MCM2/3/5 family, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H829_LEIDO

TriTrypDb:

LdBPK_363050.1 , LdCL_360036900 , LDHU3_36.4210

Length:

904

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

A0A3S5H829

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H829

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	3
GO:0009987	cellular process	1	3
GO:0016043	cellular component organization	3	3
GO:0032392	DNA geometric change	7	3
GO:0032508	DNA duplex unwinding	8	3
GO:0051276	chromosome organization	5	3
GO:0071103	DNA conformation change	6	3
GO:0071840	cellular component organization or biogenesis	2	3

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	3
GO:0003676	nucleic acid binding	3	3
GO:0003677	DNA binding	4	3
GO:0005488	binding	1	3
GO:0005524	ATP binding	5	3
GO:0017076	purine nucleotide binding	4	3
GO:0030554	adenyl nucleotide binding	5	3
GO:0032553	ribonucleotide binding	3	3
GO:0032555	purine ribonucleotide binding	4	3
GO:0032559	adenyl ribonucleotide binding	5	3
GO:0035639	purine ribonucleoside triphosphate binding	4	3
GO:0036094	small molecule binding	2	3
GO:0043167	ion binding	2	3
GO:0043168	anion binding	3	3
GO:0097159	organic cyclic compound binding	2	3
GO:0097367	carbohydrate derivative binding	2	3
GO:1901265	nucleoside phosphate binding	3	3
GO:1901363	heterocyclic compound binding	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	217	219	PF00675	0.642
CLV_NRD_NRD_1	256	258	PF00675	0.578
CLV_NRD_NRD_1	33	35	PF00675	0.550
CLV_NRD_NRD_1	357	359	PF00675	0.389
CLV_NRD_NRD_1	453	455	PF00675	0.669
CLV_NRD_NRD_1	605	607	PF00675	0.559
CLV_NRD_NRD_1	626	628	PF00675	0.715
CLV_NRD_NRD_1	751	753	PF00675	0.616
CLV_NRD_NRD_1	896	898	PF00675	0.581
CLV_PCSK_KEX2_1	217	219	PF00082	0.642
CLV_PCSK_KEX2_1	256	258	PF00082	0.578
CLV_PCSK_KEX2_1	33	35	PF00082	0.550
CLV_PCSK_KEX2_1	357	359	PF00082	0.389
CLV_PCSK_KEX2_1	453	455	PF00082	0.711
CLV_PCSK_KEX2_1	605	607	PF00082	0.559
CLV_PCSK_KEX2_1	626	628	PF00082	0.715
CLV_PCSK_KEX2_1	751	753	PF00082	0.616
CLV_PCSK_KEX2_1	835	837	PF00082	0.531
CLV_PCSK_KEX2_1	896	898	PF00082	0.581
CLV_PCSK_PC1ET2_1	835	837	PF00082	0.558
CLV_PCSK_PC7_1	622	628	PF00082	0.513
CLV_PCSK_SKI1_1	186	190	PF00082	0.619
CLV_PCSK_SKI1_1	26	30	PF00082	0.469
CLV_PCSK_SKI1_1	321	325	PF00082	0.699
CLV_PCSK_SKI1_1	335	339	PF00082	0.611
CLV_PCSK_SKI1_1	370	374	PF00082	0.301
CLV_PCSK_SKI1_1	409	413	PF00082	0.290
CLV_PCSK_SKI1_1	712	716	PF00082	0.491
CLV_PCSK_SKI1_1	838	842	PF00082	0.546
CLV_Separin_Metazoa	719	723	PF03568	0.568
CLV_Separin_Metazoa	766	770	PF03568	0.675
DEG_APCC_DBOX_1	217	225	PF00400	0.592
DEG_APCC_DBOX_1	393	401	PF00400	0.507
DEG_APCC_DBOX_1	835	843	PF00400	0.560
DOC_CDC14_PxL_1	221	229	PF14671	0.655
DOC_CDC14_PxL_1	6	14	PF14671	0.489
DOC_CKS1_1	48	53	PF01111	0.572
DOC_CKS1_1	829	834	PF01111	0.594
DOC_CYCLIN_RxL_1	180	191	PF00134	0.616
DOC_CYCLIN_RxL_1	709	719	PF00134	0.586
DOC_MAPK_FxFP_2	7	10	PF00069	0.485
DOC_MAPK_gen_1	21	29	PF00069	0.455
DOC_MAPK_gen_1	217	226	PF00069	0.588
DOC_MAPK_gen_1	834	842	PF00069	0.483
DOC_MAPK_MEF2A_6	173	181	PF00069	0.534
DOC_MAPK_MEF2A_6	273	281	PF00069	0.496
DOC_MAPK_MEF2A_6	370	378	PF00069	0.492
DOC_MAPK_MEF2A_6	394	401	PF00069	0.514
DOC_MAPK_NFAT4_5	370	378	PF00069	0.490
DOC_MAPK_RevD_3	883	897	PF00069	0.517
DOC_PP1_RVXF_1	166	172	PF00149	0.601
DOC_PP1_RVXF_1	24	30	PF00149	0.467
DOC_PP1_RVXF_1	836	842	PF00149	0.551
DOC_PP2B_LxvP_1	669	672	PF13499	0.755
DOC_PP2B_LxvP_1	851	854	PF13499	0.466
DOC_PP4_FxxP_1	139	142	PF00568	0.611
DOC_PP4_FxxP_1	7	10	PF00568	0.485
DOC_PP4_FxxP_1	877	880	PF00568	0.582
DOC_USP7_MATH_1	127	131	PF00917	0.540
DOC_USP7_MATH_1	13	17	PF00917	0.504
DOC_USP7_MATH_1	159	163	PF00917	0.745
DOC_USP7_MATH_1	308	312	PF00917	0.666
DOC_USP7_MATH_1	389	393	PF00917	0.573
DOC_USP7_MATH_1	441	445	PF00917	0.669
DOC_USP7_MATH_1	547	551	PF00917	0.613
DOC_USP7_MATH_1	567	571	PF00917	0.382
DOC_USP7_MATH_1	590	594	PF00917	0.779
DOC_USP7_MATH_1	597	601	PF00917	0.764
DOC_USP7_MATH_1	661	665	PF00917	0.625
DOC_USP7_MATH_1	687	691	PF00917	0.679
DOC_USP7_MATH_1	758	762	PF00917	0.733
DOC_USP7_MATH_1	816	820	PF00917	0.773
DOC_USP7_UBL2_3	830	834	PF12436	0.531
DOC_WW_Pin1_4	133	138	PF00397	0.545
DOC_WW_Pin1_4	47	52	PF00397	0.514
DOC_WW_Pin1_4	586	591	PF00397	0.681
DOC_WW_Pin1_4	828	833	PF00397	0.618
DOC_WW_Pin1_4	94	99	PF00397	0.526
LIG_14-3-3_CanoR_1	15	23	PF00244	0.484
LIG_14-3-3_CanoR_1	453	459	PF00244	0.648
LIG_14-3-3_CanoR_1	573	579	PF00244	0.693
LIG_14-3-3_CanoR_1	615	623	PF00244	0.723
LIG_14-3-3_CanoR_1	751	759	PF00244	0.638
LIG_14-3-3_CanoR_1	769	774	PF00244	0.452
LIG_14-3-3_CanoR_1	848	854	PF00244	0.548
LIG_BIR_III_4	779	783	PF00653	0.619
LIG_BRCT_BRCA1_1	135	139	PF00533	0.508
LIG_BRCT_BRCA1_1	166	170	PF00533	0.529
LIG_BRCT_BRCA1_1	774	778	PF00533	0.651
LIG_BRCT_BRCA1_1	873	877	PF00533	0.522
LIG_Clathr_ClatBox_1	419	423	PF01394	0.527
LIG_Clathr_ClatBox_1	839	843	PF01394	0.552
LIG_CSL_BTD_1	825	828	PF09270	0.693
LIG_deltaCOP1_diTrp_1	104	111	PF00928	0.586
LIG_EVH1_2	795	799	PF00568	0.524
LIG_FHA_1	141	147	PF00498	0.544
LIG_FHA_1	183	189	PF00498	0.561
LIG_FHA_1	245	251	PF00498	0.462
LIG_FHA_1	466	472	PF00498	0.505
LIG_FHA_1	546	552	PF00498	0.501
LIG_FHA_2	189	195	PF00498	0.578
LIG_FHA_2	615	621	PF00498	0.714
LIG_FHA_2	99	105	PF00498	0.596
LIG_LIR_Apic_2	136	142	PF02991	0.602
LIG_LIR_Apic_2	874	880	PF02991	0.585
LIG_LIR_Nem_3	116	121	PF02991	0.495
LIG_LIR_Nem_3	62	68	PF02991	0.489
LIG_LIR_Nem_3	732	738	PF02991	0.517
LIG_LIR_Nem_3	865	871	PF02991	0.540
LIG_LYPXL_S_1	8	12	PF13949	0.480
LIG_LYPXL_yS_3	9	12	PF13949	0.522
LIG_MLH1_MIPbox_1	774	778	PF16413	0.656
LIG_NRBOX	118	124	PF00104	0.449
LIG_NRBOX	84	90	PF00104	0.494
LIG_NRBOX	866	872	PF00104	0.608
LIG_Pex14_1	773	777	PF04695	0.614
LIG_Rb_LxCxE_1	311	331	PF01857	0.609
LIG_RPA_C_Fungi	252	264	PF08784	0.542
LIG_SH2_NCK_1	286	290	PF00017	0.473
LIG_SH2_NCK_1	347	351	PF00017	0.416
LIG_SH2_NCK_1	68	72	PF00017	0.528
LIG_SH2_STAP1	644	648	PF00017	0.595
LIG_SH2_STAT5	118	121	PF00017	0.416
LIG_SH2_STAT5	251	254	PF00017	0.435
LIG_SH2_STAT5	286	289	PF00017	0.513
LIG_SH2_STAT5	379	382	PF00017	0.426
LIG_SH2_STAT5	538	541	PF00017	0.618
LIG_SH2_STAT5	6	9	PF00017	0.615
LIG_SH2_STAT5	623	626	PF00017	0.710
LIG_SH3_2	10	15	PF14604	0.516
LIG_SH3_3	238	244	PF00018	0.571
LIG_SH3_3	7	13	PF00018	0.503
LIG_SUMO_SIM_anti_2	371	377	PF11976	0.238
LIG_SUMO_SIM_anti_2	87	94	PF11976	0.577
LIG_SUMO_SIM_anti_2	879	886	PF11976	0.550
LIG_SUMO_SIM_par_1	467	472	PF11976	0.546
LIG_SUMO_SIM_par_1	694	700	PF11976	0.632
LIG_TRAF2_1	525	528	PF00917	0.604
LIG_TRFH_1	6	10	PF08558	0.523
MOD_CDK_SPxK_1	828	834	PF00069	0.607
MOD_CDK_SPxxK_3	828	835	PF00069	0.601
MOD_CK1_1	130	136	PF00069	0.519
MOD_CK1_1	444	450	PF00069	0.601
MOD_CK1_1	462	468	PF00069	0.436
MOD_CK1_1	47	53	PF00069	0.484
MOD_CK1_1	569	575	PF00069	0.621
MOD_CK1_1	580	586	PF00069	0.662
MOD_CK1_1	595	601	PF00069	0.699
MOD_CK1_1	610	616	PF00069	0.754
MOD_CK1_1	636	642	PF00069	0.644
MOD_CK1_1	685	691	PF00069	0.622
MOD_CK1_1	753	759	PF00069	0.701
MOD_CK1_1	772	778	PF00069	0.434
MOD_CK1_1	797	803	PF00069	0.742
MOD_CK1_1	94	100	PF00069	0.368
MOD_CK2_1	188	194	PF00069	0.596
MOD_CK2_1	285	291	PF00069	0.452
MOD_CK2_1	312	318	PF00069	0.630
MOD_CK2_1	382	388	PF00069	0.243
MOD_CK2_1	815	821	PF00069	0.682
MOD_CK2_1	859	865	PF00069	0.561
MOD_Cter_Amidation	31	34	PF01082	0.541
MOD_GlcNHglycan	104	109	PF01048	0.525
MOD_GlcNHglycan	129	132	PF01048	0.558
MOD_GlcNHglycan	161	164	PF01048	0.694
MOD_GlcNHglycan	287	290	PF01048	0.482
MOD_GlcNHglycan	310	313	PF01048	0.652
MOD_GlcNHglycan	409	412	PF01048	0.354
MOD_GlcNHglycan	436	439	PF01048	0.644
MOD_GlcNHglycan	446	449	PF01048	0.455
MOD_GlcNHglycan	454	457	PF01048	0.564
MOD_GlcNHglycan	461	464	PF01048	0.426
MOD_GlcNHglycan	527	531	PF01048	0.548
MOD_GlcNHglycan	585	588	PF01048	0.734
MOD_GlcNHglycan	594	597	PF01048	0.651
MOD_GlcNHglycan	608	612	PF01048	0.633
MOD_GlcNHglycan	672	675	PF01048	0.694
MOD_GlcNHglycan	684	687	PF01048	0.583
MOD_GlcNHglycan	69	72	PF01048	0.527
MOD_GlcNHglycan	755	758	PF01048	0.710
MOD_GlcNHglycan	799	802	PF01048	0.707
MOD_GlcNHglycan	851	854	PF01048	0.652
MOD_GlcNHglycan	874	877	PF01048	0.494
MOD_GlcNHglycan	93	96	PF01048	0.518
MOD_GSK3_1	13	20	PF00069	0.491
MOD_GSK3_1	155	162	PF00069	0.560
MOD_GSK3_1	188	195	PF00069	0.540
MOD_GSK3_1	308	315	PF00069	0.510
MOD_GSK3_1	427	434	PF00069	0.548
MOD_GSK3_1	43	50	PF00069	0.605
MOD_GSK3_1	547	554	PF00069	0.536
MOD_GSK3_1	562	569	PF00069	0.502
MOD_GSK3_1	573	580	PF00069	0.622
MOD_GSK3_1	586	593	PF00069	0.699
MOD_GSK3_1	595	602	PF00069	0.673
MOD_GSK3_1	610	617	PF00069	0.700
MOD_GSK3_1	632	639	PF00069	0.480
MOD_GSK3_1	768	775	PF00069	0.726
MOD_GSK3_1	94	101	PF00069	0.576
MOD_LATS_1	571	577	PF00433	0.766
MOD_NEK2_1	188	193	PF00069	0.555
MOD_NEK2_1	284	289	PF00069	0.505
MOD_NEK2_1	427	432	PF00069	0.578
MOD_NEK2_1	452	457	PF00069	0.641
MOD_NEK2_1	459	464	PF00069	0.553
MOD_NEK2_1	551	556	PF00069	0.578
MOD_NEK2_1	585	590	PF00069	0.733
MOD_NEK2_1	633	638	PF00069	0.616
MOD_NEK2_1	768	773	PF00069	0.688
MOD_NEK2_1	871	876	PF00069	0.533
MOD_NEK2_1	91	96	PF00069	0.499
MOD_NEK2_2	687	692	PF00069	0.683
MOD_NEK2_2	773	778	PF00069	0.615
MOD_PIKK_1	130	136	PF00454	0.565
MOD_PIKK_1	192	198	PF00454	0.605
MOD_PIKK_1	228	234	PF00454	0.563
MOD_PIKK_1	555	561	PF00454	0.553
MOD_PIKK_1	580	586	PF00454	0.778
MOD_PIKK_1	590	596	PF00454	0.789
MOD_PIKK_1	597	603	PF00454	0.753
MOD_PIKK_1	883	889	PF00454	0.594
MOD_PKA_2	14	20	PF00069	0.486
MOD_PKA_2	32	38	PF00069	0.425
MOD_PKA_2	452	458	PF00069	0.664
MOD_PKA_2	567	573	PF00069	0.658
MOD_PKA_2	580	586	PF00069	0.676
MOD_PKA_2	614	620	PF00069	0.718
MOD_PKA_2	750	756	PF00069	0.622
MOD_PKA_2	768	774	PF00069	0.549
MOD_PKA_2	797	803	PF00069	0.774
MOD_PKA_2	849	855	PF00069	0.603
MOD_Plk_1	38	44	PF00069	0.746
MOD_Plk_1	427	433	PF00069	0.597
MOD_Plk_1	551	557	PF00069	0.622
MOD_Plk_4	427	433	PF00069	0.534
MOD_Plk_4	465	471	PF00069	0.524
MOD_Plk_4	517	523	PF00069	0.615
MOD_Plk_4	633	639	PF00069	0.596
MOD_Plk_4	773	779	PF00069	0.658
MOD_ProDKin_1	133	139	PF00069	0.543
MOD_ProDKin_1	47	53	PF00069	0.511
MOD_ProDKin_1	586	592	PF00069	0.681
MOD_ProDKin_1	828	834	PF00069	0.607
MOD_ProDKin_1	94	100	PF00069	0.530
TRG_DiLeu_BaEn_1	371	376	PF01217	0.243
TRG_DiLeu_BaEn_1	415	420	PF01217	0.462
TRG_DiLeu_BaEn_1	716	721	PF01217	0.477
TRG_DiLeu_BaEn_1	87	92	PF01217	0.574
TRG_DiLeu_BaEn_1	890	895	PF01217	0.615
TRG_DiLeu_BaEn_4	890	896	PF01217	0.581
TRG_DiLeu_BaLyEn_6	222	227	PF01217	0.711
TRG_DiLeu_BaLyEn_6	483	488	PF01217	0.629
TRG_ENDOCYTIC_2	251	254	PF00928	0.490
TRG_ENDOCYTIC_2	538	541	PF00928	0.618
TRG_ENDOCYTIC_2	644	647	PF00928	0.684
TRG_ENDOCYTIC_2	9	12	PF00928	0.622
TRG_ER_diArg_1	217	220	PF00400	0.599
TRG_ER_diArg_1	357	359	PF00400	0.483
TRG_ER_diArg_1	452	454	PF00400	0.676
TRG_ER_diArg_1	605	607	PF00400	0.559
TRG_ER_diArg_1	625	627	PF00400	0.587
TRG_ER_diArg_1	710	713	PF00400	0.394
TRG_ER_diArg_1	836	839	PF00400	0.565
TRG_ER_diArg_1	845	848	PF00400	0.559
TRG_ER_diArg_1	895	897	PF00400	0.551
TRG_NLS_MonoExtC_3	833	838	PF00514	0.575
TRG_NLS_MonoExtN_4	832	839	PF00514	0.584
TRG_Pf-PMV_PEXEL_1	124	129	PF00026	0.507
TRG_Pf-PMV_PEXEL_1	712	716	PF00026	0.498

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P797	Leptomonas seymouri	46%	100%
A0A1X0NKL2	Trypanosomatidae	25%	100%
A0A3R7LZS8	Trypanosoma rangeli	27%	100%
A4HPF6	Leishmania braziliensis	75%	100%
A4ID78	Leishmania infantum	99%	100%
E9AT68	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q1C9	Leishmania major	89%	100%
V5B0C2	Trypanosoma cruzi	26%	100%