RNA helicase

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

RNA helicase

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WNN7_LEIDO

TriTrypDb:

LdBPK_040350.1 , LdCL_040009000 , LDHU3_04.0420

Length:

190

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7WNN7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WNN7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	27	31	PF00656	0.671
CLV_NRD_NRD_1	106	108	PF00675	0.495
CLV_NRD_NRD_1	180	182	PF00675	0.633
CLV_NRD_NRD_1	20	22	PF00675	0.609
CLV_NRD_NRD_1	91	93	PF00675	0.475
CLV_PCSK_KEX2_1	105	107	PF00082	0.490
CLV_PCSK_KEX2_1	11	13	PF00082	0.581
CLV_PCSK_KEX2_1	180	182	PF00082	0.653
CLV_PCSK_KEX2_1	91	93	PF00082	0.475
CLV_PCSK_PC1ET2_1	105	107	PF00082	0.557
CLV_PCSK_PC1ET2_1	11	13	PF00082	0.613
CLV_PCSK_PC1ET2_1	180	182	PF00082	0.653
CLV_PCSK_SKI1_1	11	15	PF00082	0.530
CLV_PCSK_SKI1_1	172	176	PF00082	0.705
CLV_PCSK_SKI1_1	22	26	PF00082	0.574
CLV_PCSK_SKI1_1	86	90	PF00082	0.506
CLV_PCSK_SKI1_1	91	95	PF00082	0.476
DOC_MAPK_gen_1	11	20	PF00069	0.543
DOC_PP2B_LxvP_1	3	6	PF13499	0.680
DOC_USP7_MATH_1	158	162	PF00917	0.731
DOC_USP7_UBL2_3	105	109	PF12436	0.628
DOC_USP7_UBL2_3	7	11	PF12436	0.572
DOC_WW_Pin1_4	123	128	PF00397	0.708
LIG_BIR_II_1	1	5	PF00653	0.649
LIG_BRCT_BRCA1_1	63	67	PF00533	0.566
LIG_FHA_1	80	86	PF00498	0.552
LIG_FHA_2	14	20	PF00498	0.629
LIG_FHA_2	92	98	PF00498	0.588
LIG_MAD2	163	171	PF02301	0.705
LIG_Pex14_2	174	178	PF04695	0.730
LIG_REV1ctd_RIR_1	172	181	PF16727	0.725
LIG_SH2_STAP1	37	41	PF00017	0.537
LIG_WRC_WIRS_1	80	85	PF05994	0.525
MOD_CDK_SPK_2	123	128	PF00069	0.708
MOD_CK2_1	13	19	PF00069	0.624
MOD_CK2_1	91	97	PF00069	0.588
MOD_GlcNHglycan	160	163	PF01048	0.717
MOD_GSK3_1	22	29	PF00069	0.685
MOD_NEK2_1	35	40	PF00069	0.576
MOD_NEK2_1	50	55	PF00069	0.615
MOD_PKA_1	91	97	PF00069	0.588
MOD_PKA_2	91	97	PF00069	0.544
MOD_ProDKin_1	123	129	PF00069	0.708
TRG_ER_diArg_1	90	92	PF00400	0.483
TRG_NLS_Bipartite_1	91	109	PF00514	0.598
TRG_NLS_MonoCore_2	104	109	PF00514	0.607
TRG_NLS_MonoCore_2	178	183	PF00514	0.659
TRG_NLS_MonoExtC_3	104	109	PF00514	0.635
TRG_NLS_MonoExtC_3	178	184	PF00514	0.657
TRG_NLS_MonoExtN_4	177	183	PF00514	0.607

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC96	Leptomonas seymouri	79%	99%
A0A0S4J1V1	Bodo saltans	52%	98%
A0A1X0NLC2	Trypanosomatidae	62%	100%
A0A3R7MRB1	Trypanosoma rangeli	58%	88%
A4HS31	Leishmania infantum	99%	100%
C9ZY23	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9AK18	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q9XZX5	Leishmania major	98%	100%