Membrane-bound acid phosphatase

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

membrane-bound acid phosphatase precursor

Species:

Leishmania donovani

UniProt:

A0A3S5H827_LEIDO

TriTrypDb:

LdBPK_362700.1 , LdCL_360033400 , LDHU3_36.3720

Length:

514

Annotations

LeishMANIAdb annotations

An extensively expanded family of exophosphatase enzymes presumed to be active at acidic pH

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 1
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 65

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 7

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 14

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 34, no: 4
NetGPI	no	yes: 0, no: 38

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	27
GO:0110165	cellular anatomical entity	1	27

Expansion

Sequence features

A0A3S5H827

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H827

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	5
GO:0006796	phosphate-containing compound metabolic process	4	5
GO:0008152	metabolic process	1	5
GO:0009987	cellular process	1	5
GO:0016311	dephosphorylation	5	5
GO:0044237	cellular metabolic process	2	5

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	6
GO:0003993	acid phosphatase activity	6	1
GO:0016787	hydrolase activity	2	6
GO:0016788	hydrolase activity, acting on ester bonds	3	6
GO:0016791	phosphatase activity	5	6
GO:0042578	phosphoric ester hydrolase activity	4	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	306	310	PF00656	0.257
CLV_C14_Caspase3-7	329	333	PF00656	0.412
CLV_NRD_NRD_1	2	4	PF00675	0.627
CLV_NRD_NRD_1	434	436	PF00675	0.493
CLV_PCSK_KEX2_1	2	4	PF00082	0.650
CLV_PCSK_KEX2_1	499	501	PF00082	0.380
CLV_PCSK_PC1ET2_1	499	501	PF00082	0.434
CLV_PCSK_SKI1_1	125	129	PF00082	0.515
CLV_PCSK_SKI1_1	369	373	PF00082	0.552
CLV_PCSK_SKI1_1	502	506	PF00082	0.380
DEG_MDM2_SWIB_1	96	103	PF02201	0.183
DEG_Nend_UBRbox_1	1	4	PF02207	0.554
DOC_CDC14_PxL_1	224	232	PF14671	0.418
DOC_CYCLIN_RxL_1	122	132	PF00134	0.295
DOC_MAPK_gen_1	505	514	PF00069	0.635
DOC_MAPK_MEF2A_6	10	19	PF00069	0.603
DOC_PP1_RVXF_1	1	8	PF00149	0.471
DOC_PP2B_LxvP_1	25	28	PF13499	0.486
DOC_PP4_MxPP_1	315	318	PF00568	0.341
DOC_SPAK_OSR1_1	339	343	PF12202	0.213
DOC_USP7_MATH_1	129	133	PF00917	0.349
DOC_USP7_MATH_1	242	246	PF00917	0.323
DOC_USP7_MATH_1	334	338	PF00917	0.415
DOC_USP7_MATH_1	461	465	PF00917	0.481
DOC_USP7_MATH_1	470	474	PF00917	0.473
DOC_USP7_UBL2_3	499	503	PF12436	0.603
DOC_WW_Pin1_4	298	303	PF00397	0.288
DOC_WW_Pin1_4	396	401	PF00397	0.304
DOC_WW_Pin1_4	42	47	PF00397	0.259
DOC_WW_Pin1_4	466	471	PF00397	0.535
LIG_14-3-3_CanoR_1	109	117	PF00244	0.299
LIG_14-3-3_CanoR_1	390	400	PF00244	0.309
LIG_14-3-3_CanoR_1	81	91	PF00244	0.389
LIG_APCC_ABBA_1	382	387	PF00400	0.351
LIG_BIR_III_4	370	374	PF00653	0.419
LIG_BIR_III_4	419	423	PF00653	0.342
LIG_BRCT_BRCA1_1	131	135	PF00533	0.292
LIG_BRCT_BRCA1_1	193	197	PF00533	0.370
LIG_BRCT_BRCA1_1	243	247	PF00533	0.324
LIG_BRCT_BRCA1_1	336	340	PF00533	0.401
LIG_Clathr_ClatBox_1	179	183	PF01394	0.221
LIG_Clathr_ClatBox_1	411	415	PF01394	0.241
LIG_eIF4E_1	266	272	PF01652	0.339
LIG_eIF4E_1	405	411	PF01652	0.217
LIG_FHA_1	109	115	PF00498	0.339
LIG_FHA_1	219	225	PF00498	0.368
LIG_FHA_1	319	325	PF00498	0.312
LIG_FHA_1	356	362	PF00498	0.319
LIG_FHA_1	377	383	PF00498	0.344
LIG_FHA_1	401	407	PF00498	0.334
LIG_FHA_2	384	390	PF00498	0.320
LIG_GBD_Chelix_1	268	276	PF00786	0.498
LIG_LIR_Apic_2	403	408	PF02991	0.312
LIG_LIR_Gen_1	338	345	PF02991	0.384
LIG_LIR_Gen_1	386	396	PF02991	0.278
LIG_LIR_Nem_3	132	138	PF02991	0.325
LIG_LIR_Nem_3	338	344	PF02991	0.385
LIG_LIR_Nem_3	386	391	PF02991	0.296
LIG_LIR_Nem_3	496	501	PF02991	0.497
LIG_LIR_Nem_3	92	98	PF02991	0.372
LIG_LIR_Nem_3	99	103	PF02991	0.336
LIG_MLH1_MIPbox_1	131	135	PF16413	0.347
LIG_NRBOX	267	273	PF00104	0.296
LIG_PCNA_yPIPBox_3	115	128	PF02747	0.226
LIG_PDZ_Class_2	509	514	PF00595	0.541
LIG_Pex14_2	319	323	PF04695	0.255
LIG_Pex14_2	60	64	PF04695	0.222
LIG_Pex14_2	96	100	PF04695	0.395
LIG_SH2_CRK	501	505	PF00017	0.633
LIG_SH2_CRK	9	13	PF00017	0.523
LIG_SH2_PTP2	341	344	PF00017	0.367
LIG_SH2_SRC	291	294	PF00017	0.302
LIG_SH2_SRC	405	408	PF00017	0.304
LIG_SH2_SRC	448	451	PF00017	0.380
LIG_SH2_STAP1	291	295	PF00017	0.345
LIG_SH2_STAT3	67	70	PF00017	0.219
LIG_SH2_STAT5	107	110	PF00017	0.259
LIG_SH2_STAT5	201	204	PF00017	0.353
LIG_SH2_STAT5	341	344	PF00017	0.321
LIG_SH2_STAT5	376	379	PF00017	0.277
LIG_SH2_STAT5	405	408	PF00017	0.282
LIG_SH2_STAT5	448	451	PF00017	0.343
LIG_SH2_STAT5	79	82	PF00017	0.309
LIG_SH2_STAT5	84	87	PF00017	0.307
LIG_SH2_STAT5	95	98	PF00017	0.276
LIG_SH3_3	394	400	PF00018	0.262
LIG_SH3_3	464	470	PF00018	0.478
LIG_SH3_3	88	94	PF00018	0.352
LIG_Sin3_3	269	276	PF02671	0.203
LIG_SUMO_SIM_par_1	301	306	PF11976	0.362
LIG_SUMO_SIM_par_1	323	329	PF11976	0.312
LIG_TRAF2_1	164	167	PF00917	0.375
MOD_CK1_1	355	361	PF00069	0.354
MOD_CK1_1	439	445	PF00069	0.323
MOD_CK1_1	469	475	PF00069	0.458
MOD_CK1_1	506	512	PF00069	0.660
MOD_CK1_1	89	95	PF00069	0.381
MOD_CK2_1	307	313	PF00069	0.217
MOD_CK2_1	383	389	PF00069	0.197
MOD_GlcNHglycan	118	121	PF01048	0.505
MOD_GlcNHglycan	19	22	PF01048	0.614
MOD_GlcNHglycan	292	296	PF01048	0.513
MOD_GlcNHglycan	348	351	PF01048	0.550
MOD_GlcNHglycan	472	475	PF01048	0.669
MOD_GSK3_1	101	108	PF00069	0.275
MOD_GSK3_1	238	245	PF00069	0.294
MOD_GSK3_1	291	298	PF00069	0.295
MOD_GSK3_1	303	310	PF00069	0.281
MOD_GSK3_1	355	362	PF00069	0.347
MOD_GSK3_1	372	379	PF00069	0.287
MOD_GSK3_1	391	398	PF00069	0.263
MOD_GSK3_1	461	468	PF00069	0.454
MOD_GSK3_1	82	89	PF00069	0.373
MOD_N-GLC_1	101	106	PF02516	0.526
MOD_N-GLC_1	129	134	PF02516	0.546
MOD_N-GLC_1	199	204	PF02516	0.579
MOD_N-GLC_1	251	256	PF02516	0.542
MOD_N-GLC_1	355	360	PF02516	0.502
MOD_N-GLC_1	392	397	PF02516	0.455
MOD_N-GLC_1	423	428	PF02516	0.532
MOD_N-GLC_1	439	444	PF02516	0.391
MOD_N-GLC_1	461	466	PF02516	0.742
MOD_N-GLC_1	50	55	PF02516	0.534
MOD_N-GLC_2	381	383	PF02516	0.506
MOD_NEK2_1	103	108	PF00069	0.305
MOD_NEK2_1	148	153	PF00069	0.348
MOD_NEK2_1	271	276	PF00069	0.345
MOD_NEK2_1	303	308	PF00069	0.256
MOD_NEK2_1	359	364	PF00069	0.350
MOD_NEK2_1	391	396	PF00069	0.248
MOD_NEK2_1	96	101	PF00069	0.293
MOD_NEK2_2	199	204	PF00069	0.370
MOD_NEK2_2	400	405	PF00069	0.306
MOD_OFUCOSY	438	443	PF10250	0.516
MOD_PIKK_1	191	197	PF00454	0.226
MOD_PKA_2	108	114	PF00069	0.305
MOD_PKA_2	281	287	PF00069	0.461
MOD_PKA_2	82	88	PF00069	0.375
MOD_Plk_1	101	107	PF00069	0.298
MOD_Plk_1	199	205	PF00069	0.365
MOD_Plk_1	296	302	PF00069	0.293
MOD_Plk_1	308	314	PF00069	0.311
MOD_Plk_1	355	361	PF00069	0.290
MOD_Plk_1	423	429	PF00069	0.367
MOD_Plk_1	462	468	PF00069	0.515
MOD_Plk_1	50	56	PF00069	0.316
MOD_Plk_1	86	92	PF00069	0.347
MOD_Plk_2-3	326	332	PF00069	0.223
MOD_Plk_4	148	154	PF00069	0.320
MOD_Plk_4	372	378	PF00069	0.300
MOD_Plk_4	50	56	PF00069	0.322
MOD_Plk_4	96	102	PF00069	0.337
MOD_ProDKin_1	298	304	PF00069	0.288
MOD_ProDKin_1	396	402	PF00069	0.301
MOD_ProDKin_1	42	48	PF00069	0.260
MOD_ProDKin_1	466	472	PF00069	0.531
MOD_SUMO_for_1	164	167	PF00179	0.227
TRG_DiLeu_BaEn_1	144	149	PF01217	0.318
TRG_DiLeu_BaEn_4	144	150	PF01217	0.188
TRG_DiLeu_BaLyEn_6	267	272	PF01217	0.178
TRG_DiLeu_BaLyEn_6	340	345	PF01217	0.377
TRG_DiLeu_LyEn_5	225	230	PF01217	0.344
TRG_ENDOCYTIC_2	341	344	PF00928	0.367
TRG_ENDOCYTIC_2	501	504	PF00928	0.644
TRG_ENDOCYTIC_2	9	12	PF00928	0.477
TRG_ER_diArg_1	1	3	PF00400	0.568
TRG_ER_diArg_1	157	160	PF00400	0.310
TRG_ER_diArg_1	203	206	PF00400	0.214
TRG_ER_diArg_1	80	83	PF00400	0.338
TRG_NES_CRM1_1	313	326	PF08389	0.298
TRG_NLS_MonoExtC_3	498	503	PF00514	0.504
TRG_NLS_MonoExtN_4	499	506	PF00514	0.506
TRG_Pf-PMV_PEXEL_1	232	236	PF00026	0.544
TRG_Pf-PMV_PEXEL_1	425	430	PF00026	0.597

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5Y5	Leptomonas seymouri	36%	90%
A0A0N1I756	Leptomonas seymouri	65%	99%
A0A0N1PEH4	Leptomonas seymouri	38%	100%
A0A0S4IRF5	Bodo saltans	26%	77%
A0A0S4IUV8	Bodo saltans	26%	100%
A0A0S4IV77	Bodo saltans	34%	99%
A0A0S4JEA9	Bodo saltans	24%	100%
A0A0S4JJK3	Bodo saltans	29%	100%
A0A0S4JW09	Bodo saltans	27%	100%
A0A1X0NNY4	Trypanosomatidae	36%	93%
A0A1X0NQL4	Trypanosomatidae	27%	94%
A0A1X0NY34	Trypanosomatidae	27%	100%
A0A1X0P7V5	Trypanosomatidae	40%	98%
A0A3Q8IR23	Leishmania donovani	38%	100%
A0A3R7KSH4	Trypanosoma rangeli	25%	100%
A0A3R7MEN7	Trypanosoma rangeli	38%	99%
A0A3R7MHJ7	Trypanosoma rangeli	26%	100%
A0A3S7WXU0	Leishmania donovani	39%	97%
A0A3S7X1W4	Leishmania donovani	35%	94%
A4HCZ0	Leishmania braziliensis	39%	100%
A4HGW8	Leishmania braziliensis	36%	100%
A4HPC1	Leishmania braziliensis	70%	100%
A4HPC5	Leishmania braziliensis	38%	100%
A4HQG6	Leishmania braziliensis	39%	100%
A4HQG9	Leishmania braziliensis	38%	100%
A4I0H5	Leishmania infantum	39%	100%
A4I3Z8	Leishmania infantum	35%	100%
A4ICA5	Leishmania infantum	36%	100%
A4ICG3	Leishmania infantum	100%	100%
A4ICG5	Leishmania infantum	38%	100%
B1H1P9	Xenopus laevis	27%	100%
D0A3E0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	97%
D0A947	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	100%
D0A948	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
D0A9J5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	98%
E9AT34	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
E9AT36	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	100%
E9AWD7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	100%
E9B088	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	100%
P11117	Homo sapiens	26%	100%
P24638	Mus musculus	26%	100%
Q0P5F0	Bos taurus	26%	100%
Q4Q0A9	Leishmania major	29%	100%
Q4Q1G2	Leishmania major	38%	100%
Q4Q1G4	Leishmania major	93%	100%
Q4Q7Z7	Leishmania major	34%	100%
Q4QB35	Leishmania major	39%	100%
V5BCI2	Trypanosoma cruzi	27%	100%
V5BK91	Trypanosoma cruzi	39%	100%
V5BL75	Trypanosoma cruzi	28%	100%