WD_REPEATS_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WNM2_LEIDO

TriTrypDb:

LdBPK_020590.1 , LdCL_020011500 , LDHU3_02.0760

Length:

567

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7WNM2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WNM2

Function

Biological processes
Term	Name	Level	Count
GO:0006417	regulation of translation	6	1
GO:0006448	regulation of translational elongation	7	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009058	biosynthetic process	2	1
GO:0009889	regulation of biosynthetic process	4	1
GO:0009987	cellular process	1	1
GO:0010468	regulation of gene expression	5	1
GO:0010556	regulation of macromolecule biosynthetic process	5	1
GO:0010608	post-transcriptional regulation of gene expression	6	1
GO:0017182	peptidyl-diphthamide metabolic process	7	1
GO:0017183	peptidyl-diphthamide biosynthetic process from peptidyl-histidine	4	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018202	peptidyl-histidine modification	6	1
GO:0019222	regulation of metabolic process	3	1
GO:0019538	protein metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031326	regulation of cellular biosynthetic process	5	1
GO:0034248	regulation of amide metabolic process	5	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051246	regulation of protein metabolic process	5	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0071704	organic substance metabolic process	2	1
GO:0080090	regulation of primary metabolic process	4	1
GO:1900247	regulation of cytoplasmic translational elongation	8	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:2000112	obsolete regulation of cellular macromolecule biosynthetic process	6	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016787	hydrolase activity	2	1
GO:0016788	hydrolase activity, acting on ester bonds	3	1
GO:0052689	carboxylic ester hydrolase activity	4	1
GO:0061685	diphthine methylesterase activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	106	110	PF00656	0.762
CLV_C14_Caspase3-7	171	175	PF00656	0.554
CLV_C14_Caspase3-7	282	286	PF00656	0.753
CLV_C14_Caspase3-7	342	346	PF00656	0.492
CLV_C14_Caspase3-7	510	514	PF00656	0.483
CLV_C14_Caspase3-7	527	531	PF00656	0.393
CLV_NRD_NRD_1	145	147	PF00675	0.502
CLV_NRD_NRD_1	37	39	PF00675	0.350
CLV_NRD_NRD_1	374	376	PF00675	0.550
CLV_NRD_NRD_1	432	434	PF00675	0.481
CLV_NRD_NRD_1	553	555	PF00675	0.429
CLV_PCSK_KEX2_1	145	147	PF00082	0.502
CLV_PCSK_KEX2_1	37	39	PF00082	0.412
CLV_PCSK_KEX2_1	374	376	PF00082	0.438
CLV_PCSK_KEX2_1	432	434	PF00082	0.501
CLV_PCSK_KEX2_1	437	439	PF00082	0.718
CLV_PCSK_KEX2_1	553	555	PF00082	0.404
CLV_PCSK_PC1ET2_1	437	439	PF00082	0.734
CLV_PCSK_PC7_1	428	434	PF00082	0.441
CLV_PCSK_SKI1_1	241	245	PF00082	0.450
CLV_PCSK_SKI1_1	392	396	PF00082	0.513
CLV_PCSK_SKI1_1	80	84	PF00082	0.556
DEG_APCC_DBOX_1	79	87	PF00400	0.554
DEG_SCF_TRCP1_1	399	405	PF00400	0.624
DEG_SPOP_SBC_1	94	98	PF00917	0.560
DOC_CKS1_1	219	224	PF01111	0.336
DOC_CKS1_1	42	47	PF01111	0.426
DOC_CYCLIN_RxL_1	389	399	PF00134	0.510
DOC_MAPK_gen_1	389	397	PF00069	0.602
DOC_MAPK_gen_1	77	85	PF00069	0.556
DOC_MAPK_MEF2A_6	27	36	PF00069	0.504
DOC_MAPK_MEF2A_6	77	85	PF00069	0.496
DOC_PP2B_LxvP_1	456	459	PF13499	0.349
DOC_PP2B_LxvP_1	52	55	PF13499	0.522
DOC_USP7_MATH_1	295	299	PF00917	0.668
DOC_USP7_MATH_1	402	406	PF00917	0.682
DOC_USP7_MATH_1	410	414	PF00917	0.685
DOC_USP7_MATH_1	450	454	PF00917	0.626
DOC_USP7_MATH_1	494	498	PF00917	0.617
DOC_USP7_MATH_1	538	542	PF00917	0.562
DOC_USP7_MATH_1	546	550	PF00917	0.416
DOC_USP7_MATH_1	67	71	PF00917	0.729
DOC_USP7_MATH_1	95	99	PF00917	0.654
DOC_WW_Pin1_4	194	199	PF00397	0.548
DOC_WW_Pin1_4	218	223	PF00397	0.462
DOC_WW_Pin1_4	269	274	PF00397	0.627
DOC_WW_Pin1_4	335	340	PF00397	0.435
DOC_WW_Pin1_4	350	355	PF00397	0.480
DOC_WW_Pin1_4	41	46	PF00397	0.488
DOC_WW_Pin1_4	54	59	PF00397	0.492
LIG_14-3-3_CanoR_1	145	153	PF00244	0.551
LIG_14-3-3_CanoR_1	27	36	PF00244	0.573
LIG_14-3-3_CanoR_1	296	303	PF00244	0.519
LIG_14-3-3_CanoR_1	37	43	PF00244	0.467
LIG_14-3-3_CanoR_1	432	439	PF00244	0.600
LIG_14-3-3_CanoR_1	473	480	PF00244	0.540
LIG_14-3-3_CanoR_1	93	102	PF00244	0.498
LIG_Actin_WH2_2	79	95	PF00022	0.476
LIG_AP2alpha_2	192	194	PF02296	0.410
LIG_BIR_III_2	174	178	PF00653	0.356
LIG_BRCT_BRCA1_1	160	164	PF00533	0.506
LIG_eIF4E_1	219	225	PF01652	0.327
LIG_FHA_1	145	151	PF00498	0.546
LIG_FHA_1	164	170	PF00498	0.407
LIG_FHA_1	219	225	PF00498	0.535
LIG_FHA_1	228	234	PF00498	0.328
LIG_FHA_1	242	248	PF00498	0.419
LIG_FHA_1	255	261	PF00498	0.475
LIG_FHA_1	297	303	PF00498	0.553
LIG_FHA_1	336	342	PF00498	0.455
LIG_FHA_1	351	357	PF00498	0.350
LIG_FHA_1	450	456	PF00498	0.521
LIG_FHA_1	8	14	PF00498	0.546
LIG_FHA_2	4	10	PF00498	0.598
LIG_FHA_2	508	514	PF00498	0.551
LIG_FHA_2	534	540	PF00498	0.669
LIG_LIR_Gen_1	308	317	PF02991	0.487
LIG_LIR_Gen_1	353	361	PF02991	0.369
LIG_LIR_Nem_3	308	314	PF02991	0.484
LIG_LIR_Nem_3	353	358	PF02991	0.372
LIG_MLH1_MIPbox_1	160	164	PF16413	0.506
LIG_NRBOX	343	349	PF00104	0.379
LIG_NRBOX	419	425	PF00104	0.530
LIG_SH2_CRK	311	315	PF00017	0.485
LIG_SH2_NCK_1	125	129	PF00017	0.447
LIG_SH2_NCK_1	236	240	PF00017	0.456
LIG_SH2_SRC	234	237	PF00017	0.460
LIG_SH2_SRC	361	364	PF00017	0.387
LIG_SH2_STAP1	125	129	PF00017	0.447
LIG_SH2_STAP1	361	365	PF00017	0.337
LIG_SH2_STAP1	470	474	PF00017	0.523
LIG_SH2_STAP1	518	522	PF00017	0.361
LIG_SH2_STAP1	551	555	PF00017	0.498
LIG_SH2_STAP1	90	94	PF00017	0.465
LIG_SH2_STAT5	234	237	PF00017	0.392
LIG_SH2_STAT5	311	314	PF00017	0.486
LIG_SH2_STAT5	355	358	PF00017	0.393
LIG_SH2_STAT5	489	492	PF00017	0.418
LIG_SH3_2	270	275	PF14604	0.444
LIG_SH3_3	154	160	PF00018	0.448
LIG_SH3_3	17	23	PF00018	0.506
LIG_SH3_3	187	193	PF00018	0.511
LIG_SH3_3	196	202	PF00018	0.526
LIG_SH3_3	264	270	PF00018	0.583
LIG_SH3_3	39	45	PF00018	0.506
LIG_SH3_3	519	525	PF00018	0.471
LIG_SH3_3	52	58	PF00018	0.516
LIG_SH3_3	75	81	PF00018	0.710
LIG_SUMO_SIM_anti_2	362	369	PF11976	0.451
LIG_SUMO_SIM_anti_2	452	459	PF11976	0.501
LIG_SUMO_SIM_par_1	333	338	PF11976	0.422
LIG_SUMO_SIM_par_1	366	372	PF11976	0.505
LIG_TRAF2_1	475	478	PF00917	0.496
LIG_TRFH_1	194	198	PF08558	0.472
LIG_TYR_ITSM	351	358	PF00017	0.448
MOD_CDC14_SPxK_1	272	275	PF00782	0.450
MOD_CDK_SPK_2	41	46	PF00069	0.367
MOD_CDK_SPxK_1	269	275	PF00069	0.446
MOD_CK1_1	11	17	PF00069	0.624
MOD_CK1_1	158	164	PF00069	0.502
MOD_CK1_1	165	171	PF00069	0.593
MOD_CK1_1	227	233	PF00069	0.470
MOD_CK1_1	41	47	PF00069	0.422
MOD_CK1_1	444	450	PF00069	0.519
MOD_CK1_1	57	63	PF00069	0.560
MOD_CK1_1	66	72	PF00069	0.718
MOD_CK1_1	97	103	PF00069	0.573
MOD_CK2_1	234	240	PF00069	0.501
MOD_CK2_1	3	9	PF00069	0.631
MOD_CK2_1	357	363	PF00069	0.350
MOD_CK2_1	472	478	PF00069	0.496
MOD_CK2_1	494	500	PF00069	0.594
MOD_CK2_1	546	552	PF00069	0.472
MOD_GlcNHglycan	129	132	PF01048	0.572
MOD_GlcNHglycan	170	173	PF01048	0.591
MOD_GlcNHglycan	226	229	PF01048	0.491
MOD_GlcNHglycan	29	32	PF01048	0.616
MOD_GlcNHglycan	299	302	PF01048	0.437
MOD_GlcNHglycan	304	307	PF01048	0.309
MOD_GlcNHglycan	399	402	PF01048	0.664
MOD_GlcNHglycan	425	428	PF01048	0.577
MOD_GlcNHglycan	446	449	PF01048	0.542
MOD_GlcNHglycan	474	477	PF01048	0.562
MOD_GlcNHglycan	539	543	PF01048	0.581
MOD_GlcNHglycan	65	68	PF01048	0.719
MOD_GlcNHglycan	69	72	PF01048	0.736
MOD_GlcNHglycan	97	100	PF01048	0.734
MOD_GSK3_1	101	108	PF00069	0.657
MOD_GSK3_1	155	162	PF00069	0.483
MOD_GSK3_1	3	10	PF00069	0.619
MOD_GSK3_1	319	326	PF00069	0.590
MOD_GSK3_1	357	364	PF00069	0.363
MOD_GSK3_1	63	70	PF00069	0.741
MOD_GSK3_1	93	100	PF00069	0.579
MOD_N-GLC_1	418	423	PF02516	0.531
MOD_N-GLC_1	450	455	PF02516	0.562
MOD_NEK2_1	163	168	PF00069	0.543
MOD_NEK2_1	210	215	PF00069	0.410
MOD_NEK2_1	224	229	PF00069	0.449
MOD_NEK2_1	302	307	PF00069	0.470
MOD_NEK2_1	397	402	PF00069	0.616
MOD_NEK2_1	423	428	PF00069	0.552
MOD_NEK2_2	546	551	PF00069	0.471
MOD_OFUCOSY	12	18	PF10250	0.514
MOD_PIKK_1	241	247	PF00454	0.468
MOD_PK_1	38	44	PF00069	0.521
MOD_PKA_2	144	150	PF00069	0.559
MOD_PKA_2	295	301	PF00069	0.637
MOD_PKA_2	388	394	PF00069	0.391
MOD_PKA_2	431	437	PF00069	0.584
MOD_PKA_2	472	478	PF00069	0.539
MOD_Plk_1	137	143	PF00069	0.649
MOD_Plk_1	361	367	PF00069	0.463
MOD_Plk_1	418	424	PF00069	0.578
MOD_Plk_1	512	518	PF00069	0.455
MOD_Plk_1	8	14	PF00069	0.599
MOD_Plk_2-3	363	369	PF00069	0.479
MOD_Plk_4	159	165	PF00069	0.561
MOD_Plk_4	229	235	PF00069	0.367
MOD_Plk_4	418	424	PF00069	0.528
MOD_Plk_4	485	491	PF00069	0.519
MOD_Plk_4	512	518	PF00069	0.455
MOD_Plk_4	546	552	PF00069	0.370
MOD_ProDKin_1	194	200	PF00069	0.546
MOD_ProDKin_1	218	224	PF00069	0.453
MOD_ProDKin_1	269	275	PF00069	0.630
MOD_ProDKin_1	335	341	PF00069	0.438
MOD_ProDKin_1	350	356	PF00069	0.473
MOD_ProDKin_1	41	47	PF00069	0.484
MOD_ProDKin_1	54	60	PF00069	0.503
MOD_SUMO_rev_2	434	439	PF00179	0.585
TRG_DiLeu_BaEn_1	363	368	PF01217	0.368
TRG_ENDOCYTIC_2	125	128	PF00928	0.479
TRG_ENDOCYTIC_2	311	314	PF00928	0.486
TRG_ENDOCYTIC_2	355	358	PF00928	0.365
TRG_ER_diArg_1	327	330	PF00400	0.519
TRG_ER_diArg_1	36	38	PF00400	0.376
TRG_ER_diArg_1	373	375	PF00400	0.548
TRG_ER_diArg_1	553	555	PF00400	0.436
TRG_Pf-PMV_PEXEL_1	204	209	PF00026	0.507
TRG_PTS1	564	567	PF00515	0.466

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHU3	Leptomonas seymouri	50%	100%
A0A1X0NJL9	Trypanosomatidae	30%	100%
A0A3R7NH89	Trypanosoma rangeli	30%	100%
A4H3F3	Leishmania braziliensis	75%	100%
A4HRQ7	Leishmania infantum	99%	100%
C9ZJ47	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9ACD6	Leishmania major	90%	100%
E9AJM4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
V5BER3	Trypanosoma cruzi	29%	100%