Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WNR7_LEIDO

TriTrypDb:

LdBPK_040480.1 , LdCL_040010300 , LDHU3_04.0640

Length:

323

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7WNR7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WNR7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	106	110	PF00656	0.710
CLV_C14_Caspase3-7	119	123	PF00656	0.469
CLV_C14_Caspase3-7	165	169	PF00656	0.758
CLV_C14_Caspase3-7	170	174	PF00656	0.678
CLV_NRD_NRD_1	14	16	PF00675	0.474
CLV_NRD_NRD_1	142	144	PF00675	0.587
CLV_NRD_NRD_1	192	194	PF00675	0.714
CLV_NRD_NRD_1	272	274	PF00675	0.640
CLV_NRD_NRD_1	310	312	PF00675	0.661
CLV_NRD_NRD_1	70	72	PF00675	0.676
CLV_PCSK_KEX2_1	14	16	PF00082	0.459
CLV_PCSK_KEX2_1	142	144	PF00082	0.587
CLV_PCSK_KEX2_1	192	194	PF00082	0.714
CLV_PCSK_KEX2_1	27	29	PF00082	0.440
CLV_PCSK_KEX2_1	54	56	PF00082	0.649
CLV_PCSK_PC1ET2_1	27	29	PF00082	0.455
CLV_PCSK_PC1ET2_1	54	56	PF00082	0.627
CLV_PCSK_SKI1_1	211	215	PF00082	0.772
CLV_PCSK_SKI1_1	91	95	PF00082	0.600
DEG_APCC_DBOX_1	78	86	PF00400	0.649
DEG_SPOP_SBC_1	230	234	PF00917	0.683
DOC_CYCLIN_RxL_1	28	39	PF00134	0.561
DOC_MAPK_gen_1	34	40	PF00069	0.492
DOC_PP2B_LxvP_1	95	98	PF13499	0.537
DOC_PP4_FxxP_1	58	61	PF00568	0.555
DOC_USP7_MATH_1	2	6	PF00917	0.511
DOC_USP7_MATH_1	217	221	PF00917	0.706
DOC_USP7_MATH_1	223	227	PF00917	0.724
DOC_USP7_MATH_1	230	234	PF00917	0.689
DOC_USP7_MATH_1	278	282	PF00917	0.573
DOC_USP7_MATH_1	317	321	PF00917	0.763
DOC_USP7_UBL2_3	199	203	PF12436	0.789
DOC_USP7_UBL2_3	289	293	PF12436	0.711
DOC_USP7_UBL2_3	308	312	PF12436	0.600
DOC_USP7_UBL2_3	318	322	PF12436	0.676
LIG_14-3-3_CanoR_1	301	309	PF00244	0.642
LIG_Actin_WH2_2	78	96	PF00022	0.572
LIG_BIR_II_1	1	5	PF00653	0.473
LIG_BIR_III_2	188	192	PF00653	0.684
LIG_FHA_1	21	27	PF00498	0.472
LIG_FHA_1	298	304	PF00498	0.588
LIG_FHA_1	88	94	PF00498	0.544
LIG_FHA_2	104	110	PF00498	0.565
LIG_FHA_2	131	137	PF00498	0.493
LIG_LIR_Apic_2	88	92	PF02991	0.517
LIG_LIR_Gen_1	115	126	PF02991	0.500
LIG_LIR_Gen_1	53	63	PF02991	0.520
LIG_LIR_Nem_3	115	121	PF02991	0.515
LIG_LIR_Nem_3	53	59	PF02991	0.524
LIG_NRP_CendR_1	322	323	PF00754	0.683
LIG_SH2_CRK	89	93	PF00017	0.628
LIG_SH2_NCK_1	118	122	PF00017	0.623
LIG_SH2_STAT5	182	185	PF00017	0.656
LIG_SH2_STAT5	89	92	PF00017	0.601
LIG_SH3_2	49	54	PF14604	0.633
LIG_SH3_3	105	111	PF00018	0.559
LIG_SH3_3	46	52	PF00018	0.613
LIG_TRAF2_1	145	148	PF00917	0.583
LIG_TRAF2_1	162	165	PF00917	0.518
LIG_TRAF2_1	245	248	PF00917	0.660
LIG_TRAF2_1	48	51	PF00917	0.626
LIG_TYR_ITIM	116	121	PF00017	0.633
MOD_CK1_1	225	231	PF00069	0.719
MOD_CK1_1	297	303	PF00069	0.743
MOD_CK1_1	4	10	PF00069	0.456
MOD_GlcNHglycan	150	154	PF01048	0.689
MOD_GlcNHglycan	170	173	PF01048	0.725
MOD_GlcNHglycan	200	203	PF01048	0.737
MOD_GlcNHglycan	217	220	PF01048	0.758
MOD_GlcNHglycan	280	283	PF01048	0.597
MOD_GlcNHglycan	297	300	PF01048	0.602
MOD_GlcNHglycan	304	307	PF01048	0.557
MOD_GlcNHglycan	44	47	PF01048	0.582
MOD_GSK3_1	217	224	PF00069	0.789
MOD_GSK3_1	225	232	PF00069	0.720
MOD_GSK3_1	297	304	PF00069	0.631
MOD_N-GLC_1	168	173	PF02516	0.627
MOD_N-GLC_1	318	323	PF02516	0.546
MOD_NEK2_1	1	6	PF00069	0.474
MOD_NEK2_1	294	299	PF00069	0.635
MOD_NEK2_1	36	41	PF00069	0.598
MOD_NEK2_2	22	27	PF00069	0.556
MOD_PK_1	204	210	PF00069	0.621
MOD_PKA_1	204	210	PF00069	0.646
MOD_PKA_2	191	197	PF00069	0.809
MOD_Plk_1	36	42	PF00069	0.574
MOD_Plk_4	112	118	PF00069	0.557
TRG_DiLeu_BaLyEn_6	27	32	PF01217	0.380
TRG_ENDOCYTIC_2	118	121	PF00928	0.631
TRG_ER_diArg_1	14	17	PF00400	0.474
TRG_ER_diArg_1	191	193	PF00400	0.690
TRG_ER_diArg_1	28	31	PF00400	0.407
TRG_NLS_Bipartite_1	10	31	PF00514	0.466
TRG_NLS_Bipartite_1	192	207	PF00514	0.788

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1II41	Leptomonas seymouri	62%	100%
A0A1X0NL53	Trypanosomatidae	39%	100%
A0A3R7MA57	Trypanosoma rangeli	44%	100%
A4H3W9	Leishmania braziliensis	80%	100%
A4HS44	Leishmania infantum	100%	100%
E9AK31	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
O97206	Leishmania major	89%	98%
V5B9E1	Trypanosoma cruzi	37%	100%