Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H831_LEIDO

TriTrypDb:

LdBPK_363390.1 , LdCL_360040700 , LDHU3_36.4650

Length:

307

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Show entries

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0016020	membrane	2	11
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	12

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Expansion

Sequence features

A0A3S5H831

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H831

Putative motif mimicry

Show entries


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	140	142	PF00675	0.568
CLV_NRD_NRD_1	226	228	PF00675	0.458
CLV_NRD_NRD_1	249	251	PF00675	0.362
CLV_PCSK_KEX2_1	140	142	PF00082	0.570
CLV_PCSK_KEX2_1	180	182	PF00082	0.408
CLV_PCSK_KEX2_1	226	228	PF00082	0.421
CLV_PCSK_PC1ET2_1	180	182	PF00082	0.380
CLV_PCSK_SKI1_1	180	184	PF00082	0.337
CLV_PCSK_SKI1_1	226	230	PF00082	0.470
CLV_PCSK_SKI1_1	303	307	PF00082	0.529

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P459	Leptomonas seymouri	81%	100%
A0A0S4JIL7	Bodo saltans	49%	100%
A0A1X0P3F8	Trypanosomatidae	60%	100%
A0A3R7NG42	Trypanosoma rangeli	60%	100%
A4HPJ0	Leishmania braziliensis	88%	100%
A4ID73	Leishmania infantum	100%	100%
D0A8F4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	100%
E9ATA2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
Q4Q195	Leishmania major	96%	100%
V5BIN2	Trypanosoma cruzi	56%	100%

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