Metallo-peptidase_Clan_MA(E)_Family_M41/GeneDB:Lm jF.36.2710

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mitochondrial ATP-dependent zinc metallopeptidase, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H828_LEIDO

TriTrypDb:

LdBPK_362850.1 , LdCL_360034900 , LDHU3_36.3950

Length:

571

Annotations

LeishMANIAdb annotations

A large and likely artifical grouping of protease domain carrying proteins related to proteasomal proteases. Only a tiny subgroup (the AFG3-related mitochondrail proteins) seem to have a TM segment.. Localization: Cytoplasmic (by homology) / Mitochondrial (by homology)

Annotations by Jardim et al.

Metal Binding, Mitochondrial ATP-dependent zinc metallopeptidase

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0009534	chloroplast thylakoid	7	1
GO:0009579	thylakoid	5	1
GO:0016020	membrane	2	12
GO:0031976	plastid thylakoid	6	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	12

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Expansion

Sequence features

A0A3S5H828

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H828

Function

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Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0019538	protein metabolic process	3	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044238	primary metabolic process	2	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	12
GO:0004175	endopeptidase activity	4	12
GO:0004176	ATP-dependent peptidase activity	2	12
GO:0004222	metalloendopeptidase activity	5	12
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0008233	peptidase activity	3	12
GO:0008237	metallopeptidase activity	4	12
GO:0016462	pyrophosphatase activity	5	12

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	198	202	PF00656	0.398
CLV_MEL_PAP_1	416	422	PF00089	0.209
CLV_NRD_NRD_1	178	180	PF00675	0.198
CLV_NRD_NRD_1	206	208	PF00675	0.302
CLV_NRD_NRD_1	351	353	PF00675	0.209
CLV_NRD_NRD_1	565	567	PF00675	0.451
CLV_PCSK_KEX2_1	178	180	PF00082	0.198
CLV_PCSK_KEX2_1	206	208	PF00082	0.198
CLV_PCSK_KEX2_1	351	353	PF00082	0.209
CLV_PCSK_KEX2_1	405	407	PF00082	0.256

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8A5	Leptomonas seymouri	38%	96%
A0A0N1HUW7	Leptomonas seymouri	87%	89%
A0A0N1I6C1	Leptomonas seymouri	40%	73%
A0A0N1IMN9	Leptomonas seymouri	34%	81%
A0A0N1PBB9	Leptomonas seymouri	37%	97%
A0A0S4J3N2	Bodo saltans	36%	89%
A0A0S4J9Q2	Bodo saltans	66%	85%
A0A0S4JAH0	Bodo saltans	35%	98%
A0A0S4JGG9	Bodo saltans	34%	85%
A0A0S4KHE9	Bodo saltans	39%	71%

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