD_GSK3_1	154	161	PF00069	0.727
MOD_GSK3_1	250	257	PF00069	0.614
MOD_GSK3_1	272	279	PF00069	0.639
MOD_GSK3_1	285	292	PF00069	0.554
MOD_GSK3_1	308	315	PF00069	0.690
MOD_GSK3_1	324	331	PF00069	0.603
MOD_GSK3_1	352	359	PF00069	0.642
MOD_GSK3_1	44	51	PF00069	0.677
MOD_GSK3_1	442	449	PF00069	0.711
MOD_GSK3_1	455	462	PF00069	0.577
MOD_GSK3_1	610	617	PF00069	0.690
MOD_GSK3_1	628	635	PF00069	0.583
MOD_GSK3_1	664	671	PF00069	0.661
MOD_GSK3_1	733	740	PF00069	0.716
MOD_GSK3_1	746	753	PF00069	0.578
MOD_GSK3_1	80	87	PF00069	0.630
MOD_GSK3_1	821	828	PF00069	0.518
MOD_GSK3_1	900	907	PF00069	0.487
MOD_GSK3_1	955	962	PF00069	0.599
MOD_GSK3_1	990	997	PF00069	0.574
MOD_N-GLC_1	35	40	PF02516	0.608
MOD_N-GLC_1	809	814	PF02516	0.551
MOD_NEK2_1	148	153	PF00069	0.656
MOD_NEK2_1	224	229	PF00069	0.694
MOD_NEK2_1	324	329	PF00069	0.658
MOD_NEK2_1	392	397	PF00069	0.599
MOD_NEK2_1	625	630	PF00069	0.750
MOD_NEK2_1	750	755	PF00069	0.750
MOD_NEK2_1	770	775	PF00069	0.453
MOD_NEK2_1	821	826	PF00069	0.476
MOD_NEK2_1	889	894	PF00069	0.527
MOD_NEK2_1	900	905	PF00069	0.583
MOD_NEK2_1	965	970	PF00069	0.566
MOD_NEK2_2	734	739	PF00069	0.712
MOD_NEK2_2	764	769	PF00069	0.687
MOD_NEK2_2	933	938	PF00069	0.648
MOD_OFUCOSY	358	363	PF10250	0.663
MOD_PIKK_1	289	295	PF00454	0.661
MOD_PIKK_1	366	372	PF00454	0.592
MOD_PIKK_1	669	675	PF00454	0.639
MOD_PIKK_1	955	961	PF00454	0.608
MOD_PIKK_1	987	993	PF00454	0.572
MOD_PKA_1	611	617	PF00069	0.650
MOD_PKA_1	633	639	PF00069	0.579
MOD_PKA_2	116	122	PF00069	0.558
MOD_PKA_2	133	139	PF00069	0.529
MOD_PKA_2	224	230	PF00069	0.648
MOD_PKA_2	324	330	PF00069	0.669
MOD_PKA_2	334	340	PF00069	0.683
MOD_PKA_2	351	357	PF00069	0.513
MOD_PKA_2	610	616	PF00069	0.602
MOD_PKA_2	625	631	PF00069	0.763
MOD_PKA_2	632	638	PF00069	0.646
MOD_PKA_2	667	673	PF00069	0.647
MOD_PKA_2	74	80	PF00069	0.587
MOD_PKA_2	753	759	PF00069	0.582
MOD_PKA_2	771	777	PF00069	0.474
MOD_PKA_2	803	809	PF00069	0.635
MOD_PKA_2	940	946	PF00069	0.746
MOD_PKB_1	78	86	PF00069	0.676
MOD_PKB_1	793	801	PF00069	0.609
MOD_PKB_1	802	810	PF00069	0.520
MOD_Plk_1	173	179	PF00069	0.651
MOD_Plk_1	89	95	PF00069	0.686
MOD_Plk_4	241	247	PF00069	0.490
MOD_Plk_4	587	593	PF00069	0.620
MOD_Plk_4	706	712	PF00069	0.577
MOD_Plk_4	721	727	PF00069	0.475
MOD_Plk_4	815	821	PF00069	0.527
MOD_ProDKin_1	1054	1060	PF00069	0.505
MOD_ProDKin_1	12	18	PF00069	0.628
MOD_ProDKin_1	142	148	PF00069	0.639
MOD_ProDKin_1	215	221	PF00069	0.692
MOD_ProDKin_1	250	256	PF00069	0.619
MOD_ProDKin_1	292	298	PF00069	0.675
MOD_ProDKin_1	310	316	PF00069	0.564
MOD_ProDKin_1	326	332	PF00069	0.752
MOD_ProDKin_1	437	443	PF00069	0.661
MOD_ProDKin_1	49	55	PF00069	0.677
MOD_ProDKin_1	569	575	PF00069	0.675
MOD_ProDKin_1	585	591	PF00069	0.693
MOD_ProDKin_1	756	762	PF00069	0.595
MOD_ProDKin_1	915	921	PF00069	0.699
MOD_ProDKin_1	92	98	PF00069	0.617
MOD_ProDKin_1	968	974	PF00069	0.710
TRG_DiLeu_BaEn_1	1072	1077	PF01217	0.499
TRG_DiLeu_BaEn_2	425	431	PF01217	0.613
TRG_DiLeu_BaLyEn_6	591	596	PF01217	0.635
TRG_DiLeu_BaLyEn_6	792	797	PF01217	0.511
TRG_ENDOCYTIC_2	493	496	PF00928	0.674
TRG_ENDOCYTIC_2	546	549	PF00928	0.605
TRG_ENDOCYTIC_2	693	696	PF00928	0.562
TRG_ER_diArg_1	1073	1075	PF00400	0.555
TRG_ER_diArg_1	1089	1091	PF00400	0.504
TRG_ER_diArg_1	179	182	PF00400	0.686
TRG_ER_diArg_1	496	498	PF00400	0.621
TRG_ER_diArg_1	618	621	PF00400	0.609
TRG_ER_diArg_1	78	80	PF00400	0.671
TRG_ER_diArg_1	791	794	PF00400	0.502
TRG_ER_diArg_1	801	804	PF00400	0.571
TRG_ER_diArg_1	81	84	PF00400	0.642
TRG_NES_CRM1_1	701	716	PF08389	0.565
TRG_Pf-PMV_PEXEL_1	1074	1078	PF00026	0.598
TRG_Pf-PMV_PEXEL_1	1082	1086	PF00026	0.516
TRG_Pf-PMV_PEXEL_1	859	863	PF00026	0.666

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZU1	Leptomonas seymouri	32%	100%
A4H404	Leishmania braziliensis	64%	98%
A4HS66	Leishmania infantum	100%	100%
E9AK53	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	97%
Q9NED2	Leishmania major	89%	100%