DUF1168-domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WNR8_LEIDO

TriTrypDb:

LdBPK_040600.1 , LdCL_040011500 , LDHU3_04.0800

Length:

167

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WNR8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WNR8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	133	137	PF00656	0.558
CLV_C14_Caspase3-7	156	160	PF00656	0.611
CLV_NRD_NRD_1	115	117	PF00675	0.669
CLV_NRD_NRD_1	94	96	PF00675	0.694
CLV_PCSK_FUR_1	113	117	PF00082	0.562
CLV_PCSK_KEX2_1	112	114	PF00082	0.681
CLV_PCSK_KEX2_1	115	117	PF00082	0.640
CLV_PCSK_KEX2_1	94	96	PF00082	0.692
CLV_PCSK_PC1ET2_1	112	114	PF00082	0.558
CLV_PCSK_SKI1_1	116	120	PF00082	0.573
DEG_SPOP_SBC_1	147	151	PF00917	0.688
DOC_CDC14_PxL_1	46	54	PF14671	0.638
DOC_CKS1_1	19	24	PF01111	0.618
DOC_USP7_MATH_1	147	151	PF00917	0.746
DOC_USP7_MATH_1	152	156	PF00917	0.686
DOC_USP7_UBL2_3	119	123	PF12436	0.689
DOC_WW_Pin1_4	18	23	PF00397	0.616
LIG_14-3-3_CanoR_1	41	47	PF00244	0.595
LIG_Actin_WH2_2	39	55	PF00022	0.745
LIG_APCC_ABBAyCdc20_2	94	100	PF00400	0.520
LIG_BIR_II_1	1	5	PF00653	0.792
LIG_CaM_IQ_9	105	121	PF13499	0.521
LIG_FHA_2	101	107	PF00498	0.436
LIG_FHA_2	19	25	PF00498	0.615
LIG_MYND_1	18	22	PF01753	0.627
LIG_PDZ_Class_3	162	167	PF00595	0.650
LIG_SH2_STAT5	39	42	PF00017	0.633
LIG_TRAF2_1	21	24	PF00917	0.720
MOD_CDK_SPxxK_3	18	25	PF00069	0.620
MOD_CK1_1	139	145	PF00069	0.740
MOD_CK1_1	146	152	PF00069	0.718
MOD_CK1_1	153	159	PF00069	0.625
MOD_CK1_1	2	8	PF00069	0.807
MOD_CK1_1	42	48	PF00069	0.469
MOD_CK2_1	100	106	PF00069	0.423
MOD_CK2_1	18	24	PF00069	0.623
MOD_GlcNHglycan	144	148	PF01048	0.740
MOD_GlcNHglycan	150	153	PF01048	0.646
MOD_GlcNHglycan	6	9	PF01048	0.756
MOD_GSK3_1	100	107	PF00069	0.424
MOD_GSK3_1	130	137	PF00069	0.633
MOD_GSK3_1	139	146	PF00069	0.716
MOD_GSK3_1	148	155	PF00069	0.600
MOD_GSK3_1	35	42	PF00069	0.441
MOD_GSK3_1	60	67	PF00069	0.616
MOD_NEK2_1	1	6	PF00069	0.790
MOD_NEK2_1	148	153	PF00069	0.611
MOD_NEK2_1	52	57	PF00069	0.670
MOD_PK_1	104	110	PF00069	0.516
MOD_PKA_1	111	117	PF00069	0.478
MOD_PKA_2	157	163	PF00069	0.615
MOD_PKA_2	52	58	PF00069	0.670
MOD_PKB_1	132	140	PF00069	0.547
MOD_Plk_4	35	41	PF00069	0.565
MOD_ProDKin_1	18	24	PF00069	0.611
TRG_DiLeu_BaLyEn_6	15	20	PF01217	0.490
TRG_ER_diArg_1	113	116	PF00400	0.675
TRG_ER_diArg_1	131	134	PF00400	0.392
TRG_ER_diArg_1	50	53	PF00400	0.651
TRG_NLS_Bipartite_1	94	116	PF00514	0.555
TRG_NLS_MonoExtC_3	110	115	PF00514	0.560
TRG_NLS_MonoExtC_3	118	123	PF00514	0.487
TRG_NLS_MonoExtN_4	111	116	PF00514	0.564
TRG_NLS_MonoExtN_4	119	126	PF00514	0.478

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4H443	Leishmania braziliensis	84%	100%
A4HS56	Leishmania infantum	99%	100%
E9AK43	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q9NEE1	Leishmania major	91%	100%