Ankyrin repeats (Many copies)/Ankyrin repeats (3 copies)/Zinc finger, C3HC4 type (RING finger) containing protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ankyrin repeats (3 copies)/Zinc finger, C3HC4 type (RING finger), putative

Species:

Leishmania donovani

UniProt:

A0A3S7WNL7_LEIDO

TriTrypDb:

LdBPK_020120.1 , LdCL_020006400 , LDHU3_02.0200

Length:

895

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0051286	cell tip	3	1
GO:0060187	cell pole	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7WNL7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WNL7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	4
GO:0016740	transferase activity	2	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	185	189	PF00656	0.663
CLV_C14_Caspase3-7	368	372	PF00656	0.796
CLV_C14_Caspase3-7	686	690	PF00656	0.506
CLV_C14_Caspase3-7	803	807	PF00656	0.599
CLV_NRD_NRD_1	303	305	PF00675	0.691
CLV_NRD_NRD_1	445	447	PF00675	0.540
CLV_PCSK_KEX2_1	445	447	PF00082	0.542
CLV_PCSK_KEX2_1	532	534	PF00082	0.628
CLV_PCSK_PC1ET2_1	532	534	PF00082	0.628
CLV_PCSK_SKI1_1	343	347	PF00082	0.522
CLV_PCSK_SKI1_1	527	531	PF00082	0.628
CLV_PCSK_SKI1_1	758	762	PF00082	0.613
CLV_PCSK_SKI1_1	850	854	PF00082	0.430
CLV_Separin_Metazoa	103	107	PF03568	0.451
CLV_Separin_Metazoa	731	735	PF03568	0.550
DEG_APCC_DBOX_1	45	53	PF00400	0.499
DEG_Kelch_Keap1_1	722	727	PF01344	0.568
DEG_Nend_UBRbox_2	1	3	PF02207	0.528
DEG_ODPH_VHL_1	75	88	PF01847	0.474
DEG_SPOP_SBC_1	800	804	PF00917	0.724
DOC_ANK_TNKS_1	3	10	PF00023	0.514
DOC_CDC14_PxL_1	481	489	PF14671	0.442
DOC_CKS1_1	105	110	PF01111	0.563
DOC_CKS1_1	243	248	PF01111	0.572
DOC_CKS1_1	297	302	PF01111	0.723
DOC_CKS1_1	355	360	PF01111	0.449
DOC_CYCLIN_yCln2_LP_2	297	303	PF00134	0.697
DOC_MAPK_DCC_7	479	489	PF00069	0.501
DOC_MAPK_gen_1	428	435	PF00069	0.542
DOC_MAPK_gen_1	561	570	PF00069	0.590
DOC_PP1_SILK_1	95	100	PF00149	0.441
DOC_PP2B_LxvP_1	487	490	PF13499	0.498
DOC_PP2B_LxvP_1	579	582	PF13499	0.668
DOC_PP4_FxxP_1	401	404	PF00568	0.717
DOC_PP4_FxxP_1	809	812	PF00568	0.766
DOC_PP4_FxxP_1	878	881	PF00568	0.430
DOC_USP7_MATH_1	209	213	PF00917	0.695
DOC_USP7_MATH_1	288	292	PF00917	0.639
DOC_USP7_MATH_1	369	373	PF00917	0.714
DOC_USP7_MATH_1	382	386	PF00917	0.726
DOC_USP7_MATH_1	407	411	PF00917	0.717
DOC_USP7_MATH_1	490	494	PF00917	0.535
DOC_USP7_MATH_1	500	504	PF00917	0.591
DOC_USP7_MATH_1	531	535	PF00917	0.703
DOC_USP7_MATH_1	703	707	PF00917	0.684
DOC_USP7_MATH_1	742	746	PF00917	0.570
DOC_USP7_MATH_1	831	835	PF00917	0.720
DOC_WW_Pin1_4	104	109	PF00397	0.469
DOC_WW_Pin1_4	205	210	PF00397	0.611
DOC_WW_Pin1_4	242	247	PF00397	0.618
DOC_WW_Pin1_4	296	301	PF00397	0.749
DOC_WW_Pin1_4	354	359	PF00397	0.454
DOC_WW_Pin1_4	411	416	PF00397	0.804
DOC_WW_Pin1_4	591	596	PF00397	0.767
DOC_WW_Pin1_4	608	613	PF00397	0.576
DOC_WW_Pin1_4	643	648	PF00397	0.600
DOC_WW_Pin1_4	679	684	PF00397	0.646
DOC_WW_Pin1_4	772	777	PF00397	0.791
DOC_WW_Pin1_4	808	813	PF00397	0.733
LIG_14-3-3_CanoR_1	125	135	PF00244	0.490
LIG_14-3-3_CanoR_1	250	256	PF00244	0.548
LIG_14-3-3_CanoR_1	408	415	PF00244	0.600
LIG_14-3-3_CanoR_1	585	595	PF00244	0.723
LIG_14-3-3_CanoR_1	734	740	PF00244	0.572
LIG_14-3-3_CanoR_1	833	841	PF00244	0.468
LIG_14-3-3_CanoR_1	868	877	PF00244	0.387
LIG_Actin_WH2_2	742	760	PF00022	0.535
LIG_APCC_ABBA_1	568	573	PF00400	0.548
LIG_BRCT_BRCA1_1	177	181	PF00533	0.643
LIG_BRCT_BRCA1_1	290	294	PF00533	0.724
LIG_BRCT_BRCA1_1	492	496	PF00533	0.548
LIG_BRCT_BRCA1_2	177	183	PF00533	0.599
LIG_CtBP_PxDLS_1	223	227	PF00389	0.658
LIG_EH1_1	339	347	PF00400	0.515
LIG_FHA_1	219	225	PF00498	0.635
LIG_FHA_1	355	361	PF00498	0.447
LIG_FHA_1	468	474	PF00498	0.588
LIG_FHA_1	624	630	PF00498	0.684
LIG_FHA_1	683	689	PF00498	0.613
LIG_FHA_1	723	729	PF00498	0.567
LIG_FHA_1	800	806	PF00498	0.685
LIG_FHA_1	9	15	PF00498	0.520
LIG_FHA_1	90	96	PF00498	0.498
LIG_FHA_2	105	111	PF00498	0.483
LIG_FHA_2	183	189	PF00498	0.654
LIG_FHA_2	243	249	PF00498	0.573
LIG_FHA_2	684	690	PF00498	0.493
LIG_Integrin_RGD_1	233	235	PF01839	0.597
LIG_LIR_Apic_2	353	358	PF02991	0.522
LIG_LIR_Apic_2	448	452	PF02991	0.507
LIG_LIR_Apic_2	491	497	PF02991	0.585
LIG_LIR_Apic_2	806	812	PF02991	0.755
LIG_LIR_Apic_2	875	881	PF02991	0.430
LIG_LIR_Gen_1	178	186	PF02991	0.642
LIG_LIR_Gen_1	192	203	PF02991	0.689
LIG_LIR_Gen_1	291	301	PF02991	0.730
LIG_LIR_Gen_1	35	45	PF02991	0.448
LIG_LIR_Gen_1	463	473	PF02991	0.532
LIG_LIR_Gen_1	727	735	PF02991	0.649
LIG_LIR_Gen_1	745	753	PF02991	0.446
LIG_LIR_Nem_3	178	184	PF02991	0.643
LIG_LIR_Nem_3	192	198	PF02991	0.688
LIG_LIR_Nem_3	241	247	PF02991	0.676
LIG_LIR_Nem_3	291	297	PF02991	0.758
LIG_LIR_Nem_3	329	334	PF02991	0.462
LIG_LIR_Nem_3	35	41	PF02991	0.433
LIG_LIR_Nem_3	353	359	PF02991	0.544
LIG_LIR_Nem_3	463	469	PF02991	0.513
LIG_LIR_Nem_3	727	732	PF02991	0.650
LIG_LIR_Nem_3	745	750	PF02991	0.425
LIG_LIR_Nem_3	835	841	PF02991	0.472
LIG_PCNA_yPIPBox_3	622	635	PF02747	0.532
LIG_PDZ_Class_2	890	895	PF00595	0.573
LIG_SH2_CRK	356	360	PF00017	0.430
LIG_SH2_CRK	38	42	PF00017	0.444
LIG_SH2_CRK	466	470	PF00017	0.494
LIG_SH2_CRK	494	498	PF00017	0.593
LIG_SH2_CRK	668	672	PF00017	0.544
LIG_SH2_CRK	747	751	PF00017	0.521
LIG_SH2_NCK_1	38	42	PF00017	0.492
LIG_SH2_NCK_1	668	672	PF00017	0.616
LIG_SH2_PTP2	449	452	PF00017	0.492
LIG_SH2_PTP2	567	570	PF00017	0.521
LIG_SH2_SRC	307	310	PF00017	0.606
LIG_SH2_SRC	449	452	PF00017	0.492
LIG_SH2_SRC	557	560	PF00017	0.592
LIG_SH2_SRC	567	570	PF00017	0.485
LIG_SH2_STAP1	587	591	PF00017	0.735
LIG_SH2_STAP1	747	751	PF00017	0.521
LIG_SH2_STAT3	841	844	PF00017	0.430
LIG_SH2_STAT5	100	103	PF00017	0.493
LIG_SH2_STAT5	333	336	PF00017	0.510
LIG_SH2_STAT5	348	351	PF00017	0.364
LIG_SH2_STAT5	356	359	PF00017	0.481
LIG_SH2_STAT5	38	41	PF00017	0.437
LIG_SH2_STAT5	424	427	PF00017	0.685
LIG_SH2_STAT5	449	452	PF00017	0.492
LIG_SH2_STAT5	472	475	PF00017	0.509
LIG_SH2_STAT5	557	560	PF00017	0.598
LIG_SH2_STAT5	567	570	PF00017	0.467
LIG_SH2_STAT5	59	62	PF00017	0.451
LIG_SH2_STAT5	675	678	PF00017	0.476
LIG_SH2_STAT5	838	841	PF00017	0.438
LIG_SH3_1	494	500	PF00018	0.585
LIG_SH3_2	300	305	PF14604	0.680
LIG_SH3_2	845	850	PF14604	0.385
LIG_SH3_3	22	28	PF00018	0.501
LIG_SH3_3	240	246	PF00018	0.714
LIG_SH3_3	297	303	PF00018	0.683
LIG_SH3_3	360	366	PF00018	0.615
LIG_SH3_3	392	398	PF00018	0.616
LIG_SH3_3	494	500	PF00018	0.585
LIG_SH3_3	71	77	PF00018	0.450
LIG_SH3_3	842	848	PF00018	0.429
LIG_SUMO_SIM_par_1	221	228	PF11976	0.600
LIG_SUMO_SIM_par_1	357	362	PF11976	0.441
LIG_SUMO_SIM_par_1	485	493	PF11976	0.553
LIG_TRAF2_1	778	781	PF00917	0.777
LIG_TYR_ITIM	354	359	PF00017	0.454
LIG_TYR_ITIM	36	41	PF00017	0.483
LIG_TYR_ITIM	565	570	PF00017	0.517
LIG_WRC_WIRS_1	761	766	PF05994	0.553
LIG_WW_1	261	264	PF00397	0.520
LIG_WW_3	670	674	PF00397	0.478
MOD_CDC14_SPxK_1	646	649	PF00782	0.649
MOD_CDK_SPxK_1	296	302	PF00069	0.747
MOD_CDK_SPxK_1	643	649	PF00069	0.613
MOD_CDK_SPxxK_3	772	779	PF00069	0.721
MOD_CK1_1	144	150	PF00069	0.611
MOD_CK1_1	196	202	PF00069	0.643
MOD_CK1_1	225	231	PF00069	0.697
MOD_CK1_1	236	242	PF00069	0.587
MOD_CK1_1	251	257	PF00069	0.614
MOD_CK1_1	272	278	PF00069	0.713
MOD_CK1_1	29	35	PF00069	0.455
MOD_CK1_1	410	416	PF00069	0.775
MOD_CK1_1	44	50	PF00069	0.409
MOD_CK1_1	507	513	PF00069	0.729
MOD_CK1_1	611	617	PF00069	0.669
MOD_CK1_1	682	688	PF00069	0.583
MOD_CK1_1	706	712	PF00069	0.676
MOD_CK1_1	736	742	PF00069	0.550
MOD_CK1_1	772	778	PF00069	0.611
MOD_CK1_1	784	790	PF00069	0.618
MOD_CK1_1	811	817	PF00069	0.734
MOD_CK1_1	821	827	PF00069	0.654
MOD_CK2_1	205	211	PF00069	0.564
MOD_GlcNHglycan	143	146	PF01048	0.629
MOD_GlcNHglycan	168	171	PF01048	0.657
MOD_GlcNHglycan	177	180	PF01048	0.694
MOD_GlcNHglycan	211	214	PF01048	0.772
MOD_GlcNHglycan	238	241	PF01048	0.740
MOD_GlcNHglycan	250	253	PF01048	0.805
MOD_GlcNHglycan	270	274	PF01048	0.778
MOD_GlcNHglycan	290	293	PF01048	0.826
MOD_GlcNHglycan	367	370	PF01048	0.718
MOD_GlcNHglycan	377	380	PF01048	0.716
MOD_GlcNHglycan	384	387	PF01048	0.637
MOD_GlcNHglycan	453	456	PF01048	0.542
MOD_GlcNHglycan	507	510	PF01048	0.751
MOD_GlcNHglycan	533	536	PF01048	0.621
MOD_GlcNHglycan	603	606	PF01048	0.698
MOD_GlcNHglycan	613	616	PF01048	0.690
MOD_GlcNHglycan	692	695	PF01048	0.672
MOD_GlcNHglycan	705	708	PF01048	0.559
MOD_GlcNHglycan	742	745	PF01048	0.637
MOD_GlcNHglycan	771	774	PF01048	0.648
MOD_GlcNHglycan	784	787	PF01048	0.828
MOD_GlcNHglycan	820	823	PF01048	0.723
MOD_GlcNHglycan	826	830	PF01048	0.710
MOD_GlcNHglycan	835	838	PF01048	0.388
MOD_GSK3_1	126	133	PF00069	0.588
MOD_GSK3_1	137	144	PF00069	0.493
MOD_GSK3_1	182	189	PF00069	0.628
MOD_GSK3_1	205	212	PF00069	0.587
MOD_GSK3_1	218	225	PF00069	0.580
MOD_GSK3_1	234	241	PF00069	0.836
MOD_GSK3_1	272	279	PF00069	0.650
MOD_GSK3_1	288	295	PF00069	0.768
MOD_GSK3_1	32	39	PF00069	0.446
MOD_GSK3_1	346	353	PF00069	0.536
MOD_GSK3_1	365	372	PF00069	0.744
MOD_GSK3_1	407	414	PF00069	0.708
MOD_GSK3_1	44	51	PF00069	0.498
MOD_GSK3_1	500	507	PF00069	0.664
MOD_GSK3_1	54	61	PF00069	0.409
MOD_GSK3_1	587	594	PF00069	0.728
MOD_GSK3_1	601	608	PF00069	0.712
MOD_GSK3_1	679	686	PF00069	0.516
MOD_GSK3_1	702	709	PF00069	0.769
MOD_GSK3_1	736	743	PF00069	0.600
MOD_GSK3_1	760	767	PF00069	0.543
MOD_GSK3_1	821	828	PF00069	0.798
MOD_N-GLC_1	32	37	PF02516	0.506
MOD_N-GLC_1	500	505	PF02516	0.594
MOD_N-GLC_1	740	745	PF02516	0.503
MOD_NEK2_1	158	163	PF00069	0.690
MOD_NEK2_1	166	171	PF00069	0.604
MOD_NEK2_1	224	229	PF00069	0.629
MOD_NEK2_1	36	41	PF00069	0.427
MOD_NEK2_1	441	446	PF00069	0.495
MOD_NEK2_1	505	510	PF00069	0.747
MOD_NEK2_1	764	769	PF00069	0.527
MOD_NEK2_1	813	818	PF00069	0.677
MOD_NEK2_1	88	93	PF00069	0.475
MOD_NEK2_2	350	355	PF00069	0.609
MOD_NEK2_2	54	59	PF00069	0.532
MOD_NEK2_2	742	747	PF00069	0.565
MOD_PIKK_1	225	231	PF00454	0.781
MOD_PIKK_1	407	413	PF00454	0.731
MOD_PIKK_1	500	506	PF00454	0.704
MOD_PIKK_1	623	629	PF00454	0.669
MOD_PIKK_1	733	739	PF00454	0.578
MOD_PIKK_1	811	817	PF00454	0.694
MOD_PKA_2	215	221	PF00069	0.749
MOD_PKA_2	350	356	PF00069	0.569
MOD_PKA_2	407	413	PF00069	0.749
MOD_PKA_2	722	728	PF00069	0.640
MOD_PKA_2	733	739	PF00069	0.472
MOD_PKA_2	832	838	PF00069	0.645
MOD_Plk_1	32	38	PF00069	0.506
MOD_Plk_1	500	506	PF00069	0.632
MOD_Plk_1	545	551	PF00069	0.591
MOD_Plk_2-3	8	14	PF00069	0.545
MOD_Plk_4	130	136	PF00069	0.455
MOD_Plk_4	251	257	PF00069	0.587
MOD_Plk_4	32	38	PF00069	0.455
MOD_Plk_4	350	356	PF00069	0.610
MOD_Plk_4	683	689	PF00069	0.580
MOD_Plk_4	742	748	PF00069	0.511
MOD_Plk_4	764	770	PF00069	0.537
MOD_ProDKin_1	104	110	PF00069	0.473
MOD_ProDKin_1	205	211	PF00069	0.615
MOD_ProDKin_1	242	248	PF00069	0.619
MOD_ProDKin_1	296	302	PF00069	0.747
MOD_ProDKin_1	354	360	PF00069	0.454
MOD_ProDKin_1	411	417	PF00069	0.797
MOD_ProDKin_1	591	597	PF00069	0.762
MOD_ProDKin_1	608	614	PF00069	0.577
MOD_ProDKin_1	643	649	PF00069	0.613
MOD_ProDKin_1	679	685	PF00069	0.646
MOD_ProDKin_1	772	778	PF00069	0.796
MOD_ProDKin_1	808	814	PF00069	0.733
MOD_SUMO_rev_2	2	11	PF00179	0.463
MOD_SUMO_rev_2	572	577	PF00179	0.636
MOD_SUMO_rev_2	68	72	PF00179	0.475
TRG_DiLeu_BaLyEn_6	483	488	PF01217	0.519
TRG_ENDOCYTIC_2	356	359	PF00928	0.429
TRG_ENDOCYTIC_2	38	41	PF00928	0.437
TRG_ENDOCYTIC_2	466	469	PF00928	0.499
TRG_ENDOCYTIC_2	567	570	PF00928	0.521
TRG_ENDOCYTIC_2	747	750	PF00928	0.517
TRG_ER_diArg_1	301	304	PF00400	0.710
TRG_NES_CRM1_1	467	482	PF08389	0.515
TRG_Pf-PMV_PEXEL_1	64	68	PF00026	0.458
TRG_Pf-PMV_PEXEL_1	640	644	PF00026	0.398
TRG_Pf-PMV_PEXEL_1	850	854	PF00026	0.430
TRG_Pf-PMV_PEXEL_1	99	103	PF00026	0.499

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PB49	Leptomonas seymouri	53%	100%
A0A3R7M1K8	Trypanosoma rangeli	28%	100%
A4H3A8	Leishmania braziliensis	67%	99%
A4HRL7	Leishmania infantum	100%	100%
E9AC88	Leishmania major	90%	100%
E9AJI1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%