Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania donovani

UniProt:

A0A3S7WNS4_LEIDO

TriTrypDb:

LdBPK_040580.1 , LdCL_040011300 , LDHU3_04.0780

Length:

267

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A0A3S7WNS4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WNS4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	53	57	PF00656	0.420
CLV_NRD_NRD_1	118	120	PF00675	0.496
CLV_NRD_NRD_1	162	164	PF00675	0.423
CLV_NRD_NRD_1	170	172	PF00675	0.447
CLV_NRD_NRD_1	19	21	PF00675	0.481
CLV_NRD_NRD_1	5	7	PF00675	0.531
CLV_NRD_NRD_1	66	68	PF00675	0.661
CLV_PCSK_KEX2_1	118	120	PF00082	0.496
CLV_PCSK_KEX2_1	162	164	PF00082	0.423
CLV_PCSK_KEX2_1	170	172	PF00082	0.447
CLV_PCSK_KEX2_1	19	21	PF00082	0.481
CLV_PCSK_KEX2_1	7	9	PF00082	0.477
CLV_PCSK_PC1ET2_1	7	9	PF00082	0.462
CLV_PCSK_SKI1_1	141	145	PF00082	0.472
DEG_Nend_UBRbox_1	1	4	PF02207	0.645
DOC_CKS1_1	9	14	PF01111	0.688
DOC_MAPK_gen_1	170	179	PF00069	0.659
DOC_MAPK_gen_1	19	26	PF00069	0.680
DOC_MAPK_gen_1	6	15	PF00069	0.667
DOC_MAPK_MEF2A_6	81	90	PF00069	0.413
DOC_PP1_RVXF_1	150	156	PF00149	0.645
DOC_PP2B_LxvP_1	13	16	PF13499	0.670
DOC_PP4_MxPP_1	206	209	PF00568	0.441
DOC_USP7_MATH_1	101	105	PF00917	0.437
DOC_USP7_MATH_1	107	111	PF00917	0.559
DOC_USP7_MATH_1	130	134	PF00917	0.654
DOC_USP7_MATH_1	260	264	PF00917	0.453
DOC_WW_Pin1_4	26	31	PF00397	0.604
DOC_WW_Pin1_4	8	13	PF00397	0.674
LIG_14-3-3_CanoR_1	235	241	PF00244	0.756
LIG_14-3-3_CanoR_1	261	265	PF00244	0.335
LIG_BRCT_BRCA1_1	21	25	PF00533	0.683
LIG_BRCT_BRCA1_1	41	45	PF00533	0.214
LIG_FHA_1	184	190	PF00498	0.492
LIG_FHA_1	8	14	PF00498	0.734
LIG_FHA_2	135	141	PF00498	0.707
LIG_FHA_2	26	32	PF00498	0.620
LIG_FHA_2	51	57	PF00498	0.434
LIG_IRF3_LxIS_1	82	89	PF10401	0.493
LIG_LIR_Gen_1	42	49	PF02991	0.453
LIG_LIR_Gen_1	89	97	PF02991	0.453
LIG_LIR_Nem_3	42	48	PF02991	0.453
LIG_LIR_Nem_3	89	93	PF02991	0.453
LIG_MLH1_MIPbox_1	41	45	PF16413	0.453
LIG_NRBOX	33	39	PF00104	0.358
LIG_SH2_CRK	202	206	PF00017	0.389
LIG_SH2_GRB2like	246	249	PF00017	0.325
LIG_SH2_PTP2	246	249	PF00017	0.335
LIG_SH2_STAP1	202	206	PF00017	0.389
LIG_SH2_STAT5	14	17	PF00017	0.620
LIG_SH2_STAT5	236	239	PF00017	0.657
LIG_SH2_STAT5	243	246	PF00017	0.580
LIG_SH2_STAT5	44	47	PF00017	0.453
LIG_SH3_1	6	12	PF00018	0.735
LIG_SH3_3	129	135	PF00018	0.681
LIG_SH3_3	15	21	PF00018	0.640
LIG_SH3_3	6	12	PF00018	0.675
LIG_SH3_3	79	85	PF00018	0.503
LIG_Sin3_3	253	260	PF02671	0.421
LIG_SUMO_SIM_anti_2	186	193	PF11976	0.360
LIG_SUMO_SIM_anti_2	254	259	PF11976	0.453
LIG_SUMO_SIM_anti_2	91	97	PF11976	0.358
LIG_SUMO_SIM_par_1	186	193	PF11976	0.344
LIG_SUMO_SIM_par_1	83	89	PF11976	0.493
MOD_CK1_1	75	81	PF00069	0.608
MOD_CK2_1	130	136	PF00069	0.707
MOD_CK2_1	25	31	PF00069	0.628
MOD_Cter_Amidation	65	68	PF01082	0.746
MOD_DYRK1A_RPxSP_1	8	12	PF00069	0.691
MOD_GlcNHglycan	34	37	PF01048	0.413
MOD_GSK3_1	130	137	PF00069	0.728
MOD_GSK3_1	190	197	PF00069	0.335
MOD_GSK3_1	47	54	PF00069	0.598
MOD_NEK2_1	25	30	PF00069	0.656
MOD_NEK2_1	39	44	PF00069	0.284
MOD_NEK2_2	236	241	PF00069	0.706
MOD_PK_1	19	25	PF00069	0.639
MOD_PKA_1	19	25	PF00069	0.685
MOD_PKA_1	7	13	PF00069	0.648
MOD_PKA_2	19	25	PF00069	0.616
MOD_PKA_2	260	266	PF00069	0.335
MOD_PKA_2	66	72	PF00069	0.465
MOD_PKA_2	7	13	PF00069	0.666
MOD_PKA_2	75	81	PF00069	0.497
MOD_PKB_1	70	78	PF00069	0.568
MOD_Plk_4	101	107	PF00069	0.514
MOD_Plk_4	19	25	PF00069	0.614
MOD_Plk_4	190	196	PF00069	0.275
MOD_Plk_4	200	206	PF00069	0.360
MOD_Plk_4	260	266	PF00069	0.320
MOD_Plk_4	44	50	PF00069	0.313
MOD_ProDKin_1	26	32	PF00069	0.597
MOD_ProDKin_1	8	14	PF00069	0.672
TRG_ENDOCYTIC_2	202	205	PF00928	0.405
TRG_ENDOCYTIC_2	246	249	PF00928	0.348
TRG_ER_diArg_1	118	120	PF00400	0.696
TRG_ER_diArg_1	18	20	PF00400	0.697
TRG_ER_diArg_1	6	9	PF00400	0.731
TRG_ER_diArg_1	70	73	PF00400	0.597
TRG_Pf-PMV_PEXEL_1	111	116	PF00026	0.406

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PB33	Leptomonas seymouri	52%	100%
A4H3X9	Leishmania braziliensis	74%	100%
A4HS54	Leishmania infantum	100%	100%
E9AK41	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q95Z83	Leishmania major	94%	100%