LeishMANIAdb
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Eukaryotic initiation factor 2a, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Eukaryotic initiation factor 2a, putative
Gene product:
eukaryotic translation initiation factor 2 subunit alpha
Species:
Leishmania donovani
UniProt:
A0A3S7WNN3_LEIDO
TriTrypDb:
LdBPK_030960.1 * , LdCL_030014900 , LDHU3_03.1070
Length:
413

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 3
Silverman et al. no yes: 0
Pissara et al. no yes: 16
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 6
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 6
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
TermNameLevelCount
GO:0005730 nucleolus 5 1
GO:0005737 cytoplasm 2 1
GO:0005850 eukaryotic translation initiation factor 2 complex 2 1
GO:0005851 eukaryotic translation initiation factor 2B complex 2 1
GO:0032991 protein-containing complex 1 1
GO:0033290 eukaryotic 48S preinitiation complex 4 1
GO:0043226 organelle 2 1
GO:0043228 non-membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043232 intracellular non-membrane-bounded organelle 4 1
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Expansion

Sequence features

A0A3S7WNN3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WNN3

Function

Biological processes
TermNameLevelCount
GO:0006413 translational initiation 3 1
GO:0006950 response to stress 2 1
GO:0007154 cell communication 2 1
GO:0008152 metabolic process 1 1
GO:0009267 cellular response to starvation 4 1
GO:0009605 response to external stimulus 2 1
GO:0009987 cellular process 1 1
GO:0009991 response to extracellular stimulus 3 1
GO:0010468 regulation of gene expression 5 1
GO:0010608 post-transcriptional regulation of gene expression 6 1
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Molecular functions
TermNameLevelCount
GO:0003676 nucleic acid binding 3 12
GO:0003723 RNA binding 4 12
GO:0003743 translation initiation factor activity 4 12
GO:0005488 binding 1 12
GO:0008135 translation factor activity, RNA binding 3 12
GO:0043021 ribonucleoprotein complex binding 3 1
GO:0043022 ribosome binding 4 1
GO:0044877 protein-containing complex binding 2 1
GO:0045182 translation regulator activity 1 12
GO:0090079 translation regulator activity, nucleic acid binding 2 12
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Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_NRD_NRD_1 168 170 PF00675 0.310
CLV_NRD_NRD_1 44 46 PF00675 0.451
CLV_PCSK_KEX2_1 100 102 PF00082 0.401
CLV_PCSK_KEX2_1 155 157 PF00082 0.310
CLV_PCSK_KEX2_1 167 169 PF00082 0.310
CLV_PCSK_KEX2_1 378 380 PF00082 0.437
CLV_PCSK_KEX2_1 44 46 PF00082 0.451
CLV_PCSK_PC1ET2_1 100 102 PF00082 0.401
CLV_PCSK_PC1ET2_1 155 157 PF00082 0.310
CLV_PCSK_PC1ET2_1 378 380 PF00082 0.408
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N0P537 Leptomonas seymouri 86% 100%
A0A0S4IW47 Bodo saltans 45% 100%
A0A1X0P943 Trypanosomatidae 62% 99%
A0A422NET9 Trypanosoma rangeli 60% 99%
A4H3R0 Leishmania braziliensis 95% 100%
A4HRY4 Leishmania infantum 100% 100%
C9ZKJ3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 61% 99%
E9ACP3 Leishmania major 99% 100%
E9AJY2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 99% 100%
P05198 Homo sapiens 31% 100%
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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS