Zinc_finger_C3HC4_type_(RING_finger)_containing_p rotein_putative/Pfam:PF13920/Pfam:PF00097/Pfam:PF13923

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Zinc finger, C3HC4 type (RING finger), putative

Species:

Leishmania donovani

UniProt:

A0A3S7WNQ6_LEIDO

TriTrypDb:

LdBPK_040640.1 , LdCL_040012000 , LDHU3_04.0860

Length:

328

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A0A3S7WNQ6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WNQ6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004842	ubiquitin-protein transferase activity	4	7
GO:0016740	transferase activity	2	7
GO:0019787	ubiquitin-like protein transferase activity	3	7
GO:0061630	ubiquitin protein ligase activity	5	7
GO:0061659	ubiquitin-like protein ligase activity	4	7
GO:0140096	catalytic activity, acting on a protein	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	258	262	PF00656	0.439
CLV_NRD_NRD_1	167	169	PF00675	0.326
CLV_NRD_NRD_1	75	77	PF00675	0.523
CLV_PCSK_KEX2_1	167	169	PF00082	0.326
CLV_PCSK_KEX2_1	75	77	PF00082	0.523
CLV_PCSK_SKI1_1	223	227	PF00082	0.421
CLV_PCSK_SKI1_1	324	328	PF00082	0.671
DEG_Nend_UBRbox_2	1	3	PF02207	0.543
DOC_CYCLIN_yCln2_LP_2	180	186	PF00134	0.539
DOC_MAPK_DCC_7	49	57	PF00069	0.294
DOC_MAPK_MEF2A_6	229	237	PF00069	0.510
DOC_MAPK_MEF2A_6	49	57	PF00069	0.311
DOC_SPAK_OSR1_1	66	70	PF12202	0.383
DOC_USP7_MATH_1	105	109	PF00917	0.712
DOC_USP7_MATH_1	282	286	PF00917	0.383
DOC_USP7_MATH_1	35	39	PF00917	0.476
DOC_WW_Pin1_4	113	118	PF00397	0.701
LIG_14-3-3_CanoR_1	223	232	PF00244	0.655
LIG_14-3-3_CanoR_1	78	88	PF00244	0.648
LIG_Actin_WH2_2	208	225	PF00022	0.626
LIG_APCC_ABBA_1	68	73	PF00400	0.499
LIG_BRCT_BRCA1_1	319	323	PF00533	0.345
LIG_FHA_1	207	213	PF00498	0.650
LIG_FHA_1	255	261	PF00498	0.448
LIG_FHA_1	289	295	PF00498	0.383
LIG_FHA_1	312	318	PF00498	0.310
LIG_FHA_2	133	139	PF00498	0.522
LIG_LIR_Gen_1	245	253	PF02991	0.383
LIG_LIR_Gen_1	89	98	PF02991	0.634
LIG_LIR_Nem_3	163	169	PF02991	0.526
LIG_LIR_Nem_3	302	307	PF02991	0.608
LIG_LIR_Nem_3	320	326	PF02991	0.379
LIG_LIR_Nem_3	82	87	PF02991	0.762
LIG_LIR_Nem_3	89	93	PF02991	0.651
LIG_PDZ_Class_2	323	328	PF00595	0.409
LIG_Pex14_1	63	67	PF04695	0.383
LIG_SH2_CRK	166	170	PF00017	0.474
LIG_SH2_CRK	283	287	PF00017	0.345
LIG_SH2_GRB2like	16	19	PF00017	0.450
LIG_SH2_NCK_1	90	94	PF00017	0.633
LIG_SH2_STAP1	283	287	PF00017	0.400
LIG_SH2_STAP1	300	304	PF00017	0.534
LIG_SH2_STAT5	16	19	PF00017	0.474
LIG_SH2_STAT5	295	298	PF00017	0.534
LIG_SH2_STAT5	90	93	PF00017	0.545
LIG_SH3_3	134	140	PF00018	0.499
LIG_SH3_3	269	275	PF00018	0.485
LIG_SH3_3	47	53	PF00018	0.274
LIG_SH3_3	99	105	PF00018	0.661
LIG_SUMO_SIM_anti_2	194	200	PF11976	0.550
LIG_SUMO_SIM_par_1	290	296	PF11976	0.336
LIG_SUMO_SIM_par_1	305	310	PF11976	0.279
LIG_TRAF2_1	107	110	PF00917	0.720
LIG_TRFH_1	249	253	PF08558	0.561
LIG_UBA3_1	322	327	PF00899	0.505
MOD_CK1_1	189	195	PF00069	0.603
MOD_CK1_1	36	42	PF00069	0.418
MOD_CK2_1	104	110	PF00069	0.611
MOD_CK2_1	252	258	PF00069	0.457
MOD_CK2_1	86	92	PF00069	0.656
MOD_GlcNHglycan	162	165	PF01048	0.308
MOD_GlcNHglycan	276	279	PF01048	0.526
MOD_GlcNHglycan	319	322	PF01048	0.345
MOD_GlcNHglycan	38	41	PF01048	0.669
MOD_GSK3_1	100	107	PF00069	0.699
MOD_GSK3_1	17	24	PF00069	0.490
MOD_GSK3_1	206	213	PF00069	0.641
MOD_GSK3_1	307	314	PF00069	0.383
MOD_GSK3_1	35	42	PF00069	0.415
MOD_GSK3_1	79	86	PF00069	0.761
MOD_N-GLC_1	17	22	PF02516	0.633
MOD_NEK2_1	206	211	PF00069	0.678
MOD_NEK2_1	242	247	PF00069	0.310
MOD_NEK2_1	317	322	PF00069	0.311
MOD_PIKK_1	105	111	PF00454	0.742
MOD_PKA_1	210	216	PF00069	0.611
MOD_PKA_2	100	106	PF00069	0.667
MOD_PKB_1	221	229	PF00069	0.606
MOD_Plk_1	7	13	PF00069	0.498
MOD_Plk_4	132	138	PF00069	0.466
MOD_Plk_4	210	216	PF00069	0.614
MOD_Plk_4	242	248	PF00069	0.310
MOD_Plk_4	282	288	PF00069	0.328
MOD_Plk_4	307	313	PF00069	0.481
MOD_ProDKin_1	113	119	PF00069	0.699
MOD_SUMO_rev_2	320	328	PF00179	0.537
TRG_DiLeu_BaLyEn_6	226	231	PF01217	0.603
TRG_ENDOCYTIC_2	166	169	PF00928	0.474
TRG_ENDOCYTIC_2	249	252	PF00928	0.489
TRG_ENDOCYTIC_2	283	286	PF00928	0.345
TRG_ENDOCYTIC_2	90	93	PF00928	0.635
TRG_ER_diArg_1	166	168	PF00400	0.526
TRG_ER_diArg_1	220	223	PF00400	0.593
TRG_ER_diArg_1	4	7	PF00400	0.510
TRG_ER_diArg_1	75	78	PF00400	0.658
TRG_Pf-PMV_PEXEL_1	154	158	PF00026	0.299

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HRM4	Leptomonas seymouri	52%	100%
A4H3Y1	Leishmania braziliensis	78%	100%
A4HS60	Leishmania infantum	100%	100%
E9AK47	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	98%
Q9NED8	Leishmania major	96%	100%