Zinc_finger_C3HC4_type_(RING_finger)_containing_p rotein_putative/Pfam:PF13920/Pfam:PF00097/Pfam:PF13923

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Zinc finger, C3HC4 type (RING finger), putative

Species:

Leishmania donovani

UniProt:

A0A3S7WNQ6_LEIDO

TriTrypDb:

LdBPK_040640.1 , LdCL_040012000 , LDHU3_04.0860

Length:

328

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

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Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

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Expansion

Sequence features

A0A3S7WNQ6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WNQ6

Function

Could not find GO biological_process term for this entry.

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004842	ubiquitin-protein transferase activity	4	7
GO:0016740	transferase activity	2	7
GO:0019787	ubiquitin-like protein transferase activity	3	7
GO:0061630	ubiquitin protein ligase activity	5	7
GO:0061659	ubiquitin-like protein ligase activity	4	7
GO:0140096	catalytic activity, acting on a protein	2	7

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	258	262	PF00656	0.439
CLV_NRD_NRD_1	167	169	PF00675	0.326
CLV_NRD_NRD_1	75	77	PF00675	0.523
CLV_PCSK_KEX2_1	167	169	PF00082	0.326
CLV_PCSK_KEX2_1	75	77	PF00082	0.523
CLV_PCSK_SKI1_1	223	227	PF00082	0.421
CLV_PCSK_SKI1_1	324	328	PF00082	0.671
DEG_Nend_UBRbox_2	1	3	PF02207	0.543
DOC_CYCLIN_yCln2_LP_2	180	186	PF00134	0.539
DOC_MAPK_DCC_7	49	57	PF00069	0.294

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HRM4	Leptomonas seymouri	52%	100%
A4H3Y1	Leishmania braziliensis	78%	100%
A4HS60	Leishmania infantum	100%	100%
E9AK47	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	98%
Q9NED8	Leishmania major	96%	100%

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