Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WNL4_LEIDO

TriTrypDb:

LdBPK_010820.1 , LdCL_010013300 , LDHU3_01.0930

Length:

490

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WNL4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WNL4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	274	278	PF00656	0.614
CLV_C14_Caspase3-7	399	403	PF00656	0.559
CLV_NRD_NRD_1	135	137	PF00675	0.560
CLV_NRD_NRD_1	298	300	PF00675	0.459
CLV_NRD_NRD_1	471	473	PF00675	0.615
CLV_NRD_NRD_1	72	74	PF00675	0.672
CLV_NRD_NRD_1	86	88	PF00675	0.510
CLV_PCSK_FUR_1	296	300	PF00082	0.453
CLV_PCSK_KEX2_1	135	137	PF00082	0.586
CLV_PCSK_KEX2_1	146	148	PF00082	0.428
CLV_PCSK_KEX2_1	298	300	PF00082	0.459
CLV_PCSK_KEX2_1	478	480	PF00082	0.592
CLV_PCSK_KEX2_1	72	74	PF00082	0.672
CLV_PCSK_KEX2_1	86	88	PF00082	0.510
CLV_PCSK_PC1ET2_1	146	148	PF00082	0.472
CLV_PCSK_PC1ET2_1	478	480	PF00082	0.609
CLV_PCSK_SKI1_1	102	106	PF00082	0.565
CLV_PCSK_SKI1_1	146	150	PF00082	0.432
CLV_PCSK_SKI1_1	268	272	PF00082	0.643
CLV_PCSK_SKI1_1	418	422	PF00082	0.688
DEG_APCC_DBOX_1	53	61	PF00400	0.556
DEG_Nend_Nbox_1	1	3	PF02207	0.510
DEG_ODPH_VHL_1	57	68	PF01847	0.630
DEG_SCF_FBW7_1	123	129	PF00400	0.600
DOC_CKS1_1	123	128	PF01111	0.599
DOC_MAPK_DCC_7	54	62	PF00069	0.603
DOC_MAPK_gen_1	158	166	PF00069	0.458
DOC_MAPK_gen_1	304	312	PF00069	0.487
DOC_MAPK_gen_1	54	62	PF00069	0.603
DOC_MAPK_JIP1_4	299	305	PF00069	0.447
DOC_MAPK_MEF2A_6	23	32	PF00069	0.500
DOC_MAPK_NFAT4_5	23	31	PF00069	0.502
DOC_MAPK_RevD_3	457	473	PF00069	0.567
DOC_PP1_RVXF_1	282	289	PF00149	0.411
DOC_PP1_RVXF_1	311	318	PF00149	0.496
DOC_PP2B_LxvP_1	105	108	PF13499	0.595
DOC_PP2B_LxvP_1	28	31	PF13499	0.562
DOC_PP2B_LxvP_1	411	414	PF13499	0.566
DOC_USP7_MATH_1	117	121	PF00917	0.625
DOC_USP7_MATH_1	126	130	PF00917	0.556
DOC_USP7_MATH_1	167	171	PF00917	0.452
DOC_USP7_MATH_1	217	221	PF00917	0.620
DOC_USP7_MATH_1	273	277	PF00917	0.649
DOC_USP7_MATH_1	33	37	PF00917	0.601
DOC_USP7_MATH_1	360	364	PF00917	0.476
DOC_USP7_MATH_1	453	457	PF00917	0.656
DOC_USP7_UBL2_3	392	396	PF12436	0.536
DOC_USP7_UBL2_3	474	478	PF12436	0.584
DOC_WW_Pin1_4	107	112	PF00397	0.576
DOC_WW_Pin1_4	122	127	PF00397	0.520
DOC_WW_Pin1_4	268	273	PF00397	0.649
DOC_WW_Pin1_4	275	280	PF00397	0.555
DOC_WW_Pin1_4	401	406	PF00397	0.681
DOC_WW_Pin1_4	419	424	PF00397	0.513
DOC_WW_Pin1_4	458	463	PF00397	0.628
DOC_WW_Pin1_4	480	485	PF00397	0.587
LIG_14-3-3_CanoR_1	41	47	PF00244	0.546
LIG_14-3-3_CanoR_1	418	423	PF00244	0.686
LIG_14-3-3_CanoR_1	479	484	PF00244	0.622
LIG_14-3-3_CanoR_1	72	81	PF00244	0.599
LIG_Actin_WH2_2	184	201	PF00022	0.503
LIG_BIR_III_4	381	385	PF00653	0.518
LIG_BRCT_BRCA1_1	79	83	PF00533	0.600
LIG_Clathr_ClatBox_1	227	231	PF01394	0.557
LIG_eIF4E_1	306	312	PF01652	0.480
LIG_FHA_1	205	211	PF00498	0.579
LIG_FHA_1	222	228	PF00498	0.578
LIG_FHA_1	338	344	PF00498	0.634
LIG_FHA_1	480	486	PF00498	0.646
LIG_FHA_2	420	426	PF00498	0.662
LIG_FHA_2	43	49	PF00498	0.615
LIG_LIR_Gen_1	363	373	PF02991	0.461
LIG_LIR_Nem_3	363	368	PF02991	0.466
LIG_MYND_1	55	59	PF01753	0.665
LIG_SH2_CRK	365	369	PF00017	0.434
LIG_SH2_CRK	85	89	PF00017	0.623
LIG_SH2_NCK_1	365	369	PF00017	0.434
LIG_SH2_STAT5	314	317	PF00017	0.441
LIG_SH3_3	105	111	PF00018	0.573
LIG_SH3_3	120	126	PF00018	0.543
LIG_SH3_3	255	261	PF00018	0.398
LIG_SH3_3	332	338	PF00018	0.632
LIG_SH3_3	456	462	PF00018	0.667
LIG_SH3_3	481	487	PF00018	0.557
LIG_SH3_CIN85_PxpxPR_1	279	284	PF14604	0.527
LIG_SUMO_SIM_par_1	260	266	PF11976	0.533
LIG_SUMO_SIM_par_1	58	64	PF11976	0.628
MOD_CDC14_SPxK_1	483	486	PF00782	0.570
MOD_CDK_SPK_2	458	463	PF00069	0.558
MOD_CDK_SPxK_1	480	486	PF00069	0.576
MOD_CDK_SPxxK_3	458	465	PF00069	0.561
MOD_CK1_1	110	116	PF00069	0.596
MOD_CK1_1	122	128	PF00069	0.676
MOD_CK1_1	16	22	PF00069	0.600
MOD_CK1_1	250	256	PF00069	0.454
MOD_CK1_1	36	42	PF00069	0.533
MOD_CK1_1	369	375	PF00069	0.597
MOD_CK1_1	441	447	PF00069	0.668
MOD_CK1_1	480	486	PF00069	0.621
MOD_CK2_1	165	171	PF00069	0.452
MOD_CK2_1	42	48	PF00069	0.616
MOD_Cter_Amidation	144	147	PF01082	0.479
MOD_GlcNHglycan	112	115	PF01048	0.567
MOD_GlcNHglycan	128	131	PF01048	0.569
MOD_GlcNHglycan	167	170	PF01048	0.612
MOD_GlcNHglycan	18	21	PF01048	0.608
MOD_GlcNHglycan	200	204	PF01048	0.462
MOD_GlcNHglycan	215	218	PF01048	0.615
MOD_GlcNHglycan	219	222	PF01048	0.623
MOD_GlcNHglycan	240	243	PF01048	0.577
MOD_GlcNHglycan	273	276	PF01048	0.629
MOD_GlcNHglycan	330	333	PF01048	0.673
MOD_GlcNHglycan	41	44	PF01048	0.619
MOD_GlcNHglycan	411	414	PF01048	0.735
MOD_GlcNHglycan	440	443	PF01048	0.670
MOD_GlcNHglycan	455	458	PF01048	0.525
MOD_GlcNHglycan	469	472	PF01048	0.748
MOD_GlcNHglycan	63	66	PF01048	0.706
MOD_GlcNHglycan	74	77	PF01048	0.580
MOD_GlcNHglycan	88	91	PF01048	0.517
MOD_GlcNHglycan	96	99	PF01048	0.588
MOD_GSK3_1	117	124	PF00069	0.703
MOD_GSK3_1	213	220	PF00069	0.711
MOD_GSK3_1	250	257	PF00069	0.451
MOD_GSK3_1	271	278	PF00069	0.646
MOD_GSK3_1	392	399	PF00069	0.561
MOD_GSK3_1	414	421	PF00069	0.706
MOD_GSK3_1	42	49	PF00069	0.565
MOD_GSK3_1	473	480	PF00069	0.699
MOD_GSK3_1	68	75	PF00069	0.565
MOD_GSK3_1	9	16	PF00069	0.613
MOD_N-GLC_2	99	101	PF02516	0.624
MOD_NEK2_1	1	6	PF00069	0.546
MOD_NEK2_1	305	310	PF00069	0.523
MOD_NEK2_1	68	73	PF00069	0.596
MOD_NEK2_1	9	14	PF00069	0.497
MOD_NEK2_2	254	259	PF00069	0.368
MOD_PIKK_1	403	409	PF00454	0.634
MOD_PK_1	13	19	PF00069	0.605
MOD_PKA_1	472	478	PF00069	0.649
MOD_PKA_1	72	78	PF00069	0.615
MOD_PKA_1	86	92	PF00069	0.559
MOD_PKA_2	157	163	PF00069	0.513
MOD_PKA_2	238	244	PF00069	0.623
MOD_PKA_2	478	484	PF00069	0.617
MOD_PKA_2	72	78	PF00069	0.556
MOD_PKA_2	86	92	PF00069	0.626
MOD_PKB_1	92	100	PF00069	0.553
MOD_Plk_4	247	253	PF00069	0.532
MOD_Plk_4	42	48	PF00069	0.546
MOD_ProDKin_1	107	113	PF00069	0.577
MOD_ProDKin_1	122	128	PF00069	0.520
MOD_ProDKin_1	268	274	PF00069	0.650
MOD_ProDKin_1	275	281	PF00069	0.547
MOD_ProDKin_1	401	407	PF00069	0.683
MOD_ProDKin_1	419	425	PF00069	0.513
MOD_ProDKin_1	458	464	PF00069	0.629
MOD_ProDKin_1	480	486	PF00069	0.586
TRG_DiLeu_BaLyEn_6	339	344	PF01217	0.582
TRG_ENDOCYTIC_2	365	368	PF00928	0.438
TRG_ER_diArg_1	298	300	PF00400	0.459
TRG_ER_diArg_1	54	57	PF00400	0.578
TRG_ER_diArg_1	72	74	PF00400	0.476
TRG_ER_diArg_1	85	87	PF00400	0.528
TRG_ER_diArg_1	91	94	PF00400	0.462
TRG_Pf-PMV_PEXEL_1	147	151	PF00026	0.479
TRG_Pf-PMV_PEXEL_1	196	200	PF00026	0.576

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HS86	Leptomonas seymouri	50%	100%
A4H395	Leishmania braziliensis	72%	100%
A4HRK3	Leishmania infantum	100%	100%
E9AC71	Leishmania major	91%	100%
E9AJG6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%