C-type lectin domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania donovani

UniProt:

A0A3S7WNP1_LEIDO

TriTrypDb:

LdBPK_040370.1 , LdCL_040009200 , LDHU3_04.0480

Length:

242

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 6, no: 0
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A0A3S7WNP1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WNP1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	210	214	PF00656	0.677
CLV_C14_Caspase3-7	235	239	PF00656	0.677
CLV_NRD_NRD_1	183	185	PF00675	0.440
CLV_NRD_NRD_1	226	228	PF00675	0.604
CLV_NRD_NRD_1	83	85	PF00675	0.660
CLV_PCSK_KEX2_1	155	157	PF00082	0.653
CLV_PCSK_KEX2_1	183	185	PF00082	0.507
CLV_PCSK_KEX2_1	226	228	PF00082	0.604
CLV_PCSK_KEX2_1	83	85	PF00082	0.610
CLV_PCSK_PC1ET2_1	155	157	PF00082	0.653
CLV_PCSK_PC1ET2_1	183	185	PF00082	0.507
CLV_PCSK_SKI1_1	68	72	PF00082	0.611
DEG_SPOP_SBC_1	121	125	PF00917	0.397
DOC_MAPK_RevD_3	169	184	PF00069	0.416
DOC_PP2B_LxvP_1	21	24	PF13499	0.450
DOC_USP7_MATH_1	24	28	PF00917	0.411
DOC_USP7_MATH_1	73	77	PF00917	0.419
DOC_WW_Pin1_4	148	153	PF00397	0.570
DOC_WW_Pin1_4	45	50	PF00397	0.373
LIG_14-3-3_CanoR_1	83	88	PF00244	0.338
LIG_BIR_II_1	1	5	PF00653	0.508
LIG_BRCT_BRCA1_1	219	223	PF00533	0.652
LIG_BRCT_BRCA1_1	26	30	PF00533	0.344
LIG_deltaCOP1_diTrp_1	82	88	PF00928	0.449
LIG_FHA_1	172	178	PF00498	0.398
LIG_FHA_1	56	62	PF00498	0.364
LIG_FHA_1	84	90	PF00498	0.416
LIG_FHA_2	131	137	PF00498	0.471
LIG_LIR_Apic_2	148	153	PF02991	0.568
LIG_LIR_Gen_1	27	36	PF02991	0.379
LIG_LIR_Gen_1	82	90	PF02991	0.366
LIG_LIR_Nem_3	115	120	PF02991	0.345
LIG_LIR_Nem_3	133	138	PF02991	0.463
LIG_LIR_Nem_3	203	207	PF02991	0.713
LIG_LIR_Nem_3	27	33	PF02991	0.358
LIG_LIR_Nem_3	82	88	PF02991	0.443
LIG_LYPXL_yS_3	138	141	PF13949	0.442
LIG_SH2_CRK	150	154	PF00017	0.502
LIG_SH2_GRB2like	135	138	PF00017	0.476
LIG_SH2_GRB2like	144	147	PF00017	0.418
LIG_SH2_GRB2like	78	81	PF00017	0.447
LIG_SH2_NCK_1	150	154	PF00017	0.567
LIG_SH2_SRC	78	81	PF00017	0.447
LIG_SH2_STAP1	53	57	PF00017	0.473
LIG_SH2_STAT3	144	147	PF00017	0.440
LIG_SH2_STAT5	53	56	PF00017	0.361
LIG_SH2_STAT5	74	77	PF00017	0.383
LIG_SH2_STAT5	78	81	PF00017	0.276
LIG_SUMO_SIM_anti_2	161	167	PF11976	0.420
LIG_TYR_ITSM	113	120	PF00017	0.349
LIG_Vh1_VBS_1	164	182	PF01044	0.416
LIG_WRC_WIRS_1	30	35	PF05994	0.434
MOD_CDK_SPxxK_3	148	155	PF00069	0.569
MOD_CK1_1	14	20	PF00069	0.513
MOD_CK1_1	195	201	PF00069	0.726
MOD_CK1_1	203	209	PF00069	0.670
MOD_CK1_1	214	220	PF00069	0.624
MOD_CK1_1	221	227	PF00069	0.693
MOD_CK1_1	228	234	PF00069	0.711
MOD_CK2_1	228	234	PF00069	0.721
MOD_Cter_Amidation	153	156	PF01082	0.711
MOD_GlcNHglycan	130	133	PF01048	0.631
MOD_GlcNHglycan	16	19	PF01048	0.638
MOD_GlcNHglycan	230	233	PF01048	0.483
MOD_GlcNHglycan	75	78	PF01048	0.623
MOD_GSK3_1	100	107	PF00069	0.430
MOD_GSK3_1	108	115	PF00069	0.369
MOD_GSK3_1	192	199	PF00069	0.710
MOD_GSK3_1	203	210	PF00069	0.673
MOD_GSK3_1	214	221	PF00069	0.671
MOD_GSK3_1	222	229	PF00069	0.634
MOD_GSK3_1	230	237	PF00069	0.764
MOD_GSK3_1	24	31	PF00069	0.450
MOD_GSK3_1	40	47	PF00069	0.462
MOD_GSK3_1	51	58	PF00069	0.372
MOD_N-GLC_1	100	105	PF02516	0.564
MOD_N-GLC_1	145	150	PF02516	0.702
MOD_N-GLC_1	200	205	PF02516	0.500
MOD_N-GLC_1	214	219	PF02516	0.478
MOD_NEK2_1	11	16	PF00069	0.559
MOD_NEK2_1	222	227	PF00069	0.701
MOD_NEK2_1	99	104	PF00069	0.405
MOD_PIKK_1	100	106	PF00454	0.423
MOD_PIKK_1	232	238	PF00454	0.675
MOD_PIKK_1	40	46	PF00454	0.428
MOD_PKA_1	226	232	PF00069	0.801
MOD_PKA_1	68	74	PF00069	0.394
MOD_PKA_1	83	89	PF00069	0.388
MOD_PKA_2	225	231	PF00069	0.710
MOD_PKA_2	83	89	PF00069	0.332
MOD_Plk_1	100	106	PF00069	0.447
MOD_Plk_4	218	224	PF00069	0.744
MOD_ProDKin_1	148	154	PF00069	0.570
MOD_ProDKin_1	45	51	PF00069	0.369
MOD_SUMO_rev_2	66	71	PF00179	0.323
TRG_ENDOCYTIC_2	117	120	PF00928	0.321
TRG_ENDOCYTIC_2	138	141	PF00928	0.336
TRG_ER_diArg_1	83	85	PF00400	0.410
TRG_NLS_MonoExtC_3	182	188	PF00514	0.652

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBW5	Leptomonas seymouri	38%	83%
A4H3V9	Leishmania braziliensis	66%	100%
A4HS33	Leishmania infantum	99%	100%
E9AK20	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q9XZX6	Leishmania major	91%	100%