DNA-damage inducible protein DDI1-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DNA-damage inducible protein DDI1-like protein

Species:

Leishmania donovani

UniProt:

A0A3S7WNK4_LEIDO

TriTrypDb:

LdBPK_010630.1 , LdCL_010011300 , LDHU3_01.0710

Length:

243

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WNK4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WNK4

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	5
GO:0006807	nitrogen compound metabolic process	2	5
GO:0008152	metabolic process	1	5
GO:0019538	protein metabolic process	3	5
GO:0043170	macromolecule metabolic process	3	5
GO:0044238	primary metabolic process	2	5
GO:0071704	organic substance metabolic process	2	5
GO:1901564	organonitrogen compound metabolic process	3	5

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	5
GO:0004175	endopeptidase activity	4	5
GO:0004190	aspartic-type endopeptidase activity	5	5
GO:0008233	peptidase activity	3	5
GO:0016787	hydrolase activity	2	5
GO:0070001	aspartic-type peptidase activity	4	5
GO:0140096	catalytic activity, acting on a protein	2	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	10	12	PF00675	0.488
CLV_NRD_NRD_1	134	136	PF00675	0.279
CLV_PCSK_KEX2_1	10	12	PF00082	0.488
CLV_PCSK_KEX2_1	134	136	PF00082	0.308
CLV_PCSK_KEX2_1	68	70	PF00082	0.316
CLV_PCSK_PC1ET2_1	68	70	PF00082	0.308
DEG_APCC_DBOX_1	72	80	PF00400	0.508
DEG_Nend_UBRbox_2	1	3	PF02207	0.635
DEG_SCF_TRCP1_1	58	64	PF00400	0.508
DOC_CDC14_PxL_1	192	200	PF14671	0.508
DOC_MAPK_gen_1	134	142	PF00069	0.508
DOC_MAPK_gen_1	203	213	PF00069	0.367
DOC_MAPK_gen_1	83	91	PF00069	0.508
DOC_MAPK_MEF2A_6	134	142	PF00069	0.508
DOC_MAPK_MEF2A_6	83	91	PF00069	0.508
DOC_PP2B_LxvP_1	42	45	PF13499	0.508
DOC_USP7_MATH_1	61	65	PF00917	0.508
DOC_WW_Pin1_4	100	105	PF00397	0.508
DOC_WW_Pin1_4	29	34	PF00397	0.508
LIG_CtBP_PxDLS_1	104	108	PF00389	0.508
LIG_FHA_2	164	170	PF00498	0.532
LIG_LIR_Gen_1	208	216	PF02991	0.367
LIG_LIR_Gen_1	34	44	PF02991	0.508
LIG_LIR_Nem_3	208	213	PF02991	0.367
LIG_LIR_Nem_3	34	39	PF02991	0.508
LIG_PCNA_yPIPBox_3	203	211	PF02747	0.367
LIG_SH2_CRK	13	17	PF00017	0.577
LIG_SH2_NCK_1	13	17	PF00017	0.577
LIG_SH2_STAT5	111	114	PF00017	0.508
LIG_SH2_STAT5	117	120	PF00017	0.464
LIG_SH2_STAT5	31	34	PF00017	0.527
LIG_SH2_STAT5	43	46	PF00017	0.475
LIG_SH3_3	152	158	PF00018	0.459
LIG_SH3_3	190	196	PF00018	0.638
LIG_UBA3_1	138	143	PF00899	0.461
LIG_WRC_WIRS_1	210	215	PF05994	0.326
MOD_CK1_1	214	220	PF00069	0.367
MOD_CK2_1	196	202	PF00069	0.548
MOD_GlcNHglycan	213	216	PF01048	0.367
MOD_GlcNHglycan	58	61	PF01048	0.308
MOD_NEK2_1	211	216	PF00069	0.367
MOD_NEK2_1	56	61	PF00069	0.508
MOD_PIKK_1	217	223	PF00454	0.326
MOD_Plk_4	61	67	PF00069	0.508
MOD_ProDKin_1	100	106	PF00069	0.508
MOD_ProDKin_1	29	35	PF00069	0.508
TRG_DiLeu_BaEn_1	72	77	PF01217	0.508
TRG_ENDOCYTIC_2	111	114	PF00928	0.508
TRG_ENDOCYTIC_2	13	16	PF00928	0.579
TRG_ER_diArg_1	10	12	PF00400	0.488
TRG_ER_diArg_1	133	135	PF00400	0.479
TRG_ER_diArg_1	82	85	PF00400	0.571
TRG_Pf-PMV_PEXEL_1	4	9	PF00026	0.454

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HRI4	Leishmania infantum	99%	100%
E9AC52	Leishmania major	95%	100%
E9AJE8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q10256	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	38%	73%